Protein SDA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein SDA1

Gene product:

NUC130/3NT domain/SDA1, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H720_LEIDO

TriTrypDb:

LdBPK_171480.1 , LdCL_170021100 , LDHU3_17.2020

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S5H720

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H720

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	11
GO:0000055	ribosomal large subunit export from nucleus	4	11
GO:0006810	transport	3	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0030029	actin filament-based process	2	11
GO:0030036	actin cytoskeleton organization	3	11
GO:0031503	protein-containing complex localization	2	11
GO:0033036	macromolecule localization	2	11
GO:0033750	ribosome localization	3	11
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051168	nuclear export	6	11
GO:0051169	nuclear transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051640	organelle localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051656	establishment of organelle localization	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.380
CLV_C14_Caspase3-7	509	513	PF00656	0.321
CLV_C14_Caspase3-7	520	524	PF00656	0.274
CLV_C14_Caspase3-7	529	533	PF00656	0.235
CLV_C14_Caspase3-7	537	541	PF00656	0.192
CLV_C14_Caspase3-7	570	574	PF00656	0.707
CLV_C14_Caspase3-7	609	613	PF00656	0.405
CLV_NRD_NRD_1	130	132	PF00675	0.330
CLV_NRD_NRD_1	142	144	PF00675	0.367
CLV_NRD_NRD_1	18	20	PF00675	0.402
CLV_NRD_NRD_1	189	191	PF00675	0.374
CLV_NRD_NRD_1	272	274	PF00675	0.460
CLV_NRD_NRD_1	577	579	PF00675	0.738
CLV_NRD_NRD_1	749	751	PF00675	0.353
CLV_NRD_NRD_1	798	800	PF00675	0.313
CLV_NRD_NRD_1	808	810	PF00675	0.242
CLV_NRD_NRD_1	836	838	PF00675	0.242
CLV_PCSK_FUR_1	16	20	PF00082	0.404
CLV_PCSK_FUR_1	747	751	PF00082	0.427
CLV_PCSK_FUR_1	834	838	PF00082	0.261
CLV_PCSK_FUR_1	864	868	PF00082	0.274
CLV_PCSK_KEX2_1	158	160	PF00082	0.536
CLV_PCSK_KEX2_1	18	20	PF00082	0.402
CLV_PCSK_KEX2_1	188	190	PF00082	0.370
CLV_PCSK_KEX2_1	259	261	PF00082	0.438
CLV_PCSK_KEX2_1	265	267	PF00082	0.415
CLV_PCSK_KEX2_1	272	274	PF00082	0.418
CLV_PCSK_KEX2_1	409	411	PF00082	0.356
CLV_PCSK_KEX2_1	579	581	PF00082	0.669
CLV_PCSK_KEX2_1	749	751	PF00082	0.348
CLV_PCSK_KEX2_1	759	761	PF00082	0.266
CLV_PCSK_KEX2_1	783	785	PF00082	0.271
CLV_PCSK_KEX2_1	808	810	PF00082	0.289
CLV_PCSK_KEX2_1	824	826	PF00082	0.226
CLV_PCSK_KEX2_1	833	835	PF00082	0.271
CLV_PCSK_KEX2_1	836	838	PF00082	0.271
CLV_PCSK_KEX2_1	866	868	PF00082	0.283
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.393
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.451
