L-galactonolactone_oxidase_putative/GeneDB:LmjF.1 7.1360

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-galactonolactone oxidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H719_LEIDO

TriTrypDb:

LdBPK_171470.1 , LdCL_170020900 , LDHU3_17.2000

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0020022	acidocalcisome	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S5H719

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H719

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006766	vitamin metabolic process	3	1
GO:0006767	water-soluble vitamin metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009110	vitamin biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0019852	L-ascorbic acid metabolic process	4	1
GO:0019853	L-ascorbic acid biosynthetic process	5	1
GO:0042364	water-soluble vitamin biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046364	monosaccharide biosynthetic process	4	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901334	lactone metabolic process	4	1
GO:1901336	lactone biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003885	D-arabinono-1,4-lactone oxidase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0071949	FAD binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0010181	FMN binding	4	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	2
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	2
GO:0032553	ribonucleotide binding	3	1
GO:0050024	L-galactonolactone oxidase activity	5	2
GO:0050105	L-gulonolactone oxidase activity	5	4
GO:0097367	carbohydrate derivative binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.636
CLV_C14_Caspase3-7	32	36	PF00656	0.267
CLV_NRD_NRD_1	420	422	PF00675	0.384
CLV_NRD_NRD_1	466	468	PF00675	0.327
CLV_PCSK_KEX2_1	420	422	PF00082	0.384
CLV_PCSK_KEX2_1	465	467	PF00082	0.377
CLV_PCSK_SKI1_1	141	145	PF00082	0.370
CLV_PCSK_SKI1_1	200	204	PF00082	0.455
CLV_PCSK_SKI1_1	283	287	PF00082	0.314
CLV_PCSK_SKI1_1	322	326	PF00082	0.297
CLV_PCSK_SKI1_1	448	452	PF00082	0.316
CLV_Separin_Metazoa	38	42	PF03568	0.293
CLV_Separin_Metazoa	95	99	PF03568	0.267
DEG_MDM2_SWIB_1	474	482	PF02201	0.259
DEG_SPOP_SBC_1	236	240	PF00917	0.374
DOC_CDC14_PxL_1	242	250	PF14671	0.486
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.401
DOC_MAPK_MEF2A_6	372	379	PF00069	0.353
DOC_MAPK_MEF2A_6	399	408	PF00069	0.259
DOC_MAPK_MEF2A_6	98	107	PF00069	0.319
DOC_MAPK_NFAT4_5	372	380	PF00069	0.401
DOC_PP1_RVXF_1	185	191	PF00149	0.494
DOC_PP1_RVXF_1	320	326	PF00149	0.228
DOC_PP4_FxxP_1	325	328	PF00568	0.267
DOC_PP4_FxxP_1	385	388	PF00568	0.345
DOC_USP7_MATH_1	125	129	PF00917	0.319
DOC_USP7_MATH_1	273	277	PF00917	0.602
DOC_USP7_MATH_1	285	289	PF00917	0.333
DOC_USP7_MATH_1	388	392	PF00917	0.384
DOC_USP7_UBL2_3	283	287	PF12436	0.426
DOC_WW_Pin1_4	260	265	PF00397	0.517
DOC_WW_Pin1_4	391	396	PF00397	0.259
DOC_WW_Pin1_4	52	57	PF00397	0.259
