Major facilitator superfamily protein (MFS), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H721_LEIDO

TriTrypDb:

LdBPK_180040.1 , LdCL_180005300 , LDHU3_18.0050

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S5H721

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H721

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.270
CLV_C14_Caspase3-7	26	30	PF00656	0.532
CLV_C14_Caspase3-7	446	450	PF00656	0.527
CLV_NRD_NRD_1	486	488	PF00675	0.509
CLV_PCSK_KEX2_1	486	488	PF00082	0.508
CLV_PCSK_KEX2_1	533	535	PF00082	0.606
CLV_PCSK_KEX2_1	83	85	PF00082	0.542
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.583
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.542
CLV_PCSK_SKI1_1	39	43	PF00082	0.240
CLV_PCSK_SKI1_1	461	465	PF00082	0.193
CLV_PCSK_SKI1_1	56	60	PF00082	0.415
CLV_PCSK_SKI1_1	84	88	PF00082	0.524
DEG_APCC_DBOX_1	460	468	PF00400	0.393
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DOC_CDC14_PxL_1	194	202	PF14671	0.265
DOC_CKS1_1	35	40	PF01111	0.296
DOC_CKS1_1	505	510	PF01111	0.396
DOC_MAPK_MEF2A_6	112	119	PF00069	0.444
DOC_MAPK_MEF2A_6	461	468	PF00069	0.444
DOC_MAPK_NFAT4_5	461	469	PF00069	0.530
DOC_PP1_RVXF_1	37	44	PF00149	0.381
DOC_PP2B_LxvP_1	12	15	PF13499	0.625
DOC_PP2B_LxvP_1	473	476	PF13499	0.224
DOC_PP4_FxxP_1	408	411	PF00568	0.410
DOC_PP4_FxxP_1	472	475	PF00568	0.397
DOC_USP7_MATH_1	108	112	PF00917	0.527
DOC_USP7_MATH_1	15	19	PF00917	0.678
DOC_USP7_MATH_1	236	240	PF00917	0.419
DOC_USP7_MATH_1	351	355	PF00917	0.188
DOC_USP7_MATH_1	492	496	PF00917	0.411
DOC_USP7_MATH_1	499	503	PF00917	0.422
DOC_USP7_MATH_1	62	66	PF00917	0.259
DOC_WW_Pin1_4	201	206	PF00397	0.307
DOC_WW_Pin1_4	34	39	PF00397	0.271
DOC_WW_Pin1_4	407	412	PF00397	0.414
DOC_WW_Pin1_4	504	509	PF00397	0.450
DOC_WW_Pin1_4	74	79	PF00397	0.230
DOC_WW_Pin1_4	96	101	PF00397	0.270
LIG_14-3-3_CanoR_1	169	173	PF00244	0.445
LIG_14-3-3_CanoR_1	56	61	PF00244	0.272
LIG_Actin_WH2_2	448	463	PF00022	0.557
LIG_APCC_ABBA_1	50	55	PF00400	0.330
LIG_BIR_III_4	29	33	PF00653	0.516
LIG_BRCT_BRCA1_1	417	421	PF00533	0.486
LIG_BRCT_BRCA1_1	98	102	PF00533	0.270
LIG_Clathr_ClatBox_1	51	55	PF01394	0.414
LIG_FHA_1	1	7	PF00498	0.721
LIG_FHA_1	134	140	PF00498	0.219
LIG_FHA_1	154	160	PF00498	0.296
LIG_FHA_1	168	174	PF00498	0.419
LIG_FHA_1	247	253	PF00498	0.402
LIG_FHA_1	270	276	PF00498	0.360
LIG_FHA_1	292	298	PF00498	0.242
LIG_FHA_1	353	359	PF00498	0.283
LIG_FHA_1	361	367	PF00498	0.227
LIG_FHA_1	373	379	PF00498	0.130
LIG_FHA_1	489	495	PF00498	0.453
LIG_FHA_1	505	511	PF00498	0.475
LIG_FHA_1	8	14	PF00498	0.733
LIG_FHA_2	156	162	PF00498	0.225
LIG_FHA_2	233	239	PF00498	0.435
LIG_FXI_DFP_1	405	409	PF00024	0.230
LIG_HP1_1	219	223	PF01393	0.276
LIG_LIR_Apic_2	276	281	PF02991	0.270
LIG_LIR_Apic_2	33	38	PF02991	0.507
LIG_LIR_Apic_2	407	411	PF02991	0.413
LIG_LIR_Gen_1	132	143	PF02991	0.205
