LeishMANIAdb
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MSP (Major sperm protein) domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MSP (Major sperm protein) domain containing protein, putative
Gene product:
MSP (Major sperm protein) domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H717_LEIDO
TriTrypDb:
LdBPK_171310.1 , LdCL_170019300 , LDHU3_17.1820
Length:
455

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 6
GO:0016020 membrane 2 6
GO:0031090 organelle membrane 3 6
GO:0110165 cellular anatomical entity 1 6
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A0A3S5H717
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H717

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022406 membrane docking 2 1
GO:0051179 localization 1 1
GO:0051640 organelle localization 2 1
GO:0051643 endoplasmic reticulum localization 3 1
GO:0061024 membrane organization 4 1
GO:0061817 endoplasmic reticulum-plasma membrane tethering 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090158 endoplasmic reticulum membrane organization 5 1
GO:0140056 organelle localization by membrane tethering 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 22 24 PF00675 0.515
CLV_NRD_NRD_1 231 233 PF00675 0.518
CLV_NRD_NRD_1 32 34 PF00675 0.521
CLV_PCSK_KEX2_1 171 173 PF00082 0.461
CLV_PCSK_KEX2_1 219 221 PF00082 0.472
CLV_PCSK_KEX2_1 233 235 PF00082 0.462
CLV_PCSK_KEX2_1 32 34 PF00082 0.520
CLV_PCSK_PC1ET2_1 171 173 PF00082 0.461
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.463
CLV_PCSK_PC1ET2_1 233 235 PF00082 0.462
CLV_PCSK_SKI1_1 219 223 PF00082 0.463
CLV_PCSK_SKI1_1 307 311 PF00082 0.720
DEG_Nend_UBRbox_2 1 3 PF02207 0.755
DEG_SPOP_SBC_1 17 21 PF00917 0.678
DEG_SPOP_SBC_1 211 215 PF00917 0.751
DOC_CYCLIN_yCln2_LP_2 133 139 PF00134 0.539
DOC_MAPK_gen_1 126 133 PF00069 0.592
DOC_MAPK_MEF2A_6 38 45 PF00069 0.610
DOC_MAPK_MEF2A_6 86 95 PF00069 0.542
DOC_PP2B_PxIxI_1 40 46 PF00149 0.489
DOC_PP4_FxxP_1 182 185 PF00568 0.617
DOC_PP4_FxxP_1 52 55 PF00568 0.542
DOC_USP7_MATH_1 101 105 PF00917 0.542
DOC_USP7_MATH_1 17 21 PF00917 0.678
DOC_USP7_MATH_1 211 215 PF00917 0.752
DOC_USP7_UBL2_3 255 259 PF12436 0.680
DOC_WW_Pin1_4 141 146 PF00397 0.623
DOC_WW_Pin1_4 171 176 PF00397 0.653
DOC_WW_Pin1_4 365 370 PF00397 0.625
DOC_WW_Pin1_4 8 13 PF00397 0.694
LIG_14-3-3_CanoR_1 103 109 PF00244 0.542
LIG_14-3-3_CanoR_1 126 132 PF00244 0.602
LIG_14-3-3_CanoR_1 298 308 PF00244 0.529
LIG_14-3-3_CanoR_1 4 8 PF00244 0.749
LIG_BIR_III_4 237 241 PF00653 0.652
LIG_deltaCOP1_diTrp_1 423 431 PF00928 0.468
LIG_EH1_1 271 279 PF00400 0.274
LIG_EVH1_2 53 57 PF00568 0.542
LIG_FHA_1 11 17 PF00498 0.769
LIG_FHA_1 262 268 PF00498 0.538
LIG_FHA_1 321 327 PF00498 0.528
LIG_FHA_2 105 111 PF00498 0.542
LIG_FHA_2 168 174 PF00498 0.631
LIG_FHA_2 404 410 PF00498 0.520
LIG_FHA_2 412 418 PF00498 0.525
LIG_Integrin_RGD_1 155 157 PF01839 0.425
LIG_LIR_Apic_2 181 185 PF02991 0.615
LIG_LIR_Apic_2 321 325 PF02991 0.516
LIG_LIR_Apic_2 393 399 PF02991 0.486
LIG_LIR_Apic_2 423 429 PF02991 0.488
LIG_LIR_Apic_2 449 455 PF02991 0.511
