LeishMANIAdb
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META domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
META domain family protein
Gene product:
META domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H712_LEIDO
TriTrypDb:
LdBPK_170990.1 , LdCL_170015900 , LDHU3_17.1420
Length:
112

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H712
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H712

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 91 95 PF00656 0.464
CLV_NRD_NRD_1 55 57 PF00675 0.505
CLV_PCSK_SKI1_1 11 15 PF00082 0.420
CLV_PCSK_SKI1_1 4 8 PF00082 0.533
DEG_Nend_UBRbox_2 1 3 PF02207 0.691
DOC_MAPK_RevD_3 41 57 PF00069 0.464
DOC_USP7_MATH_1 61 65 PF00917 0.478
DOC_USP7_UBL2_3 93 97 PF12436 0.497
LIG_BRCT_BRCA1_1 80 84 PF00533 0.483
LIG_Clathr_ClatBox_1 73 77 PF01394 0.521
LIG_FHA_1 102 108 PF00498 0.544
LIG_FHA_1 63 69 PF00498 0.455
LIG_FHA_1 87 93 PF00498 0.537
LIG_FHA_2 89 95 PF00498 0.567
LIG_Integrin_isoDGR_2 16 18 PF01839 0.402
LIG_MAD2 11 19 PF02301 0.505
LIG_PDZ_Class_2 107 112 PF00595 0.645
LIG_SH2_STAT5 90 93 PF00017 0.551
MOD_GlcNHglycan 32 36 PF01048 0.501
MOD_GlcNHglycan 58 61 PF01048 0.526
MOD_NEK2_1 62 67 PF00069 0.408
MOD_NEK2_1 88 93 PF00069 0.562
MOD_PIKK_1 78 84 PF00454 0.505
MOD_PKA_1 56 62 PF00069 0.505
MOD_Plk_4 62 68 PF00069 0.453
TRG_DiLeu_BaEn_1 2 7 PF01217 0.626

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L5 Leptomonas seymouri 45% 100%
A0A0N1PC21 Leptomonas seymouri 37% 97%
A0A1X0NST7 Trypanosomatidae 39% 100%
A0A1X0NT42 Trypanosomatidae 34% 92%
A0A422NGZ1 Trypanosoma rangeli 36% 93%
A4H942 Leishmania braziliensis 59% 100%
A4HXG7 Leishmania infantum 98% 100%
C9ZP48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 84%
C9ZP50 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 84%
C9ZP53 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 84%
E9AR62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q25307 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS