Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H747_LEIDO

TriTrypDb:

LdBPK_181590.1 , LdCL_180021200 , LDHU3_18.2030

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H747

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H747

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.426
CLV_C14_Caspase3-7	618	622	PF00656	0.668
CLV_NRD_NRD_1	151	153	PF00675	0.354
CLV_NRD_NRD_1	187	189	PF00675	0.322
CLV_NRD_NRD_1	367	369	PF00675	0.664
CLV_NRD_NRD_1	4	6	PF00675	0.451
CLV_NRD_NRD_1	403	405	PF00675	0.570
CLV_NRD_NRD_1	409	411	PF00675	0.533
CLV_NRD_NRD_1	47	49	PF00675	0.449
CLV_NRD_NRD_1	567	569	PF00675	0.597
CLV_NRD_NRD_1	774	776	PF00675	0.747
CLV_PCSK_FUR_1	313	317	PF00082	0.408
CLV_PCSK_KEX2_1	150	152	PF00082	0.350
CLV_PCSK_KEX2_1	187	189	PF00082	0.329
CLV_PCSK_KEX2_1	315	317	PF00082	0.378
CLV_PCSK_KEX2_1	366	368	PF00082	0.667
CLV_PCSK_KEX2_1	4	6	PF00082	0.451
CLV_PCSK_KEX2_1	403	405	PF00082	0.570
CLV_PCSK_KEX2_1	409	411	PF00082	0.518
CLV_PCSK_KEX2_1	47	49	PF00082	0.449
CLV_PCSK_KEX2_1	567	569	PF00082	0.606
CLV_PCSK_KEX2_1	773	775	PF00082	0.733
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.378
CLV_PCSK_PC1ET2_1	773	775	PF00082	0.753
CLV_PCSK_PC7_1	147	153	PF00082	0.339
CLV_PCSK_SKI1_1	280	284	PF00082	0.447
CLV_PCSK_SKI1_1	567	571	PF00082	0.533
CLV_PCSK_SKI1_1	63	67	PF00082	0.417
CLV_PCSK_SKI1_1	75	79	PF00082	0.389
CLV_PCSK_SKI1_1	783	787	PF00082	0.769
CLV_Separin_Metazoa	117	121	PF03568	0.447
DEG_SCF_FBW7_2	664	670	PF00400	0.730
DEG_SPOP_SBC_1	562	566	PF00917	0.542
DOC_ANK_TNKS_1	776	783	PF00023	0.731
DOC_CDC14_PxL_1	420	428	PF14671	0.495
DOC_CKS1_1	664	669	PF01111	0.730
DOC_MAPK_DCC_7	418	428	PF00069	0.507
DOC_MAPK_gen_1	208	216	PF00069	0.347
DOC_MAPK_gen_1	346	353	PF00069	0.594
DOC_MAPK_gen_1	4	12	PF00069	0.431
DOC_MAPK_MEF2A_6	120	129	PF00069	0.438
DOC_MAPK_MEF2A_6	208	216	PF00069	0.335
DOC_MAPK_MEF2A_6	270	278	PF00069	0.319
DOC_MAPK_MEF2A_6	4	12	PF00069	0.431
DOC_PP1_RVXF_1	211	217	PF00149	0.447
DOC_PP2B_LxvP_1	738	741	PF13499	0.649
DOC_PP2B_PxIxI_1	157	163	PF00149	0.447
DOC_USP7_MATH_1	196	200	PF00917	0.368
DOC_USP7_MATH_1	387	391	PF00917	0.679
DOC_USP7_MATH_1	392	396	PF00917	0.613
DOC_USP7_MATH_1	450	454	PF00917	0.577
DOC_USP7_MATH_1	524	528	PF00917	0.450
DOC_USP7_MATH_1	637	641	PF00917	0.778
DOC_USP7_MATH_1	690	694	PF00917	0.728
DOC_USP7_MATH_1	720	724	PF00917	0.720
DOC_USP7_MATH_1	732	736	PF00917	0.721
DOC_WW_Pin1_4	226	231	PF00397	0.335
DOC_WW_Pin1_4	595	600	PF00397	0.655
DOC_WW_Pin1_4	658	663	PF00397	0.691
DOC_WW_Pin1_4	703	708	PF00397	0.692
DOC_WW_Pin1_4	733	738	PF00397	0.703
DOC_WW_Pin1_4	745	750	PF00397	0.636