LIG_14-3-3_CanoR_1	115	119	PF00244	0.360
LIG_14-3-3_CanoR_1	213	221	PF00244	0.343
LIG_14-3-3_CanoR_1	322	328	PF00244	0.420
LIG_14-3-3_CanoR_1	384	388	PF00244	0.370
LIG_14-3-3_CanoR_1	480	488	PF00244	0.346
LIG_Actin_WH2_2	149	167	PF00022	0.453
LIG_APCC_Cbox_1	459	465	PF00515	0.293
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_Clathr_ClatBox_1	66	70	PF01394	0.343
LIG_CSL_BTD_1	221	224	PF09270	0.284
LIG_deltaCOP1_diTrp_1	300	304	PF00928	0.379
LIG_deltaCOP1_diTrp_1	456	461	PF00928	0.345
LIG_EVH1_1	245	249	PF00568	0.467
LIG_FHA_1	179	185	PF00498	0.413
LIG_FHA_1	237	243	PF00498	0.498
LIG_FHA_1	28	34	PF00498	0.375
LIG_FHA_1	289	295	PF00498	0.365
LIG_FHA_1	399	405	PF00498	0.268
LIG_FHA_2	251	257	PF00498	0.501
LIG_FHA_2	26	32	PF00498	0.311
LIG_FHA_2	384	390	PF00498	0.294
LIG_LIR_Apic_2	382	388	PF02991	0.345
LIG_LIR_Gen_1	340	349	PF02991	0.259
LIG_LIR_Gen_1	361	370	PF02991	0.319
LIG_LIR_Gen_1	424	433	PF02991	0.384
LIG_LIR_Gen_1	456	464	PF02991	0.266
LIG_LIR_Gen_1	8	16	PF02991	0.441
LIG_LIR_Nem_3	227	233	PF02991	0.401
LIG_LIR_Nem_3	340	344	PF02991	0.259
LIG_LIR_Nem_3	361	366	PF02991	0.319
LIG_LIR_Nem_3	401	406	PF02991	0.258
LIG_LIR_Nem_3	424	429	PF02991	0.384
LIG_LIR_Nem_3	456	461	PF02991	0.289
LIG_LIR_Nem_3	8	13	PF02991	0.444
LIG_LYPXL_S_1	308	312	PF13949	0.324
LIG_LYPXL_yS_3	309	312	PF13949	0.324
LIG_PALB2_WD40_1	474	482	PF16756	0.401
LIG_Pex14_1	439	443	PF04695	0.259
LIG_Pex14_2	341	345	PF04695	0.259
LIG_Pex14_2	379	383	PF04695	0.262
LIG_Pex14_2	474	478	PF04695	0.259
LIG_PTB_Apo_2	314	321	PF02174	0.275
LIG_PTB_Apo_2	473	480	PF02174	0.401
LIG_PTB_Phospho_1	314	320	PF10480	0.275
LIG_SH2_CRK	320	324	PF00017	0.235
LIG_SH2_GRB2like	315	318	PF00017	0.294
LIG_SH2_STAT5	113	116	PF00017	0.319
LIG_SH2_STAT5	139	142	PF00017	0.307
LIG_SH2_STAT5	315	318	PF00017	0.272
LIG_SH3_3	190	196	PF00018	0.499
LIG_SH3_3	243	249	PF00018	0.534
LIG_SH3_3	256	262	PF00018	0.529
LIG_SH3_3	394	400	PF00018	0.293
LIG_SUMO_SIM_anti_2	35	42	PF11976	0.336
LIG_SUMO_SIM_par_1	74	80	PF11976	0.318
LIG_TRAF2_1	266	269	PF00917	0.511
LIG_TRAF2_1	29	32	PF00917	0.255
LIG_WRPW_2	409	412	PF00400	0.271
LIG_WW_2	246	249	PF00397	0.477
MOD_CK1_1	128	134	PF00069	0.339
MOD_CK1_1	2	8	PF00069	0.590
MOD_CK1_1	271	277	PF00069	0.681
MOD_CK1_1	288	294	PF00069	0.327
MOD_CK1_1	391	397	PF00069	0.401
MOD_CK1_1	55	61	PF00069	0.319
MOD_CK1_1	77	83	PF00069	0.401
MOD_CK2_1	25	31	PF00069	0.276
MOD_CK2_1	331	337	PF00069	0.333
MOD_CMANNOS	301	304	PF00535	0.379
MOD_GlcNHglycan	1	4	PF01048	0.579
MOD_GlcNHglycan	128	131	PF01048	0.259
MOD_GlcNHglycan	241	245	PF01048	0.580
MOD_GlcNHglycan	271	274	PF01048	0.685
MOD_GlcNHglycan	275	279	PF01048	0.399
MOD_GlcNHglycan	283	286	PF01048	0.290
MOD_GlcNHglycan	325	328	PF01048	0.319
MOD_GlcNHglycan	333	336	PF01048	0.259
MOD_GSK3_1	109	116	PF00069	0.268
MOD_GSK3_1	121	128	PF00069	0.241
MOD_GSK3_1	15	22	PF00069	0.546
MOD_GSK3_1	236	243	PF00069	0.467
MOD_GSK3_1	269	276	PF00069	0.563
MOD_GSK3_1	281	288	PF00069	0.206
MOD_GSK3_1	487	494	PF00069	0.528
MOD_GSK3_1	55	62	PF00069	0.311
MOD_GSK3_1	77	84	PF00069	0.376
MOD_N-GLC_1	488	493	PF02516	0.368
MOD_NEK2_1	383	388	PF00069	0.353
MOD_NEK2_1	39	44	PF00069	0.345
MOD_NEK2_2	15	20	PF00069	0.544
MOD_PIKK_1	128	134	PF00454	0.333
MOD_PIKK_1	191	197	PF00454	0.420
MOD_PIKK_1	39	45	PF00454	0.329
MOD_PK_1	74	80	PF00069	0.275
MOD_PKA_2	114	120	PF00069	0.371
MOD_PKA_2	212	218	PF00069	0.306
MOD_PKA_2	331	337	PF00069	0.397
MOD_PKA_2	383	389	PF00069	0.271
MOD_PKA_2	398	404	PF00069	0.228
MOD_PKA_2	416	422	PF00069	0.259
MOD_PKA_2	8	14	PF00069	0.528
MOD_Plk_1	178	184	PF00069	0.448
MOD_Plk_1	240	246	PF00069	0.544
MOD_Plk_1	299	305	PF00069	0.392
MOD_Plk_2-3	337	343	PF00069	0.275
MOD_Plk_4	109	115	PF00069	0.259
MOD_Plk_4	276	282	PF00069	0.360
MOD_ProDKin_1	260	266	PF00069	0.510
MOD_ProDKin_1	391	397	PF00069	0.259
MOD_ProDKin_1	52	58	PF00069	0.259
TRG_ENDOCYTIC_2	233	236	PF00928	0.490
TRG_ENDOCYTIC_2	309	312	PF00928	0.269
TRG_ENDOCYTIC_2	320	323	PF00928	0.193
TRG_ENDOCYTIC_2	423	426	PF00928	0.268
TRG_ER_diArg_1	464	467	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA41	Leptomonas seymouri	62%	93%
A0A0S4J5V1	Bodo saltans	44%	91%
A0A1X0NU47	Trypanosomatidae	42%	89%
A0A422NB30	Trypanosoma rangeli	45%	97%
A0R607	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	24%	100%
A4H992	Leishmania braziliensis	83%	100%
A4HXL3	Leishmania infantum	100%	100%
C9ZPA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	95%
E9ARA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O47881	Brassica oleracea	22%	82%
O81030	Arabidopsis thaliana	23%	84%
O93852	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	89%
P10867	Rattus norvegicus	27%	100%
P54783	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P58710	Mus musculus	26%	100%
P9WIT2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WIT3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
P9WJF0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	24%	100%
P9WJF1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	100%
Q2QXY1	Oryza sativa subsp. japonica	23%	85%
Q2RAP0	Oryza sativa subsp. japonica	23%	85%
Q3ZC33	Bos taurus	27%	100%
Q4QE54	Leishmania major	93%	100%
Q6BZA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	89%
Q6CG88	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	94%
Q6CSY3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	94%
Q6FS20	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	23%	94%
Q6NQ66	Arabidopsis thaliana	22%	84%
Q752Y3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	93%
Q7SGY1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	89%
Q8HXW0	Sus scrofa	26%	100%
Q90YK3	Scyliorhinus torazame	26%	100%
Q9HDX8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9SU56	Arabidopsis thaliana	23%	81%
V5BEU1	Trypanosoma cruzi	47%	89%