Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6Z9_LEIDO

TriTrypDb:

LdBPK_170210.1 , LdCL_170007600 , LDHU3_17.0420

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.642
CLV_C14_Caspase3-7	663	667	PF00656	0.621
CLV_MEL_PAP_1	146	152	PF00089	0.650
CLV_NRD_NRD_1	141	143	PF00675	0.562
CLV_NRD_NRD_1	201	203	PF00675	0.628
CLV_NRD_NRD_1	591	593	PF00675	0.487
CLV_PCSK_KEX2_1	141	143	PF00082	0.562
CLV_PCSK_KEX2_1	201	203	PF00082	0.606
CLV_PCSK_KEX2_1	591	593	PF00082	0.521
CLV_PCSK_KEX2_1	622	624	PF00082	0.746
CLV_PCSK_KEX2_1	657	659	PF00082	0.623
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.746
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.623
CLV_PCSK_SKI1_1	221	225	PF00082	0.738
CLV_PCSK_SKI1_1	272	276	PF00082	0.521
CLV_PCSK_SKI1_1	354	358	PF00082	0.735
DEG_APCC_DBOX_1	353	361	PF00400	0.733
DEG_APCC_DBOX_1	591	599	PF00400	0.608
DEG_Nend_UBRbox_3	1	3	PF02207	0.694
DEG_SCF_FBW7_1	18	25	PF00400	0.502
DEG_SPOP_SBC_1	405	409	PF00917	0.707
DEG_SPOP_SBC_1	445	449	PF00917	0.726
DEG_SPOP_SBC_1	529	533	PF00917	0.610
DOC_CDC14_PxL_1	315	323	PF14671	0.639
DOC_CYCLIN_yCln2_LP_2	320	323	PF00134	0.439
DOC_MAPK_HePTP_8	91	103	PF00069	0.626
DOC_MAPK_MEF2A_6	256	263	PF00069	0.563
DOC_MAPK_MEF2A_6	94	103	PF00069	0.591
DOC_PP2B_LxvP_1	320	323	PF13499	0.583
DOC_PP2B_LxvP_1	495	498	PF13499	0.775
DOC_PP4_FxxP_1	563	566	PF00568	0.584
DOC_PP4_FxxP_1	640	643	PF00568	0.712
DOC_USP7_MATH_1	118	122	PF00917	0.735
DOC_USP7_MATH_1	22	26	PF00917	0.749
DOC_USP7_MATH_1	281	285	PF00917	0.559
DOC_USP7_MATH_1	36	40	PF00917	0.743
DOC_USP7_MATH_1	406	410	PF00917	0.720
DOC_USP7_MATH_1	445	449	PF00917	0.721
DOC_USP7_MATH_1	498	502	PF00917	0.747
DOC_USP7_MATH_1	529	533	PF00917	0.690
DOC_USP7_MATH_1	55	59	PF00917	0.561
DOC_USP7_MATH_1	612	616	PF00917	0.581
DOC_USP7_MATH_1	75	79	PF00917	0.684
DOC_USP7_UBL2_3	596	600	PF12436	0.660
DOC_WW_Pin1_4	18	23	PF00397	0.701
DOC_WW_Pin1_4	433	438	PF00397	0.634
LIG_14-3-3_CanoR_1	12	18	PF00244	0.704
LIG_14-3-3_CanoR_1	127	136	PF00244	0.667
LIG_14-3-3_CanoR_1	268	274	PF00244	0.481
LIG_14-3-3_CanoR_1	359	367	PF00244	0.646
LIG_BIR_III_4	116	120	PF00653	0.636
LIG_BRCT_BRCA1_1	376	380	PF00533	0.571
LIG_BRCT_BRCA1_1	382	386	PF00533	0.605
LIG_BRCT_BRCA1_1	540	544	PF00533	0.539
LIG_BRCT_BRCA1_1	648	652	PF00533	0.613
LIG_BRCT_BRCA1_1	7	11	PF00533	0.656
LIG_Clathr_ClatBox_1	251	255	PF01394	0.506
LIG_Clathr_ClatBox_1	659	663	PF01394	0.621
LIG_Dynein_DLC8_1	357	363	PF01221	0.606
LIG_EH1_1	462	470	PF00400	0.510
LIG_EVH1_2	437	441	PF00568	0.512
LIG_FHA_1	165	171	PF00498	0.544
LIG_FHA_1	232	238	PF00498	0.475
LIG_FHA_1	490	496	PF00498	0.710
LIG_FHA_1	608	614	PF00498	0.530
