Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H718_LEIDO

TriTrypDb:

LdBPK_171400.1 , LdCL_170020200 , LDHU3_17.1920

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H718

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H718

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	53	59	PF00089	0.414
CLV_NRD_NRD_1	185	187	PF00675	0.621
CLV_NRD_NRD_1	64	66	PF00675	0.445
DEG_APCC_DBOX_1	78	86	PF00400	0.497
DEG_ODPH_VHL_1	53	64	PF01847	0.651
DOC_CKS1_1	113	118	PF01111	0.411
DOC_CKS1_1	43	48	PF01111	0.623
DOC_PP1_RVXF_1	133	139	PF00149	0.412
DOC_PP1_RVXF_1	31	37	PF00149	0.642
DOC_PP1_RVXF_1	64	71	PF00149	0.588
DOC_USP7_MATH_1	129	133	PF00917	0.477
DOC_USP7_MATH_1	159	163	PF00917	0.447
DOC_USP7_UBL2_3	72	76	PF12436	0.602
DOC_WW_Pin1_4	112	117	PF00397	0.408
DOC_WW_Pin1_4	42	47	PF00397	0.619
LIG_14-3-3_CanoR_1	107	111	PF00244	0.359
LIG_14-3-3_CanoR_1	65	71	PF00244	0.694
LIG_14-3-3_CanoR_1	79	83	PF00244	0.250
LIG_BIR_III_2	18	22	PF00653	0.562
LIG_BIR_III_4	24	28	PF00653	0.583
LIG_FHA_1	131	137	PF00498	0.425
LIG_FHA_2	11	17	PF00498	0.644
LIG_LIR_Apic_2	40	46	PF02991	0.615
LIG_LIR_Apic_2	6	12	PF02991	0.605
LIG_LIR_Gen_1	13	22	PF02991	0.628
LIG_LIR_Gen_1	81	92	PF02991	0.345
LIG_LIR_Nem_3	13	17	PF02991	0.635
LIG_LIR_Nem_3	69	73	PF02991	0.583
LIG_LIR_Nem_3	81	87	PF02991	0.306
LIG_LYPXL_yS_3	77	80	PF13949	0.609
LIG_NRP_CendR_1	186	188	PF00754	0.630
LIG_Pex14_1	97	101	PF04695	0.286
LIG_SH2_CRK	43	47	PF00017	0.654
LIG_SH2_CRK	59	63	PF00017	0.557
LIG_SH2_GRB2like	84	87	PF00017	0.345
LIG_SH2_NCK_1	59	63	PF00017	0.729
LIG_SH2_PTP2	84	87	PF00017	0.472
LIG_SH2_SRC	14	17	PF00017	0.652
LIG_SH2_SRC	84	87	PF00017	0.345
LIG_SH2_STAT5	163	166	PF00017	0.410
LIG_SH2_STAT5	169	172	PF00017	0.411
LIG_SH2_STAT5	29	32	PF00017	0.602
LIG_SH2_STAT5	84	87	PF00017	0.345
LIG_SH3_3	31	37	PF00018	0.639
LIG_TYR_ITIM	82	87	PF00017	0.349
MOD_GlcNHglycan	179	183	PF01048	0.644
MOD_GSK3_1	130	137	PF00069	0.468
MOD_GSK3_1	159	166	PF00069	0.488
MOD_N-GLC_1	130	135	PF02516	0.677
MOD_PIKK_1	130	136	PF00454	0.444
MOD_PKA_2	106	112	PF00069	0.403
MOD_PKA_2	78	84	PF00069	0.452
MOD_Plk_1	159	165	PF00069	0.510
MOD_Plk_4	159	165	PF00069	0.450
MOD_Plk_4	66	72	PF00069	0.582
MOD_ProDKin_1	112	118	PF00069	0.409
MOD_ProDKin_1	42	48	PF00069	0.619
MOD_SUMO_for_1	25	28	PF00179	0.588
TRG_DiLeu_BaEn_1	142	147	PF01217	0.411
TRG_ENDOCYTIC_2	14	17	PF00928	0.633
TRG_ENDOCYTIC_2	59	62	PF00928	0.607
TRG_ENDOCYTIC_2	77	80	PF00928	0.564
TRG_ENDOCYTIC_2	84	87	PF00928	0.286
TRG_ER_diArg_1	185	188	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J6W1	Bodo saltans	61%	72%
A0A422NAT4	Trypanosoma rangeli	66%	67%
A4HXK7	Leishmania infantum	99%	100%
E9ARA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QE61	Leishmania major	96%	100%