Origin recognition complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H733_LEIDO

TriTrypDb:

LdBPK_180720.1 , LdCL_180012300 , LDHU3_18.0970

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H733

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H733

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.759
CLV_NRD_NRD_1	180	182	PF00675	0.774
CLV_NRD_NRD_1	200	202	PF00675	0.716
CLV_NRD_NRD_1	438	440	PF00675	0.552
CLV_NRD_NRD_1	604	606	PF00675	0.583
CLV_NRD_NRD_1	663	665	PF00675	0.703
CLV_NRD_NRD_1	70	72	PF00675	0.528
CLV_PCSK_KEX2_1	180	182	PF00082	0.774
CLV_PCSK_KEX2_1	200	202	PF00082	0.759
CLV_PCSK_KEX2_1	333	335	PF00082	0.573
CLV_PCSK_KEX2_1	407	409	PF00082	0.588
CLV_PCSK_KEX2_1	438	440	PF00082	0.611
CLV_PCSK_KEX2_1	604	606	PF00082	0.583
CLV_PCSK_KEX2_1	663	665	PF00082	0.703
CLV_PCSK_KEX2_1	70	72	PF00082	0.528
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.573
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.588
CLV_PCSK_PC7_1	329	335	PF00082	0.578
CLV_PCSK_SKI1_1	354	358	PF00082	0.693
CLV_PCSK_SKI1_1	439	443	PF00082	0.531
CLV_PCSK_SKI1_1	604	608	PF00082	0.569
CLV_PCSK_SKI1_1	740	744	PF00082	0.579
CLV_PCSK_SKI1_1	783	787	PF00082	0.530
CLV_PCSK_SKI1_1	819	823	PF00082	0.525
CLV_PCSK_SKI1_1	83	87	PF00082	0.640
CLV_Separin_Metazoa	528	532	PF03568	0.647
CLV_Separin_Metazoa	843	847	PF03568	0.498
DEG_APCC_DBOX_1	437	445	PF00400	0.617
DEG_APCC_DBOX_1	604	612	PF00400	0.577
DEG_APCC_DBOX_1	739	747	PF00400	0.580
DEG_APCC_DBOX_1	794	802	PF00400	0.545
DEG_APCC_DBOX_1	818	826	PF00400	0.511
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	244	248	PF00917	0.618
DEG_SPOP_SBC_1	493	497	PF00917	0.649
DOC_CYCLIN_RxL_1	435	446	PF00134	0.617
DOC_CYCLIN_RxL_1	54	68	PF00134	0.533
DOC_CYCLIN_yClb5_NLxxxL_5	718	727	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.704
DOC_CYCLIN_yCln2_LP_2	718	721	PF00134	0.651
DOC_MAPK_DCC_7	475	485	PF00069	0.700
DOC_MAPK_DCC_7	708	718	PF00069	0.776
DOC_MAPK_gen_1	435	444	PF00069	0.577
DOC_MAPK_gen_1	817	825	PF00069	0.618
DOC_MAPK_MEF2A_6	475	483	PF00069	0.639
DOC_MAPK_MEF2A_6	740	747	PF00069	0.476
DOC_PP2B_LxvP_1	479	482	PF13499	0.602
DOC_PP2B_LxvP_1	718	721	PF13499	0.683
DOC_USP7_MATH_1	219	223	PF00917	0.814
DOC_USP7_MATH_1	3	7	PF00917	0.709
DOC_USP7_MATH_1	513	517	PF00917	0.694
DOC_USP7_MATH_1	53	57	PF00917	0.569
DOC_USP7_MATH_1	542	546	PF00917	0.734
DOC_USP7_MATH_1	551	555	PF00917	0.585