LIG_FHA_1	651	657	PF00498	0.527
LIG_FHA_1	69	75	PF00498	0.691
LIG_FHA_2	159	165	PF00498	0.642
LIG_FHA_2	222	228	PF00498	0.646
LIG_FHA_2	576	582	PF00498	0.653
LIG_LIR_Apic_2	560	566	PF02991	0.579
LIG_LIR_Apic_2	637	643	PF02991	0.697
LIG_LIR_Gen_1	234	243	PF02991	0.638
LIG_LIR_Gen_1	383	393	PF02991	0.672
LIG_LIR_Gen_1	579	589	PF02991	0.656
LIG_LIR_Nem_3	148	153	PF02991	0.618
LIG_LIR_Nem_3	188	192	PF02991	0.520
LIG_LIR_Nem_3	198	203	PF02991	0.489
LIG_LIR_Nem_3	234	239	PF02991	0.624
LIG_LIR_Nem_3	244	248	PF02991	0.630
LIG_LIR_Nem_3	383	389	PF02991	0.672
LIG_LIR_Nem_3	579	585	PF02991	0.584
LIG_LIR_Nem_3	81	86	PF02991	0.580
LIG_LYPXL_yS_3	29	32	PF13949	0.707
LIG_MYND_1	30	34	PF01753	0.602
LIG_MYND_1	319	323	PF01753	0.679
LIG_NRBOX	247	253	PF00104	0.553
LIG_PDZ_Class_2	662	667	PF00595	0.615
LIG_Pex14_1	646	650	PF04695	0.511
LIG_Rb_LxCxE_1	247	267	PF01857	0.553
LIG_REV1ctd_RIR_1	461	471	PF16727	0.594
LIG_SH2_CRK	89	93	PF00017	0.635
LIG_SH2_NCK_1	144	148	PF00017	0.636
LIG_SH2_PTP2	236	239	PF00017	0.477
LIG_SH2_STAT5	155	158	PF00017	0.407
LIG_SH2_STAT5	192	195	PF00017	0.522
LIG_SH2_STAT5	236	239	PF00017	0.477
LIG_SH2_STAT5	429	432	PF00017	0.653
LIG_SH3_1	432	438	PF00018	0.612
LIG_SH3_3	107	113	PF00018	0.692
LIG_SH3_3	163	169	PF00018	0.759
LIG_SH3_3	291	297	PF00018	0.449
LIG_SH3_3	313	319	PF00018	0.514
LIG_SH3_3	432	438	PF00018	0.546
LIG_SH3_3	81	87	PF00018	0.569
LIG_SUMO_SIM_par_1	658	664	PF11976	0.598
LIG_TYR_ITIM	86	91	PF00017	0.686
MOD_CK1_1	176	182	PF00069	0.690
MOD_CK1_1	267	273	PF00069	0.465
MOD_CK1_1	365	371	PF00069	0.677
MOD_CK1_1	373	379	PF00069	0.576
MOD_CK1_1	408	414	PF00069	0.755
MOD_CK1_1	436	442	PF00069	0.719
MOD_CK1_1	448	454	PF00069	0.511
MOD_CK1_1	499	505	PF00069	0.715
MOD_CK1_1	521	527	PF00069	0.668
MOD_CK1_1	530	536	PF00069	0.469
MOD_CK1_1	538	544	PF00069	0.479
MOD_CK1_1	615	621	PF00069	0.744
MOD_CK1_1	78	84	PF00069	0.698
MOD_CK2_1	158	164	PF00069	0.663
MOD_CK2_1	575	581	PF00069	0.663
MOD_CK2_1	90	96	PF00069	0.627
MOD_CMANNOS	309	312	PF00535	0.532
MOD_GlcNHglycan	104	108	PF01048	0.679
MOD_GlcNHglycan	120	123	PF01048	0.670
MOD_GlcNHglycan	175	178	PF01048	0.661
MOD_GlcNHglycan	203	206	PF01048	0.558
MOD_GlcNHglycan	217	220	PF01048	0.690
MOD_GlcNHglycan	247	251	PF01048	0.599
MOD_GlcNHglycan	336	339	PF01048	0.766
MOD_GlcNHglycan	349	352	PF01048	0.698
MOD_GlcNHglycan	367	370	PF01048	0.688
MOD_GlcNHglycan	410	413	PF01048	0.785
MOD_GlcNHglycan	448	451	PF01048	0.732
MOD_GlcNHglycan	506	509	PF01048	0.744
MOD_GlcNHglycan	51	54	PF01048	0.777
MOD_GlcNHglycan	540	543	PF01048	0.553
MOD_GlcNHglycan	614	618	PF01048	0.679
MOD_GlcNHglycan	77	80	PF01048	0.742
MOD_GSK3_1	154	161	PF00069	0.638
MOD_GSK3_1	175	182	PF00069	0.643
