Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H739_LEIDO

TriTrypDb:

LdBPK_181150.1 , LdCL_180016700 , LDHU3_18.1460

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H739

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H739

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.576
CLV_C14_Caspase3-7	500	504	PF00656	0.553
CLV_NRD_NRD_1	365	367	PF00675	0.570
CLV_NRD_NRD_1	376	378	PF00675	0.495
CLV_NRD_NRD_1	485	487	PF00675	0.616
CLV_NRD_NRD_1	59	61	PF00675	0.544
CLV_NRD_NRD_1	662	664	PF00675	0.676
CLV_NRD_NRD_1	666	668	PF00675	0.719
CLV_NRD_NRD_1	693	695	PF00675	0.700
CLV_NRD_NRD_1	855	857	PF00675	0.702
CLV_NRD_NRD_1	934	936	PF00675	0.739
CLV_PCSK_FUR_1	374	378	PF00082	0.638
CLV_PCSK_FUR_1	656	660	PF00082	0.677
CLV_PCSK_KEX2_1	262	264	PF00082	0.670
CLV_PCSK_KEX2_1	278	280	PF00082	0.485
CLV_PCSK_KEX2_1	358	360	PF00082	0.588
CLV_PCSK_KEX2_1	365	367	PF00082	0.547
CLV_PCSK_KEX2_1	376	378	PF00082	0.487
CLV_PCSK_KEX2_1	485	487	PF00082	0.616
CLV_PCSK_KEX2_1	517	519	PF00082	0.597
CLV_PCSK_KEX2_1	658	660	PF00082	0.651
CLV_PCSK_KEX2_1	661	663	PF00082	0.681
CLV_PCSK_KEX2_1	666	668	PF00082	0.720
CLV_PCSK_KEX2_1	695	697	PF00082	0.739
CLV_PCSK_KEX2_1	854	856	PF00082	0.835
CLV_PCSK_KEX2_1	934	936	PF00082	0.696
CLV_PCSK_KEX2_1	95	97	PF00082	0.483
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.665
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.421
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.642
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.624
CLV_PCSK_PC1ET2_1	695	697	PF00082	0.792
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.495
CLV_PCSK_PC7_1	656	662	PF00082	0.729
CLV_PCSK_SKI1_1	186	190	PF00082	0.614
CLV_PCSK_SKI1_1	278	282	PF00082	0.631
CLV_PCSK_SKI1_1	485	489	PF00082	0.561
CLV_PCSK_SKI1_1	547	551	PF00082	0.552
CLV_PCSK_SKI1_1	92	96	PF00082	0.586
CLV_Separin_Metazoa	590	594	PF03568	0.540
CLV_Separin_Metazoa	649	653	PF03568	0.629
DEG_APCC_DBOX_1	300	308	PF00400	0.652
DEG_APCC_DBOX_1	501	509	PF00400	0.649
DEG_SPOP_SBC_1	345	349	PF00917	0.648
DEG_SPOP_SBC_1	673	677	PF00917	0.775
DOC_CYCLIN_RxL_1	275	284	PF00134	0.463
DOC_CYCLIN_RxL_1	37	51	PF00134	0.584
DOC_CYCLIN_RxL_1	746	759	PF00134	0.585
DOC_CYCLIN_yClb5_NLxxxL_5	260	269	PF00134	0.615
DOC_MAPK_gen_1	438	446	PF00069	0.538
DOC_MAPK_gen_1	746	755	PF00069	0.581
DOC_MAPK_MEF2A_6	440	448	PF00069	0.543
DOC_USP7_MATH_1	181	185	PF00917	0.536
DOC_USP7_MATH_1	188	192	PF00917	0.517
DOC_USP7_MATH_1	346	350	PF00917	0.650
