UDP-galactopyranose_mutase/GeneDB:LmjF.18.0200

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactopyranose mutase

Species:

Leishmania donovani

UniProt:

A0A3S5H724_LEIDO

TriTrypDb:

LdBPK_180200.1 , LdCL_180006900 , LDHU3_18.0240

Length:

492

Annotations

Annotations by Jardim et al.

Glycosylation, UDP-galactopyranose mutase GLF

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H724

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H724

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006778	porphyrin-containing compound metabolic process	5	1
GO:0006779	porphyrin-containing compound biosynthetic process	6	1
GO:0006783	heme biosynthetic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0033013	tetrapyrrole metabolic process	4	1
GO:0033014	tetrapyrrole biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042168	heme metabolic process	3	1
GO:0042440	pigment metabolic process	2	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046148	pigment biosynthetic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008767	UDP-galactopyranose mutase activity	4	7
GO:0016491	oxidoreductase activity	2	11
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	1
GO:0070818	protoporphyrinogen oxidase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	193	195	PF00082	0.514
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.570
CLV_PCSK_SKI1_1	245	249	PF00082	0.450
CLV_PCSK_SKI1_1	384	388	PF00082	0.553
CLV_PCSK_SKI1_1	45	49	PF00082	0.429
CLV_PCSK_SKI1_1	51	55	PF00082	0.392
DEG_SPOP_SBC_1	302	306	PF00917	0.478
DOC_ANK_TNKS_1	142	149	PF00023	0.478
DOC_MAPK_FxFP_2	205	208	PF00069	0.435
DOC_MAPK_gen_1	185	192	PF00069	0.547
DOC_MAPK_gen_1	404	411	PF00069	0.594
DOC_MAPK_MEF2A_6	160	168	PF00069	0.508
DOC_MAPK_RevD_3	179	194	PF00069	0.502
DOC_PP4_FxxP_1	153	156	PF00568	0.429
DOC_PP4_FxxP_1	205	208	PF00568	0.435
DOC_USP7_MATH_1	259	263	PF00917	0.550
DOC_USP7_MATH_1	284	288	PF00917	0.541
DOC_USP7_MATH_1	99	103	PF00917	0.580
DOC_USP7_UBL2_3	218	222	PF12436	0.580
DOC_WW_Pin1_4	288	293	PF00397	0.397
LIG_14-3-3_CanoR_1	384	389	PF00244	0.611
LIG_14-3-3_CanoR_1	484	488	PF00244	0.722
LIG_Actin_WH2_2	14	29	PF00022	0.463
LIG_Actin_WH2_2	368	386	PF00022	0.638
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	141	145	PF00533	0.538
LIG_CSL_BTD_1	94	97	PF09270	0.508
LIG_CtBP_PxDLS_1	318	322	PF00389	0.541
LIG_deltaCOP1_diTrp_1	195	205	PF00928	0.435
LIG_deltaCOP1_diTrp_1	86	95	PF00928	0.459
LIG_FHA_1	169	175	PF00498	0.436
LIG_FHA_1	211	217	PF00498	0.423
LIG_FHA_1	242	248	PF00498	0.524
LIG_FHA_1	261	267	PF00498	0.547
LIG_FHA_1	304	310	PF00498	0.426
LIG_FHA_1	383	389	PF00498	0.644
LIG_FHA_2	372	378	PF00498	0.563
LIG_FHA_2	463	469	PF00498	0.610
LIG_IRF3_LxIS_1	72	78	PF10401	0.580
LIG_LIR_Apic_2	151	156	PF02991	0.426
LIG_LIR_Apic_2	204	208	PF02991	0.435
LIG_LIR_Gen_1	256	265	PF02991	0.454
LIG_LIR_Gen_1	323	334	PF02991	0.483
LIG_LIR_Gen_1	352	361	PF02991	0.519
LIG_LIR_Gen_1	397	407	PF02991	0.615
