Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6Z6_LEIDO

TriTrypDb:

LdBPK_170060.1 , LdCL_170005600 , LDHU3_17.0080

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Z6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.673
CLV_C14_Caspase3-7	35	39	PF00656	0.597
CLV_NRD_NRD_1	21	23	PF00675	0.727
CLV_NRD_NRD_1	227	229	PF00675	0.715
CLV_NRD_NRD_1	89	91	PF00675	0.582
CLV_NRD_NRD_1	98	100	PF00675	0.634
CLV_PCSK_KEX2_1	21	23	PF00082	0.642
CLV_PCSK_KEX2_1	227	229	PF00082	0.715
CLV_PCSK_KEX2_1	84	86	PF00082	0.545
CLV_PCSK_KEX2_1	88	90	PF00082	0.558
CLV_PCSK_KEX2_1	98	100	PF00082	0.595
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.613
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.559
CLV_PCSK_PC7_1	223	229	PF00082	0.720
CLV_PCSK_PC7_1	85	91	PF00082	0.675
CLV_PCSK_SKI1_1	100	104	PF00082	0.618
CLV_PCSK_SKI1_1	168	172	PF00082	0.632
CLV_PCSK_SKI1_1	211	215	PF00082	0.638
CLV_PCSK_SKI1_1	227	231	PF00082	0.538
CLV_PCSK_SKI1_1	59	63	PF00082	0.558
DEG_SCF_FBW7_1	108	115	PF00400	0.639
DOC_CYCLIN_RxL_1	18	29	PF00134	0.656
DOC_CYCLIN_RxL_1	97	106	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.663
DOC_MAPK_MEF2A_6	199	206	PF00069	0.734
DOC_PP1_RVXF_1	19	26	PF00149	0.619
DOC_PP2B_LxvP_1	30	33	PF13499	0.631
DOC_USP7_MATH_1	112	116	PF00917	0.729
DOC_USP7_MATH_1	51	55	PF00917	0.635
DOC_USP7_UBL2_3	205	209	PF12436	0.628
DOC_WW_Pin1_4	108	113	PF00397	0.620
LIG_14-3-3_CanoR_1	22	28	PF00244	0.701
LIG_BIR_III_4	191	195	PF00653	0.663
LIG_BRCT_BRCA1_1	53	57	PF00533	0.678
LIG_deltaCOP1_diTrp_1	46	56	PF00928	0.581
LIG_FHA_1	138	144	PF00498	0.674
LIG_FHA_2	120	126	PF00498	0.660
LIG_FHA_2	129	135	PF00498	0.541
LIG_FHA_2	179	185	PF00498	0.749
LIG_LIR_Gen_1	46	57	PF02991	0.559
LIG_LIR_LC3C_4	12	15	PF02991	0.680
LIG_LIR_Nem_3	155	160	PF02991	0.684
LIG_LIR_Nem_3	46	52	PF02991	0.565
LIG_LIR_Nem_3	54	60	PF02991	0.583
LIG_PTB_Apo_2	36	43	PF02174	0.637
LIG_SH2_STAP1	45	49	PF00017	0.627
LIG_SH2_STAT3	45	48	PF00017	0.672
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.598
LIG_UBA3_1	203	211	PF00899	0.415
LIG_WRC_WIRS_1	52	57	PF05994	0.664
MOD_CK2_1	119	125	PF00069	0.623
MOD_CK2_1	128	134	PF00069	0.543
MOD_CK2_1	178	184	PF00069	0.705
MOD_CK2_1	204	210	PF00069	0.651
MOD_Cter_Amidation	19	22	PF01082	0.644
MOD_GlcNHglycan	105	108	PF01048	0.741
MOD_GlcNHglycan	181	184	PF01048	0.727
MOD_GlcNHglycan	63	66	PF01048	0.627
MOD_GSK3_1	108	115	PF00069	0.707
MOD_GSK3_1	116	123	PF00069	0.609
MOD_GSK3_1	175	182	PF00069	0.745
MOD_N-GLC_1	119	124	PF02516	0.675
MOD_NEK2_1	103	108	PF00069	0.753
MOD_NEK2_1	204	209	PF00069	0.614
MOD_NEK2_1	219	224	PF00069	0.518
MOD_NEK2_1	23	28	PF00069	0.657
MOD_NEK2_1	61	66	PF00069	0.622
MOD_Plk_1	119	125	PF00069	0.674
MOD_Plk_1	91	97	PF00069	0.650
MOD_Plk_4	112	118	PF00069	0.723
MOD_Plk_4	51	57	PF00069	0.657
MOD_Plk_4	9	15	PF00069	0.696
MOD_Plk_4	91	97	PF00069	0.693
MOD_ProDKin_1	108	114	PF00069	0.622
MOD_SUMO_rev_2	132	138	PF00179	0.593
MOD_SUMO_rev_2	26	33	PF00179	0.693
TRG_DiLeu_BaEn_1	134	139	PF01217	0.660
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.629
TRG_ER_diArg_1	21	23	PF00400	0.727
TRG_ER_diArg_1	227	229	PF00400	0.715
TRG_ER_diArg_1	88	90	PF00400	0.584
TRG_ER_diArg_1	99	102	PF00400	0.613
TRG_NLS_Bipartite_1	84	103	PF00514	0.596
TRG_NLS_MonoCore_2	96	101	PF00514	0.648
TRG_NLS_MonoExtC_3	96	101	PF00514	0.608
TRG_NLS_MonoExtN_4	97	103	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I083	Leptomonas seymouri	61%	97%
A0A1X0NT13	Trypanosomatidae	44%	96%
A0A3R7KLV2	Trypanosoma rangeli	44%	92%
A4H8V1	Leishmania braziliensis	75%	100%
A4HX70	Leishmania infantum	99%	100%
C9ZTU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ARC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEJ3	Leishmania major	92%	100%