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.440
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.453
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.356
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.654
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.339
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.297
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.271
CLV_PCSK_PC1ET2_1	824	826	PF00082	0.271
CLV_PCSK_PC1ET2_1	833	835	PF00082	0.271
CLV_PCSK_PC1ET2_1	866	868	PF00082	0.349
CLV_PCSK_PC7_1	405	411	PF00082	0.338
CLV_PCSK_SKI1_1	132	136	PF00082	0.339
CLV_PCSK_SKI1_1	214	218	PF00082	0.335
CLV_PCSK_SKI1_1	252	256	PF00082	0.466
CLV_PCSK_SKI1_1	262	266	PF00082	0.398
CLV_PCSK_SKI1_1	269	273	PF00082	0.376
CLV_PCSK_SKI1_1	723	727	PF00082	0.316
CLV_PCSK_SKI1_1	788	792	PF00082	0.334
CLV_PCSK_SKI1_1	859	863	PF00082	0.297
CLV_PCSK_SKI1_1	94	98	PF00082	0.291
CLV_Separin_Metazoa	79	83	PF03568	0.389
DEG_APCC_DBOX_1	217	225	PF00400	0.342
DEG_APCC_DBOX_1	6	14	PF00400	0.400
DEG_APCC_DBOX_1	824	832	PF00400	0.271
DEG_Kelch_Keap1_1	512	517	PF01344	0.380
DEG_SPOP_SBC_1	511	515	PF00917	0.325
DEG_SPOP_SBC_1	713	717	PF00917	0.389
DOC_ANK_TNKS_1	568	575	PF00023	0.665
DOC_CDC14_PxL_1	480	488	PF14671	0.266
DOC_CYCLIN_RxL_1	126	136	PF00134	0.457
DOC_MAPK_DCC_7	287	295	PF00069	0.388
DOC_MAPK_gen_1	126	135	PF00069	0.345
DOC_MAPK_HePTP_8	174	186	PF00069	0.323
DOC_MAPK_MEF2A_6	177	186	PF00069	0.317
DOC_MAPK_MEF2A_6	68	76	PF00069	0.356
DOC_PP1_RVXF_1	857	864	PF00149	0.271
DOC_PP2B_LxvP_1	222	225	PF13499	0.416
DOC_PP2B_LxvP_1	337	340	PF13499	0.476
DOC_PP4_MxPP_1	370	373	PF00568	0.384
DOC_SPAK_OSR1_1	316	320	PF12202	0.359
DOC_USP7_MATH_1	519	523	PF00917	0.440
DOC_USP7_MATH_1	539	543	PF00917	0.338
DOC_USP7_MATH_1	699	703	PF00917	0.385
DOC_USP7_UBL2_3	128	132	PF12436	0.429
DOC_USP7_UBL2_3	246	250	PF12436	0.443
DOC_USP7_UBL2_3	252	256	PF12436	0.468
DOC_USP7_UBL2_3	810	814	PF12436	0.247
DOC_USP7_UBL2_3	854	858	PF12436	0.273
DOC_USP7_UBL2_3	862	866	PF12436	0.274
DOC_WW_Pin1_4	207	212	PF00397	0.480
LIG_14-3-3_CanoR_1	189	198	PF00244	0.475
LIG_14-3-3_CanoR_1	226	231	PF00244	0.538
LIG_14-3-3_CanoR_1	329	337	PF00244	0.380
LIG_14-3-3_CanoR_1	36	43	PF00244	0.482
LIG_14-3-3_CanoR_1	391	399	PF00244	0.496
LIG_14-3-3_CanoR_1	723	730	PF00244	0.250
LIG_14-3-3_CanoR_1	799	807	PF00244	0.397
LIG_Actin_WH2_2	69	84	PF00022	0.397
LIG_APCC_ABBA_1	116	121	PF00400	0.351
LIG_APCC_ABBA_1	443	448	PF00400	0.291
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_1	1	5	PF00653	0.554
LIG_BIR_III_2	551	555	PF00653	0.246