DOC_USP7_MATH_1	623	627	PF00917	0.682
DOC_USP7_MATH_1	631	635	PF00917	0.640
DOC_USP7_MATH_1	652	656	PF00917	0.504
DOC_WW_Pin1_4	102	107	PF00397	0.509
DOC_WW_Pin1_4	13	18	PF00397	0.778
DOC_WW_Pin1_4	460	465	PF00397	0.736
DOC_WW_Pin1_4	69	74	PF00397	0.619
LIG_14-3-3_CanoR_1	183	188	PF00244	0.839
LIG_14-3-3_CanoR_1	338	346	PF00244	0.568
LIG_14-3-3_CanoR_1	396	405	PF00244	0.646
LIG_14-3-3_CanoR_1	423	431	PF00244	0.578
LIG_14-3-3_CanoR_1	439	445	PF00244	0.529
LIG_14-3-3_CanoR_1	475	483	PF00244	0.709
LIG_14-3-3_CanoR_1	504	509	PF00244	0.624
LIG_14-3-3_CanoR_1	605	611	PF00244	0.579
LIG_14-3-3_CanoR_1	71	77	PF00244	0.500
LIG_14-3-3_CanoR_1	846	851	PF00244	0.614
LIG_Actin_WH2_2	786	802	PF00022	0.627
LIG_Actin_WH2_2	96	114	PF00022	0.484
LIG_BRCT_BRCA1_1	496	500	PF00533	0.804
LIG_Clathr_ClatBox_1	128	132	PF01394	0.615
LIG_EH1_1	58	66	PF00400	0.521
LIG_eIF4E_1	295	301	PF01652	0.491
LIG_FHA_1	158	164	PF00498	0.628
LIG_FHA_1	246	252	PF00498	0.629
LIG_FHA_1	341	347	PF00498	0.538
LIG_FHA_1	451	457	PF00498	0.750
LIG_FHA_1	503	509	PF00498	0.740
LIG_FHA_1	516	522	PF00498	0.445
LIG_FHA_1	73	79	PF00498	0.409
LIG_FHA_1	752	758	PF00498	0.541
LIG_FHA_2	229	235	PF00498	0.727
LIG_FHA_2	428	434	PF00498	0.612
LIG_FHA_2	566	572	PF00498	0.729
LIG_FHA_2	759	765	PF00498	0.547
LIG_GBD_Chelix_1	562	570	PF00786	0.713
LIG_GBD_Chelix_1	95	103	PF00786	0.487
LIG_LIR_Apic_2	704	709	PF02991	0.764
LIG_LIR_Nem_3	122	128	PF02991	0.496
LIG_LIR_Nem_3	26	32	PF02991	0.543
LIG_LIR_Nem_3	342	348	PF02991	0.562
LIG_LIR_Nem_3	675	680	PF02991	0.664
LIG_MYND_1	711	715	PF01753	0.635
LIG_NRBOX	352	358	PF00104	0.597
LIG_NRBOX	440	446	PF00104	0.632
LIG_NRBOX	722	728	PF00104	0.687
LIG_PDZ_Class_1	846	851	PF00595	0.614
LIG_Pex14_2	125	129	PF04695	0.501
LIG_SH2_CRK	29	33	PF00017	0.532
LIG_SH2_CRK	706	710	PF00017	0.761
LIG_SH2_PTP2	345	348	PF00017	0.553
LIG_SH2_STAT5	116	119	PF00017	0.625
LIG_SH2_STAT5	250	253	PF00017	0.651
LIG_SH2_STAT5	295	298	PF00017	0.490
LIG_SH2_STAT5	345	348	PF00017	0.553
LIG_SH3_1	344	350	PF00018	0.572
LIG_SH3_1	616	622	PF00018	0.647
LIG_SH3_1	708	714	PF00018	0.694
LIG_SH3_3	184	190	PF00018	0.751
LIG_SH3_3	344	350	PF00018	0.572
LIG_SH3_3	616	622	PF00018	0.740
LIG_SH3_3	708	714	PF00018	0.694
LIG_SUMO_SIM_anti_2	574	585	PF11976	0.620
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.473
LIG_SUMO_SIM_par_1	159	166	PF11976	0.621
LIG_SUMO_SIM_par_1	265	271	PF11976	0.480
