Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H705_LEIDO

TriTrypDb:

LdBPK_170550.1 , LdCL_170010900 , LDHU3_17.0840

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H705

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H705

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.779
CLV_C14_Caspase3-7	64	68	PF00656	0.720
CLV_MEL_PAP_1	286	292	PF00089	0.467
CLV_NRD_NRD_1	209	211	PF00675	0.792
CLV_NRD_NRD_1	212	214	PF00675	0.798
CLV_NRD_NRD_1	280	282	PF00675	0.460
CLV_NRD_NRD_1	292	294	PF00675	0.433
CLV_NRD_NRD_1	452	454	PF00675	0.578
CLV_NRD_NRD_1	52	54	PF00675	0.733
CLV_NRD_NRD_1	592	594	PF00675	0.405
CLV_NRD_NRD_1	686	688	PF00675	0.272
CLV_NRD_NRD_1	74	76	PF00675	0.704
CLV_NRD_NRD_1	874	876	PF00675	0.354
CLV_NRD_NRD_1	92	94	PF00675	0.728
CLV_PCSK_FUR_1	210	214	PF00082	0.734
CLV_PCSK_KEX2_1	209	211	PF00082	0.802
CLV_PCSK_KEX2_1	212	214	PF00082	0.802
CLV_PCSK_KEX2_1	280	282	PF00082	0.459
CLV_PCSK_KEX2_1	452	454	PF00082	0.609
CLV_PCSK_KEX2_1	592	594	PF00082	0.405
CLV_PCSK_KEX2_1	686	688	PF00082	0.272
CLV_PCSK_KEX2_1	74	76	PF00082	0.707
CLV_PCSK_KEX2_1	747	749	PF00082	0.272
CLV_PCSK_KEX2_1	873	875	PF00082	0.324
CLV_PCSK_KEX2_1	92	94	PF00082	0.679
CLV_PCSK_PC1ET2_1	747	749	PF00082	0.272
CLV_PCSK_PC1ET2_1	873	875	PF00082	0.297
CLV_PCSK_PC7_1	276	282	PF00082	0.581
CLV_PCSK_PC7_1	870	876	PF00082	0.328
CLV_PCSK_SKI1_1	227	231	PF00082	0.606
CLV_PCSK_SKI1_1	268	272	PF00082	0.525
CLV_PCSK_SKI1_1	281	285	PF00082	0.419
CLV_PCSK_SKI1_1	293	297	PF00082	0.509
CLV_PCSK_SKI1_1	521	525	PF00082	0.618
CLV_PCSK_SKI1_1	635	639	PF00082	0.331
CLV_PCSK_SKI1_1	645	649	PF00082	0.224
CLV_PCSK_SKI1_1	688	692	PF00082	0.364
CLV_PCSK_SKI1_1	706	710	PF00082	0.225
CLV_PCSK_SKI1_1	723	727	PF00082	0.413
CLV_PCSK_SKI1_1	833	837	PF00082	0.354
CLV_PCSK_SKI1_1	874	878	PF00082	0.324
CLV_Separin_Metazoa	798	802	PF03568	0.386
DEG_APCC_DBOX_1	705	713	PF00400	0.315
DEG_SCF_FBW7_1	81	86	PF00400	0.552
DEG_SPOP_SBC_1	192	196	PF00917	0.664
DOC_CYCLIN_RxL_1	518	528	PF00134	0.609
DOC_CYCLIN_RxL_1	576	587	PF00134	0.482
DOC_MAPK_gen_1	258	267	PF00069	0.604
DOC_MAPK_gen_1	381	390	PF00069	0.729
DOC_MAPK_gen_1	635	643	PF00069	0.339
DOC_MAPK_gen_1	691	700	PF00069	0.291
DOC_MAPK_gen_1	723	732	PF00069	0.272
DOC_MAPK_gen_1	854	861	PF00069	0.281
