Pumilio protein 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H745_LEIDO

TriTrypDb:

LdBPK_181400.1 , LdCL_180019300 , LDHU3_18.1780

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H745

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H745

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.530
CLV_C14_Caspase3-7	830	834	PF00656	0.792
CLV_NRD_NRD_1	105	107	PF00675	0.684
CLV_NRD_NRD_1	45	47	PF00675	0.804
CLV_NRD_NRD_1	521	523	PF00675	0.615
CLV_NRD_NRD_1	782	784	PF00675	0.868
CLV_PCSK_KEX2_1	104	106	PF00082	0.779
CLV_PCSK_KEX2_1	45	47	PF00082	0.647
CLV_PCSK_KEX2_1	782	784	PF00082	0.868
CLV_PCSK_SKI1_1	265	269	PF00082	0.499
CLV_PCSK_SKI1_1	442	446	PF00082	0.530
CLV_PCSK_SKI1_1	457	461	PF00082	0.282
CLV_PCSK_SKI1_1	518	522	PF00082	0.608
DEG_APCC_DBOX_1	517	525	PF00400	0.615
DOC_CKS1_1	422	427	PF01111	0.572
DOC_CKS1_1	682	687	PF01111	0.789
DOC_CKS1_1	756	761	PF01111	0.738
DOC_CKS1_1	762	767	PF01111	0.796
DOC_CKS1_1	770	775	PF01111	0.673
DOC_CKS1_1	887	892	PF01111	0.652
DOC_MAPK_gen_1	416	423	PF00069	0.530
DOC_PP1_RVXF_1	314	321	PF00149	0.530
DOC_PP2B_LxvP_1	409	412	PF13499	0.530
DOC_PP4_FxxP_1	739	742	PF00568	0.836
DOC_PP4_MxPP_1	98	101	PF00568	0.734
DOC_SPAK_OSR1_1	418	422	PF12202	0.530
DOC_USP7_MATH_1	120	124	PF00917	0.832
DOC_USP7_MATH_1	152	156	PF00917	0.548
DOC_USP7_MATH_1	551	555	PF00917	0.735
DOC_USP7_MATH_1	644	648	PF00917	0.760
DOC_USP7_MATH_1	851	855	PF00917	0.771
DOC_USP7_MATH_1	861	865	PF00917	0.612
DOC_USP7_UBL2_3	457	461	PF12436	0.452
DOC_WW_Pin1_4	421	426	PF00397	0.585
DOC_WW_Pin1_4	490	495	PF00397	0.452
DOC_WW_Pin1_4	681	686	PF00397	0.786
DOC_WW_Pin1_4	755	760	PF00397	0.741
DOC_WW_Pin1_4	761	766	PF00397	0.793
DOC_WW_Pin1_4	769	774	PF00397	0.668
DOC_WW_Pin1_4	785	790	PF00397	0.754
DOC_WW_Pin1_4	806	811	PF00397	0.840
DOC_WW_Pin1_4	886	891	PF00397	0.656
LIG_14-3-3_CanoR_1	79	87	PF00244	0.768
LIG_APCC_ABBA_1	177	182	PF00400	0.615
LIG_APCC_ABBA_1	221	226	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_BRCT_BRCA1_1	811	815	PF00533	0.862
LIG_CtBP_PxDLS_1	412	416	PF00389	0.530
LIG_FHA_1	166	172	PF00498	0.590
LIG_FHA_1	272	278	PF00498	0.433
LIG_FHA_1	422	428	PF00498	0.572
LIG_FHA_1	531	537	PF00498	0.512
LIG_FHA_2	21	27	PF00498	0.748
LIG_FHA_2	444	450	PF00498	0.530
LIG_FHA_2	493	499	PF00498	0.530
LIG_FHA_2	860	866	PF00498	0.745
LIG_Integrin_isoDGR_2	589	591	PF01839	0.780
LIG_LIR_Apic_2	684	689	PF02991	0.775
LIG_LIR_Apic_2	738	742	PF02991	0.731
LIG_LIR_Apic_2	753	759	PF02991	0.611
LIG_LIR_Gen_1	187	197	PF02991	0.611
LIG_LIR_Gen_1	222	231	PF02991	0.452
LIG_LIR_Gen_1	81	89	PF02991	0.756
LIG_LIR_Nem_3	187	193	PF02991	0.607
LIG_LIR_Nem_3	222	227	PF02991	0.503
LIG_LIR_Nem_3	229	234	PF02991	0.497
LIG_LIR_Nem_3	236	242	PF02991	0.326
LIG_LIR_Nem_3	478	483	PF02991	0.400
LIG_LIR_Nem_3	728	733	PF02991	0.773
LIG_LIR_Nem_3	81	87	PF02991	0.759
LIG_PCNA_yPIPBox_3	241	253	PF02747	0.530
LIG_Pex14_2	184	188	PF04695	0.631
LIG_PTB_Apo_2	791	798	PF02174	0.843
