Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H708_LEIDO

TriTrypDb:

LdBPK_170710.1 , LdCL_170012800 , LDHU3_17.1040

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H708

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H708

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.530
CLV_NRD_NRD_1	253	255	PF00675	0.560
CLV_NRD_NRD_1	265	267	PF00675	0.524
CLV_NRD_NRD_1	303	305	PF00675	0.451
CLV_NRD_NRD_1	347	349	PF00675	0.426
CLV_NRD_NRD_1	350	352	PF00675	0.387
CLV_NRD_NRD_1	4	6	PF00675	0.629
CLV_NRD_NRD_1	94	96	PF00675	0.559
CLV_PCSK_FUR_1	92	96	PF00082	0.520
CLV_PCSK_KEX2_1	252	254	PF00082	0.565
CLV_PCSK_KEX2_1	265	267	PF00082	0.530
CLV_PCSK_KEX2_1	303	305	PF00082	0.451
CLV_PCSK_KEX2_1	4	6	PF00082	0.621
CLV_PCSK_KEX2_1	92	94	PF00082	0.574
CLV_PCSK_SKI1_1	198	202	PF00082	0.457
CLV_PCSK_SKI1_1	224	228	PF00082	0.591
CLV_PCSK_SKI1_1	363	367	PF00082	0.408
DEG_APCC_DBOX_1	362	370	PF00400	0.388
DEG_COP1_1	148	156	PF00400	0.448
DEG_Nend_UBRbox_3	1	3	PF02207	0.581
DEG_SCF_FBW7_2	73	79	PF00400	0.563
DOC_CKS1_1	115	120	PF01111	0.543
DOC_CKS1_1	326	331	PF01111	0.429
DOC_CKS1_1	73	78	PF01111	0.562
DOC_CYCLIN_RxL_1	92	102	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.603
DOC_MAPK_DCC_7	136	144	PF00069	0.494
DOC_MAPK_gen_1	112	121	PF00069	0.489
DOC_MAPK_gen_1	351	360	PF00069	0.377
DOC_MAPK_gen_1	92	99	PF00069	0.599
DOC_PP2B_LxvP_1	434	437	PF13499	0.601
DOC_PP2B_LxvP_1	438	441	PF13499	0.567
DOC_USP7_MATH_1	122	126	PF00917	0.628
DOC_USP7_MATH_1	163	167	PF00917	0.498
DOC_USP7_MATH_1	216	220	PF00917	0.617
DOC_USP7_MATH_1	271	275	PF00917	0.423
DOC_USP7_MATH_1	8	12	PF00917	0.622
DOC_USP7_MATH_2	143	149	PF00917	0.524
DOC_USP7_UBL2_3	190	194	PF12436	0.410
DOC_USP7_UBL2_3	423	427	PF12436	0.614
DOC_USP7_UBL2_3	60	64	PF12436	0.586
DOC_WW_Pin1_4	114	119	PF00397	0.701
DOC_WW_Pin1_4	259	264	PF00397	0.560
DOC_WW_Pin1_4	325	330	PF00397	0.447
DOC_WW_Pin1_4	395	400	PF00397	0.564
DOC_WW_Pin1_4	72	77	PF00397	0.655
LIG_14-3-3_CanoR_1	114	118	PF00244	0.618
LIG_14-3-3_CanoR_1	127	135	PF00244	0.539
LIG_14-3-3_CanoR_1	173	178	PF00244	0.440
LIG_14-3-3_CanoR_1	193	197	PF00244	0.285
LIG_14-3-3_CanoR_1	363	369	PF00244	0.391
LIG_14-3-3_CanoR_1	383	389	PF00244	0.572
LIG_14-3-3_CanoR_1	69	74	PF00244	0.654
LIG_Actin_WH2_2	56	71	PF00022	0.588
LIG_CSL_BTD_1	438	441	PF09270	0.543
LIG_CtBP_PxDLS_1	118	122	PF00389	0.544
LIG_FHA_1	417	423	PF00498	0.582
LIG_FHA_2	115	121	PF00498	0.611
LIG_FHA_2	244	250	PF00498	0.583
LIG_FHA_2	36	42	PF00498	0.595
LIG_GBD_Chelix_1	314	322	PF00786	0.465
LIG_LIR_Apic_2	79	85	PF02991	0.626
LIG_PCNA_yPIPBox_3	40	52	PF02747	0.532
LIG_Pex14_2	280	284	PF04695	0.370
LIG_SH2_NCK_1	17	21	PF00017	0.622
LIG_SH2_NCK_1	27	31	PF00017	0.535
LIG_SH2_STAT3	308	311	PF00017	0.397
LIG_SH2_STAT5	168	171	PF00017	0.576
