Tubulin binding cofactor C, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin cofactor C domain-containing protein RP2, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H730_LEIDO

TriTrypDb:

LdBPK_180530.1 , LdCL_180010200 , LDHU3_18.0660

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H730

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H730

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0034453	microtubule anchoring	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	11
GO:0008047	enzyme activator activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.482
CLV_C14_Caspase3-7	39	43	PF00656	0.715
CLV_PCSK_KEX2_1	186	188	PF00082	0.626
CLV_PCSK_KEX2_1	460	462	PF00082	0.758
CLV_PCSK_KEX2_1	64	66	PF00082	0.653
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.622
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.758
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.653
CLV_PCSK_SKI1_1	244	248	PF00082	0.405
DEG_SCF_FBW7_2	322	328	PF00400	0.561
DEG_SPOP_SBC_1	439	443	PF00917	0.886
DEG_SPOP_SBC_1	444	448	PF00917	0.905
DOC_CDC14_PxL_1	474	482	PF14671	0.721
DOC_CKS1_1	322	327	PF01111	0.559
DOC_CYCLIN_RxL_1	47	57	PF00134	0.661
DOC_CYCLIN_RxL_1	85	93	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.637
DOC_MAPK_gen_1	241	250	PF00069	0.401
DOC_MAPK_gen_1	256	265	PF00069	0.356
DOC_MAPK_HePTP_8	238	250	PF00069	0.403
DOC_MAPK_HePTP_8	255	267	PF00069	0.337
DOC_MAPK_MEF2A_6	241	250	PF00069	0.403
DOC_MAPK_MEF2A_6	258	267	PF00069	0.337
DOC_PP1_RVXF_1	48	55	PF00149	0.671
DOC_PP2B_LxvP_1	288	291	PF13499	0.425
DOC_USP7_MATH_1	162	166	PF00917	0.823
DOC_USP7_MATH_1	364	368	PF00917	0.516
DOC_USP7_MATH_1	40	44	PF00917	0.708
DOC_USP7_MATH_1	414	418	PF00917	0.871
DOC_USP7_MATH_1	434	438	PF00917	0.839
DOC_USP7_MATH_1	439	443	PF00917	0.823
DOC_USP7_MATH_1	463	467	PF00917	0.709
DOC_WW_Pin1_4	313	318	PF00397	0.588
DOC_WW_Pin1_4	321	326	PF00397	0.564
DOC_WW_Pin1_4	480	485	PF00397	0.838
LIG_14-3-3_CanoR_1	341	346	PF00244	0.642
LIG_14-3-3_CanoR_1	65	74	PF00244	0.676
LIG_Actin_WH2_2	22	38	PF00022	0.655
LIG_Actin_WH2_2	89	104	PF00022	0.711
LIG_BIR_II_1	1	5	PF00653	0.729
LIG_BIR_III_4	146	150	PF00653	0.733
LIG_CAP-Gly_1	520	528	PF01302	0.719
LIG_FHA_1	176	182	PF00498	0.522
LIG_FHA_1	208	214	PF00498	0.409
LIG_FHA_1	245	251	PF00498	0.425
LIG_FHA_1	269	275	PF00498	0.395
LIG_FHA_1	481	487	PF00498	0.822
LIG_FHA_1	55	61	PF00498	0.702
LIG_FHA_1	7	13	PF00498	0.593
LIG_FHA_1	84	90	PF00498	0.544
LIG_FHA_2	101	107	PF00498	0.669
LIG_FHA_2	151	157	PF00498	0.831
LIG_FHA_2	218	224	PF00498	0.390
LIG_FHA_2	3	9	PF00498	0.700
LIG_FHA_2	314	320	PF00498	0.508
LIG_LIR_Apic_2	344	348	PF02991	0.639
LIG_LIR_Gen_1	501	510	PF02991	0.751
LIG_LIR_Nem_3	282	286	PF02991	0.486
LIG_LIR_Nem_3	339	345	PF02991	0.624
LIG_LIR_Nem_3	501	506	PF02991	0.731
LIG_LIR_Nem_3	76	80	PF02991	0.573
LIG_MYND_1	478	482	PF01753	0.727
LIG_PDZ_Class_3	523	528	PF00595	0.712
LIG_Pex14_2	180	184	PF04695	0.474
LIG_Pex14_2	327	331	PF04695	0.615
LIG_PTB_Apo_2	497	504	PF02174	0.834
LIG_PTB_Phospho_1	497	503	PF10480	0.835
LIG_SH2_STAP1	85	89	PF00017	0.546
LIG_SH2_STAT5	179	182	PF00017	0.482
LIG_SH2_STAT5	204	207	PF00017	0.437