LIG_BIR_III_3	1	5	PF00653	0.554
LIG_BIR_III_4	571	575	PF00653	0.665
LIG_BRCT_BRCA1_1	313	317	PF00533	0.411
LIG_BRCT_BRCA1_1	801	805	PF00533	0.397
LIG_CtBP_PxDLS_1	90	94	PF00389	0.294
LIG_FAT_LD_1	303	311	PF03623	0.356
LIG_FHA_1	113	119	PF00498	0.417
LIG_FHA_1	134	140	PF00498	0.466
LIG_FHA_1	195	201	PF00498	0.341
LIG_FHA_1	208	214	PF00498	0.349
LIG_FHA_1	355	361	PF00498	0.354
LIG_FHA_1	396	402	PF00498	0.333
LIG_FHA_1	468	474	PF00498	0.415
LIG_FHA_1	7	13	PF00498	0.386
LIG_FHA_1	714	720	PF00498	0.369
LIG_FHA_1	802	808	PF00498	0.368
LIG_FHA_2	15	21	PF00498	0.385
LIG_FHA_2	226	232	PF00498	0.485
LIG_FHA_2	328	334	PF00498	0.396
LIG_FHA_2	401	407	PF00498	0.326
LIG_FHA_2	518	524	PF00498	0.446
LIG_FHA_2	568	574	PF00498	0.795
LIG_FHA_2	602	608	PF00498	0.393
LIG_FHA_2	647	653	PF00498	0.349
LIG_FHA_2	724	730	PF00498	0.316
LIG_FHA_2	816	822	PF00498	0.271
LIG_Integrin_RGD_1	430	432	PF01839	0.271
LIG_LIR_Apic_2	346	351	PF02991	0.359
LIG_LIR_Gen_1	487	497	PF02991	0.325
LIG_LIR_Gen_1	532	543	PF02991	0.349
LIG_LIR_Gen_1	685	694	PF02991	0.366
LIG_LIR_Gen_1	727	736	PF02991	0.271
LIG_LIR_Nem_3	113	119	PF02991	0.360
LIG_LIR_Nem_3	33	38	PF02991	0.284
LIG_LIR_Nem_3	448	453	PF02991	0.324
LIG_LIR_Nem_3	487	493	PF02991	0.325
LIG_LIR_Nem_3	532	538	PF02991	0.349
LIG_LIR_Nem_3	685	690	PF02991	0.366
LIG_LIR_Nem_3	727	733	PF02991	0.271
LIG_LRP6_Inhibitor_1	399	405	PF00058	0.328
LIG_LYPXL_S_1	449	453	PF13949	0.291
LIG_LYPXL_yS_3	450	453	PF13949	0.291
LIG_MYND_1	451	455	PF01753	0.271
LIG_MYND_1	554	558	PF01753	0.642
LIG_PALB2_WD40_1	682	690	PF16756	0.389
LIG_Pex14_2	116	120	PF04695	0.342
LIG_PTB_Apo_2	46	53	PF02174	0.375
LIG_SH2_GRB2like	323	326	PF00017	0.355
LIG_SH2_NCK_1	480	484	PF00017	0.267
LIG_SH2_SRC	323	326	PF00017	0.355
LIG_SH2_SRC	490	493	PF00017	0.283
LIG_SH2_STAT3	275	278	PF00017	0.539
LIG_SH2_STAT3	426	429	PF00017	0.242
LIG_SH2_STAT5	323	326	PF00017	0.367
LIG_SH2_STAT5	480	483	PF00017	0.286
LIG_SH2_STAT5	58	61	PF00017	0.295
LIG_SH3_3	533	539	PF00018	0.367
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.316
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.357
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.371
LIG_SUMO_SIM_par_1	180	185	PF11976	0.315
LIG_SUMO_SIM_par_1	193	202	PF11976	0.347
LIG_SUMO_SIM_par_1	357	363	PF11976	0.364
LIG_SUMO_SIM_par_1	587	593	PF11976	0.654
LIG_TRAF2_1	542	545	PF00917	0.465
LIG_TRAF2_1	624	627	PF00917	0.274
LIG_TRAF2_1	665	668	PF00917	0.370
LIG_TYR_ITIM	321	326	PF00017	0.358
LIG_TYR_ITIM	488	493	PF00017	0.357
LIG_UBA3_1	101	107	PF00899	0.345
LIG_UBA3_1	306	312	PF00899	0.328
LIG_UBA3_1	419	427	PF00899	0.291
