Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H715_LEIDO

TriTrypDb:

LdBPK_171180.1 , LdCL_170017900 , LDHU3_17.1670

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H715

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H715

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.697
CLV_C14_Caspase3-7	190	194	PF00656	0.646
CLV_C14_Caspase3-7	472	476	PF00656	0.720
CLV_C14_Caspase3-7	493	497	PF00656	0.548
CLV_C14_Caspase3-7	639	643	PF00656	0.638
CLV_NRD_NRD_1	72	74	PF00675	0.454
CLV_PCSK_SKI1_1	214	218	PF00082	0.582
CLV_PCSK_SKI1_1	402	406	PF00082	0.710
CLV_PCSK_SKI1_1	460	464	PF00082	0.745
CLV_PCSK_SKI1_1	48	52	PF00082	0.644
CLV_PCSK_SKI1_1	503	507	PF00082	0.552
CLV_PCSK_SKI1_1	523	527	PF00082	0.467
CLV_PCSK_SKI1_1	573	577	PF00082	0.636
CLV_PCSK_SKI1_1	653	657	PF00082	0.593
CLV_PCSK_SKI1_1	7	11	PF00082	0.466
DEG_APCC_DBOX_1	502	510	PF00400	0.595
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SCF_FBW7_1	447	454	PF00400	0.652
DEG_SCF_FBW7_2	131	138	PF00400	0.716
DEG_SPOP_SBC_1	109	113	PF00917	0.741
DEG_SPOP_SBC_1	250	254	PF00917	0.658
DOC_CKS1_1	132	137	PF01111	0.779
DOC_CKS1_1	407	412	PF01111	0.733
DOC_CKS1_1	448	453	PF01111	0.662
DOC_CYCLIN_RxL_1	276	287	PF00134	0.630
DOC_CYCLIN_RxL_1	500	510	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.646
DOC_MAPK_gen_1	500	508	PF00069	0.554
DOC_MAPK_gen_1	98	107	PF00069	0.618
DOC_MAPK_MEF2A_6	347	355	PF00069	0.807
DOC_PP2B_LxvP_1	106	109	PF13499	0.627
DOC_PP2B_LxvP_1	340	343	PF13499	0.663
DOC_USP7_MATH_1	110	114	PF00917	0.705
DOC_USP7_MATH_1	251	255	PF00917	0.762
DOC_USP7_MATH_1	288	292	PF00917	0.665
DOC_USP7_MATH_1	325	329	PF00917	0.693
DOC_USP7_MATH_1	357	361	PF00917	0.835
DOC_USP7_MATH_1	367	371	PF00917	0.667
DOC_USP7_MATH_1	431	435	PF00917	0.680
DOC_USP7_MATH_1	451	455	PF00917	0.472
DOC_USP7_MATH_1	462	466	PF00917	0.684
DOC_USP7_MATH_1	481	485	PF00917	0.494
DOC_USP7_MATH_1	612	616	PF00917	0.574
DOC_USP7_MATH_1	726	730	PF00917	0.763
DOC_WW_Pin1_4	131	136	PF00397	0.739
DOC_WW_Pin1_4	199	204	PF00397	0.680
DOC_WW_Pin1_4	406	411	PF00397	0.734
DOC_WW_Pin1_4	447	452	PF00397	0.641
DOC_WW_Pin1_4	539	544	PF00397	0.659
DOC_WW_Pin1_4	562	567	PF00397	0.730
DOC_WW_Pin1_4	586	591	PF00397	0.753
DOC_WW_Pin1_4	692	697	PF00397	0.797
DOC_WW_Pin1_4	698	703	PF00397	0.796
DOC_WW_Pin1_4	729	734	PF00397	0.746
LIG_14-3-3_CanoR_1	507	516	PF00244	0.558
LIG_14-3-3_CanoR_1	57	65	PF00244	0.462
LIG_14-3-3_CanoR_1	632	641	PF00244	0.675
LIG_14-3-3_CanoR_1	713	721	PF00244	0.577
LIG_14-3-3_CanoR_1	73	79	PF00244	0.492
LIG_14-3-3_CanoR_1	98	107	PF00244	0.719
LIG_Actin_WH2_2	428	445	PF00022	0.643
LIG_BIR_III_4	496	500	PF00653	0.577
LIG_BRCT_BRCA1_1	682	686	PF00533	0.731
LIG_BRCT_BRCA1_1	714	718	PF00533	0.562
LIG_Clathr_ClatBox_1	489	493	PF01394	0.551
