BTB/POZ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H729_LEIDO

TriTrypDb:

LdBPK_180490.1 , LdCL_180009800 , LDHU3_18.0610

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H729

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H729

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0051259	protein complex oligomerization	6	7
GO:0051260	protein homooligomerization	7	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.338
CLV_NRD_NRD_1	126	128	PF00675	0.479
CLV_NRD_NRD_1	36	38	PF00675	0.304
CLV_PCSK_KEX2_1	126	128	PF00082	0.414
CLV_PCSK_KEX2_1	36	38	PF00082	0.304
CLV_PCSK_SKI1_1	184	188	PF00082	0.674
CLV_PCSK_SKI1_1	279	283	PF00082	0.371
CLV_PCSK_SKI1_1	41	45	PF00082	0.369
DEG_APCC_DBOX_1	36	44	PF00400	0.304
DEG_SCF_FBW7_1	162	167	PF00400	0.514
DOC_CDC14_PxL_1	225	233	PF14671	0.344
DOC_CYCLIN_RxL_1	276	283	PF00134	0.388
DOC_MAPK_DCC_7	226	236	PF00069	0.411
DOC_MAPK_gen_1	277	284	PF00069	0.441
DOC_MAPK_MEF2A_6	277	284	PF00069	0.441
DOC_PP1_RVXF_1	240	247	PF00149	0.471
DOC_PP2B_LxvP_1	282	285	PF13499	0.380
DOC_PP2B_LxvP_1	86	89	PF13499	0.304
DOC_USP7_MATH_1	139	143	PF00917	0.478
DOC_USP7_MATH_1	206	210	PF00917	0.646
DOC_WW_Pin1_4	160	165	PF00397	0.580
LIG_14-3-3_CanoR_1	208	215	PF00244	0.608
LIG_14-3-3_CanoR_1	279	285	PF00244	0.380
LIG_14-3-3_CanoR_1	36	41	PF00244	0.369
LIG_14-3-3_CanoR_1	85	89	PF00244	0.333
LIG_APCC_ABBAyCdc20_2	242	248	PF00400	0.476
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_CSL_BTD_1	135	138	PF09270	0.370
LIG_FHA_1	189	195	PF00498	0.675
LIG_FHA_1	247	253	PF00498	0.475
LIG_FHA_1	258	264	PF00498	0.323
LIG_FHA_2	37	43	PF00498	0.369
LIG_LIR_Gen_1	240	251	PF02991	0.315
LIG_LIR_Gen_1	94	102	PF02991	0.410
LIG_LIR_Nem_3	101	107	PF02991	0.356
LIG_LIR_Nem_3	240	246	PF02991	0.302
LIG_LIR_Nem_3	72	77	PF02991	0.308
LIG_LIR_Nem_3	94	98	PF02991	0.355
LIG_SH2_NCK_1	105	109	PF00017	0.369
LIG_SH2_SRC	76	79	PF00017	0.358
LIG_SH2_STAT5	134	137	PF00017	0.373
LIG_SH2_STAT5	33	36	PF00017	0.335
LIG_SH2_STAT5	38	41	PF00017	0.329
LIG_SH2_STAT5	76	79	PF00017	0.304
LIG_SH2_STAT5	80	83	PF00017	0.304
LIG_SH3_1	226	232	PF00018	0.414
LIG_SH3_3	132	138	PF00018	0.373
LIG_SH3_3	159	165	PF00018	0.660
LIG_SH3_3	226	232	PF00018	0.587
LIG_SUMO_SIM_par_1	259	264	PF11976	0.431
LIG_TYR_ITIM	102	107	PF00017	0.369
LIG_WW_2	229	232	PF00397	0.532
MOD_CK1_1	160	166	PF00069	0.542
MOD_CK1_1	216	222	PF00069	0.543
MOD_CK2_1	139	145	PF00069	0.507
MOD_CK2_1	36	42	PF00069	0.369
MOD_GlcNHglycan	1	4	PF01048	0.475
MOD_GlcNHglycan	159	162	PF01048	0.760
MOD_GlcNHglycan	209	212	PF01048	0.724
MOD_GlcNHglycan	219	222	PF01048	0.596
MOD_GlcNHglycan	239	242	PF01048	0.321
MOD_GSK3_1	160	167	PF00069	0.569
MOD_GSK3_1	171	178	PF00069	0.603
MOD_GSK3_1	184	191	PF00069	0.555
MOD_GSK3_1	213	220	PF00069	0.601
MOD_GSK3_1	257	264	PF00069	0.481
MOD_GSK3_1	28	35	PF00069	0.369
MOD_NEK2_1	110	115	PF00069	0.437
MOD_NEK2_1	120	125	PF00069	0.398
MOD_NEK2_1	169	174	PF00069	0.551
MOD_NEK2_1	246	251	PF00069	0.422
MOD_NEK2_1	32	37	PF00069	0.304
MOD_NEK2_1	8	13	PF00069	0.474
MOD_PIKK_1	246	252	PF00454	0.410
MOD_PKA_1	36	42	PF00069	0.369
MOD_PKA_2	175	181	PF00069	0.527
MOD_PKA_2	207	213	PF00069	0.614
MOD_PKA_2	246	252	PF00069	0.410
MOD_PKA_2	36	42	PF00069	0.369
MOD_PKA_2	84	90	PF00069	0.325
MOD_Plk_1	110	116	PF00069	0.450
MOD_Plk_4	110	116	PF00069	0.444
MOD_Plk_4	120	126	PF00069	0.369
MOD_Plk_4	164	170	PF00069	0.576
MOD_Plk_4	257	263	PF00069	0.357
MOD_Plk_4	28	34	PF00069	0.369
MOD_Plk_4	3	9	PF00069	0.456
MOD_Plk_4	61	67	PF00069	0.304
MOD_Plk_4	69	75	PF00069	0.304
MOD_ProDKin_1	160	166	PF00069	0.581
TRG_DiLeu_BaEn_1	94	99	PF01217	0.304
TRG_DiLeu_BaEn_2	60	66	PF01217	0.304
TRG_ENDOCYTIC_2	104	107	PF00928	0.369
TRG_ER_diArg_1	125	127	PF00400	0.467
TRG_ER_diArg_1	277	280	PF00400	0.447
TRG_ER_diArg_1	36	38	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z1	Leptomonas seymouri	56%	100%
A4H9F7	Leishmania braziliensis	77%	100%
A4HXS4	Leishmania infantum	99%	100%
E9ARI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDZ3	Leishmania major	92%	100%