LIG_UBA3_1	828	833	PF00899	0.271
MOD_CDK_SPxxK_3	207	214	PF00069	0.473
MOD_CK1_1	207	213	PF00069	0.379
MOD_CK1_1	389	395	PF00069	0.428
MOD_CK1_1	44	50	PF00069	0.549
MOD_CK1_1	504	510	PF00069	0.295
MOD_CK1_1	590	596	PF00069	0.648
MOD_CK1_1	600	606	PF00069	0.458
MOD_CK1_1	707	713	PF00069	0.344
MOD_CK1_1	715	721	PF00069	0.334
MOD_CK1_1	742	748	PF00069	0.291
MOD_CK2_1	255	261	PF00069	0.521
MOD_CK2_1	327	333	PF00069	0.365
MOD_CK2_1	400	406	PF00069	0.339
MOD_CK2_1	499	505	PF00069	0.359
MOD_CK2_1	511	517	PF00069	0.273
MOD_CK2_1	519	525	PF00069	0.318
MOD_CK2_1	538	544	PF00069	0.179
MOD_CK2_1	601	607	PF00069	0.344
MOD_CK2_1	621	627	PF00069	0.375
MOD_CK2_1	630	636	PF00069	0.311
MOD_CK2_1	647	653	PF00069	0.372
MOD_CK2_1	658	664	PF00069	0.345
MOD_CK2_1	800	806	PF00069	0.286
MOD_CK2_1	815	821	PF00069	0.233
MOD_Cter_Amidation	747	750	PF01082	0.325
MOD_GlcNHglycan	362	365	PF01048	0.458
MOD_GlcNHglycan	38	41	PF01048	0.485
MOD_GlcNHglycan	392	395	PF01048	0.496
MOD_GlcNHglycan	500	504	PF01048	0.323
MOD_GlcNHglycan	514	517	PF01048	0.298
MOD_GlcNHglycan	540	544	PF01048	0.401
MOD_GlcNHglycan	564	567	PF01048	0.696
MOD_GlcNHglycan	673	676	PF01048	0.302
MOD_GlcNHglycan	681	684	PF01048	0.312
MOD_GSK3_1	108	115	PF00069	0.392
MOD_GSK3_1	133	140	PF00069	0.355
MOD_GSK3_1	190	197	PF00069	0.465
MOD_GSK3_1	386	393	PF00069	0.370
MOD_GSK3_1	499	506	PF00069	0.294
MOD_GSK3_1	517	524	PF00069	0.409
MOD_GSK3_1	597	604	PF00069	0.707
MOD_GSK3_1	635	642	PF00069	0.406
MOD_GSK3_1	688	695	PF00069	0.271
MOD_GSK3_1	704	711	PF00069	0.319
MOD_GSK3_1	713	720	PF00069	0.262
MOD_GSK3_1	735	742	PF00069	0.294
MOD_GSK3_1	810	817	PF00069	0.291
MOD_LATS_1	34	40	PF00433	0.367
MOD_N-GLC_1	14	19	PF02516	0.379
MOD_N-GLC_1	567	572	PF02516	0.599
MOD_N-GLC_1	697	702	PF02516	0.351
MOD_N-GLC_1	815	820	PF02516	0.291
MOD_NEK2_1	133	138	PF00069	0.353
MOD_NEK2_1	163	168	PF00069	0.394
MOD_NEK2_1	264	269	PF00069	0.526
MOD_NEK2_1	354	359	PF00069	0.369
MOD_NEK2_1	360	365	PF00069	0.329
MOD_NEK2_1	379	384	PF00069	0.455
MOD_NEK2_1	38	43	PF00069	0.348
MOD_NEK2_1	458	463	PF00069	0.371
MOD_NEK2_1	599	604	PF00069	0.789
MOD_NEK2_1	6	11	PF00069	0.392
MOD_NEK2_1	714	719	PF00069	0.368
MOD_NEK2_1	763	768	PF00069	0.184
MOD_NEK2_1	81	86	PF00069	0.322
MOD_NEK2_1	815	820	PF00069	0.288
MOD_NEK2_1	829	834	PF00069	0.271
MOD_NEK2_1	842	847	PF00069	0.245
MOD_NEK2_1	97	102	PF00069	0.312
MOD_NEK2_2	400	405	PF00069	0.324
MOD_NEK2_2	699	704	PF00069	0.214
MOD_PIKK_1	349	355	PF00454	0.374
MOD_PIKK_1	41	47	PF00454	0.494
MOD_PIKK_1	590	596	PF00454	0.729
MOD_PIKK_1	735	741	PF00454	0.325
MOD_PK_1	226	232	PF00069	0.485
MOD_PK_1	704	710	PF00069	0.389