DOC_MAPK_gen_1	873	881	PF00069	0.295
DOC_MAPK_MEF2A_6	261	269	PF00069	0.617
DOC_MAPK_MEF2A_6	854	863	PF00069	0.310
DOC_PP1_RVXF_1	266	272	PF00149	0.498
DOC_PP4_FxxP_1	794	797	PF00568	0.259
DOC_USP7_MATH_1	108	112	PF00917	0.625
DOC_USP7_MATH_1	188	192	PF00917	0.721
DOC_USP7_MATH_1	233	237	PF00917	0.710
DOC_USP7_MATH_1	27	31	PF00917	0.667
DOC_USP7_MATH_1	272	276	PF00917	0.470
DOC_USP7_MATH_1	361	365	PF00917	0.698
DOC_USP7_MATH_1	402	406	PF00917	0.746
DOC_USP7_MATH_1	540	544	PF00917	0.702
DOC_USP7_MATH_1	558	562	PF00917	0.546
DOC_USP7_MATH_2	203	209	PF00917	0.578
DOC_WW_Pin1_4	12	17	PF00397	0.739
DOC_WW_Pin1_4	23	28	PF00397	0.742
DOC_WW_Pin1_4	337	342	PF00397	0.780
DOC_WW_Pin1_4	343	348	PF00397	0.741
DOC_WW_Pin1_4	36	41	PF00397	0.692
DOC_WW_Pin1_4	406	411	PF00397	0.683
DOC_WW_Pin1_4	47	52	PF00397	0.614
DOC_WW_Pin1_4	490	495	PF00397	0.779
DOC_WW_Pin1_4	508	513	PF00397	0.627
DOC_WW_Pin1_4	514	519	PF00397	0.751
DOC_WW_Pin1_4	770	775	PF00397	0.426
DOC_WW_Pin1_4	788	793	PF00397	0.235
DOC_WW_Pin1_4	79	84	PF00397	0.762
DOC_WW_Pin1_4	897	902	PF00397	0.504
DOC_WW_Pin1_4	904	909	PF00397	0.558
LIG_14-3-3_CanoR_1	293	301	PF00244	0.523
LIG_14-3-3_CanoR_1	386	391	PF00244	0.614
LIG_14-3-3_CanoR_1	499	506	PF00244	0.571
LIG_14-3-3_CanoR_1	592	597	PF00244	0.405
LIG_14-3-3_CanoR_1	874	882	PF00244	0.263
LIG_APCC_ABBA_1	670	675	PF00400	0.272
LIG_BRCT_BRCA1_1	565	569	PF00533	0.595
LIG_BRCT_BRCA1_1	790	794	PF00533	0.393
LIG_DLG_GKlike_1	386	394	PF00625	0.598
LIG_FHA_1	199	205	PF00498	0.583
LIG_FHA_1	41	47	PF00498	0.625
LIG_FHA_1	500	506	PF00498	0.728
LIG_FHA_1	526	532	PF00498	0.710
LIG_FHA_1	578	584	PF00498	0.580
LIG_FHA_1	658	664	PF00498	0.315
LIG_FHA_1	703	709	PF00498	0.428
LIG_FHA_2	131	137	PF00498	0.712
LIG_FHA_2	176	182	PF00498	0.620
LIG_FHA_2	294	300	PF00498	0.505
LIG_FHA_2	312	318	PF00498	0.408
LIG_FHA_2	602	608	PF00498	0.405
LIG_FHA_2	875	881	PF00498	0.249
LIG_FHA_2	886	892	PF00498	0.393
LIG_LIR_Apic_2	791	797	PF02991	0.270
LIG_LIR_Gen_1	315	325	PF02991	0.573
LIG_LIR_Nem_3	296	301	PF02991	0.454
LIG_LIR_Nem_3	315	321	PF02991	0.541
LIG_LIR_Nem_3	601	605	PF02991	0.324
LIG_LIR_Nem_3	671	676	PF02991	0.412
LIG_LRP6_Inhibitor_1	19	25	PF00058	0.624
LIG_MLH1_MIPbox_1	790	794	PF16413	0.393
LIG_MYND_1	350	354	PF01753	0.544
LIG_Pex14_2	836	840	PF04695	0.393