LIG_SUMO_SIM_par_1	440	449	PF11976	0.647
LIG_SUMO_SIM_par_1	820	827	PF11976	0.518
LIG_TYR_ITIM	746	751	PF00017	0.478
LIG_UBA3_1	266	270	PF00899	0.472
LIG_UBA3_1	822	828	PF00899	0.606
LIG_ULM_U2AF65_1	200	205	PF00076	0.833
LIG_WRC_WIRS_1	99	104	PF05994	0.591
MOD_CK1_1	105	111	PF00069	0.518
MOD_CK1_1	176	182	PF00069	0.767
MOD_CK1_1	185	191	PF00069	0.720
MOD_CK1_1	246	252	PF00069	0.629
MOD_CK1_1	337	343	PF00069	0.576
MOD_CK1_1	390	396	PF00069	0.523
MOD_CK1_1	427	433	PF00069	0.584
MOD_CK1_1	460	466	PF00069	0.742
MOD_CK1_1	492	498	PF00069	0.713
MOD_CK1_1	499	505	PF00069	0.693
MOD_CK1_1	507	513	PF00069	0.642
MOD_CK1_1	515	521	PF00069	0.438
MOD_CK1_1	574	580	PF00069	0.668
MOD_CK1_1	626	632	PF00069	0.702
MOD_CK1_1	655	661	PF00069	0.658
MOD_CK1_1	772	778	PF00069	0.569
MOD_CK2_1	13	19	PF00069	0.752
MOD_CK2_1	228	234	PF00069	0.755
MOD_CK2_1	427	433	PF00069	0.609
MOD_CK2_1	565	571	PF00069	0.725
MOD_CK2_1	699	705	PF00069	0.827
MOD_Cter_Amidation	602	605	PF01082	0.579
MOD_GlcNHglycan	107	110	PF01048	0.618
MOD_GlcNHglycan	150	153	PF01048	0.655
MOD_GlcNHglycan	175	178	PF01048	0.726
MOD_GlcNHglycan	220	224	PF01048	0.763
MOD_GlcNHglycan	239	242	PF01048	0.742
MOD_GlcNHglycan	256	259	PF01048	0.452
MOD_GlcNHglycan	297	300	PF01048	0.484
MOD_GlcNHglycan	322	325	PF01048	0.509
MOD_GlcNHglycan	389	392	PF01048	0.510
MOD_GlcNHglycan	459	462	PF01048	0.670
MOD_GlcNHglycan	471	474	PF01048	0.598
MOD_GlcNHglycan	476	479	PF01048	0.579
MOD_GlcNHglycan	491	494	PF01048	0.697
MOD_GlcNHglycan	544	547	PF01048	0.633
MOD_GlcNHglycan	55	58	PF01048	0.533
MOD_GlcNHglycan	553	556	PF01048	0.597
MOD_GlcNHglycan	592	595	PF01048	0.734
MOD_GlcNHglycan	6	9	PF01048	0.800
MOD_GlcNHglycan	601	604	PF01048	0.656
MOD_GlcNHglycan	628	631	PF01048	0.699
MOD_GlcNHglycan	754	757	PF01048	0.665
MOD_GSK3_1	163	170	PF00069	0.631
MOD_GSK3_1	185	192	PF00069	0.814
MOD_GSK3_1	242	249	PF00069	0.614
MOD_GSK3_1	268	275	PF00069	0.478
MOD_GSK3_1	28	35	PF00069	0.532
MOD_GSK3_1	333	340	PF00069	0.583
MOD_GSK3_1	440	447	PF00069	0.634
MOD_GSK3_1	469	476	PF00069	0.790
MOD_GSK3_1	488	495	PF00069	0.714
MOD_GSK3_1	498	505	PF00069	0.692
MOD_GSK3_1	561	568	PF00069	0.642
MOD_GSK3_1	571	578	PF00069	0.579
MOD_GSK3_1	768	775	PF00069	0.550
MOD_GSK3_1	98	105	PF00069	0.591
MOD_N-GLC_1	572	577	PF02516	0.740
MOD_N-GLC_1	699	704	PF02516	0.734
MOD_NEK2_1	117	122	PF00069	0.598
MOD_NEK2_1	162	167	PF00069	0.578
