Clathrin light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H749_LEIDO

TriTrypDb:

LdBPK_190100.1 , LdCL_190006000 , LDHU3_19.0110

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0030117	membrane coat	3	3
GO:0030118	clathrin coat	4	3
GO:0030120	vesicle coat	4	3
GO:0030125	clathrin vesicle coat	5	3
GO:0030130	clathrin coat of trans-Golgi network vesicle	6	3
GO:0030132	clathrin coat of coated pit	4	3
GO:0032991	protein-containing complex	1	3
GO:0098796	membrane protein complex	2	3
GO:0098797	plasma membrane protein complex	3	3
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H749

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H749

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006886	intracellular protein transport	4	3
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016192	vesicle-mediated transport	4	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.511
CLV_NRD_NRD_1	55	57	PF00675	0.423
CLV_PCSK_KEX2_1	326	328	PF00082	0.312
CLV_PCSK_KEX2_1	353	355	PF00082	0.330
CLV_PCSK_KEX2_1	55	57	PF00082	0.423
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.312
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.330
CLV_PCSK_SKI1_1	311	315	PF00082	0.432
CLV_PCSK_SKI1_1	382	386	PF00082	0.253
DEG_APCC_DBOX_1	381	389	PF00400	0.253
DOC_CKS1_1	199	204	PF01111	0.573
DOC_CKS1_1	272	277	PF01111	0.528
DOC_CYCLIN_RxL_1	52	60	PF00134	0.423
DOC_MAPK_gen_1	55	61	PF00069	0.431
DOC_PP2B_LxvP_1	178	181	PF13499	0.554
DOC_PP2B_LxvP_1	218	221	PF13499	0.558
DOC_PP4_FxxP_1	43	46	PF00568	0.397
DOC_PP4_MxPP_1	251	254	PF00568	0.551
DOC_USP7_MATH_1	110	114	PF00917	0.528
DOC_USP7_MATH_1	138	142	PF00917	0.573
DOC_USP7_MATH_1	170	174	PF00917	0.563
DOC_USP7_MATH_1	181	185	PF00917	0.535
DOC_USP7_MATH_1	206	210	PF00917	0.562
DOC_USP7_MATH_1	334	338	PF00917	0.235
DOC_USP7_MATH_2	275	281	PF00917	0.518
DOC_USP7_UBL2_3	335	339	PF12436	0.253
DOC_WW_Pin1_4	116	121	PF00397	0.551
DOC_WW_Pin1_4	126	131	PF00397	0.536
DOC_WW_Pin1_4	134	139	PF00397	0.520
DOC_WW_Pin1_4	165	170	PF00397	0.569
DOC_WW_Pin1_4	198	203	PF00397	0.566
DOC_WW_Pin1_4	237	242	PF00397	0.581
DOC_WW_Pin1_4	244	249	PF00397	0.562
DOC_WW_Pin1_4	261	266	PF00397	0.507
DOC_WW_Pin1_4	271	276	PF00397	0.510
DOC_WW_Pin1_4	42	47	PF00397	0.401
LIG_14-3-3_CanoR_1	382	392	PF00244	0.246
LIG_14-3-3_CanoR_1	56	62	PF00244	0.437
LIG_APCC_ABBA_1	154	159	PF00400	0.580
LIG_APCC_ABBA_1	59	64	PF00400	0.454
LIG_BRCT_BRCA1_1	255	259	PF00533	0.549
LIG_BRCT_BRCA1_1	44	48	PF00533	0.397
LIG_EVH1_1	218	222	PF00568	0.556
LIG_FHA_1	99	105	PF00498	0.502
LIG_FHA_2	272	278	PF00498	0.530
LIG_LIR_Apic_2	106	112	PF02991	0.537
LIG_LIR_Apic_2	196	202	PF02991	0.560
LIG_LIR_Gen_1	26	37	PF02991	0.400
LIG_LIR_Gen_1	45	54	PF02991	0.390
LIG_LIR_Nem_3	26	32	PF02991	0.405