LIG_SH2_STAT5	77	80	PF00017	0.512
LIG_SH2_STAT5	85	88	PF00017	0.549
LIG_SH3_1	345	351	PF00018	0.499
LIG_SH3_3	314	320	PF00018	0.558
LIG_SH3_3	326	332	PF00018	0.486
LIG_SH3_3	345	351	PF00018	0.393
LIG_SH3_3	476	482	PF00018	0.779
LIG_SH3_3	50	56	PF00018	0.711
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.611
LIG_SUMO_SIM_par_1	209	215	PF11976	0.508
LIG_SUMO_SIM_par_1	56	62	PF11976	0.715
LIG_TRAF2_1	148	151	PF00917	0.903
LIG_TRAF2_1	417	420	PF00917	0.732
LIG_TYR_ITIM	78	83	PF00017	0.627
LIG_WRC_WIRS_1	503	508	PF05994	0.743
MOD_CK1_1	164	170	PF00069	0.742
MOD_CK1_1	367	373	PF00069	0.607
MOD_CK1_1	43	49	PF00069	0.671
MOD_CK1_1	442	448	PF00069	0.849
MOD_CK1_1	449	455	PF00069	0.855
MOD_CK2_1	100	106	PF00069	0.648
MOD_CK2_1	150	156	PF00069	0.860
MOD_CK2_1	2	8	PF00069	0.723
MOD_CK2_1	313	319	PF00069	0.636
MOD_CK2_1	413	419	PF00069	0.829
MOD_CK2_1	447	453	PF00069	0.898
MOD_GlcNHglycan	103	106	PF01048	0.641
MOD_GlcNHglycan	123	126	PF01048	0.525
MOD_GlcNHglycan	164	167	PF01048	0.792
MOD_GlcNHglycan	18	22	PF01048	0.533
MOD_GlcNHglycan	195	198	PF01048	0.526
MOD_GlcNHglycan	2	5	PF01048	0.674
MOD_GlcNHglycan	369	372	PF01048	0.640
MOD_GlcNHglycan	38	41	PF01048	0.497
MOD_GlcNHglycan	408	411	PF01048	0.775
MOD_GlcNHglycan	436	439	PF01048	0.836
MOD_GlcNHglycan	44	48	PF01048	0.773
MOD_GlcNHglycan	442	445	PF01048	0.847
MOD_GlcNHglycan	465	468	PF01048	0.806
MOD_GSK3_1	175	182	PF00069	0.531
MOD_GSK3_1	2	9	PF00069	0.662
MOD_GSK3_1	203	210	PF00069	0.530
MOD_GSK3_1	275	282	PF00069	0.482
MOD_GSK3_1	34	41	PF00069	0.676
MOD_GSK3_1	434	441	PF00069	0.837
MOD_GSK3_1	442	449	PF00069	0.803
MOD_N-GLC_1	175	180	PF02516	0.623
MOD_N-GLC_1	244	249	PF02516	0.449
MOD_N-GLC_1	372	377	PF02516	0.652
MOD_NEK2_1	17	22	PF00069	0.663
MOD_NEK2_1	83	88	PF00069	0.569
MOD_NEK2_2	234	239	PF00069	0.389
MOD_PKA_2	101	107	PF00069	0.669
MOD_Plk_1	174	180	PF00069	0.543
MOD_Plk_1	244	250	PF00069	0.449
MOD_Plk_1	372	378	PF00069	0.663
MOD_Plk_1	501	507	PF00069	0.805
MOD_Plk_1	69	75	PF00069	0.617
MOD_Plk_2-3	217	223	PF00069	0.389
MOD_Plk_2-3	426	432	PF00069	0.861
MOD_Plk_2-3	502	508	PF00069	0.839
MOD_Plk_4	175	181	PF00069	0.518
MOD_Plk_4	2	8	PF00069	0.744
MOD_Plk_4	207	213	PF00069	0.385
MOD_Plk_4	234	240	PF00069	0.401
MOD_Plk_4	69	75	PF00069	0.581
MOD_ProDKin_1	313	319	PF00069	0.586
MOD_ProDKin_1	321	327	PF00069	0.560
MOD_ProDKin_1	480	486	PF00069	0.843
MOD_SUMO_rev_2	299	306	PF00179	0.436
TRG_DiLeu_BaEn_1	130	135	PF01217	0.524
TRG_DiLeu_BaEn_1	225	230	PF01217	0.405
TRG_DiLeu_BaEn_1	353	358	PF01217	0.475
TRG_DiLeu_BaEn_2	234	240	PF01217	0.416
TRG_ENDOCYTIC_2	23	26	PF00928	0.727
TRG_ENDOCYTIC_2	503	506	PF00928	0.744
TRG_ENDOCYTIC_2	80	83	PF00928	0.611
TRG_ER_diArg_1	255	258	PF00400	0.389
TRG_NLS_MonoExtN_4	183	189	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z4	Leptomonas seymouri	60%	100%
A0A0S4J201	Bodo saltans	49%	100%
A0A1X0P6T6	Trypanosomatidae	53%	100%
A0A3R7NEX5	Trypanosoma rangeli	52%	100%
A4H9G1	Leishmania braziliensis	79%	99%
A4HXS8	Leishmania infantum	98%	99%
D0A060	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ARJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BRP2	Trypanosoma cruzi	52%	100%