DOC_WW_Pin1_4	75	80	PF00397	0.447
LIG_14-3-3_CanoR_1	187	191	PF00244	0.334
LIG_14-3-3_CanoR_1	19	26	PF00244	0.484
LIG_14-3-3_CanoR_1	194	204	PF00244	0.310
LIG_14-3-3_CanoR_1	224	228	PF00244	0.328
LIG_14-3-3_CanoR_1	245	250	PF00244	0.335
LIG_14-3-3_CanoR_1	309	317	PF00244	0.335
LIG_14-3-3_CanoR_1	333	341	PF00244	0.676
LIG_14-3-3_CanoR_1	457	466	PF00244	0.423
LIG_14-3-3_CanoR_1	47	51	PF00244	0.424
LIG_14-3-3_CanoR_1	488	494	PF00244	0.549
LIG_14-3-3_CanoR_1	727	734	PF00244	0.698
LIG_Actin_WH2_2	301	317	PF00022	0.335
LIG_APCC_ABBA_1	130	135	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BIR_III_4	532	536	PF00653	0.656
LIG_Clathr_ClatBox_1	649	653	PF01394	0.657
LIG_eIF4E_1	50	56	PF01652	0.447
LIG_FHA_1	165	171	PF00498	0.357
LIG_FHA_1	271	277	PF00498	0.353
LIG_FHA_1	28	34	PF00498	0.440
LIG_FHA_1	286	292	PF00498	0.308
LIG_FHA_1	309	315	PF00498	0.334
LIG_FHA_1	356	362	PF00498	0.630
LIG_FHA_1	406	412	PF00498	0.524
LIG_FHA_1	564	570	PF00498	0.596
LIG_FHA_1	659	665	PF00498	0.740
LIG_FHA_1	96	102	PF00498	0.319
LIG_FHA_2	169	175	PF00498	0.391
LIG_FHA_2	246	252	PF00498	0.323
LIG_FHA_2	320	326	PF00498	0.654
LIG_FHA_2	776	782	PF00498	0.739
LIG_KLC1_Yacidic_2	131	135	PF13176	0.480
LIG_LIR_Apic_2	435	440	PF02991	0.501
LIG_LIR_Gen_1	174	184	PF02991	0.333
LIG_LIR_Gen_1	263	274	PF02991	0.314
LIG_LIR_Nem_3	174	179	PF02991	0.314
LIG_LIR_Nem_3	263	269	PF02991	0.314
LIG_LIR_Nem_3	431	437	PF02991	0.432
LIG_LIR_Nem_3	746	750	PF02991	0.655
LIG_LIR_Nem_3	84	90	PF02991	0.335
LIG_MYND_1	737	741	PF01753	0.618
LIG_NRBOX	273	279	PF00104	0.335
LIG_Pex14_2	434	438	PF04695	0.456
LIG_PTAP_UEV_1	709	714	PF05743	0.583
LIG_SH2_GRB2like	266	269	PF00017	0.335
LIG_SH2_NCK_1	99	103	PF00017	0.434
LIG_SH2_SRC	133	136	PF00017	0.468
LIG_SH2_STAP1	310	314	PF00017	0.335
LIG_SH2_STAP1	430	434	PF00017	0.542
LIG_SH2_STAP1	546	550	PF00017	0.363
LIG_SH2_STAT5	133	136	PF00017	0.432
LIG_SH2_STAT5	266	269	PF00017	0.320
LIG_SH2_STAT5	281	284	PF00017	0.322
LIG_SH2_STAT5	310	313	PF00017	0.344
LIG_SH2_STAT5	433	436	PF00017	0.421
LIG_SH2_STAT5	437	440	PF00017	0.417
LIG_SH2_STAT5	447	450	PF00017	0.398
LIG_SH2_STAT5	513	516	PF00017	0.444
LIG_SH2_STAT5	546	549	PF00017	0.574
LIG_SH2_STAT5	99	102	PF00017	0.480
LIG_SH3_3	224	230	PF00018	0.447
LIG_SH3_3	548	554	PF00018	0.450
LIG_SH3_3	704	710	PF00018	0.743
LIG_SH3_3	731	737	PF00018	0.753
LIG_SH3_3	746	752	PF00018	0.639
LIG_SH3_3	756	762	PF00018	0.735
LIG_SH3_3	76	82	PF00018	0.381
LIG_SH3_5	296	300	PF00018	0.480
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.335
LIG_SUMO_SIM_par_1	157	163	PF11976	0.382
LIG_SUMO_SIM_par_1	648	653	PF11976	0.665
LIG_TRAF2_1	104	107	PF00917	0.402
LIG_TRAF2_1	667	670	PF00917	0.718
LIG_TRAF2_1	683	686	PF00917	0.591
LIG_UBA3_1	204	208	PF00899	0.335
LIG_WRC_WIRS_1	287	292	PF05994	0.447
LIG_WW_3	713	717	PF00397	0.791
MOD_CDC14_SPxK_1	706	709	PF00782	0.679
MOD_CDC14_SPxK_1	748	751	PF00782	0.674
MOD_CDK_SPxK_1	703	709	PF00069	0.790
MOD_CDK_SPxK_1	745	751	PF00069	0.612
MOD_CK1_1	169	175	PF00069	0.373
MOD_CK1_1	186	192	PF00069	0.268
MOD_CK1_1	198	204	PF00069	0.249
MOD_CK1_1	22	28	PF00069	0.388
MOD_CK1_1	244	250	PF00069	0.335
MOD_CK1_1	286	292	PF00069	0.357
MOD_CK1_1	492	498	PF00069	0.534
MOD_CK1_1	600	606	PF00069	0.674
MOD_CK1_1	615	621	PF00069	0.527
MOD_CK1_1	638	644	PF00069	0.724
MOD_CK1_1	680	686	PF00069	0.718
MOD_CK1_1	708	714	PF00069	0.708
MOD_CK1_1	753	759	PF00069	0.757
MOD_CK1_1	95	101	PF00069	0.319
MOD_CK2_1	101	107	PF00069	0.355
MOD_CK2_1	168	174	PF00069	0.314
MOD_CK2_1	245	251	PF00069	0.335
MOD_CK2_1	46	52	PF00069	0.348
MOD_CK2_1	495	501	PF00069	0.520
MOD_CK2_1	626	632	PF00069	0.752
MOD_CK2_1	680	686	PF00069	0.671
MOD_CK2_1	775	781	PF00069	0.744
MOD_Cter_Amidation	45	48	PF01082	0.480
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.402
MOD_GlcNHglycan	296	299	PF01048	0.438
MOD_GlcNHglycan	328	332	PF01048	0.555
MOD_GlcNHglycan	33	36	PF01048	0.323
MOD_GlcNHglycan	389	392	PF01048	0.696
MOD_GlcNHglycan	394	397	PF01048	0.654
MOD_GlcNHglycan	448	451	PF01048	0.488
MOD_GlcNHglycan	526	529	PF01048	0.573
MOD_GlcNHglycan	548	551	PF01048	0.576
MOD_GlcNHglycan	614	617	PF01048	0.779
MOD_GlcNHglycan	634	640	PF01048	0.726
MOD_GlcNHglycan	644	647	PF01048	0.708
MOD_GlcNHglycan	670	676	PF01048	0.699
MOD_GlcNHglycan	692	695	PF01048	0.798
MOD_GlcNHglycan	710	713	PF01048	0.754
MOD_GlcNHglycan	721	725	PF01048	0.516
MOD_GlcNHglycan	752	755	PF01048	0.764
MOD_GlcNHglycan	756	759	PF01048	0.630
MOD_GlcNHglycan	94	97	PF01048	0.350
MOD_GSK3_1	15	22	PF00069	0.402
MOD_GSK3_1	164	171	PF00069	0.347
MOD_GSK3_1	182	189	PF00069	0.294
MOD_GSK3_1	219	226	PF00069	0.328
MOD_GSK3_1	235	242	PF00069	0.335
MOD_GSK3_1	27	34	PF00069	0.434
MOD_GSK3_1	304	311	PF00069	0.335
MOD_GSK3_1	351	358	PF00069	0.691
MOD_GSK3_1	387	394	PF00069	0.674
MOD_GSK3_1	42	49	PF00069	0.265
MOD_GSK3_1	446	453	PF00069	0.551
MOD_GSK3_1	492	499	PF00069	0.559
MOD_GSK3_1	520	527	PF00069	0.560
MOD_GSK3_1	591	598	PF00069	0.632
MOD_GSK3_1	600	607	PF00069	0.712
MOD_GSK3_1	626	633	PF00069	0.738
MOD_GSK3_1	637	644	PF00069	0.742
MOD_GSK3_1	673	680	PF00069	0.738
MOD_GSK3_1	750	757	PF00069	0.700
MOD_GSK3_1	91	98	PF00069	0.361
MOD_N-GLC_1	239	244	PF02516	0.319
MOD_N-GLC_1	355	360	PF02516	0.648
MOD_N-GLC_1	626	631	PF02516	0.808
MOD_N-GLC_1	775	780	PF02516	0.725