LIG_LIR_Gen_1	149	160	PF02991	0.209
LIG_LIR_Gen_1	266	275	PF02991	0.376
LIG_LIR_Gen_1	396	405	PF02991	0.431
LIG_LIR_Nem_3	132	138	PF02991	0.196
LIG_LIR_Nem_3	149	155	PF02991	0.199
LIG_LIR_Nem_3	170	175	PF02991	0.415
LIG_LIR_Nem_3	195	200	PF02991	0.259
LIG_LIR_Nem_3	204	209	PF02991	0.218
LIG_LIR_Nem_3	266	271	PF02991	0.376
LIG_LIR_Nem_3	396	400	PF02991	0.437
LIG_LIR_Nem_3	48	53	PF02991	0.375
LIG_LYPXL_yS_3	197	200	PF13949	0.305
LIG_MLH1_MIPbox_1	417	421	PF16413	0.468
LIG_PCNA_yPIPBox_3	379	391	PF02747	0.225
LIG_Pex14_1	172	176	PF04695	0.225
LIG_Pex14_1	206	210	PF04695	0.193
LIG_Pex14_1	278	282	PF04695	0.221
LIG_Pex14_1	531	535	PF04695	0.330
LIG_Pex14_2	360	364	PF04695	0.248
LIG_Pex14_2	440	444	PF04695	0.547
LIG_Pex14_2	468	472	PF04695	0.347
LIG_Pex14_2	50	54	PF04695	0.381
LIG_PTB_Apo_2	252	259	PF02174	0.393
LIG_PTB_Phospho_1	252	258	PF10480	0.401
LIG_REV1ctd_RIR_1	418	427	PF16727	0.478
LIG_SH2_CRK	135	139	PF00017	0.244
LIG_SH2_CRK	177	181	PF00017	0.236
LIG_SH2_CRK	258	262	PF00017	0.296
LIG_SH2_CRK	268	272	PF00017	0.188
LIG_SH2_NCK_1	177	181	PF00017	0.236
LIG_SH2_SRC	226	229	PF00017	0.276
LIG_SH2_STAP1	135	139	PF00017	0.212
LIG_SH2_STAP1	393	397	PF00017	0.393
LIG_SH2_STAT5	135	138	PF00017	0.323
LIG_SH2_STAT5	210	213	PF00017	0.276
LIG_SH2_STAT5	226	229	PF00017	0.146
LIG_SH2_STAT5	268	271	PF00017	0.311
LIG_SH2_STAT5	470	473	PF00017	0.334
LIG_SH2_STAT5	53	56	PF00017	0.381
LIG_SH2_STAT5	95	98	PF00017	0.407
LIG_SH3_3	238	244	PF00018	0.549
LIG_SH3_3	505	511	PF00018	0.484
LIG_SH3_3	94	100	PF00018	0.330
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.212
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.270
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.289
LIG_SUMO_SIM_par_1	155	161	PF11976	0.270
LIG_SUMO_SIM_par_1	348	356	PF11976	0.209
LIG_TYR_ITIM	133	138	PF00017	0.212
LIG_WRC_WIRS_1	42	47	PF05994	0.381
MOD_CDK_SPK_2	34	39	PF00069	0.225
MOD_CDK_SPxK_1	201	207	PF00069	0.305
MOD_CK1_1	196	202	PF00069	0.263
MOD_CK1_1	381	387	PF00069	0.291
MOD_CK1_1	503	509	PF00069	0.415
MOD_CK1_1	65	71	PF00069	0.286
MOD_CK1_1	7	13	PF00069	0.716
MOD_CK2_1	232	238	PF00069	0.467
MOD_CK2_1	515	521	PF00069	0.475
MOD_GlcNHglycan	106	109	PF01048	0.288
MOD_GlcNHglycan	238	241	PF01048	0.192
MOD_GlcNHglycan	25	28	PF01048	0.443
MOD_GlcNHglycan	305	308	PF01048	0.411
MOD_GlcNHglycan	88	91	PF01048	0.250
MOD_GSK3_1	104	111	PF00069	0.453
MOD_GSK3_1	129	136	PF00069	0.353
MOD_GSK3_1	16	23	PF00069	0.605
MOD_GSK3_1	160	167	PF00069	0.451
MOD_GSK3_1	192	199	PF00069	0.277
MOD_GSK3_1	232	239	PF00069	0.367
MOD_GSK3_1	269	276	PF00069	0.365
MOD_GSK3_1	4	11	PF00069	0.691
MOD_GSK3_1	41	48	PF00069	0.451
MOD_GSK3_1	488	495	PF00069	0.311
MOD_GSK3_1	499	506	PF00069	0.266
MOD_GSK3_1	61	68	PF00069	0.221
MOD_GSK3_1	96	103	PF00069	0.460
MOD_N-GLC_1	133	138	PF02516	0.367