DOC_USP7_MATH_1	665	669	PF00917	0.775
DOC_USP7_MATH_1	673	677	PF00917	0.745
DOC_USP7_MATH_1	705	709	PF00917	0.817
DOC_USP7_MATH_1	803	807	PF00917	0.760
DOC_USP7_MATH_1	886	890	PF00917	0.753
DOC_USP7_MATH_1	916	920	PF00917	0.623
DOC_USP7_UBL2_3	170	174	PF12436	0.635
DOC_WW_Pin1_4	10	15	PF00397	0.647
DOC_WW_Pin1_4	812	817	PF00397	0.636
DOC_WW_Pin1_4	865	870	PF00397	0.725
DOC_WW_Pin1_4	878	883	PF00397	0.739
LIG_14-3-3_CanoR_1	180	190	PF00244	0.613
LIG_14-3-3_CanoR_1	204	212	PF00244	0.611
LIG_14-3-3_CanoR_1	303	308	PF00244	0.629
LIG_14-3-3_CanoR_1	586	594	PF00244	0.584
LIG_14-3-3_CanoR_1	875	880	PF00244	0.701
LIG_14-3-3_CanoR_1	900	905	PF00244	0.686
LIG_14-3-3_CanoR_1	96	104	PF00244	0.501
LIG_Actin_WH2_2	202	219	PF00022	0.607
LIG_Actin_WH2_2	766	784	PF00022	0.479
LIG_CaM_IQ_9	209	225	PF13499	0.618
LIG_FHA_1	13	19	PF00498	0.697
LIG_FHA_1	473	479	PF00498	0.567
LIG_FHA_1	587	593	PF00498	0.588
LIG_FHA_1	716	722	PF00498	0.706
LIG_FHA_2	100	106	PF00498	0.625
LIG_FHA_2	190	196	PF00498	0.528
LIG_FHA_2	284	290	PF00498	0.568
LIG_FHA_2	318	324	PF00498	0.632
LIG_FHA_2	346	352	PF00498	0.563
LIG_FHA_2	355	361	PF00498	0.499
LIG_FHA_2	387	393	PF00498	0.591
LIG_FHA_2	523	529	PF00498	0.599
LIG_FHA_2	597	603	PF00498	0.704
LIG_FHA_2	862	868	PF00498	0.574
LIG_FHA_2	900	906	PF00498	0.688
LIG_LIR_Apic_2	874	880	PF02991	0.728
LIG_LIR_Gen_1	17	24	PF02991	0.557
LIG_LIR_Gen_1	638	647	PF02991	0.591
LIG_LIR_Nem_3	17	23	PF02991	0.583
LIG_NRBOX	772	778	PF00104	0.470
LIG_RPA_C_Fungi	562	574	PF08784	0.541
LIG_SH2_CRK	70	74	PF00017	0.533
LIG_SH2_CRK	877	881	PF00017	0.724
LIG_SH2_NCK_1	70	74	PF00017	0.576
LIG_SH2_NCK_1	877	881	PF00017	0.724
LIG_SH2_PTP2	20	23	PF00017	0.596
LIG_SH2_SRC	20	23	PF00017	0.540
LIG_SH2_STAP1	322	326	PF00017	0.640
LIG_SH2_STAP1	647	651	PF00017	0.627
LIG_SH2_STAT5	140	143	PF00017	0.610
LIG_SH2_STAT5	146	149	PF00017	0.515
LIG_SH2_STAT5	20	23	PF00017	0.596
LIG_SH3_2	3	8	PF14604	0.611
LIG_SH3_3	3	9	PF00018	0.723
LIG_SH3_3	708	714	PF00018	0.755
LIG_SUMO_SIM_par_1	392	399	PF11976	0.551
LIG_SUMO_SIM_par_1	769	775	PF11976	0.488
LIG_TRAF2_1	175	178	PF00917	0.625
LIG_TRAF2_1	232	235	PF00917	0.679
LIG_TRAF2_1	287	290	PF00917	0.648
LIG_TRAF2_1	368	371	PF00917	0.629
LIG_TRAF2_1	434	437	PF00917	0.500
LIG_TRAF2_1	646	649	PF00917	0.624
LIG_TRAF2_1	79	82	PF00917	0.518
LIG_TYR_ITIM	18	23	PF00017	0.648
LIG_UBA3_1	507	512	PF00899	0.546
MOD_CDK_SPxxK_3	865	872	PF00069	0.669
MOD_CK1_1	13	19	PF00069	0.608