MOD_N-GLC_2	21	23	PF02516	0.480
MOD_NEK2_1	269	274	PF00069	0.340
MOD_NEK2_1	308	313	PF00069	0.340
MOD_NEK2_1	372	377	PF00069	0.632
MOD_NEK2_1	474	479	PF00069	0.439
MOD_NEK2_1	489	494	PF00069	0.568
MOD_NEK2_1	601	606	PF00069	0.713
MOD_NEK2_2	203	208	PF00069	0.355
MOD_OFUCOSY	679	684	PF10250	0.557
MOD_PIKK_1	308	314	PF00454	0.335
MOD_PIKK_1	505	511	PF00454	0.448
MOD_PKA_2	186	192	PF00069	0.336
MOD_PKA_2	196	202	PF00069	0.294
MOD_PKA_2	223	229	PF00069	0.328
MOD_PKA_2	244	250	PF00069	0.346
MOD_PKA_2	269	275	PF00069	0.315
MOD_PKA_2	308	314	PF00069	0.335
MOD_PKA_2	319	325	PF00069	0.490
MOD_PKA_2	332	338	PF00069	0.565
MOD_PKA_2	405	411	PF00069	0.558
MOD_PKA_2	46	52	PF00069	0.463
MOD_PKA_2	708	714	PF00069	0.799
MOD_PKA_2	750	756	PF00069	0.733
MOD_PKB_1	11	19	PF00069	0.480
MOD_Plk_1	239	245	PF00069	0.319
MOD_Plk_1	270	276	PF00069	0.355
MOD_Plk_1	372	378	PF00069	0.573
MOD_Plk_2-3	496	502	PF00069	0.508
MOD_Plk_2-3	630	636	PF00069	0.640
MOD_Plk_4	223	229	PF00069	0.447
MOD_Plk_4	245	251	PF00069	0.322
MOD_Plk_4	272	278	PF00069	0.358
MOD_Plk_4	286	292	PF00069	0.327
MOD_Plk_4	450	456	PF00069	0.577
MOD_Plk_4	474	480	PF00069	0.425
MOD_Plk_4	554	560	PF00069	0.507
MOD_Plk_4	601	607	PF00069	0.662
MOD_Plk_4	615	621	PF00069	0.679
MOD_ProDKin_1	226	232	PF00069	0.335
MOD_ProDKin_1	595	601	PF00069	0.657
MOD_ProDKin_1	658	664	PF00069	0.699
MOD_ProDKin_1	703	709	PF00069	0.694
MOD_ProDKin_1	733	739	PF00069	0.705
MOD_ProDKin_1	745	751	PF00069	0.637
MOD_ProDKin_1	75	81	PF00069	0.447
MOD_SUMO_for_1	569	572	PF00179	0.585
TRG_DiLeu_BaEn_1	336	341	PF01217	0.543
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.582
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.649
TRG_ENDOCYTIC_2	266	269	PF00928	0.335
TRG_ER_diArg_1	10	13	PF00400	0.329
TRG_ER_diArg_1	149	152	PF00400	0.346
TRG_ER_diArg_1	317	320	PF00400	0.532
TRG_ER_diArg_1	366	368	PF00400	0.667
TRG_ER_diArg_1	4	6	PF00400	0.455
TRG_ER_diArg_1	403	406	PF00400	0.540
TRG_ER_diArg_1	409	411	PF00400	0.549
TRG_ER_diArg_1	567	569	PF00400	0.606
TRG_ER_diArg_1	715	718	PF00400	0.739
TRG_ER_diArg_1	774	777	PF00400	0.802
TRG_NES_CRM1_1	342	355	PF08389	0.596
TRG_NLS_MonoExtC_3	772	777	PF00514	0.734
TRG_NLS_MonoExtN_4	313	319	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F8	Leptomonas seymouri	59%	95%
A0A1X0P728	Trypanosomatidae	51%	90%
A0A3R7KGY3	Trypanosoma rangeli	49%	91%
A4H9R1	Leishmania braziliensis	80%	99%
A4HY30	Leishmania infantum	99%	100%
D0A556	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	92%
E9ARU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDM9	Leishmania major	92%	100%
V5D4P5	Trypanosoma cruzi	53%	100%