Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H709_LEIDO

TriTrypDb:

LdBPK_170830.1 , LdCL_170014300 , LDHU3_17.1220

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H709

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H709

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	478	482	PF00656	0.581
CLV_NRD_NRD_1	42	44	PF00675	0.493
CLV_NRD_NRD_1	437	439	PF00675	0.573
CLV_NRD_NRD_1	85	87	PF00675	0.470
CLV_PCSK_KEX2_1	42	44	PF00082	0.496
CLV_PCSK_KEX2_1	437	439	PF00082	0.573
CLV_PCSK_SKI1_1	61	65	PF00082	0.464
CLV_PCSK_SKI1_1	93	97	PF00082	0.514
DEG_APCC_DBOX_1	42	50	PF00400	0.494
DEG_SCF_FBW7_1	344	351	PF00400	0.640
DEG_SPOP_SBC_1	105	109	PF00917	0.496
DEG_SPOP_SBC_1	310	314	PF00917	0.630
DEG_SPOP_SBC_1	462	466	PF00917	0.696
DOC_CDC14_PxL_1	337	345	PF14671	0.690
DOC_CKS1_1	220	225	PF01111	0.697
DOC_CKS1_1	255	260	PF01111	0.739
DOC_CKS1_1	345	350	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.576
DOC_MAPK_gen_1	145	154	PF00069	0.500
DOC_MAPK_MEF2A_6	145	154	PF00069	0.500
DOC_PP1_RVXF_1	435	442	PF00149	0.523
DOC_PP2B_LxvP_1	416	419	PF13499	0.586
DOC_PP4_FxxP_1	20	23	PF00568	0.455
DOC_USP7_MATH_1	103	107	PF00917	0.562
DOC_USP7_MATH_1	119	123	PF00917	0.717
DOC_USP7_MATH_1	128	132	PF00917	0.510
DOC_USP7_MATH_1	16	20	PF00917	0.483
DOC_USP7_MATH_1	210	214	PF00917	0.761
DOC_USP7_MATH_1	276	280	PF00917	0.676
DOC_USP7_MATH_1	305	309	PF00917	0.740
DOC_USP7_MATH_1	310	314	PF00917	0.600
DOC_USP7_MATH_1	318	322	PF00917	0.652
DOC_USP7_MATH_1	331	335	PF00917	0.685
DOC_USP7_MATH_1	348	352	PF00917	0.554
DOC_USP7_MATH_1	370	374	PF00917	0.786
DOC_USP7_MATH_1	375	379	PF00917	0.645
DOC_USP7_MATH_1	391	395	PF00917	0.677
DOC_USP7_MATH_1	486	490	PF00917	0.735
DOC_USP7_MATH_1	97	101	PF00917	0.510
DOC_USP7_UBL2_3	141	145	PF12436	0.480
DOC_WW_Pin1_4	219	224	PF00397	0.648
DOC_WW_Pin1_4	254	259	PF00397	0.696
DOC_WW_Pin1_4	260	265	PF00397	0.673
DOC_WW_Pin1_4	272	277	PF00397	0.536
DOC_WW_Pin1_4	314	319	PF00397	0.739
DOC_WW_Pin1_4	344	349	PF00397	0.633
DOC_WW_Pin1_4	355	360	PF00397	0.640
DOC_WW_Pin1_4	402	407	PF00397	0.681
DOC_WW_Pin1_4	464	469	PF00397	0.641
LIG_14-3-3_CanoR_1	162	168	PF00244	0.607
LIG_14-3-3_CanoR_1	173	180	PF00244	0.461
LIG_14-3-3_CanoR_1	240	248	PF00244	0.640
LIG_14-3-3_CanoR_1	409	417	PF00244	0.586
LIG_14-3-3_CanoR_1	93	102	PF00244	0.536
LIG_BRCT_BRCA1_1	184	188	PF00533	0.670
LIG_BRCT_BRCA1_1	488	492	PF00533	0.613
LIG_EVH1_1	340	344	PF00568	0.606
LIG_FHA_1	133	139	PF00498	0.653
LIG_FHA_1	147	153	PF00498	0.348
LIG_FHA_1	200	206	PF00498	0.655
LIG_FHA_1	255	261	PF00498	0.714
LIG_FHA_1	402	408	PF00498	0.661
LIG_FHA_1	412	418	PF00498	0.545
LIG_FHA_2	193	199	PF00498	0.713
LIG_LIR_Apic_2	17	23	PF02991	0.446
LIG_LIR_Gen_1	169	179	PF02991	0.504
LIG_LIR_Gen_1	233	241	PF02991	0.569
LIG_LIR_Gen_1	489	498	PF02991	0.604
LIG_LIR_Nem_3	169	174	PF02991	0.497
LIG_LIR_Nem_3	233	238	PF02991	0.573
LIG_LIR_Nem_3	489	495	PF02991	0.609
LIG_NRBOX	34	40	PF00104	0.429
LIG_NRBOX	454	460	PF00104	0.594
LIG_Pex14_2	20	24	PF04695	0.457
LIG_PTB_Apo_2	73	80	PF02174	0.445
LIG_PTB_Phospho_1	73	79	PF10480	0.445
LIG_SH2_STAP1	235	239	PF00017	0.634
LIG_SH2_STAT3	392	395	PF00017	0.718
LIG_SH3_3	225	231	PF00018	0.683
LIG_SH3_3	338	344	PF00018	0.688
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.529
LIG_TRAF2_1	431	434	PF00917	0.548
LIG_UBA3_1	38	45	PF00899	0.416