MOD_NEK2_1	243	248	PF00069	0.632
MOD_NEK2_1	268	273	PF00069	0.488
MOD_NEK2_1	32	37	PF00069	0.617
MOD_NEK2_1	357	362	PF00069	0.602
MOD_NEK2_1	384	389	PF00069	0.512
MOD_NEK2_1	413	418	PF00069	0.569
MOD_NEK2_1	512	517	PF00069	0.648
MOD_NEK2_1	572	577	PF00069	0.625
MOD_NEK2_1	599	604	PF00069	0.636
MOD_NEK2_1	821	826	PF00069	0.501
MOD_NEK2_2	28	33	PF00069	0.531
MOD_OFUCOSY	40	47	PF10250	0.517
MOD_PIKK_1	163	169	PF00454	0.674
MOD_PIKK_1	803	809	PF00454	0.558
MOD_PK_1	504	510	PF00069	0.683
MOD_PKA_1	333	339	PF00069	0.580
MOD_PKA_2	182	188	PF00069	0.855
MOD_PKA_2	204	210	PF00069	0.752
MOD_PKA_2	32	38	PF00069	0.520
MOD_PKA_2	333	339	PF00069	0.580
MOD_PKA_2	395	401	PF00069	0.540
MOD_PKA_2	469	475	PF00069	0.744
MOD_PKA_2	53	59	PF00069	0.549
MOD_PKA_2	542	548	PF00069	0.608
MOD_PKA_2	682	688	PF00069	0.612
MOD_PKB_1	181	189	PF00069	0.850
MOD_Plk_1	427	433	PF00069	0.609
MOD_Plk_1	758	764	PF00069	0.658
MOD_Plk_2-3	228	234	PF00069	0.732
MOD_Plk_2-3	565	571	PF00069	0.725
MOD_Plk_4	157	163	PF00069	0.711
MOD_Plk_4	246	252	PF00069	0.619
MOD_Plk_4	272	278	PF00069	0.458
MOD_Plk_4	315	321	PF00069	0.490
MOD_Plk_4	440	446	PF00069	0.726
MOD_Plk_4	507	513	PF00069	0.662
MOD_Plk_4	576	582	PF00069	0.587
MOD_Plk_4	606	612	PF00069	0.578
MOD_Plk_4	652	658	PF00069	0.630
MOD_Plk_4	714	720	PF00069	0.658
MOD_Plk_4	72	78	PF00069	0.485
MOD_Plk_4	821	827	PF00069	0.508
MOD_Plk_4	98	104	PF00069	0.590
MOD_ProDKin_1	102	108	PF00069	0.504
MOD_ProDKin_1	13	19	PF00069	0.775
MOD_ProDKin_1	460	466	PF00069	0.735
MOD_ProDKin_1	69	75	PF00069	0.613
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.565
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.532
TRG_DiLeu_BaLyEn_6	788	793	PF01217	0.507
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.549
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.285
TRG_ENDOCYTIC_2	29	32	PF00928	0.531
TRG_ENDOCYTIC_2	345	348	PF00928	0.553
TRG_ENDOCYTIC_2	748	751	PF00928	0.481
TRG_ER_diArg_1	180	183	PF00400	0.865
TRG_ER_diArg_1	200	203	PF00400	0.750
TRG_ER_diArg_1	604	606	PF00400	0.583
TRG_ER_diArg_1	611	614	PF00400	0.595
TRG_ER_diArg_1	69	71	PF00400	0.513
TRG_ER_FFAT_2	494	505	PF00635	0.794
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN4	Leptomonas seymouri	55%	76%
A4H9I3	Leishmania braziliensis	79%	100%
A4HXU7	Leishmania infantum	100%	100%
E9ARK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDX0	Leishmania major	92%	100%