LIG_LIR_Gen_1 102 111 PF02991 0.587
LIG_LIR_Gen_1 147 154 PF02991 0.612
LIG_LIR_Nem_3 102 108 PF02991 0.587
LIG_LIR_Nem_3 147 152 PF02991 0.604
LIG_LIR_Nem_3 186 190 PF02991 0.658
LIG_MYND_1 141 145 PF01753 0.621
LIG_NRBOX 147 153 PF00104 0.571
LIG_Pex14_1 268 272 PF04695 0.324
LIG_SH2_CRK 322 326 PF00017 0.516
LIG_SH2_CRK 339 343 PF00017 0.506
LIG_SH2_NCK_1 339 343 PF00017 0.506
LIG_SH2_PTP2 187 190 PF00017 0.660
LIG_SH2_SRC 187 190 PF00017 0.624
LIG_SH2_SRC 375 378 PF00017 0.526
LIG_SH2_SRC 447 450 PF00017 0.509
LIG_SH2_SRC 452 455 PF00017 0.490
LIG_SH2_STAT3 433 436 PF00017 0.499
LIG_SH2_STAT5 168 171 PF00017 0.613
LIG_SH2_STAT5 187 190 PF00017 0.660
LIG_SH2_STAT5 322 325 PF00017 0.521
LIG_SH2_STAT5 87 90 PF00017 0.542
LIG_SH3_1 322 328 PF00018 0.511
LIG_SH3_3 186 192 PF00018 0.673
LIG_SH3_3 322 328 PF00018 0.614
LIG_SH3_3 368 374 PF00018 0.568
LIG_SH3_3 396 402 PF00018 0.529
LIG_SH3_3 404 410 PF00018 0.497
LIG_SH3_3 448 454 PF00018 0.557
LIG_SH3_3 48 54 PF00018 0.542
LIG_SH3_3 85 91 PF00018 0.542
LIG_SH3_5 429 433 PF00018 0.474
LIG_SUMO_SIM_anti_2 280 286 PF11976 0.399
LIG_SUMO_SIM_par_1 275 280 PF11976 0.349
LIG_TRAF2_1 309 312 PF00917 0.477
LIG_TRAF2_1 382 385 PF00917 0.549
LIG_TRAF2_1 420 423 PF00917 0.526
LIG_WRC_WIRS_1 179 184 PF05994 0.615
LIG_WW_1 184 187 PF00397 0.637
MOD_CDK_SPK_2 141 146 PF00069 0.623
MOD_CK1_1 104 110 PF00069 0.542
MOD_CK1_1 210 216 PF00069 0.726
MOD_CK1_1 3 9 PF00069 0.714
MOD_CK2_1 359 365 PF00069 0.508
MOD_CK2_1 403 409 PF00069 0.523
MOD_CK2_1 411 417 PF00069 0.520
MOD_CK2_1 437 443 PF00069 0.491
MOD_CK2_1 8 14 PF00069 0.750
MOD_GlcNHglycan 20 23 PF01048 0.539
MOD_GlcNHglycan 203 206 PF01048 0.570
MOD_GlcNHglycan 209 212 PF01048 0.527
MOD_GlcNHglycan 225 229 PF01048 0.565
MOD_GlcNHglycan 304 307 PF01048 0.805
MOD_GlcNHglycan 99 102 PF01048 0.351
MOD_GSK3_1 135 142 PF00069 0.674
MOD_GSK3_1 167 174 PF00069 0.708
MOD_GSK3_1 203 210 PF00069 0.786
MOD_GSK3_1 97 104 PF00069 0.565
MOD_N-GLC_1 68 73 PF02516 0.342
MOD_N-GLC_1 8 13 PF02516 0.530
MOD_NEK2_1 127 132 PF00069 0.587
MOD_NEK2_1 16 21 PF00069 0.736
MOD_NEK2_2 178 183 PF00069 0.613
MOD_PIKK_1 120 126 PF00454 0.599
MOD_PIKK_1 312 318 PF00454 0.523
MOD_PIKK_1 359 365 PF00454 0.547
MOD_PIKK_1 411 417 PF00454 0.548
MOD_PIKK_1 78 84 PF00454 0.607
MOD_PKA_2 127 133 PF00069 0.588
MOD_PKA_2 3 9 PF00069 0.752
MOD_Plk_2-3 135 141 PF00069 0.626
MOD_Plk_4 178 184 PF00069 0.655
MOD_ProDKin_1 141 147 PF00069 0.623
MOD_ProDKin_1 171 177 PF00069 0.654
MOD_ProDKin_1 365 371 PF00069 0.624
MOD_ProDKin_1 8 14 PF00069 0.696
MOD_SUMO_for_1 43 46 PF00179 0.542
TRG_DiLeu_BaEn_1 46 51 PF01217 0.542
TRG_ENDOCYTIC_2 134 137 PF00928 0.546
TRG_ENDOCYTIC_2 187 190 PF00928 0.660
TRG_NLS_Bipartite_1 219 236 PF00514 0.660
TRG_NLS_MonoExtC_3 231 237 PF00514 0.660
TRG_Pf-PMV_PEXEL_1 117 121 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A4H978 Leishmania braziliensis 65% 100%
A4HXJ8 Leishmania infantum 100% 100%
E9AR93 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
Q4QE70 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS