Monocyte to macrophage differentiation factor 2

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3522), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6Z5_LEIDO

TriTrypDb:

LdBPK_170030.1 , LdCL_170005300 , LDHU3_17.0050

Length:

225

Annotations

LeishMANIAdb annotations

Very distantly similar to animal TMEM8 and MMD2 proteins. Its function is obscure, although gene fusions with lipid hydrolases suggest a related function

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A0A3S5H6Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.258
CLV_NRD_NRD_1	204	206	PF00675	0.435
CLV_NRD_NRD_1	207	209	PF00675	0.449
CLV_NRD_NRD_1	32	34	PF00675	0.303
CLV_PCSK_FUR_1	205	209	PF00082	0.336
CLV_PCSK_KEX2_1	142	144	PF00082	0.249
CLV_PCSK_KEX2_1	206	208	PF00082	0.454
CLV_PCSK_KEX2_1	32	34	PF00082	0.287
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.447
CLV_PCSK_SKI1_1	9	13	PF00082	0.444
CLV_PCSK_SKI1_1	94	98	PF00082	0.266
DEG_APCC_DBOX_1	93	101	PF00400	0.444
DOC_CYCLIN_RxL_1	205	216	PF00134	0.682
DOC_MAPK_DCC_7	120	128	PF00069	0.359
DOC_MAPK_gen_1	205	212	PF00069	0.659
DOC_MAPK_MEF2A_6	120	128	PF00069	0.365
DOC_MAPK_RevD_3	128	143	PF00069	0.407
DOC_PP1_RVXF_1	31	38	PF00149	0.444
DOC_PP2B_LxvP_1	210	213	PF13499	0.694
DOC_PP4_FxxP_1	147	150	PF00568	0.558
DOC_USP7_MATH_1	133	137	PF00917	0.377
DOC_USP7_MATH_1	5	9	PF00917	0.417
DOC_USP7_MATH_1	77	81	PF00917	0.342
LIG_14-3-3_CanoR_1	205	211	PF00244	0.625
LIG_Actin_WH2_2	185	202	PF00022	0.262
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_4	217	221	PF00653	0.505
LIG_FHA_1	13	19	PF00498	0.347
LIG_FHA_1	187	193	PF00498	0.486
LIG_LIR_Gen_1	118	128	PF02991	0.270
LIG_LIR_Gen_1	66	77	PF02991	0.267
LIG_LIR_Gen_1	7	18	PF02991	0.241
LIG_LIR_Nem_3	118	124	PF02991	0.142
LIG_LIR_Nem_3	191	197	PF02991	0.365
LIG_LIR_Nem_3	34	40	PF02991	0.505
LIG_LIR_Nem_3	66	72	PF02991	0.261
LIG_LIR_Nem_3	7	13	PF02991	0.241
LIG_LIR_Nem_3	98	102	PF02991	0.305
LIG_PCNA_PIPBox_1	23	32	PF02747	0.473
LIG_PDZ_Class_2	220	225	PF00595	0.575
LIG_Pex14_1	117	121	PF04695	0.266
LIG_Rb_LxCxE_1	84	98	PF01857	0.367
LIG_SH2_CRK	121	125	PF00017	0.305
LIG_SH2_NCK_1	121	125	PF00017	0.322
LIG_SH2_PTP2	102	105	PF00017	0.293
LIG_SH2_STAP1	10	14	PF00017	0.444
LIG_SH2_STAP1	44	48	PF00017	0.303
LIG_SH2_STAT5	121	124	PF00017	0.318
LIG_SH2_STAT5	99	102	PF00017	0.299
LIG_SUMO_SIM_par_1	107	113	PF11976	0.340
LIG_TRFH_1	197	201	PF08558	0.322
LIG_TYR_ITIM	100	105	PF00017	0.344
LIG_TYR_ITIM	119	124	PF00017	0.169
MOD_GlcNHglycan	201	204	PF01048	0.437
MOD_GSK3_1	12	19	PF00069	0.330
MOD_GSK3_1	42	49	PF00069	0.444
MOD_GSK3_1	58	65	PF00069	0.339
MOD_GSK3_1	77	84	PF00069	0.380
MOD_NEK2_1	12	17	PF00069	0.371
MOD_NEK2_1	58	63	PF00069	0.290
MOD_PKA_1	206	212	PF00069	0.673
MOD_PKA_2	119	125	PF00069	0.364
MOD_PKA_2	199	205	PF00069	0.648
MOD_PKA_2	206	212	PF00069	0.667
MOD_Plk_1	58	64	PF00069	0.311
MOD_Plk_4	119	125	PF00069	0.258
MOD_Plk_4	46	52	PF00069	0.318
MOD_Plk_4	58	64	PF00069	0.261
MOD_SUMO_rev_2	6	11	PF00179	0.315
TRG_DiLeu_BaEn_1	92	97	PF01217	0.547
TRG_DiLeu_BaEn_2	58	64	PF01217	0.244
TRG_ENDOCYTIC_2	10	13	PF00928	0.468
TRG_ENDOCYTIC_2	102	105	PF00928	0.271
TRG_ENDOCYTIC_2	121	124	PF00928	0.196
TRG_ENDOCYTIC_2	180	183	PF00928	0.259
TRG_ER_diArg_1	141	144	PF00400	0.475
TRG_ER_diArg_1	205	208	PF00400	0.612
TRG_ER_diArg_1	31	33	PF00400	0.504
TRG_NES_CRM1_1	98	113	PF08389	0.439
TRG_NLS_MonoExtN_4	205	210	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L8	Leptomonas seymouri	60%	100%
A0A0N1IHQ2	Leptomonas seymouri	37%	100%
A0A0S4J3W8	Bodo saltans	37%	100%
A0A0S4J4A1	Bodo saltans	36%	100%
A0A1X0NUH8	Trypanosomatidae	42%	100%
A0A1X0NUR6	Trypanosomatidae	34%	100%
A0A3Q8ICP7	Leishmania donovani	33%	100%
A0A3R7NKX5	Trypanosoma rangeli	32%	100%
A4H8U8	Leishmania braziliensis	35%	100%
A4HX66	Leishmania infantum	33%	100%
A4HX67	Leishmania infantum	100%	100%
C9ZTT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZTT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ARC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEJ6	Leishmania major	96%	100%
Q4QEJ7	Leishmania major	33%	100%
V5ASR1	Trypanosoma cruzi	33%	100%
V5BCQ2	Trypanosoma cruzi	40%	100%