Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6Z3_LEIDO

TriTrypDb:

LdBPK_161660.1 , LdCL_160021600 , LDHU3_16.1980

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.687
CLV_C14_Caspase3-7	391	395	PF00656	0.462
CLV_C14_Caspase3-7	450	454	PF00656	0.434
CLV_C14_Caspase3-7	510	514	PF00656	0.542
CLV_MEL_PAP_1	657	663	PF00089	0.469
CLV_NRD_NRD_1	659	661	PF00675	0.470
CLV_PCSK_KEX2_1	121	123	PF00082	0.426
CLV_PCSK_KEX2_1	364	366	PF00082	0.557
CLV_PCSK_KEX2_1	659	661	PF00082	0.470
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.426
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.553
CLV_PCSK_SKI1_1	144	148	PF00082	0.396
CLV_PCSK_SKI1_1	432	436	PF00082	0.446
CLV_PCSK_SKI1_1	547	551	PF00082	0.411
CLV_PCSK_SKI1_1	643	647	PF00082	0.604
CLV_PCSK_SKI1_1	67	71	PF00082	0.449
DEG_APCC_DBOX_1	168	176	PF00400	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.639
DEG_SPOP_SBC_1	69	73	PF00917	0.566
DOC_CKS1_1	139	144	PF01111	0.431
DOC_CKS1_1	635	640	PF01111	0.601
DOC_MAPK_gen_1	121	129	PF00069	0.408
DOC_MAPK_gen_1	166	174	PF00069	0.522
DOC_MAPK_MEF2A_6	292	299	PF00069	0.482
DOC_MAPK_MEF2A_6	577	586	PF00069	0.522
DOC_PP2B_LxvP_1	380	383	PF13499	0.540
DOC_PP2B_LxvP_1	582	585	PF13499	0.509
DOC_USP7_MATH_1	15	19	PF00917	0.491
DOC_USP7_MATH_1	157	161	PF00917	0.406
DOC_USP7_MATH_1	285	289	PF00917	0.461
DOC_USP7_MATH_1	308	312	PF00917	0.700
DOC_USP7_MATH_1	313	317	PF00917	0.721
DOC_USP7_MATH_1	323	327	PF00917	0.742
DOC_USP7_MATH_1	531	535	PF00917	0.421
DOC_USP7_MATH_1	565	569	PF00917	0.423
DOC_USP7_MATH_1	620	624	PF00917	0.629
DOC_WW_Pin1_4	103	108	PF00397	0.580
DOC_WW_Pin1_4	138	143	PF00397	0.428
DOC_WW_Pin1_4	327	332	PF00397	0.739
DOC_WW_Pin1_4	470	475	PF00397	0.380
DOC_WW_Pin1_4	634	639	PF00397	0.611
DOC_WW_Pin1_4	683	688	PF00397	0.508
LIG_14-3-3_CanoR_1	144	151	PF00244	0.398
LIG_14-3-3_CanoR_1	180	185	PF00244	0.425
LIG_14-3-3_CanoR_1	365	373	PF00244	0.431
LIG_14-3-3_CanoR_1	375	380	PF00244	0.412
LIG_14-3-3_CanoR_1	399	403	PF00244	0.446
LIG_14-3-3_CanoR_1	432	441	PF00244	0.474
LIG_14-3-3_CanoR_1	552	558	PF00244	0.382
LIG_14-3-3_CanoR_1	577	582	PF00244	0.504
LIG_14-3-3_CanoR_1	67	77	PF00244	0.566
LIG_14-3-3_CanoR_1	9	15	PF00244	0.554
LIG_APCC_ABBA_1	464	469	PF00400	0.514
LIG_BIR_III_4	239	243	PF00653	0.545
LIG_BIR_III_4	332	336	PF00653	0.594
LIG_BRCT_BRCA1_1	310	314	PF00533	0.703
LIG_BRCT_BRCA1_1	7	11	PF00533	0.434
LIG_Clathr_ClatBox_1	126	130	PF01394	0.456
LIG_deltaCOP1_diTrp_1	177	184	PF00928	0.432
LIG_deltaCOP1_diTrp_1	221	226	PF00928	0.503
LIG_deltaCOP1_diTrp_1	353	360	PF00928	0.375
LIG_FHA_1	145	151	PF00498	0.391
LIG_FHA_1	249	255	PF00498	0.442
LIG_FHA_1	291	297	PF00498	0.459
LIG_FHA_1	352	358	PF00498	0.444
LIG_FHA_1	38	44	PF00498	0.577
LIG_FHA_1	382	388	PF00498	0.517
LIG_FHA_1	548	554	PF00498	0.402
LIG_FHA_1	570	576	PF00498	0.407
LIG_FHA_1	630	636	PF00498	0.645
LIG_FHA_2	206	212	PF00498	0.381
LIG_FHA_2	448	454	PF00498	0.423
LIG_FHA_2	483	489	PF00498	0.539
LIG_FHA_2	623	629	PF00498	0.609
LIG_LIR_Apic_2	544	548	PF02991	0.545
LIG_LIR_Gen_1	148	157	PF02991	0.402
LIG_LIR_Gen_1	177	184	PF02991	0.483
LIG_LIR_Gen_1	188	199	PF02991	0.336
LIG_LIR_Gen_1	252	263	PF02991	0.350
LIG_LIR_Gen_1	371	380	PF02991	0.432
LIG_LIR_Gen_1	435	446	PF02991	0.403
LIG_LIR_Gen_1	8	19	PF02991	0.447
LIG_LIR_Nem_3	115	120	PF02991	0.484
LIG_LIR_Nem_3	148	154	PF02991	0.406
LIG_LIR_Nem_3	177	181	PF02991	0.523
LIG_LIR_Nem_3	223	229	PF02991	0.411
LIG_LIR_Nem_3	252	258	PF02991	0.345
LIG_LIR_Nem_3	343	347	PF02991	0.500
LIG_LIR_Nem_3	353	358	PF02991	0.304
LIG_LIR_Nem_3	359	363	PF02991	0.293
LIG_LIR_Nem_3	435	441	PF02991	0.422
LIG_LIR_Nem_3	533	539	PF02991	0.474
LIG_LIR_Nem_3	580	584	PF02991	0.529
LIG_LIR_Nem_3	59	65	PF02991	0.456
LIG_LIR_Nem_3	8	14	PF02991	0.458
LIG_NRBOX	553	559	PF00104	0.404
LIG_PCNA_yPIPBox_3	137	150	PF02747	0.510
LIG_Pex14_2	441	445	PF04695	0.375
LIG_Rb_pABgroove_1	513	521	PF01858	0.479
LIG_SH2_CRK	151	155	PF00017	0.437
LIG_SH2_CRK	255	259	PF00017	0.487
LIG_SH2_CRK	536	540	PF00017	0.514
LIG_SH2_CRK	545	549	PF00017	0.519
LIG_SH2_CRK	579	583	PF00017	0.584
LIG_SH2_STAP1	255	259	PF00017	0.487
LIG_SH2_STAP1	461	465	PF00017	0.432
LIG_SH2_STAP1	519	523	PF00017	0.354
LIG_SH2_STAT5	114	117	PF00017	0.424
LIG_SH2_STAT5	119	122	PF00017	0.410
LIG_SH2_STAT5	229	232	PF00017	0.458
LIG_SH2_STAT5	253	256	PF00017	0.383
LIG_SH2_STAT5	347	350	PF00017	0.536
LIG_SH2_STAT5	421	424	PF00017	0.420
LIG_SH2_STAT5	438	441	PF00017	0.275
LIG_SH3_3	151	157	PF00018	0.425
LIG_SH3_3	632	638	PF00018	0.599
LIG_SH3_3	91	97	PF00018	0.450
LIG_SH3_4	489	496	PF00018	0.472
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.541
LIG_SUMO_SIM_par_1	125	130	PF11976	0.404
LIG_SUMO_SIM_par_1	293	298	PF11976	0.461
LIG_SUMO_SIM_par_1	383	388	PF11976	0.465
LIG_SxIP_EBH_1	674	685	PF03271	0.533
LIG_TRAF2_1	300	303	PF00917	0.539
LIG_TRAF2_1	52	55	PF00917	0.492
LIG_UBA3_1	126	131	PF00899	0.414
LIG_WRC_WIRS_1	181	186	PF05994	0.545
LIG_WRC_WIRS_1	578	583	PF05994	0.355
LIG_WRC_WIRS_1	607	612	PF05994	0.543
MOD_CDK_SPxK_1	138	144	PF00069	0.435
MOD_CDK_SPxxK_3	103	110	PF00069	0.574
MOD_CDK_SPxxK_3	634	641	PF00069	0.527
MOD_CDK_SPxxK_3	683	690	PF00069	0.554
MOD_CK1_1	18	24	PF00069	0.543
MOD_CK1_1	25	31	PF00069	0.659
MOD_CK1_1	316	322	PF00069	0.724
MOD_CK1_1	324	330	PF00069	0.695
MOD_CK1_1	570	576	PF00069	0.451
MOD_CK2_1	205	211	PF00069	0.387
MOD_CK2_1	600	606	PF00069	0.559
MOD_CK2_1	622	628	PF00069	0.616
MOD_CK2_1	683	689	PF00069	0.508
MOD_GlcNHglycan	17	20	PF01048	0.519
MOD_GlcNHglycan	311	314	PF01048	0.719
MOD_GlcNHglycan	315	318	PF01048	0.728
MOD_GlcNHglycan	323	326	PF01048	0.748
MOD_GlcNHglycan	327	330	PF01048	0.736
MOD_GlcNHglycan	337	340	PF01048	0.727
MOD_GlcNHglycan	533	536	PF01048	0.412
MOD_GlcNHglycan	563	566	PF01048	0.493
MOD_GlcNHglycan	58	61	PF01048	0.535
MOD_GlcNHglycan	603	606	PF01048	0.524
MOD_GlcNHglycan	622	625	PF01048	0.375
MOD_GlcNHglycan	72	75	PF01048	0.534
MOD_GSK3_1	1	8	PF00069	0.581
MOD_GSK3_1	18	25	PF00069	0.564
MOD_GSK3_1	28	35	PF00069	0.513
MOD_GSK3_1	309	316	PF00069	0.663
MOD_GSK3_1	317	324	PF00069	0.658
MOD_GSK3_1	359	366	PF00069	0.557
MOD_GSK3_1	561	568	PF00069	0.436
MOD_GSK3_1	597	604	PF00069	0.410
MOD_GSK3_1	672	679	PF00069	0.509
MOD_N-GLC_1	103	108	PF02516	0.460
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	112	117	PF00069	0.521
MOD_NEK2_1	194	199	PF00069	0.430
MOD_NEK2_1	22	27	PF00069	0.557
MOD_NEK2_1	248	253	PF00069	0.476
MOD_NEK2_1	290	295	PF00069	0.477
MOD_NEK2_1	439	444	PF00069	0.452
MOD_NEK2_1	676	681	PF00069	0.497
MOD_NEK2_1	70	75	PF00069	0.551
MOD_NEK2_2	408	413	PF00069	0.493
MOD_PIKK_1	427	433	PF00454	0.424
MOD_PIKK_1	447	453	PF00454	0.190
MOD_PKA_1	364	370	PF00069	0.537
MOD_PKA_2	112	118	PF00069	0.489
MOD_PKA_2	285	291	PF00069	0.399
MOD_PKA_2	364	370	PF00069	0.402
MOD_PKA_2	398	404	PF00069	0.413
MOD_PKA_2	653	659	PF00069	0.571
MOD_Plk_1	587	593	PF00069	0.505
MOD_Plk_2-3	353	359	PF00069	0.458
MOD_Plk_2-3	388	394	PF00069	0.474
MOD_Plk_2-3	507	513	PF00069	0.511
MOD_Plk_4	170	176	PF00069	0.475
MOD_Plk_4	18	24	PF00069	0.543
MOD_Plk_4	249	255	PF00069	0.387
MOD_Plk_4	285	291	PF00069	0.424
MOD_Plk_4	37	43	PF00069	0.552
MOD_Plk_4	375	381	PF00069	0.411
MOD_Plk_4	507	513	PF00069	0.496
MOD_Plk_4	553	559	PF00069	0.385
MOD_Plk_4	577	583	PF00069	0.570
MOD_Plk_4	629	635	PF00069	0.613
MOD_Plk_4	653	659	PF00069	0.566
MOD_Plk_4	672	678	PF00069	0.517
MOD_ProDKin_1	103	109	PF00069	0.577
MOD_ProDKin_1	138	144	PF00069	0.435
MOD_ProDKin_1	327	333	PF00069	0.735
MOD_ProDKin_1	470	476	PF00069	0.377
MOD_ProDKin_1	634	640	PF00069	0.610
MOD_ProDKin_1	683	689	PF00069	0.508
TRG_DiLeu_BaEn_3	506	512	PF01217	0.397
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.390
TRG_ENDOCYTIC_2	117	120	PF00928	0.417
TRG_ENDOCYTIC_2	151	154	PF00928	0.438
TRG_ENDOCYTIC_2	255	258	PF00928	0.487
TRG_ENDOCYTIC_2	373	376	PF00928	0.370
TRG_ENDOCYTIC_2	438	441	PF00928	0.430
TRG_ENDOCYTIC_2	461	464	PF00928	0.518
TRG_ENDOCYTIC_2	536	539	PF00928	0.508
TRG_ENDOCYTIC_2	579	582	PF00928	0.569
TRG_ENDOCYTIC_2	62	65	PF00928	0.451
TRG_ER_diArg_1	283	286	PF00400	0.425
TRG_ER_diArg_1	651	654	PF00400	0.482
TRG_ER_diArg_1	658	660	PF00400	0.434
TRG_NES_CRM1_1	455	469	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T2	Leptomonas seymouri	74%	100%
A0A0S4IYN7	Bodo saltans	40%	100%
A0A1X0NYU0	Trypanosomatidae	57%	100%
A0A422NE62	Trypanosoma rangeli	58%	100%
A4H8T5	Leishmania braziliensis	89%	100%
A4HX54	Leishmania infantum	100%	100%
C9ZVT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QEK9	Leishmania major	97%	100%
V5BMQ0	Trypanosoma cruzi	58%	97%