LIG_SH2_STAT5	308	311	PF00017	0.456
LIG_SH2_STAT5	331	334	PF00017	0.414
LIG_SH2_STAT5	62	65	PF00017	0.618
LIG_SH3_1	151	157	PF00018	0.448
LIG_SH3_3	112	118	PF00018	0.541
LIG_SH3_3	132	138	PF00018	0.749
LIG_SH3_3	151	157	PF00018	0.398
LIG_SH3_3	210	216	PF00018	0.532
LIG_SH3_3	239	245	PF00018	0.568
LIG_SH3_3	317	323	PF00018	0.425
LIG_SH3_3	70	76	PF00018	0.580
LIG_SUMO_SIM_par_1	364	371	PF11976	0.396
LIG_TRFH_1	393	397	PF08558	0.545
MOD_CDC14_SPxK_1	262	265	PF00782	0.533
MOD_CDK_SPxK_1	259	265	PF00069	0.550
MOD_CDK_SPxK_1	72	78	PF00069	0.655
MOD_CDK_SPxxK_3	259	266	PF00069	0.540
MOD_CK1_1	219	225	PF00069	0.616
MOD_CK1_1	28	34	PF00069	0.604
MOD_CK1_1	370	376	PF00069	0.462
MOD_CK1_1	400	406	PF00069	0.643
MOD_CK1_1	410	416	PF00069	0.527
MOD_CK1_1	72	78	PF00069	0.647
MOD_CK2_1	114	120	PF00069	0.610
MOD_CK2_1	243	249	PF00069	0.603
MOD_CK2_1	35	41	PF00069	0.597
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.541
MOD_GlcNHglycan	124	127	PF01048	0.644
MOD_GlcNHglycan	147	150	PF01048	0.528
MOD_GlcNHglycan	17	20	PF01048	0.593
MOD_GlcNHglycan	370	373	PF01048	0.499
MOD_GSK3_1	163	170	PF00069	0.428
MOD_GSK3_1	364	371	PF00069	0.457
MOD_GSK3_1	407	414	PF00069	0.546
MOD_GSK3_1	9	16	PF00069	0.553
MOD_GSK3_1	95	102	PF00069	0.620
MOD_LATS_1	381	387	PF00433	0.524
MOD_N-GLC_1	340	345	PF02516	0.396
MOD_NEK2_1	129	134	PF00069	0.636
MOD_NEK2_1	147	152	PF00069	0.376
MOD_NEK2_1	407	412	PF00069	0.636
MOD_NEK2_2	35	40	PF00069	0.598
MOD_PIKK_1	271	277	PF00454	0.404
MOD_PIKK_1	343	349	PF00454	0.391
MOD_PK_1	173	179	PF00069	0.474
MOD_PK_1	69	75	PF00069	0.560
MOD_PKA_1	351	357	PF00069	0.371
MOD_PKA_2	113	119	PF00069	0.538
MOD_PKA_2	192	198	PF00069	0.433
MOD_PKA_2	243	249	PF00069	0.795
MOD_PKA_2	302	308	PF00069	0.455
MOD_PKB_1	171	179	PF00069	0.463
MOD_PKB_1	93	101	PF00069	0.557
MOD_Plk_1	95	101	PF00069	0.617
MOD_Plk_4	163	169	PF00069	0.427
MOD_Plk_4	192	198	PF00069	0.393
MOD_Plk_4	364	370	PF00069	0.461
MOD_Plk_4	47	53	PF00069	0.489
MOD_ProDKin_1	114	120	PF00069	0.700
MOD_ProDKin_1	259	265	PF00069	0.562
MOD_ProDKin_1	325	331	PF00069	0.439
MOD_ProDKin_1	395	401	PF00069	0.563
MOD_ProDKin_1	72	78	PF00069	0.655
MOD_SUMO_rev_2	155	163	PF00179	0.448
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.605
TRG_ER_diArg_1	252	254	PF00400	0.565
TRG_ER_diArg_1	264	266	PF00400	0.497
TRG_ER_diArg_1	3	5	PF00400	0.639
TRG_ER_diArg_1	303	306	PF00400	0.459
TRG_ER_diArg_1	52	55	PF00400	0.476
TRG_ER_diArg_1	91	94	PF00400	0.583
TRG_NES_CRM1_1	275	287	PF08389	0.471
TRG_NES_CRM1_1	325	337	PF08389	0.429
TRG_NLS_MonoExtC_3	347	352	PF00514	0.333
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E0	Leptomonas seymouri	43%	92%
A4HXD9	Leishmania infantum	98%	100%
E9AR34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QEC9	Leishmania major	82%	99%