G-patch_domain_containing_protein_putative/Pfam:P F01585

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H710_LEIDO

TriTrypDb:

LdBPK_170910.1 , LdCL_170015100 , LDHU3_17.1320

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H710

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H710

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.685
CLV_C14_Caspase3-7	155	159	PF00656	0.682
CLV_C14_Caspase3-7	95	99	PF00656	0.684
CLV_NRD_NRD_1	120	122	PF00675	0.632
CLV_NRD_NRD_1	35	37	PF00675	0.308
CLV_NRD_NRD_1	75	77	PF00675	0.621
CLV_PCSK_KEX2_1	136	138	PF00082	0.712
CLV_PCSK_KEX2_1	160	162	PF00082	0.698
CLV_PCSK_KEX2_1	201	203	PF00082	0.519
CLV_PCSK_KEX2_1	35	37	PF00082	0.284
CLV_PCSK_KEX2_1	77	79	PF00082	0.556
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.712
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.694
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.611
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.554
CLV_PCSK_PC7_1	132	138	PF00082	0.670
CLV_PCSK_PC7_1	156	162	PF00082	0.603
CLV_PCSK_SKI1_1	176	180	PF00082	0.506
DEG_SPOP_SBC_1	106	110	PF00917	0.572
DEG_SPOP_SBC_1	113	117	PF00917	0.595
DOC_MAPK_gen_1	121	129	PF00069	0.537
DOC_USP7_MATH_1	113	117	PF00917	0.762
DOC_USP7_MATH_1	146	150	PF00917	0.614
DOC_USP7_UBL2_3	122	126	PF12436	0.692
DOC_USP7_UBL2_3	28	32	PF12436	0.360
DOC_USP7_UBL2_3	7	11	PF12436	0.400
DOC_USP7_UBL2_3	73	77	PF12436	0.512
DOC_WW_Pin1_4	138	143	PF00397	0.720
LIG_14-3-3_CanoR_1	121	129	PF00244	0.512
LIG_14-3-3_CanoR_1	140	146	PF00244	0.648
LIG_14-3-3_CanoR_1	172	179	PF00244	0.572
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_FHA_1	57	63	PF00498	0.577
LIG_FHA_2	90	96	PF00498	0.595
LIG_LIR_Gen_1	29	38	PF02991	0.284
LIG_LIR_Gen_1	65	74	PF02991	0.456
LIG_LIR_Nem_3	29	33	PF02991	0.284
LIG_LIR_Nem_3	65	71	PF02991	0.496
LIG_SH2_CRK	68	72	PF00017	0.528
LIG_SH2_PTP2	30	33	PF00017	0.308
LIG_SH2_STAT5	30	33	PF00017	0.308
MOD_CK1_1	104	110	PF00069	0.710
MOD_CK1_1	111	117	PF00069	0.628
MOD_CK1_1	144	150	PF00069	0.686
MOD_CK1_1	159	165	PF00069	0.653
MOD_CK1_1	55	61	PF00069	0.566
MOD_CK2_1	159	165	PF00069	0.637
MOD_CK2_1	171	177	PF00069	0.607
MOD_CK2_1	90	96	PF00069	0.666
MOD_GlcNHglycan	1	4	PF01048	0.492
MOD_GlcNHglycan	110	113	PF01048	0.711
MOD_GlcNHglycan	117	120	PF01048	0.654
MOD_GlcNHglycan	148	151	PF01048	0.785
MOD_GlcNHglycan	23	27	PF01048	0.459
MOD_GSK3_1	101	108	PF00069	0.680
MOD_GSK3_1	111	118	PF00069	0.651
MOD_GSK3_1	138	145	PF00069	0.634
MOD_GSK3_1	22	29	PF00069	0.383
MOD_GSK3_1	52	59	PF00069	0.686
MOD_NEK2_1	56	61	PF00069	0.634
MOD_PIKK_1	66	72	PF00454	0.448
MOD_PKA_2	120	126	PF00069	0.630
MOD_PKA_2	171	177	PF00069	0.595
MOD_PKA_2	79	85	PF00069	0.598
MOD_Plk_1	168	174	PF00069	0.521
MOD_Plk_4	26	32	PF00069	0.308
MOD_ProDKin_1	138	144	PF00069	0.720
MOD_SUMO_rev_2	114	123	PF00179	0.736
MOD_SUMO_rev_2	152	162	PF00179	0.737
TRG_ENDOCYTIC_2	30	33	PF00928	0.313
TRG_ENDOCYTIC_2	68	71	PF00928	0.489
TRG_ER_diArg_1	192	195	PF00400	0.584
TRG_NLS_MonoExtC_3	159	165	PF00514	0.688
TRG_NLS_MonoExtC_3	75	80	PF00514	0.610
TRG_NLS_MonoExtN_4	73	80	PF00514	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6K7	Leptomonas seymouri	52%	99%
A0A0S4J7Y3	Bodo saltans	37%	100%
A4H945	Leishmania braziliensis	74%	100%
A4HXF9	Leishmania infantum	100%	100%
C9ZP33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AR54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEA9	Leishmania major	96%	100%
V5AQX6	Trypanosoma cruzi	42%	78%