LIG_PTB_Phospho_1	791	797	PF10480	0.845
LIG_Rb_pABgroove_1	242	250	PF01858	0.530
LIG_SH2_CRK	190	194	PF00017	0.609
LIG_SH2_CRK	682	686	PF00017	0.795
LIG_SH2_CRK	703	707	PF00017	0.663
LIG_SH2_CRK	756	760	PF00017	0.748
LIG_SH2_CRK	84	88	PF00017	0.755
LIG_SH2_GRB2like	480	483	PF00017	0.530
LIG_SH2_GRB2like	583	586	PF00017	0.796
LIG_SH2_GRB2like	792	795	PF00017	0.843
LIG_SH2_GRB2like	884	887	PF00017	0.655
LIG_SH2_SRC	792	795	PF00017	0.843
LIG_SH2_STAP1	480	484	PF00017	0.530
LIG_SH2_STAP1	752	756	PF00017	0.861
LIG_SH2_STAP1	80	84	PF00017	0.769
LIG_SH2_STAT3	242	245	PF00017	0.530
LIG_SH2_STAT3	284	287	PF00017	0.530
LIG_SH2_STAT3	402	405	PF00017	0.530
LIG_SH2_STAT3	483	486	PF00017	0.530
LIG_SH2_STAT3	715	718	PF00017	0.823
LIG_SH2_STAT3	721	724	PF00017	0.724
LIG_SH2_STAT3	884	887	PF00017	0.791
LIG_SH2_STAT5	180	183	PF00017	0.446
LIG_SH2_STAT5	242	245	PF00017	0.530
LIG_SH2_STAT5	402	405	PF00017	0.530
LIG_SH2_STAT5	471	474	PF00017	0.530
LIG_SH2_STAT5	483	486	PF00017	0.331
LIG_SH2_STAT5	583	586	PF00017	0.853
LIG_SH2_STAT5	721	724	PF00017	0.745
LIG_SH2_STAT5	792	795	PF00017	0.843
LIG_SH2_STAT5	80	83	PF00017	0.717
LIG_SH3_3	539	545	PF00018	0.536
LIG_SH3_3	655	661	PF00018	0.771
LIG_SH3_3	693	699	PF00018	0.774
LIG_SH3_3	739	745	PF00018	0.653
LIG_SH3_3	90	96	PF00018	0.624
LIG_SH3_5	186	190	PF00018	0.609
LIG_TRAF2_1	260	263	PF00917	0.621
LIG_TRAF2_1	447	450	PF00917	0.530
LIG_TRAF2_1	74	77	PF00917	0.786
LIG_TRAF2_1	890	893	PF00917	0.725
LIG_UBA3_1	269	276	PF00899	0.588
LIG_UBA3_1	309	316	PF00899	0.452
LIG_UBA3_1	455	461	PF00899	0.530
LIG_WRC_WIRS_1	181	186	PF05994	0.629
LIG_WRC_WIRS_1	197	202	PF05994	0.265
MOD_CDK_SPxxK_3	490	497	PF00069	0.452
MOD_CK1_1	128	134	PF00069	0.826
MOD_CK1_1	155	161	PF00069	0.543
MOD_CK1_1	285	291	PF00069	0.530
MOD_CK1_1	3	9	PF00069	0.699
MOD_CK1_1	601	607	PF00069	0.657
MOD_CK1_1	625	631	PF00069	0.727
MOD_CK1_1	763	769	PF00069	0.737
MOD_CK1_1	809	815	PF00069	0.700
MOD_CK1_1	854	860	PF00069	0.826
MOD_CK1_1	874	880	PF00069	0.496
MOD_CK2_1	443	449	PF00069	0.530
MOD_CK2_1	492	498	PF00069	0.384
MOD_CK2_1	540	546	PF00069	0.667
MOD_CK2_1	566	572	PF00069	0.653
MOD_GlcNHglycan	122	125	PF01048	0.832
MOD_GlcNHglycan	154	157	PF01048	0.538
MOD_GlcNHglycan	338	341	PF01048	0.497
MOD_GlcNHglycan	541	545	PF01048	0.711
MOD_GlcNHglycan	553	556	PF01048	0.833
MOD_GlcNHglycan	557	560	PF01048	0.826
MOD_GlcNHglycan	568	571	PF01048	0.642
MOD_GlcNHglycan	594	597	PF01048	0.770
MOD_GlcNHglycan	603	606	PF01048	0.721
MOD_GlcNHglycan	611	614	PF01048	0.810
MOD_GlcNHglycan	727	730	PF01048	0.705
MOD_GlcNHglycan	739	742	PF01048	0.630
MOD_GlcNHglycan	8	11	PF01048	0.697
MOD_GlcNHglycan	837	840	PF01048	0.763
MOD_GlcNHglycan	843	846	PF01048	0.796
MOD_GlcNHglycan	849	852	PF01048	0.703
MOD_GlcNHglycan	854	857	PF01048	0.628
MOD_GSK3_1	125	132	PF00069	0.667
MOD_GSK3_1	151	158	PF00069	0.573
MOD_GSK3_1	165	172	PF00069	0.546
MOD_GSK3_1	192	199	PF00069	0.529
MOD_GSK3_1	430	437	PF00069	0.407
MOD_GSK3_1	507	514	PF00069	0.508