MOD_PKA_1	255	261	PF00069	0.464
MOD_PKA_1	783	789	PF00069	0.301
MOD_PKA_1	799	805	PF00069	0.300
MOD_PKA_1	810	816	PF00069	0.217
MOD_PKA_2	225	231	PF00069	0.532
MOD_PKA_2	390	396	PF00069	0.515
MOD_PKA_2	458	464	PF00069	0.380
MOD_PKA_2	6	12	PF00069	0.408
MOD_PKA_2	783	789	PF00069	0.365
MOD_PKA_2	81	87	PF00069	0.389
MOD_PKA_2	848	854	PF00069	0.397
MOD_PKB_1	188	196	PF00069	0.482
MOD_Plk_1	112	118	PF00069	0.377
MOD_Plk_1	126	132	PF00069	0.377
MOD_Plk_1	194	200	PF00069	0.348
MOD_Plk_2-3	194	200	PF00069	0.426
MOD_Plk_2-3	20	26	PF00069	0.475
MOD_Plk_2-3	517	523	PF00069	0.342
MOD_Plk_2-3	546	552	PF00069	0.463
MOD_Plk_2-3	601	607	PF00069	0.356
MOD_Plk_2-3	630	636	PF00069	0.272
MOD_Plk_2-3	647	653	PF00069	0.379
MOD_Plk_4	38	44	PF00069	0.407
MOD_Plk_4	6	12	PF00069	0.401
MOD_Plk_4	97	103	PF00069	0.397
MOD_ProDKin_1	207	213	PF00069	0.472
MOD_SUMO_for_1	665	668	PF00179	0.214
MOD_SUMO_for_1	790	793	PF00179	0.380
MOD_SUMO_rev_2	540	549	PF00179	0.211
MOD_SUMO_rev_2	855	863	PF00179	0.271
TRG_DiLeu_BaEn_4	668	674	PF01217	0.310
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.347
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.336
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.359
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.456
TRG_DiLeu_BaLyEn_6	720	725	PF01217	0.397
TRG_ENDOCYTIC_2	323	326	PF00928	0.355
TRG_ENDOCYTIC_2	342	345	PF00928	0.342
TRG_ENDOCYTIC_2	446	449	PF00928	0.279
TRG_ENDOCYTIC_2	450	453	PF00928	0.263
TRG_ENDOCYTIC_2	480	483	PF00928	0.288
TRG_ENDOCYTIC_2	490	493	PF00928	0.296
TRG_ER_diArg_1	16	19	PF00400	0.402
TRG_ER_diArg_1	187	190	PF00400	0.356
TRG_ER_diArg_1	577	580	PF00400	0.742
TRG_ER_diArg_1	807	809	PF00400	0.288
TRG_ER_diArg_1	834	837	PF00400	0.261
TRG_NLS_Bipartite_1	799	815	PF00514	0.289
TRG_NLS_MonoCore_2	808	813	PF00514	0.263
TRG_NLS_MonoExtC_3	577	582	PF00514	0.640
TRG_NLS_MonoExtC_3	809	814	PF00514	0.266
TRG_NLS_MonoExtC_3	832	837	PF00514	0.261
TRG_NLS_MonoExtN_4	577	583	PF00514	0.673
TRG_NLS_MonoExtN_4	808	815	PF00514	0.270
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.119
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R9	Leptomonas seymouri	73%	100%
A0A0S4J2U0	Bodo saltans	56%	98%
A0A1X0NT40	Trypanosomatidae	71%	100%
A4H993	Leishmania braziliensis	84%	99%
A4HXL4	Leishmania infantum	99%	100%
A7S6A5	Nematostella vectensis	33%	100%
C9ZPA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ARB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
P53313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4QE53	Leishmania major	94%	99%
V5AZE5	Trypanosoma cruzi	61%	99%