LIG_Pex14_2	864	868	PF04695	0.252
LIG_PTB_Apo_2	442	449	PF02174	0.608
LIG_PTB_Phospho_1	442	448	PF10480	0.604
LIG_REV1ctd_RIR_1	861	870	PF16727	0.253
LIG_SH2_GRB2like	443	446	PF00017	0.605
LIG_SH2_NCK_1	443	447	PF00017	0.575
LIG_SH2_SRC	714	717	PF00017	0.272
LIG_SH2_STAP1	443	447	PF00017	0.605
LIG_SH2_STAP1	704	708	PF00017	0.291
LIG_SH2_STAT3	656	659	PF00017	0.272
LIG_SH2_STAT3	704	707	PF00017	0.272
LIG_SH2_STAT5	282	285	PF00017	0.577
LIG_SH2_STAT5	301	304	PF00017	0.294
LIG_SH2_STAT5	440	443	PF00017	0.462
LIG_SH2_STAT5	448	451	PF00017	0.543
LIG_SH2_STAT5	704	707	PF00017	0.328
LIG_SH2_STAT5	714	717	PF00017	0.306
LIG_SH2_STAT5	806	809	PF00017	0.393
LIG_SH3_1	14	20	PF00018	0.616
LIG_SH3_3	14	20	PF00018	0.616
LIG_SH3_3	335	341	PF00018	0.704
LIG_SH3_3	344	350	PF00018	0.711
LIG_SH3_3	43	49	PF00018	0.684
LIG_SH3_3	476	482	PF00018	0.619
LIG_SH3_3	512	518	PF00018	0.589
LIG_SH3_3	78	84	PF00018	0.632
LIG_SH3_3	786	792	PF00018	0.301
LIG_SH3_3	895	901	PF00018	0.561
LIG_SUMO_SIM_anti_2	697	703	PF11976	0.291
LIG_SUMO_SIM_anti_2	877	883	PF11976	0.266
LIG_SUMO_SIM_par_1	199	208	PF11976	0.580
LIG_SUMO_SIM_par_1	42	50	PF11976	0.683
LIG_TRAF2_1	145	148	PF00917	0.703
LIG_TRAF2_1	163	166	PF00917	0.705
LIG_TRAF2_1	773	776	PF00917	0.295
LIG_TRAF2_1	893	896	PF00917	0.440
LIG_TRFH_1	406	410	PF08558	0.610
LIG_TYR_ITSM	602	609	PF00017	0.405
LIG_UBA3_1	643	650	PF00899	0.272
LIG_UBA3_1	731	739	PF00899	0.291
LIG_UBA3_1	835	844	PF00899	0.314
MOD_CDC14_SPxK_1	50	53	PF00782	0.587
MOD_CDK_SPK_2	406	411	PF00069	0.649
MOD_CDK_SPxK_1	47	53	PF00069	0.587
MOD_CDK_SPxxK_3	47	54	PF00069	0.618
MOD_CDK_SPxxK_3	490	497	PF00069	0.608
MOD_CDK_SPxxK_3	514	521	PF00069	0.581
MOD_CK1_1	110	116	PF00069	0.707
MOD_CK1_1	191	197	PF00069	0.812
MOD_CK1_1	208	214	PF00069	0.734
MOD_CK1_1	236	242	PF00069	0.721
MOD_CK1_1	30	36	PF00069	0.574
MOD_CK1_1	340	346	PF00069	0.626
MOD_CK1_1	364	370	PF00069	0.743
MOD_CK1_1	377	383	PF00069	0.606
MOD_CK1_1	39	45	PF00069	0.637
MOD_CK1_1	418	424	PF00069	0.740
MOD_CK1_1	432	438	PF00069	0.491
MOD_CK1_1	490	496	PF00069	0.672
MOD_CK1_1	530	536	PF00069	0.739
MOD_CK1_1	561	567	PF00069	0.575
MOD_CK1_1	601	607	PF00069	0.364
MOD_CK1_1	681	687	PF00069	0.405
MOD_CK1_1	86	92	PF00069	0.601
MOD_CK1_1	900	906	PF00069	0.582
MOD_CK2_1	130	136	PF00069	0.809