LIG_LIR_Gen_1	64	73	PF02991	0.420
LIG_LIR_Gen_1	78	86	PF02991	0.417
LIG_LIR_Nem_3	256	260	PF02991	0.454
LIG_LIR_Nem_3	323	329	PF02991	0.457
LIG_LIR_Nem_3	340	345	PF02991	0.459
LIG_LIR_Nem_3	352	358	PF02991	0.514
LIG_LIR_Nem_3	397	402	PF02991	0.528
LIG_LIR_Nem_3	427	432	PF02991	0.602
LIG_LIR_Nem_3	64	69	PF02991	0.420
LIG_LIR_Nem_3	78	83	PF02991	0.417
LIG_LIR_Nem_3	92	98	PF02991	0.380
LIG_MAD2	6	14	PF02301	0.485
LIG_SH2_CRK	257	261	PF00017	0.455
LIG_SH2_CRK	367	371	PF00017	0.523
LIG_SH2_NCK_1	442	446	PF00017	0.558
LIG_SH2_STAP1	257	261	PF00017	0.435
LIG_SH2_STAT3	98	101	PF00017	0.435
LIG_SH2_STAT5	140	143	PF00017	0.526
LIG_SH2_STAT5	328	331	PF00017	0.467
LIG_SH2_STAT5	68	71	PF00017	0.435
LIG_SH3_3	467	473	PF00018	0.547
LIG_SH3_3	93	99	PF00018	0.437
LIG_SUMO_SIM_par_1	356	362	PF11976	0.467
LIG_TRAF2_1	129	132	PF00917	0.530
LIG_TYR_ITIM	255	260	PF00017	0.435
LIG_TYR_ITIM	365	370	PF00017	0.590
LIG_UBA3_1	23	27	PF00899	0.541
LIG_UBA3_1	308	314	PF00899	0.580
MOD_CDK_SPK_2	288	293	PF00069	0.366
MOD_CDK_SPxxK_3	288	295	PF00069	0.366
MOD_CK1_1	210	216	PF00069	0.534
MOD_CK2_1	371	377	PF00069	0.539
MOD_GlcNHglycan	1	4	PF01048	0.740
MOD_GlcNHglycan	209	212	PF01048	0.534
MOD_GlcNHglycan	250	253	PF01048	0.425
MOD_GlcNHglycan	284	287	PF01048	0.596
MOD_GlcNHglycan	91	94	PF01048	0.534
MOD_GSK3_1	241	248	PF00069	0.497
MOD_GSK3_1	280	287	PF00069	0.509
MOD_GSK3_1	462	469	PF00069	0.587
MOD_GSK3_1	483	490	PF00069	0.667
MOD_GSK3_1	75	82	PF00069	0.580
MOD_N-GLC_1	201	206	PF02516	0.446
MOD_NEK2_1	260	265	PF00069	0.444
MOD_NEK2_1	301	306	PF00069	0.435
MOD_NEK2_1	359	364	PF00069	0.613
MOD_NEK2_1	43	48	PF00069	0.451
MOD_NEK2_1	483	488	PF00069	0.726
MOD_NEK2_2	201	206	PF00069	0.435
MOD_NEK2_2	337	342	PF00069	0.459
MOD_PIKK_1	359	365	PF00454	0.592
MOD_PIKK_1	475	481	PF00454	0.542
MOD_PKA_2	111	117	PF00069	0.534
MOD_PKA_2	235	241	PF00069	0.463
MOD_PKA_2	337	343	PF00069	0.456
MOD_PKA_2	483	489	PF00069	0.663
MOD_PKA_2	84	90	PF00069	0.435
MOD_Plk_1	201	207	PF00069	0.435
MOD_Plk_1	447	453	PF00069	0.478
MOD_Plk_1	466	472	PF00069	0.538
MOD_Plk_2-3	253	259	PF00069	0.478
MOD_Plk_4	337	343	PF00069	0.463
MOD_Plk_4	371	377	PF00069	0.529
MOD_Plk_4	384	390	PF00069	0.481
MOD_Plk_4	447	453	PF00069	0.478
MOD_Plk_4	84	90	PF00069	0.435
MOD_ProDKin_1	288	294	PF00069	0.397
MOD_SUMO_rev_2	2	8	PF00179	0.594
MOD_SUMO_rev_2	44	53	PF00179	0.442
TRG_ENDOCYTIC_2	217	220	PF00928	0.455
TRG_ENDOCYTIC_2	257	260	PF00928	0.419
TRG_ENDOCYTIC_2	367	370	PF00928	0.510
TRG_ENDOCYTIC_2	66	69	PF00928	0.419
TRG_ER_diArg_1	292	295	PF00400	0.580
TRG_ER_diArg_1	434	437	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X8	Leptomonas seymouri	75%	100%
A0A0S4J0D0	Bodo saltans	54%	100%
A0A1X0P6P6	Trypanosomatidae	58%	100%
A0A422NWN4	Trypanosoma rangeli	60%	100%
A4H9C5	Leishmania braziliensis	87%	100%
A4HXP6	Leishmania infantum	100%	100%
E9ARF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q5EEK0	Leishmania major	96%	100%
V5BLY6	Trypanosoma cruzi	58%	100%