MOD_N-GLC_1	15	20	PF02516	0.518
MOD_N-GLC_1	378	383	PF02516	0.296
MOD_N-GLC_1	74	79	PF02516	0.430
MOD_N-GLC_2	431	433	PF02516	0.264
MOD_NEK2_1	133	138	PF00069	0.246
MOD_NEK2_1	155	160	PF00069	0.251
MOD_NEK2_1	175	180	PF00069	0.114
MOD_NEK2_1	193	198	PF00069	0.230
MOD_NEK2_1	246	251	PF00069	0.517
MOD_NEK2_1	263	268	PF00069	0.347
MOD_NEK2_1	288	293	PF00069	0.158
MOD_NEK2_1	360	365	PF00069	0.220
MOD_NEK2_1	372	377	PF00069	0.208
MOD_NEK2_1	45	50	PF00069	0.353
MOD_NEK2_1	513	518	PF00069	0.362
MOD_NEK2_1	86	91	PF00069	0.242
MOD_NEK2_2	100	105	PF00069	0.163
MOD_PIKK_1	4	10	PF00454	0.721
MOD_PKA_2	104	110	PF00069	0.382
MOD_PKA_2	168	174	PF00069	0.445
MOD_PKA_2	20	26	PF00069	0.552
MOD_Plk_1	133	139	PF00069	0.167
MOD_Plk_1	378	384	PF00069	0.296
MOD_Plk_1	492	498	PF00069	0.297
MOD_Plk_1	500	506	PF00069	0.334
MOD_Plk_1	8	14	PF00069	0.709
MOD_Plk_4	133	139	PF00069	0.335
MOD_Plk_4	155	161	PF00069	0.247
MOD_Plk_4	168	174	PF00069	0.377
MOD_Plk_4	175	181	PF00069	0.114
MOD_Plk_4	196	202	PF00069	0.239
MOD_Plk_4	378	384	PF00069	0.266
MOD_Plk_4	395	401	PF00069	0.390
MOD_Plk_4	8	14	PF00069	0.709
MOD_ProDKin_1	201	207	PF00069	0.307
MOD_ProDKin_1	34	40	PF00069	0.271
MOD_ProDKin_1	407	413	PF00069	0.418
MOD_ProDKin_1	504	510	PF00069	0.452
MOD_ProDKin_1	74	80	PF00069	0.230
MOD_ProDKin_1	96	102	PF00069	0.270
TRG_DiLeu_BaEn_1	9	14	PF01217	0.711
TRG_ENDOCYTIC_2	135	138	PF00928	0.193
TRG_ENDOCYTIC_2	177	180	PF00928	0.225
TRG_ENDOCYTIC_2	197	200	PF00928	0.285
TRG_ENDOCYTIC_2	258	261	PF00928	0.230
TRG_ENDOCYTIC_2	268	271	PF00928	0.223
TRG_ENDOCYTIC_2	397	400	PF00928	0.430
TRG_ENDOCYTIC_2	470	473	PF00928	0.334
TRG_ER_diArg_1	485	487	PF00400	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT4	Leptomonas seymouri	63%	100%
A0A0S4JAJ6	Bodo saltans	43%	100%
A0A1X0P6Q0	Trypanosomatidae	44%	100%
A0A3R7NQ56	Trypanosoma rangeli	46%	98%
A0A3R7R683	Trypanosoma rangeli	24%	70%
A2CER7	Danio rerio	26%	100%
A2SWM2	Danio rerio	25%	100%
A4HXN0	Leishmania infantum	100%	100%
A8WGF7	Xenopus tropicalis	26%	100%
B0JZE1	Xenopus tropicalis	25%	100%
C9ZSL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	100%
C9ZZY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A070	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ARE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F4IKF6	Arabidopsis thaliana	27%	100%
Q08DX7	Bos taurus	26%	100%
Q2YDU8	Rattus norvegicus	26%	100%
Q4QE38	Leishmania major	87%	100%
Q5XGK0	Xenopus laevis	26%	100%
Q6NMN6	Arabidopsis thaliana	26%	100%
Q6ZMD2	Homo sapiens	22%	100%
Q7ZU13	Danio rerio	26%	100%
Q8IVW8	Homo sapiens	27%	98%
Q8R0G7	Mus musculus	26%	100%
Q91VM4	Mus musculus	27%	98%
Q9D232	Mus musculus	24%	100%
Q9FLG8	Arabidopsis thaliana	28%	100%
Q9GQQ0	Drosophila melanogaster	26%	89%
Q9H2V7	Homo sapiens	26%	100%
V5B601	Trypanosoma cruzi	23%	72%
V5D5S9	Trypanosoma cruzi	44%	100%