MOD_GSK3_1	18	25	PF00069	0.652
MOD_GSK3_1	263	270	PF00069	0.486
MOD_GSK3_1	358	365	PF00069	0.648
MOD_GSK3_1	36	43	PF00069	0.663
MOD_GSK3_1	370	377	PF00069	0.491
MOD_GSK3_1	404	411	PF00069	0.783
MOD_GSK3_1	444	451	PF00069	0.714
MOD_GSK3_1	498	505	PF00069	0.727
MOD_GSK3_1	514	521	PF00069	0.555
MOD_GSK3_1	603	610	PF00069	0.697
MOD_GSK3_1	646	653	PF00069	0.598
MOD_GSK3_1	75	82	PF00069	0.685
MOD_GSK3_1	99	106	PF00069	0.627
MOD_NEK2_1	162	167	PF00069	0.694
MOD_NEK2_1	263	268	PF00069	0.468
MOD_NEK2_1	370	375	PF00069	0.550
MOD_NEK2_1	380	385	PF00069	0.562
MOD_NEK2_1	4	9	PF00069	0.698
MOD_NEK2_1	410	415	PF00069	0.783
MOD_NEK2_1	453	458	PF00069	0.718
MOD_NEK2_1	463	468	PF00069	0.545
MOD_NEK2_1	514	519	PF00069	0.749
MOD_NEK2_1	535	540	PF00069	0.606
MOD_NEK2_1	650	655	PF00069	0.595
MOD_PIKK_1	182	188	PF00454	0.654
MOD_PIKK_1	267	273	PF00454	0.484
MOD_PIKK_1	358	364	PF00454	0.611
MOD_PIKK_1	38	44	PF00454	0.658
MOD_PK_1	149	155	PF00069	0.592
MOD_PKA_1	201	207	PF00069	0.518
MOD_PKA_2	201	207	PF00069	0.498
MOD_PKA_2	267	273	PF00069	0.484
MOD_PKA_2	358	364	PF00069	0.611
MOD_PKA_2	538	544	PF00069	0.563
MOD_PKA_2	550	556	PF00069	0.542
MOD_Plk_1	246	252	PF00069	0.520
MOD_Plk_1	99	105	PF00069	0.649
MOD_Plk_2-3	575	581	PF00069	0.642
MOD_Plk_2-3	594	600	PF00069	0.497
MOD_Plk_4	149	155	PF00069	0.589
MOD_Plk_4	22	28	PF00069	0.687
MOD_Plk_4	231	237	PF00069	0.630
MOD_Plk_4	518	524	PF00069	0.709
MOD_ProDKin_1	18	24	PF00069	0.698
MOD_ProDKin_1	433	439	PF00069	0.637
MOD_SUMO_rev_2	590	598	PF00179	0.616
TRG_AP2beta_CARGO_1	198	207	PF09066	0.499
TRG_DiLeu_BaEn_1	255	260	PF01217	0.557
TRG_DiLeu_BaEn_1	296	301	PF01217	0.564
TRG_DiLeu_BaEn_1	474	479	PF01217	0.618
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.729
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.587
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.575
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.624
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.611
TRG_ENDOCYTIC_2	236	239	PF00928	0.621
TRG_ENDOCYTIC_2	29	32	PF00928	0.707
TRG_ENDOCYTIC_2	88	91	PF00928	0.564
TRG_ER_diArg_1	141	143	PF00400	0.562
TRG_ER_diArg_1	200	202	PF00400	0.630
TRG_ER_diArg_1	623	626	PF00400	0.702
TRG_NLS_MonoExtC_3	621	627	PF00514	0.782
TRG_NLS_MonoExtN_4	620	626	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTE1	Leptomonas seymouri	37%	100%
A0A3S5IR37	Trypanosoma rangeli	30%	100%
A4H8V9	Leishmania braziliensis	70%	100%
A4HXA6	Leishmania infantum	100%	100%
C9ZTV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AQY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEH8	Leishmania major	88%	100%
V5D8P0	Trypanosoma cruzi	27%	100%