Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H726_LEIDO

TriTrypDb:

LdBPK_180310.1 , LdCL_180008000 , LDHU3_18.0390

Length:

102

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S5H726

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H726

PDB structure(s): 7aih_BD , 7ane_BD

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.490
CLV_PCSK_KEX2_1	49	51	PF00082	0.490
DOC_MAPK_DCC_7	27	35	PF00069	0.348
DOC_WW_Pin1_4	86	91	PF00397	0.504
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_BRCT_BRCA1_1	1	5	PF00533	0.415
LIG_FHA_1	92	98	PF00498	0.473
LIG_FHA_2	87	93	PF00498	0.553
LIG_LIR_Nem_3	71	76	PF02991	0.421
LIG_Pex14_2	5	9	PF04695	0.423

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU10	Leptomonas seymouri	83%	100%
A0A1X0P7S7	Trypanosomatidae	64%	88%
A0A3R7KLJ1	Trypanosoma rangeli	63%	92%
A4H9D5	Leishmania braziliensis	85%	100%
A4HXQ7	Leishmania infantum	98%	100%
B6DTF0	Bodo saltans	51%	84%
D0A037	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	90%
E9ARG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QE11	Leishmania major	89%	100%

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