LIG_deltaCOP1_diTrp_1	642	648	PF00928	0.577
LIG_FHA_1	139	145	PF00498	0.698
LIG_FHA_1	204	210	PF00498	0.695
LIG_FHA_1	240	246	PF00498	0.735
LIG_FHA_1	251	257	PF00498	0.619
LIG_FHA_1	336	342	PF00498	0.765
LIG_FHA_1	4	10	PF00498	0.627
LIG_FHA_1	451	457	PF00498	0.741
LIG_FHA_1	469	475	PF00498	0.789
LIG_FHA_1	496	502	PF00498	0.643
LIG_FHA_1	543	549	PF00498	0.575
LIG_FHA_1	56	62	PF00498	0.523
LIG_FHA_1	707	713	PF00498	0.595
LIG_FHA_1	74	80	PF00498	0.603
LIG_FHA_2	467	473	PF00498	0.668
LIG_FHA_2	510	516	PF00498	0.526
LIG_FHA_2	73	79	PF00498	0.591
LIG_FXI_DFP_1	62	66	PF00024	0.586
LIG_LIR_Gen_1	127	135	PF02991	0.764
LIG_LIR_Gen_1	141	147	PF02991	0.527
LIG_LIR_Gen_1	646	656	PF02991	0.678
LIG_LIR_Gen_1	715	726	PF02991	0.590
LIG_LIR_Nem_3	127	132	PF02991	0.767
LIG_LIR_Nem_3	141	145	PF02991	0.528
LIG_LIR_Nem_3	544	549	PF02991	0.554
LIG_LIR_Nem_3	646	651	PF02991	0.675
LIG_LIR_Nem_3	715	721	PF02991	0.572
LIG_NRBOX	279	285	PF00104	0.531
LIG_PDZ_Class_2	738	743	PF00595	0.687
LIG_SH2_CRK	129	133	PF00017	0.687
LIG_SH2_CRK	222	226	PF00017	0.500
LIG_SH2_NCK_1	142	146	PF00017	0.625
LIG_SH2_NCK_1	37	41	PF00017	0.629
LIG_SH2_STAT5	222	225	PF00017	0.473
LIG_SH3_3	197	203	PF00018	0.802
LIG_SH3_3	404	410	PF00018	0.598
LIG_SH3_3	563	569	PF00018	0.748
LIG_SH3_3	588	594	PF00018	0.586
LIG_SH3_3	693	699	PF00018	0.806
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.612
LIG_SUMO_SIM_anti_2	483	490	PF11976	0.663
LIG_SUMO_SIM_par_1	143	149	PF11976	0.730
LIG_TRAF2_1	359	362	PF00917	0.784
LIG_UBA3_1	9	15	PF00899	0.422
LIG_WW_3	119	123	PF00397	0.747
MOD_CK1_1	112	118	PF00069	0.810
MOD_CK1_1	149	155	PF00069	0.701
MOD_CK1_1	204	210	PF00069	0.673
MOD_CK1_1	316	322	PF00069	0.657
MOD_CK1_1	370	376	PF00069	0.787
MOD_CK1_1	382	388	PF00069	0.649
MOD_CK1_1	466	472	PF00069	0.742
MOD_CK1_1	542	548	PF00069	0.691
MOD_CK1_1	636	642	PF00069	0.628
MOD_CK1_1	677	683	PF00069	0.723
MOD_CK1_1	689	695	PF00069	0.734
MOD_CK1_1	729	735	PF00069	0.739
MOD_CK1_1	88	94	PF00069	0.607
MOD_CK2_1	158	164	PF00069	0.771
MOD_CK2_1	166	172	PF00069	0.772
MOD_CK2_1	182	188	PF00069	0.611
MOD_CK2_1	387	393	PF00069	0.564
MOD_CK2_1	466	472	PF00069	0.664
MOD_CMANNOS	645	648	PF00535	0.569
MOD_GlcNHglycan	101	104	PF01048	0.652
MOD_GlcNHglycan	117	120	PF01048	0.817
MOD_GlcNHglycan	151	154	PF01048	0.746
MOD_GlcNHglycan	160	163	PF01048	0.782
MOD_GlcNHglycan	166	171	PF01048	0.619
MOD_GlcNHglycan	228	231	PF01048	0.641
MOD_GlcNHglycan	290	293	PF01048	0.663
MOD_GlcNHglycan	3	6	PF01048	0.628
MOD_GlcNHglycan	315	318	PF01048	0.787
MOD_GlcNHglycan	323	326	PF01048	0.704
MOD_GlcNHglycan	381	384	PF01048	0.744
MOD_GlcNHglycan	520	523	PF01048	0.644
MOD_GlcNHglycan	527	530	PF01048	0.767
MOD_GlcNHglycan	573	576	PF01048	0.701
MOD_GlcNHglycan	627	630	PF01048	0.530