LIG_LIR_Nem_3	33	37	PF02991	0.387
LIG_LIR_Nem_3	45	51	PF02991	0.387
LIG_MLH1_MIPbox_1	44	48	PF16413	0.397
LIG_MYND_1	120	124	PF01753	0.534
LIG_Pex14_2	43	47	PF04695	0.400
LIG_SH2_STAT5	319	322	PF00017	0.514
LIG_SH2_STAT5	8	11	PF00017	0.404
LIG_SH3_2	273	278	PF14604	0.513
LIG_SH3_3	114	120	PF00018	0.550
LIG_SH3_3	163	169	PF00018	0.556
LIG_SH3_3	186	192	PF00018	0.574
LIG_SH3_3	199	205	PF00018	0.540
LIG_SH3_3	216	222	PF00018	0.533
LIG_SH3_3	235	241	PF00018	0.534
LIG_SH3_3	266	272	PF00018	0.545
LIG_SH3_3	273	279	PF00018	0.510
LIG_Sin3_3	72	79	PF02671	0.446
LIG_SUMO_SIM_par_1	228	234	PF11976	0.584
LIG_TRAF2_1	315	318	PF00917	0.253
LIG_TRFH_1	37	41	PF08558	0.395
LIG_UBA3_1	364	370	PF00899	0.253
LIG_WRC_WIRS_1	48	53	PF05994	0.405
LIG_WW_3	17	21	PF00397	0.427
MOD_CDC14_SPxK_1	268	271	PF00782	0.527
MOD_CDK_SPxK_1	265	271	PF00069	0.535
MOD_CDK_SPxxK_3	271	278	PF00069	0.531
MOD_CK1_1	113	119	PF00069	0.550
MOD_CK1_1	126	132	PF00069	0.525
MOD_CK1_1	137	143	PF00069	0.542
MOD_CK1_1	147	153	PF00069	0.540
MOD_CK1_1	375	381	PF00069	0.253
MOD_CK2_1	170	176	PF00069	0.582
MOD_CK2_1	228	234	PF00069	0.576
MOD_CK2_1	237	243	PF00069	0.567
MOD_CK2_1	271	277	PF00069	0.530
MOD_CK2_1	334	340	PF00069	0.235
MOD_DYRK1A_RPxSP_1	271	275	PF00069	0.523
MOD_GlcNHglycan	106	109	PF01048	0.545
MOD_GlcNHglycan	112	115	PF01048	0.526
MOD_GlcNHglycan	172	175	PF01048	0.585
MOD_GlcNHglycan	178	181	PF01048	0.555
MOD_GlcNHglycan	208	211	PF01048	0.568
MOD_GlcNHglycan	279	282	PF01048	0.504
MOD_GlcNHglycan	354	357	PF01048	0.253
MOD_GlcNHglycan	359	362	PF01048	0.239
MOD_GSK3_1	134	141	PF00069	0.568
MOD_GSK3_1	161	168	PF00069	0.579
MOD_GSK3_1	233	240	PF00069	0.575
MOD_GSK3_1	249	256	PF00069	0.570
MOD_GSK3_1	261	268	PF00069	0.681
MOD_GSK3_1	307	314	PF00069	0.246
MOD_GSK3_1	380	387	PF00069	0.470
MOD_GSK3_1	96	103	PF00069	0.486
MOD_N-GLC_1	147	152	PF02516	0.568
MOD_NEK2_1	144	149	PF00069	0.573
MOD_NEK2_1	259	264	PF00069	0.727
MOD_NEK2_1	32	37	PF00069	0.395
MOD_NEK2_1	47	52	PF00069	0.392
MOD_NEK2_1	57	62	PF00069	0.429
MOD_NEK2_1	75	80	PF00069	0.416
MOD_PIKK_1	147	153	PF00454	0.543
MOD_PKA_2	110	116	PF00069	0.519
MOD_Plk_1	147	153	PF00069	0.567
MOD_Plk_4	100	106	PF00069	0.506
MOD_Plk_4	25	31	PF00069	0.407
MOD_ProDKin_1	116	122	PF00069	0.552
MOD_ProDKin_1	126	132	PF00069	0.533
MOD_ProDKin_1	134	140	PF00069	0.521
MOD_ProDKin_1	165	171	PF00069	0.572
MOD_ProDKin_1	198	204	PF00069	0.569
MOD_ProDKin_1	237	243	PF00069	0.583
MOD_ProDKin_1	244	250	PF00069	0.559
MOD_ProDKin_1	261	267	PF00069	0.507
MOD_ProDKin_1	271	277	PF00069	0.510
MOD_ProDKin_1	42	48	PF00069	0.401
MOD_SUMO_for_1	325	328	PF00179	0.235
MOD_SUMO_rev_2	307	313	PF00179	0.253
MOD_SUMO_rev_2	347	355	PF00179	0.253
TRG_ER_diArg_1	54	56	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AGR3	Leishmania infantum	100%	100%