MOD_CK2_1	142	148	PF00069	0.782
MOD_CK2_1	160	166	PF00069	0.632
MOD_CK2_1	176	182	PF00069	0.601
MOD_CK2_1	421	427	PF00069	0.624
MOD_CK2_1	540	546	PF00069	0.648
MOD_CK2_1	601	607	PF00069	0.351
MOD_CK2_1	770	776	PF00069	0.464
MOD_CK2_1	874	880	PF00069	0.245
MOD_CK2_1	900	906	PF00069	0.716
MOD_Cter_Amidation	217	220	PF01082	0.606
MOD_DYRK1A_RPxSP_1	79	83	PF00069	0.562
MOD_GlcNHglycan	190	193	PF01048	0.733
MOD_GlcNHglycan	196	199	PF01048	0.653
MOD_GlcNHglycan	216	219	PF01048	0.577
MOD_GlcNHglycan	236	239	PF01048	0.774
MOD_GlcNHglycan	390	393	PF01048	0.605
MOD_GlcNHglycan	420	423	PF01048	0.715
MOD_GlcNHglycan	432	435	PF01048	0.626
MOD_GlcNHglycan	474	477	PF01048	0.696
MOD_GlcNHglycan	506	509	PF01048	0.768
MOD_GlcNHglycan	532	535	PF01048	0.777
MOD_GlcNHglycan	56	59	PF01048	0.739
MOD_GlcNHglycan	560	563	PF01048	0.661
MOD_GlcNHglycan	732	735	PF01048	0.390
MOD_GSK3_1	106	113	PF00069	0.707
MOD_GSK3_1	171	178	PF00069	0.773
MOD_GSK3_1	186	193	PF00069	0.811
MOD_GSK3_1	194	201	PF00069	0.754
MOD_GSK3_1	214	221	PF00069	0.583
MOD_GSK3_1	229	236	PF00069	0.709
MOD_GSK3_1	23	30	PF00069	0.764
MOD_GSK3_1	32	39	PF00069	0.628
MOD_GSK3_1	333	340	PF00069	0.627
MOD_GSK3_1	386	393	PF00069	0.571
MOD_GSK3_1	402	409	PF00069	0.594
MOD_GSK3_1	412	419	PF00069	0.700
MOD_GSK3_1	468	475	PF00069	0.755
MOD_GSK3_1	504	511	PF00069	0.757
MOD_GSK3_1	54	61	PF00069	0.709
MOD_GSK3_1	696	703	PF00069	0.276
MOD_GSK3_1	784	791	PF00069	0.284
MOD_GSK3_1	79	86	PF00069	0.656
MOD_GSK3_1	900	907	PF00069	0.750
MOD_N-GLC_1	361	366	PF02516	0.593
MOD_N-GLC_1	394	399	PF02516	0.600
MOD_N-GLC_1	459	464	PF02516	0.573
MOD_N-GLC_1	569	574	PF02516	0.561
MOD_NEK2_1	3	8	PF00069	0.752
MOD_NEK2_1	388	393	PF00069	0.710
MOD_NEK2_1	412	417	PF00069	0.678
MOD_NEK2_1	459	464	PF00069	0.608
MOD_NEK2_1	524	529	PF00069	0.724
MOD_NEK2_1	569	574	PF00069	0.491
MOD_NEK2_1	577	582	PF00069	0.549
MOD_NEK2_1	643	648	PF00069	0.252
MOD_NEK2_1	696	701	PF00069	0.278
MOD_NEK2_1	743	748	PF00069	0.334
MOD_NEK2_1	784	789	PF00069	0.404
MOD_PIKK_1	119	125	PF00454	0.671
MOD_PIKK_1	219	225	PF00454	0.582
MOD_PIKK_1	30	36	PF00454	0.750
MOD_PIKK_1	390	396	PF00454	0.585
MOD_PIKK_1	607	613	PF00454	0.441
MOD_PIKK_1	900	906	PF00454	0.716
MOD_PK_1	592	598	PF00069	0.405
MOD_PKA_1	219	225	PF00069	0.615
MOD_PKA_1	293	299	PF00069	0.554