MOD_GlcNHglycan	688	691	PF01048	0.834
MOD_GlcNHglycan	714	717	PF01048	0.570
MOD_GSK3_1	108	115	PF00069	0.700
MOD_GSK3_1	127	134	PF00069	0.791
MOD_GSK3_1	145	152	PF00069	0.444
MOD_GSK3_1	158	165	PF00069	0.612
MOD_GSK3_1	199	206	PF00069	0.755
MOD_GSK3_1	220	227	PF00069	0.520
MOD_GSK3_1	246	253	PF00069	0.761
MOD_GSK3_1	313	320	PF00069	0.758
MOD_GSK3_1	321	328	PF00069	0.713
MOD_GSK3_1	363	370	PF00069	0.786
MOD_GSK3_1	378	385	PF00069	0.637
MOD_GSK3_1	419	426	PF00069	0.807
MOD_GSK3_1	446	453	PF00069	0.651
MOD_GSK3_1	462	469	PF00069	0.518
MOD_GSK3_1	476	483	PF00069	0.567
MOD_GSK3_1	491	498	PF00069	0.572
MOD_GSK3_1	582	589	PF00069	0.767
MOD_GSK3_1	73	80	PF00069	0.640
MOD_N-GLC_1	239	244	PF02516	0.725
MOD_N-GLC_2	244	246	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.643
MOD_NEK2_1	224	229	PF00069	0.630
MOD_NEK2_1	296	301	PF00069	0.652
MOD_NEK2_1	378	383	PF00069	0.706
MOD_NEK2_1	463	468	PF00069	0.787
MOD_NEK2_1	501	506	PF00069	0.678
MOD_NEK2_1	525	530	PF00069	0.695
MOD_NEK2_1	548	553	PF00069	0.667
MOD_NEK2_1	665	670	PF00069	0.691
MOD_NEK2_1	712	717	PF00069	0.571
MOD_NEK2_1	72	77	PF00069	0.572
MOD_PIKK_1	112	118	PF00454	0.711
MOD_PIKK_1	357	363	PF00454	0.733
MOD_PIKK_1	491	497	PF00454	0.529
MOD_PIKK_1	56	62	PF00454	0.427
MOD_PIKK_1	573	579	PF00454	0.678
MOD_PIKK_1	636	642	PF00454	0.598
MOD_PK_1	294	300	PF00069	0.541
MOD_PKA_1	73	79	PF00069	0.447
MOD_PKA_2	16	22	PF00069	0.424
MOD_PKA_2	378	384	PF00069	0.726
MOD_PKA_2	56	62	PF00069	0.456
MOD_PKA_2	677	683	PF00069	0.684
MOD_PKA_2	686	692	PF00069	0.686
MOD_PKA_2	712	718	PF00069	0.570
MOD_PKA_2	72	78	PF00069	0.494
MOD_Plk_1	363	369	PF00069	0.780
MOD_Plk_1	680	686	PF00069	0.611
MOD_Plk_2-3	138	144	PF00069	0.640
MOD_Plk_4	127	133	PF00069	0.691
MOD_Plk_4	204	210	PF00069	0.594
MOD_Plk_4	220	226	PF00069	0.531
MOD_Plk_4	367	373	PF00069	0.622
MOD_Plk_4	387	393	PF00069	0.686
MOD_Plk_4	481	487	PF00069	0.637
MOD_ProDKin_1	131	137	PF00069	0.738
MOD_ProDKin_1	199	205	PF00069	0.672
MOD_ProDKin_1	406	412	PF00069	0.733
MOD_ProDKin_1	447	453	PF00069	0.651
MOD_ProDKin_1	539	545	PF00069	0.653
MOD_ProDKin_1	562	568	PF00069	0.732
MOD_ProDKin_1	586	592	PF00069	0.747
MOD_ProDKin_1	692	698	PF00069	0.797
MOD_ProDKin_1	729	735	PF00069	0.739
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.627
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.728
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.551
TRG_ENDOCYTIC_2	129	132	PF00928	0.691
TRG_ENDOCYTIC_2	142	145	PF00928	0.623
TRG_ENDOCYTIC_2	222	225	PF00928	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE2	Leptomonas seymouri	34%	100%
A4H963	Leishmania braziliensis	66%	100%
A4HXI5	Leishmania infantum	99%	100%
E9AR80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QE83	Leishmania major	87%	100%