Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H751_LEIDO

TriTrypDb:

LdBPK_190250.1 , LdCL_190007500 , LDHU3_19.0290

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3S5H751

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H751

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0005543	phospholipid binding	3	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0008289	lipid binding	2	12
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032182	ubiquitin-like protein binding	3	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035091	phosphatidylinositol binding	4	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043130	ubiquitin binding	4	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.729
CLV_C14_Caspase3-7	571	575	PF00656	0.292
CLV_MEL_PAP_1	251	257	PF00089	0.398
CLV_NRD_NRD_1	278	280	PF00675	0.679
CLV_NRD_NRD_1	304	306	PF00675	0.597
CLV_NRD_NRD_1	428	430	PF00675	0.488
CLV_NRD_NRD_1	472	474	PF00675	0.521
CLV_NRD_NRD_1	484	486	PF00675	0.375
CLV_NRD_NRD_1	489	491	PF00675	0.364
CLV_NRD_NRD_1	50	52	PF00675	0.562
CLV_NRD_NRD_1	618	620	PF00675	0.309
CLV_PCSK_FUR_1	301	305	PF00082	0.706
CLV_PCSK_KEX2_1	277	279	PF00082	0.675
CLV_PCSK_KEX2_1	303	305	PF00082	0.609
CLV_PCSK_KEX2_1	308	310	PF00082	0.600
CLV_PCSK_KEX2_1	484	486	PF00082	0.516
CLV_PCSK_KEX2_1	50	52	PF00082	0.544
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.668
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.702
CLV_PCSK_PC7_1	304	310	PF00082	0.683
CLV_PCSK_SKI1_1	103	107	PF00082	0.391
CLV_PCSK_SKI1_1	155	159	PF00082	0.490
CLV_PCSK_SKI1_1	175	179	PF00082	0.643
CLV_PCSK_SKI1_1	243	247	PF00082	0.603
CLV_PCSK_SKI1_1	305	309	PF00082	0.659
CLV_PCSK_SKI1_1	356	360	PF00082	0.496
CLV_PCSK_SKI1_1	422	426	PF00082	0.584
CLV_PCSK_SKI1_1	433	437	PF00082	0.496
CLV_PCSK_SKI1_1	473	477	PF00082	0.474
CLV_PCSK_SKI1_1	485	489	PF00082	0.423
CLV_PCSK_SKI1_1	511	515	PF00082	0.327
CLV_PCSK_SKI1_1	590	594	PF00082	0.377
CLV_PCSK_SKI1_1	640	644	PF00082	0.292
CLV_PCSK_SKI1_1	833	837	PF00082	0.625
DEG_APCC_DBOX_1	337	345	PF00400	0.516
DEG_APCC_DBOX_1	421	429	PF00400	0.488
DEG_SPOP_SBC_1	108	112	PF00917	0.497
DOC_CDC14_PxL_1	390	398	PF14671	0.684
DOC_CYCLIN_RxL_1	793	804	PF00134	0.308
DOC_MAPK_gen_1	329	337	PF00069	0.530
DOC_MAPK_gen_1	748	755	PF00069	0.401
DOC_MAPK_MEF2A_6	704	713	PF00069	0.292
DOC_MAPK_MEF2A_6	796	803	PF00069	0.327
DOC_MAPK_NFAT4_5	704	712	PF00069	0.292
DOC_PP1_RVXF_1	472	479	PF00149	0.463
DOC_PP1_RVXF_1	794	801	PF00149	0.292
DOC_PP1_RVXF_1	822	829	PF00149	0.438
DOC_USP7_MATH_1	403	407	PF00917	0.682
DOC_USP7_MATH_1	673	677	PF00917	0.323
DOC_USP7_MATH_1	770	774	PF00917	0.360
DOC_USP7_MATH_1	810	814	PF00917	0.306
DOC_USP7_UBL2_3	359	363	PF12436	0.530
DOC_WW_Pin1_4	1	6	PF00397	0.695
DOC_WW_Pin1_4	388	393	PF00397	0.643
DOC_WW_Pin1_4	411	416	PF00397	0.596
DOC_WW_Pin1_4	801	806	PF00397	0.308
LIG_14-3-3_CanoR_1	130	139	PF00244	0.462
LIG_14-3-3_CanoR_1	243	252	PF00244	0.507
LIG_14-3-3_CanoR_1	254	262	PF00244	0.391
LIG_14-3-3_CanoR_1	429	433	PF00244	0.446
LIG_14-3-3_CanoR_1	779	787	PF00244	0.327
LIG_Actin_WH2_2	418	435	PF00022	0.452
LIG_APCC_ABBA_1	632	637	PF00400	0.292
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_4	538	542	PF00653	0.360
LIG_BRCT_BRCA1_1	815	819	PF00533	0.292
LIG_CaM_IQ_9	476	492	PF13499	0.468
LIG_Clathr_ClatBox_1	545	549	PF01394	0.349
LIG_deltaCOP1_diTrp_1	98	105	PF00928	0.445
LIG_eIF4E_1	725	731	PF01652	0.349
LIG_FHA_1	13	19	PF00498	0.633
LIG_FHA_1	156	162	PF00498	0.533
LIG_FHA_1	192	198	PF00498	0.439
LIG_FHA_1	321	327	PF00498	0.523
LIG_FHA_1	330	336	PF00498	0.488
LIG_FHA_1	40	46	PF00498	0.532
LIG_FHA_1	477	483	PF00498	0.466
LIG_FHA_1	563	569	PF00498	0.292
LIG_FHA_1	604	610	PF00498	0.317
LIG_FHA_1	624	630	PF00498	0.109
LIG_FHA_1	651	657	PF00498	0.377
LIG_FHA_1	782	788	PF00498	0.292
LIG_FHA_1	99	105	PF00498	0.436
LIG_FHA_2	110	116	PF00498	0.492
LIG_FHA_2	14	20	PF00498	0.646
LIG_FHA_2	264	270	PF00498	0.461
LIG_FHA_2	287	293	PF00498	0.758
LIG_FHA_2	494	500	PF00498	0.457
LIG_FHA_2	528	534	PF00498	0.443
LIG_FHA_2	595	601	PF00498	0.406
LIG_FHA_2	643	649	PF00498	0.368
LIG_FHA_2	76	82	PF00498	0.424
LIG_LIR_Gen_1	151	161	PF02991	0.435
LIG_LIR_Gen_1	176	183	PF02991	0.630
LIG_LIR_Gen_1	260	270	PF02991	0.457
LIG_LIR_Gen_1	519	529	PF02991	0.303
LIG_LIR_Gen_1	547	556	PF02991	0.292
LIG_LIR_Gen_1	610	618	PF02991	0.278
LIG_LIR_Nem_3	151	156	PF02991	0.435
LIG_LIR_Nem_3	176	180	PF02991	0.635
LIG_LIR_Nem_3	519	525	PF02991	0.393
LIG_LIR_Nem_3	547	551	PF02991	0.292
LIG_LIR_Nem_3	610	616	PF02991	0.308
LIG_NRBOX	782	788	PF00104	0.292
LIG_PCNA_yPIPBox_3	66	80	PF02747	0.522
LIG_Pex14_1	127	131	PF04695	0.382
LIG_Pex14_2	153	157	PF04695	0.524
LIG_PTAP_UEV_1	553	558	PF05743	0.439
LIG_SH2_CRK	494	498	PF00017	0.415
LIG_SH2_CRK	507	511	PF00017	0.292
LIG_SH2_CRK	67	71	PF00017	0.563
LIG_SH2_CRK	725	729	PF00017	0.349
LIG_SH2_GRB2like	493	496	PF00017	0.428
LIG_SH2_NCK_1	494	498	PF00017	0.415
LIG_SH2_NCK_1	67	71	PF00017	0.563
LIG_SH2_PTP2	710	713	PF00017	0.292
LIG_SH2_SRC	710	713	PF00017	0.349
LIG_SH2_STAP1	372	376	PF00017	0.533
LIG_SH2_STAP1	450	454	PF00017	0.482
LIG_SH2_STAP1	522	526	PF00017	0.362
LIG_SH2_STAT3	450	453	PF00017	0.454
LIG_SH2_STAT3	528	531	PF00017	0.439
LIG_SH2_STAT3	635	638	PF00017	0.377
LIG_SH2_STAT5	439	442	PF00017	0.500
LIG_SH2_STAT5	507	510	PF00017	0.340
LIG_SH2_STAT5	635	638	PF00017	0.292
LIG_SH2_STAT5	665	668	PF00017	0.292
LIG_SH2_STAT5	710	713	PF00017	0.292
LIG_SH3_1	509	515	PF00018	0.262
LIG_SH3_3	509	515	PF00018	0.262
LIG_SH3_3	548	554	PF00018	0.297
LIG_SUMO_SIM_anti_2	628	633	PF11976	0.304
LIG_SUMO_SIM_par_1	190	198	PF11976	0.519
LIG_SUMO_SIM_par_1	625	633	PF11976	0.302
LIG_SUMO_SIM_par_1	75	81	PF11976	0.421
LIG_TRAF2_1	319	322	PF00917	0.639
LIG_TRAF2_1	496	499	PF00917	0.454
LIG_TYR_ITIM	708	713	PF00017	0.292
LIG_UBA3_1	156	162	PF00899	0.590
LIG_UBA3_1	612	620	PF00899	0.317
LIG_WRC_WIRS_1	421	426	PF05994	0.584
MOD_CDC14_SPxK_1	4	7	PF00782	0.575
MOD_CDK_SPxK_1	1	7	PF00069	0.586
MOD_CK1_1	388	394	PF00069	0.702
MOD_CK1_1	527	533	PF00069	0.413
MOD_CK1_1	588	594	PF00069	0.290
MOD_CK1_1	625	631	PF00069	0.307
MOD_CK1_1	702	708	PF00069	0.303
MOD_CK1_1	781	787	PF00069	0.304
MOD_CK1_1	804	810	PF00069	0.299
MOD_CK1_1	811	817	PF00069	0.287
MOD_CK2_1	109	115	PF00069	0.526
MOD_CK2_1	13	19	PF00069	0.659
MOD_CK2_1	247	253	PF00069	0.573
MOD_CK2_1	257	263	PF00069	0.390
MOD_CK2_1	428	434	PF00069	0.472
MOD_CK2_1	493	499	PF00069	0.456
MOD_CK2_1	527	533	PF00069	0.325
MOD_CK2_1	594	600	PF00069	0.362
MOD_CK2_1	627	633	PF00069	0.292
MOD_CK2_1	642	648	PF00069	0.292
MOD_CK2_1	739	745	PF00069	0.308
MOD_GlcNHglycan	133	136	PF01048	0.533
MOD_GlcNHglycan	237	240	PF01048	0.520
MOD_GlcNHglycan	405	408	PF01048	0.668
MOD_GlcNHglycan	450	453	PF01048	0.473
MOD_GlcNHglycan	538	542	PF01048	0.377
MOD_GlcNHglycan	587	590	PF01048	0.288
MOD_GlcNHglycan	675	678	PF01048	0.323
MOD_GlcNHglycan	740	744	PF01048	0.308
MOD_GlcNHglycan	759	762	PF01048	0.203
MOD_GlcNHglycan	780	783	PF01048	0.399
MOD_GlcNHglycan	86	89	PF01048	0.516
MOD_GSK3_1	13	20	PF00069	0.584
MOD_GSK3_1	24	31	PF00069	0.447
MOD_GSK3_1	243	250	PF00069	0.555
MOD_GSK3_1	253	260	PF00069	0.426
MOD_GSK3_1	411	418	PF00069	0.593
MOD_GSK3_1	448	455	PF00069	0.472
MOD_GSK3_1	520	527	PF00069	0.326
MOD_GSK3_1	590	597	PF00069	0.406
MOD_GSK3_1	619	626	PF00069	0.269
MOD_GSK3_1	689	696	PF00069	0.304
MOD_GSK3_1	713	720	PF00069	0.298
MOD_GSK3_1	804	811	PF00069	0.308
MOD_GSK3_1	834	841	PF00069	0.596
MOD_GSK3_1	94	101	PF00069	0.422
MOD_LATS_1	241	247	PF00433	0.535
MOD_N-GLC_1	594	599	PF02516	0.362
MOD_N-GLC_1	755	760	PF02516	0.292
MOD_N-GLC_1	808	813	PF02516	0.294
MOD_N-GLC_1	833	838	PF02516	0.638
MOD_N-GLC_2	223	225	PF02516	0.489
MOD_N-GLC_2	577	579	PF02516	0.292
MOD_NEK2_1	143	148	PF00069	0.405
MOD_NEK2_1	235	240	PF00069	0.503
MOD_NEK2_1	378	383	PF00069	0.651
MOD_NEK2_1	396	401	PF00069	0.520
MOD_NEK2_1	562	567	PF00069	0.281
MOD_NEK2_1	568	573	PF00069	0.283
MOD_NEK2_1	642	647	PF00069	0.377