LIG_UBA3_1	63	70	PF00899	0.386
LIG_WW_2	341	344	PF00397	0.601
MOD_CDK_SPxK_1	344	350	PF00069	0.613
MOD_CDK_SPxxK_3	402	409	PF00069	0.680
MOD_CK1_1	104	110	PF00069	0.538
MOD_CK1_1	112	118	PF00069	0.627
MOD_CK1_1	233	239	PF00069	0.573
MOD_CK1_1	263	269	PF00069	0.631
MOD_CK1_1	308	314	PF00069	0.595
MOD_CK1_1	317	323	PF00069	0.680
MOD_CK1_1	360	366	PF00069	0.726
MOD_CK1_1	461	467	PF00069	0.655
MOD_CK1_1	476	482	PF00069	0.709
MOD_CK1_1	493	499	PF00069	0.468
MOD_CK2_1	192	198	PF00069	0.684
MOD_CK2_1	276	282	PF00069	0.541
MOD_CK2_1	322	328	PF00069	0.655
MOD_CK2_1	467	473	PF00069	0.640
MOD_GlcNHglycan	103	106	PF01048	0.555
MOD_GlcNHglycan	111	114	PF01048	0.778
MOD_GlcNHglycan	163	166	PF01048	0.563
MOD_GlcNHglycan	184	187	PF01048	0.621
MOD_GlcNHglycan	207	210	PF01048	0.697
MOD_GlcNHglycan	212	215	PF01048	0.673
MOD_GlcNHglycan	260	263	PF01048	0.694
MOD_GlcNHglycan	324	327	PF01048	0.756
MOD_GlcNHglycan	337	340	PF01048	0.736
MOD_GlcNHglycan	359	362	PF01048	0.690
MOD_GlcNHglycan	372	375	PF01048	0.557
MOD_GlcNHglycan	383	386	PF01048	0.570
MOD_GlcNHglycan	395	398	PF01048	0.660
MOD_GlcNHglycan	460	463	PF01048	0.494
MOD_GlcNHglycan	478	481	PF01048	0.697
MOD_GlcNHglycan	488	491	PF01048	0.582
MOD_GlcNHglycan	495	498	PF01048	0.486
MOD_GSK3_1	101	108	PF00069	0.551
MOD_GSK3_1	124	131	PF00069	0.594
MOD_GSK3_1	182	189	PF00069	0.665
MOD_GSK3_1	254	261	PF00069	0.826
MOD_GSK3_1	272	279	PF00069	0.500
MOD_GSK3_1	305	312	PF00069	0.574
MOD_GSK3_1	314	321	PF00069	0.683
MOD_GSK3_1	331	338	PF00069	0.795
MOD_GSK3_1	344	351	PF00069	0.658
MOD_GSK3_1	458	465	PF00069	0.551
MOD_GSK3_1	486	493	PF00069	0.734
MOD_GSK3_1	93	100	PF00069	0.476
MOD_N-GLC_1	182	187	PF02516	0.605
MOD_NEK2_1	132	137	PF00069	0.520
MOD_NEK2_1	309	314	PF00069	0.599
MOD_NEK2_1	41	46	PF00069	0.390
MOD_NEK2_1	451	456	PF00069	0.528
MOD_NEK2_1	458	463	PF00069	0.504
MOD_NEK2_2	97	102	PF00069	0.463
MOD_PIKK_1	119	125	PF00454	0.673
MOD_PIKK_1	132	138	PF00454	0.554
MOD_PIKK_1	199	205	PF00454	0.699
MOD_PIKK_1	312	318	PF00454	0.618
MOD_PIKK_1	391	397	PF00454	0.665
MOD_PKA_2	146	152	PF00069	0.460
MOD_PKA_2	161	167	PF00069	0.415
MOD_PKA_2	205	211	PF00069	0.718
MOD_PKA_2	239	245	PF00069	0.629
MOD_PKA_2	408	414	PF00069	0.595
MOD_PKA_2	41	47	PF00069	0.390
MOD_PKA_2	473	479	PF00069	0.731
MOD_Plk_1	16	22	PF00069	0.390
MOD_Plk_1	31	37	PF00069	0.513
MOD_Plk_1	411	417	PF00069	0.670
MOD_Plk_2-3	473	479	PF00069	0.681
MOD_Plk_4	230	236	PF00069	0.766
MOD_Plk_4	31	37	PF00069	0.475
MOD_Plk_4	411	417	PF00069	0.583
MOD_ProDKin_1	219	225	PF00069	0.648
MOD_ProDKin_1	254	260	PF00069	0.698
MOD_ProDKin_1	272	278	PF00069	0.530
MOD_ProDKin_1	314	320	PF00069	0.740
MOD_ProDKin_1	344	350	PF00069	0.635
MOD_ProDKin_1	355	361	PF00069	0.640
MOD_ProDKin_1	402	408	PF00069	0.679
MOD_ProDKin_1	464	470	PF00069	0.644
TRG_DiLeu_BaEn_1	412	417	PF01217	0.552
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.468
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.525
TRG_ENDOCYTIC_2	235	238	PF00928	0.634
TRG_ER_diArg_1	297	300	PF00400	0.531
TRG_ER_diArg_1	41	43	PF00400	0.551
TRG_ER_diArg_1	437	439	PF00400	0.496
TRG_NES_CRM1_1	142	156	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW8	Leptomonas seymouri	42%	96%
A4H919	Leishmania braziliensis	70%	100%
A4HXF1	Leishmania infantum	99%	100%
E9AR46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEB7	Leishmania major	93%	100%