Tetratricopeptide repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H706_LEIDO

TriTrypDb:

LdBPK_170620.1 , LdCL_170011600 , LDHU3_17.0920

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H706

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H706

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.455
CLV_NRD_NRD_1	10	12	PF00675	0.614
CLV_NRD_NRD_1	58	60	PF00675	0.702
CLV_PCSK_KEX2_1	10	12	PF00082	0.614
CLV_PCSK_KEX2_1	58	60	PF00082	0.702
CLV_PCSK_SKI1_1	132	136	PF00082	0.514
CLV_PCSK_SKI1_1	59	63	PF00082	0.612
DOC_MAPK_gen_1	58	64	PF00069	0.706
DOC_PP2B_LxvP_1	6	9	PF13499	0.742
DOC_USP7_MATH_1	12	16	PF00917	0.646
DOC_USP7_MATH_1	47	51	PF00917	0.666
DOC_USP7_MATH_1	86	90	PF00917	0.594
DOC_WW_Pin1_4	1	6	PF00397	0.709
DOC_WW_Pin1_4	75	80	PF00397	0.642
LIG_14-3-3_CanoR_1	10	20	PF00244	0.653
LIG_14-3-3_CanoR_1	139	148	PF00244	0.441
LIG_14-3-3_CanoR_1	178	187	PF00244	0.499
LIG_14-3-3_CanoR_1	192	199	PF00244	0.477
LIG_14-3-3_CanoR_1	85	95	PF00244	0.585
LIG_Actin_WH2_2	24	40	PF00022	0.611
LIG_BIR_III_2	125	129	PF00653	0.513
LIG_BRCT_BRCA1_1	141	145	PF00533	0.443
LIG_BRCT_BRCA1_1	193	197	PF00533	0.514
LIG_deltaCOP1_diTrp_1	191	197	PF00928	0.455
LIG_FHA_1	107	113	PF00498	0.516
LIG_GBD_Chelix_1	140	148	PF00786	0.560
LIG_LIR_Gen_1	174	183	PF02991	0.501
LIG_LIR_Nem_3	142	148	PF02991	0.415
LIG_LIR_Nem_3	170	176	PF02991	0.550
LIG_MYND_3	198	202	PF01753	0.548
LIG_NRBOX	15	21	PF00104	0.557
LIG_PCNA_PIPBox_1	137	146	PF02747	0.583
LIG_PCNA_yPIPBox_3	10	20	PF02747	0.575
LIG_Pex14_1	193	197	PF04695	0.447
LIG_Rb_pABgroove_1	139	147	PF01858	0.446
LIG_SH2_CRK	124	128	PF00017	0.506
LIG_SH2_STAP1	176	180	PF00017	0.480
LIG_SH2_STAT5	27	30	PF00017	0.489
LIG_SH3_3	20	26	PF00018	0.555
LIG_TRAF2_1	128	131	PF00917	0.651
LIG_TRAF2_1	165	168	PF00917	0.477
MOD_CK1_1	4	10	PF00069	0.702
MOD_CK2_1	162	168	PF00069	0.492
MOD_CK2_1	171	177	PF00069	0.416
MOD_CK2_1	86	92	PF00069	0.587
MOD_GlcNHglycan	118	121	PF01048	0.525
MOD_GlcNHglycan	151	154	PF01048	0.433
MOD_GlcNHglycan	180	183	PF01048	0.535
MOD_GlcNHglycan	193	196	PF01048	0.527
MOD_GlcNHglycan	49	52	PF01048	0.670
MOD_GlcNHglycan	89	92	PF01048	0.604
MOD_N-GLC_1	106	111	PF02516	0.620
MOD_NEK2_2	171	176	PF00069	0.531
MOD_PIKK_1	80	86	PF00454	0.746
MOD_PKA_2	191	197	PF00069	0.486
MOD_Plk_1	130	136	PF00069	0.591
MOD_ProDKin_1	1	7	PF00069	0.706
MOD_ProDKin_1	75	81	PF00069	0.641
MOD_SUMO_rev_2	110	120	PF00179	0.654
MOD_SUMO_rev_2	125	134	PF00179	0.483
TRG_DiLeu_BaEn_4	130	136	PF01217	0.524
TRG_ENDOCYTIC_2	124	127	PF00928	0.525
TRG_ENDOCYTIC_2	176	179	PF00928	0.558
TRG_ER_diArg_1	57	59	PF00400	0.702
TRG_ER_diArg_1	9	11	PF00400	0.740
TRG_NES_CRM1_1	146	161	PF08389	0.576
TRG_NES_CRM1_1	196	209	PF08389	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6A6	Leptomonas seymouri	66%	79%
A4H8Z9	Leishmania braziliensis	82%	100%
A4HXD0	Leishmania infantum	99%	100%
E9AR25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QED8	Leishmania major	95%	100%