MOD_NEK2_1	778	783	PF00069	0.308
MOD_NEK2_1	787	792	PF00069	0.323
MOD_NEK2_1	818	823	PF00069	0.413
MOD_NEK2_1	84	89	PF00069	0.502
MOD_PIKK_1	441	447	PF00454	0.489
MOD_PIKK_1	476	482	PF00454	0.500
MOD_PIKK_1	527	533	PF00454	0.439
MOD_PIKK_1	69	75	PF00454	0.528
MOD_PKA_1	619	625	PF00069	0.308
MOD_PKA_2	167	173	PF00069	0.678
MOD_PKA_2	253	259	PF00069	0.416
MOD_PKA_2	428	434	PF00069	0.486
MOD_PKA_2	713	719	PF00069	0.308
MOD_PKA_2	778	784	PF00069	0.292
MOD_Plk_1	175	181	PF00069	0.723
MOD_Plk_1	191	197	PF00069	0.422
MOD_Plk_1	310	316	PF00069	0.703
MOD_Plk_1	39	45	PF00069	0.592
MOD_Plk_1	622	628	PF00069	0.292
MOD_Plk_1	755	761	PF00069	0.292
MOD_Plk_2-3	202	208	PF00069	0.401
MOD_Plk_2-3	247	253	PF00069	0.575
MOD_Plk_2-3	257	263	PF00069	0.390
MOD_Plk_2-3	288	294	PF00069	0.726
MOD_Plk_4	120	126	PF00069	0.394
MOD_Plk_4	191	197	PF00069	0.441
MOD_Plk_4	247	253	PF00069	0.583
MOD_Plk_4	257	263	PF00069	0.390
MOD_Plk_4	568	574	PF00069	0.285
MOD_Plk_4	627	633	PF00069	0.310
MOD_Plk_4	661	667	PF00069	0.317
MOD_Plk_4	726	732	PF00069	0.292
MOD_Plk_4	75	81	PF00069	0.403
MOD_Plk_4	781	787	PF00069	0.306
MOD_Plk_4	813	819	PF00069	0.409
MOD_ProDKin_1	1	7	PF00069	0.695
MOD_ProDKin_1	388	394	PF00069	0.642
MOD_ProDKin_1	411	417	PF00069	0.590
MOD_ProDKin_1	801	807	PF00069	0.308
MOD_SUMO_rev_2	224	231	PF00179	0.500
MOD_SUMO_rev_2	431	438	PF00179	0.554
MOD_SUMO_rev_2	466	476	PF00179	0.483
MOD_SUMO_rev_2	481	489	PF00179	0.391
MOD_SUMO_rev_2	598	604	PF00179	0.344
MOD_SUMO_rev_2	614	622	PF00179	0.232
TRG_DiLeu_BaEn_1	192	197	PF01217	0.565
TRG_DiLeu_BaEn_1	21	26	PF01217	0.563
TRG_DiLeu_BaEn_1	247	252	PF01217	0.457
TRG_DiLeu_BaEn_1	322	327	PF01217	0.628
TRG_DiLeu_BaEn_4	192	198	PF01217	0.555
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.512
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.292
TRG_ENDOCYTIC_2	494	497	PF00928	0.423
TRG_ENDOCYTIC_2	507	510	PF00928	0.331
TRG_ENDOCYTIC_2	522	525	PF00928	0.308
TRG_ENDOCYTIC_2	710	713	PF00928	0.292
TRG_ENDOCYTIC_2	725	728	PF00928	0.292
TRG_ER_diArg_1	300	303	PF00400	0.582
TRG_ER_diArg_1	483	485	PF00400	0.413
TRG_ER_diArg_1	49	51	PF00400	0.537
TRG_ER_diArg_1	509	512	PF00400	0.292
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X9	Leptomonas seymouri	77%	100%
A0A0S4KHP9	Bodo saltans	51%	93%
A0A1X0P6D6	Trypanosomatidae	61%	100%
A0A422P3A3	Trypanosoma rangeli	59%	100%
A4H9Y3	Leishmania braziliensis	80%	100%
A4HY48	Leishmania infantum	100%	100%
B3H6Z8	Arabidopsis thaliana	36%	79%
D0A0E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ARX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QDJ5	Leishmania major	96%	100%
V5BWY3	Trypanosoma cruzi	61%	100%