MOD_CK1_1	184	190	PF00069	0.628
MOD_CK1_1	191	197	PF00069	0.579
MOD_CK1_1	386	392	PF00069	0.470
MOD_CK1_1	600	606	PF00069	0.652
MOD_CK1_1	638	644	PF00069	0.615
MOD_CK1_1	672	678	PF00069	0.723
MOD_CK1_1	681	687	PF00069	0.677
MOD_CK1_1	716	722	PF00069	0.628
MOD_CK1_1	878	884	PF00069	0.736
MOD_CK2_1	189	195	PF00069	0.530
MOD_CK2_1	283	289	PF00069	0.599
MOD_CK2_1	292	298	PF00069	0.567
MOD_CK2_1	336	342	PF00069	0.614
MOD_CK2_1	345	351	PF00069	0.547
MOD_CK2_1	354	360	PF00069	0.400
MOD_CK2_1	386	392	PF00069	0.576
MOD_CK2_1	430	436	PF00069	0.539
MOD_CK2_1	522	528	PF00069	0.601
MOD_CK2_1	596	602	PF00069	0.660
MOD_CK2_1	643	649	PF00069	0.568
MOD_CK2_1	680	686	PF00069	0.753
MOD_CK2_1	861	867	PF00069	0.740
MOD_CK2_1	899	905	PF00069	0.690
MOD_CK2_1	99	105	PF00069	0.619
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.713
MOD_GlcNHglycan	10	13	PF01048	0.697
MOD_GlcNHglycan	185	189	PF01048	0.657
MOD_GlcNHglycan	243	246	PF01048	0.648
MOD_GlcNHglycan	348	351	PF01048	0.555
MOD_GlcNHglycan	426	429	PF01048	0.568
MOD_GlcNHglycan	431	435	PF01048	0.537
MOD_GlcNHglycan	671	674	PF01048	0.772
MOD_GlcNHglycan	805	808	PF01048	0.722
MOD_GlcNHglycan	81	86	PF01048	0.577
MOD_GlcNHglycan	843	846	PF01048	0.688
MOD_GlcNHglycan	877	880	PF01048	0.674
MOD_GlcNHglycan	892	895	PF01048	0.619
MOD_GSK3_1	184	191	PF00069	0.564
MOD_GSK3_1	299	306	PF00069	0.646
MOD_GSK3_1	37	44	PF00069	0.512
MOD_GSK3_1	382	389	PF00069	0.594
MOD_GSK3_1	392	399	PF00069	0.488
MOD_GSK3_1	596	603	PF00069	0.729
MOD_GSK3_1	619	626	PF00069	0.658
MOD_GSK3_1	665	672	PF00069	0.763
MOD_GSK3_1	674	681	PF00069	0.712
MOD_GSK3_1	799	806	PF00069	0.739
MOD_GSK3_1	8	15	PF00069	0.677
MOD_GSK3_1	850	857	PF00069	0.747
MOD_GSK3_1	861	868	PF00069	0.522
MOD_GSK3_1	871	878	PF00069	0.792
MOD_GSK3_1	882	889	PF00069	0.715
MOD_GSK3_1	914	921	PF00069	0.591
MOD_GSK3_1	95	102	PF00069	0.558
MOD_N-GLC_1	679	684	PF02516	0.810
MOD_N-GLC_1	850	855	PF02516	0.744
MOD_NEK2_1	299	304	PF00069	0.601
MOD_NEK2_1	344	349	PF00069	0.571
MOD_NEK2_1	354	359	PF00069	0.510
MOD_NEK2_1	41	46	PF00069	0.509
MOD_NEK2_1	430	435	PF00069	0.532
MOD_NEK2_1	522	527	PF00069	0.597
MOD_NEK2_1	573	578	PF00069	0.565
MOD_PIKK_1	549	555	PF00454	0.587
MOD_PIKK_1	886	892	PF00454	0.718
MOD_PKA_1	854	860	PF00069	0.695
MOD_PKA_1	95	101	PF00069	0.529
MOD_PKA_2	292	298	PF00069	0.625
MOD_PKA_2	327	333	PF00069	0.567
MOD_PKA_2	472	478	PF00069	0.512
MOD_PKA_2	643	649	PF00069	0.625
MOD_PKA_2	665	671	PF00069	0.727
MOD_PKA_2	716	722	PF00069	0.628
MOD_PKA_2	807	813	PF00069	0.618
MOD_PKA_2	854	860	PF00069	0.694
MOD_PKA_2	871	877	PF00069	0.554
MOD_PKA_2	899	905	PF00069	0.673
MOD_PKA_2	95	101	PF00069	0.529
MOD_PKB_1	301	309	PF00069	0.648
MOD_PKB_1	667	675	PF00069	0.735
MOD_PKB_1	839	847	PF00069	0.693
MOD_Plk_1	184	190	PF00069	0.628
MOD_Plk_1	299	305	PF00069	0.599
MOD_Plk_1	370	376	PF00069	0.631
MOD_Plk_1	41	47	PF00069	0.509
MOD_Plk_1	430	436	PF00069	0.555
MOD_Plk_1	638	644	PF00069	0.689
MOD_Plk_1	860	866	PF00069	0.734
MOD_Plk_1	99	105	PF00069	0.580
MOD_Plk_2-3	392	398	PF00069	0.554
MOD_Plk_2-3	766	772	PF00069	0.485
MOD_Plk_2-3	861	867	PF00069	0.577
MOD_Plk_4	303	309	PF00069	0.645
MOD_Plk_4	738	744	PF00069	0.562
MOD_Plk_4	766	772	PF00069	0.485
MOD_ProDKin_1	10	16	PF00069	0.640
MOD_ProDKin_1	812	818	PF00069	0.631
MOD_ProDKin_1	865	871	PF00069	0.727
MOD_ProDKin_1	878	884	PF00069	0.737
MOD_SUMO_for_1	749	752	PF00179	0.598
MOD_SUMO_rev_2	109	118	PF00179	0.549
MOD_SUMO_rev_2	420	425	PF00179	0.546
TRG_DiLeu_BaEn_1	332	337	PF01217	0.583
TRG_DiLeu_BaEn_1	766	771	PF01217	0.485
TRG_DiLeu_BaEn_4	370	376	PF01217	0.631
TRG_DiLeu_BaEn_4	50	56	PF01217	0.503
TRG_DiLeu_BaEn_4	582	588	PF01217	0.604
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.461
TRG_ENDOCYTIC_2	20	23	PF00928	0.540
TRG_ENDOCYTIC_2	640	643	PF00928	0.585
TRG_ENDOCYTIC_2	647	650	PF00928	0.537
TRG_ENDOCYTIC_2	70	73	PF00928	0.477
TRG_ENDOCYTIC_2	91	94	PF00928	0.490
TRG_ER_diArg_1	119	122	PF00400	0.546
TRG_ER_diArg_1	301	304	PF00400	0.616
TRG_ER_diArg_1	365	367	PF00400	0.591
TRG_ER_diArg_1	374	377	PF00400	0.599
TRG_ER_diArg_1	656	659	PF00400	0.650
TRG_ER_diArg_1	660	663	PF00400	0.690
TRG_ER_diArg_1	666	669	PF00400	0.697
TRG_ER_diArg_1	728	731	PF00400	0.512
TRG_ER_diArg_1	785	788	PF00400	0.602
TRG_ER_diArg_1	840	843	PF00400	0.673
TRG_ER_diArg_1	854	856	PF00400	0.604
TRG_ER_diArg_1	933	935	PF00400	0.741
TRG_NLS_MonoExtC_3	693	699	PF00514	0.734
TRG_NLS_MonoExtN_4	692	698	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	627	632	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	652	657	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBB1	Leptomonas seymouri	61%	80%
A0A3R7MU41	Trypanosoma rangeli	39%	96%
A4H9M4	Leishmania braziliensis	83%	100%
A4HXY8	Leishmania infantum	100%	100%
D0A5B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9ARQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDS8	Leishmania major	94%	100%
V5BEK2	Trypanosoma cruzi	40%	95%