MOD_GSK3_1	52	59	PF00069	0.717
MOD_GSK3_1	530	537	PF00069	0.480
MOD_GSK3_1	551	558	PF00069	0.711
MOD_GSK3_1	561	568	PF00069	0.805
MOD_GSK3_1	577	584	PF00069	0.605
MOD_GSK3_1	622	629	PF00069	0.668
MOD_GSK3_1	760	767	PF00069	0.756
MOD_GSK3_1	806	813	PF00069	0.705
MOD_GSK3_1	847	854	PF00069	0.692
MOD_GSK3_1	869	876	PF00069	0.711
MOD_GSK3_1	882	889	PF00069	0.636
MOD_N-GLC_1	3	8	PF02516	0.713
MOD_N-GLC_1	511	516	PF02516	0.639
MOD_N-GLC_1	551	556	PF02516	0.675
MOD_N-GLC_1	565	570	PF02516	0.788
MOD_N-GLC_1	601	606	PF02516	0.816
MOD_N-GLC_1	609	614	PF02516	0.650
MOD_N-GLC_1	625	630	PF02516	0.649
MOD_N-GLC_1	750	755	PF02516	0.780
MOD_N-GLC_1	810	815	PF02516	0.736
MOD_N-GLC_1	847	852	PF02516	0.755
MOD_N-GLC_1	859	864	PF02516	0.705
MOD_N-GLC_1	874	879	PF02516	0.557
MOD_NEK2_1	119	124	PF00069	0.675
MOD_NEK2_1	28	33	PF00069	0.668
MOD_NEK2_1	282	287	PF00069	0.488
MOD_NEK2_1	430	435	PF00069	0.530
MOD_NEK2_1	476	481	PF00069	0.369
MOD_NEK2_1	52	57	PF00069	0.793
MOD_NEK2_1	530	535	PF00069	0.556
MOD_NEK2_1	760	765	PF00069	0.733
MOD_NEK2_1	87	92	PF00069	0.754
MOD_NEK2_1	871	876	PF00069	0.707
MOD_NEK2_2	180	185	PF00069	0.622
MOD_NEK2_2	750	755	PF00069	0.780
MOD_NEK2_2	810	815	PF00069	0.736
MOD_PIKK_1	170	176	PF00454	0.645
MOD_PIKK_1	492	498	PF00454	0.530
MOD_PIKK_1	534	540	PF00454	0.508
MOD_PIKK_1	764	770	PF00454	0.783
MOD_PIKK_1	815	821	PF00454	0.660
MOD_PIKK_1	875	881	PF00454	0.658
MOD_PKA_2	142	148	PF00069	0.608
MOD_PKA_2	271	277	PF00069	0.588
MOD_PKA_2	561	567	PF00069	0.869
MOD_PKA_2	590	596	PF00069	0.641
MOD_PKA_2	78	84	PF00069	0.783
MOD_Plk_1	282	288	PF00069	0.530
MOD_Plk_1	392	398	PF00069	0.428
MOD_Plk_1	511	517	PF00069	0.510
MOD_Plk_1	750	756	PF00069	0.780
MOD_Plk_1	810	816	PF00069	0.680
MOD_Plk_1	832	838	PF00069	0.825
MOD_Plk_4	219	225	PF00069	0.452
MOD_Plk_4	511	517	PF00069	0.633
MOD_Plk_4	52	58	PF00069	0.647
MOD_Plk_4	530	536	PF00069	0.325
MOD_Plk_4	652	658	PF00069	0.764
MOD_Plk_4	810	816	PF00069	0.731
MOD_ProDKin_1	421	427	PF00069	0.579
MOD_ProDKin_1	490	496	PF00069	0.452
MOD_ProDKin_1	681	687	PF00069	0.786
MOD_ProDKin_1	755	761	PF00069	0.741
MOD_ProDKin_1	769	775	PF00069	0.668
MOD_ProDKin_1	785	791	PF00069	0.754
MOD_ProDKin_1	806	812	PF00069	0.841
MOD_ProDKin_1	886	892	PF00069	0.654
MOD_SUMO_for_1	252	255	PF00179	0.610
MOD_SUMO_rev_2	257	267	PF00179	0.578
MOD_SUMO_rev_2	312	318	PF00179	0.452
MOD_SUMO_rev_2	453	462	PF00179	0.530
TRG_DiLeu_BaEn_3	450	456	PF01217	0.530
TRG_DiLeu_BaEn_4	229	235	PF01217	0.530
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.369
TRG_ENDOCYTIC_2	190	193	PF00928	0.601
TRG_ENDOCYTIC_2	673	676	PF00928	0.841
TRG_ENDOCYTIC_2	84	87	PF00928	0.755
TRG_ER_diArg_1	104	106	PF00400	0.779
TRG_ER_diArg_1	415	418	PF00400	0.530
TRG_ER_diArg_1	44	46	PF00400	0.802
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9P5	Leishmania braziliensis	77%	95%
A4HY12	Leishmania infantum	99%	100%
E9ARS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4QDP7	Leishmania major	94%	99%