MOD_PKA_1	592	598	PF00069	0.405
MOD_PKA_1	874	880	PF00069	0.293
MOD_PKA_2	208	214	PF00069	0.786
MOD_PKA_2	441	447	PF00069	0.483
MOD_PKA_2	592	598	PF00069	0.382
MOD_PKA_2	840	846	PF00069	0.310
MOD_PKA_2	869	875	PF00069	0.276
MOD_PKB_1	384	392	PF00069	0.543
MOD_Plk_1	412	418	PF00069	0.721
MOD_Plk_1	459	465	PF00069	0.577
MOD_Plk_1	569	575	PF00069	0.572
MOD_Plk_1	621	627	PF00069	0.386
MOD_Plk_2-3	132	138	PF00069	0.636
MOD_Plk_2-3	142	148	PF00069	0.700
MOD_Plk_2-3	176	182	PF00069	0.708
MOD_Plk_2-3	311	317	PF00069	0.455
MOD_Plk_4	333	339	PF00069	0.687
MOD_Plk_4	396	402	PF00069	0.714
MOD_Plk_4	421	427	PF00069	0.696
MOD_Plk_4	432	438	PF00069	0.403
MOD_Plk_4	459	465	PF00069	0.581
MOD_Plk_4	592	598	PF00069	0.424
MOD_Plk_4	601	607	PF00069	0.315
MOD_Plk_4	651	657	PF00069	0.426
MOD_Plk_4	784	790	PF00069	0.256
MOD_ProDKin_1	12	18	PF00069	0.739
MOD_ProDKin_1	23	29	PF00069	0.739
MOD_ProDKin_1	337	343	PF00069	0.781
MOD_ProDKin_1	36	42	PF00069	0.693
MOD_ProDKin_1	406	412	PF00069	0.682
MOD_ProDKin_1	47	53	PF00069	0.616
MOD_ProDKin_1	490	496	PF00069	0.775
MOD_ProDKin_1	508	514	PF00069	0.626
MOD_ProDKin_1	770	776	PF00069	0.426
MOD_ProDKin_1	788	794	PF00069	0.235
MOD_ProDKin_1	79	85	PF00069	0.760
MOD_ProDKin_1	897	903	PF00069	0.514
MOD_ProDKin_1	904	910	PF00069	0.562
MOD_SUMO_for_1	637	640	PF00179	0.339
MOD_SUMO_rev_2	424	433	PF00179	0.687
MOD_SUMO_rev_2	47	55	PF00179	0.661
MOD_SUMO_rev_2	607	616	PF00179	0.272
MOD_SUMO_rev_2	733	741	PF00179	0.272
TRG_ENDOCYTIC_2	606	609	PF00928	0.272
TRG_ENDOCYTIC_2	98	101	PF00928	0.571
TRG_ER_diArg_1	209	212	PF00400	0.722
TRG_ER_diArg_1	279	281	PF00400	0.452
TRG_ER_diArg_1	591	593	PF00400	0.512
TRG_ER_diArg_1	685	687	PF00400	0.272
TRG_NES_CRM1_1	319	335	PF08389	0.455
TRG_NES_CRM1_1	571	587	PF08389	0.553
TRG_NES_CRM1_1	811	821	PF08389	0.336
TRG_NLS_MonoExtN_4	870	877	PF00514	0.295
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H5	Leptomonas seymouri	51%	69%
A0A1X0NSX9	Trypanosomatidae	43%	97%
A0A3R7M724	Trypanosoma rangeli	44%	100%
A4HXC3	Leishmania infantum	97%	100%
C9ZU16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AI55	Leishmania braziliensis	64%	100%
E9AR18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QEE5	Leishmania major	90%	100%
V5B639	Trypanosoma cruzi	43%	100%