Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H6Z1_LEIDO

TriTrypDb:

LdBPK_161540.1 , LdCL_160020500 , LDHU3_16.1840

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.515
CLV_NRD_NRD_1	106	108	PF00675	0.514
CLV_NRD_NRD_1	142	144	PF00675	0.743
CLV_NRD_NRD_1	157	159	PF00675	0.732
CLV_PCSK_FUR_1	158	162	PF00082	0.587
CLV_PCSK_KEX2_1	102	104	PF00082	0.515
CLV_PCSK_KEX2_1	106	108	PF00082	0.514
CLV_PCSK_KEX2_1	142	144	PF00082	0.743
CLV_PCSK_KEX2_1	157	159	PF00082	0.732
CLV_PCSK_KEX2_1	160	162	PF00082	0.694
CLV_PCSK_KEX2_1	290	292	PF00082	0.514
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.590
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.514
CLV_PCSK_PC7_1	102	108	PF00082	0.503
CLV_PCSK_SKI1_1	157	161	PF00082	0.683
DEG_Nend_UBRbox_3	1	3	PF02207	0.701
DEG_SPOP_SBC_1	219	223	PF00917	0.647
DEG_SPOP_SBC_1	4	8	PF00917	0.581
DOC_MAPK_gen_1	238	247	PF00069	0.657
DOC_MAPK_gen_1	296	304	PF00069	0.584
DOC_MAPK_MEF2A_6	240	249	PF00069	0.652
DOC_USP7_MATH_1	52	56	PF00917	0.482
DOC_USP7_MATH_1	66	70	PF00917	0.453
DOC_USP7_UBL2_3	290	294	PF12436	0.515
DOC_WW_Pin1_4	11	16	PF00397	0.570
DOC_WW_Pin1_4	131	136	PF00397	0.737
DOC_WW_Pin1_4	215	220	PF00397	0.718
LIG_14-3-3_CanoR_1	109	119	PF00244	0.539
LIG_14-3-3_CanoR_1	164	173	PF00244	0.742
LIG_14-3-3_CanoR_1	270	274	PF00244	0.582
LIG_BIR_III_4	187	191	PF00653	0.615
LIG_FHA_1	145	151	PF00498	0.674
LIG_FHA_1	221	227	PF00498	0.703
LIG_FHA_1	277	283	PF00498	0.552
LIG_FHA_1	52	58	PF00498	0.448
LIG_FHA_1	72	78	PF00498	0.443
LIG_FHA_2	163	169	PF00498	0.735
LIG_FHA_2	174	180	PF00498	0.580
LIG_FHA_2	254	260	PF00498	0.600
LIG_FHA_2	57	63	PF00498	0.464
LIG_FHA_2	77	83	PF00498	0.458
LIG_LIR_Gen_1	14	23	PF02991	0.646
LIG_LIR_Gen_1	272	282	PF02991	0.558
LIG_LIR_Nem_3	14	20	PF02991	0.647
LIG_Pex14_2	16	20	PF04695	0.552
LIG_SH2_STAT5	86	89	PF00017	0.440
LIG_SH3_3	132	138	PF00018	0.699
LIG_TRAF2_1	59	62	PF00917	0.567
MOD_CK1_1	167	173	PF00069	0.640
MOD_CK1_1	218	224	PF00069	0.642
MOD_CK1_1	5	11	PF00069	0.720
MOD_CK1_1	69	75	PF00069	0.577
MOD_CK2_1	162	168	PF00069	0.732
MOD_CK2_1	173	179	PF00069	0.688
MOD_CK2_1	253	259	PF00069	0.669
MOD_CK2_1	56	62	PF00069	0.584
MOD_CK2_1	76	82	PF00069	0.457
MOD_Cter_Amidation	100	103	PF01082	0.505
MOD_GlcNHglycan	144	147	PF01048	0.682
MOD_GlcNHglycan	168	172	PF01048	0.703
MOD_GlcNHglycan	191	195	PF01048	0.704
MOD_GSK3_1	144	151	PF00069	0.622
MOD_GSK3_1	160	167	PF00069	0.798
MOD_GSK3_1	2	9	PF00069	0.567
MOD_GSK3_1	215	222	PF00069	0.629
MOD_GSK3_1	52	59	PF00069	0.476
MOD_GSK3_1	67	74	PF00069	0.468
MOD_GSK3_1	76	83	PF00069	0.456
MOD_N-GLC_1	131	136	PF02516	0.737
MOD_NEK2_1	105	110	PF00069	0.502
MOD_NEK2_1	144	149	PF00069	0.679
MOD_NEK2_1	56	61	PF00069	0.468
MOD_NEK2_1	67	72	PF00069	0.456
MOD_PIKK_1	125	131	PF00454	0.705
MOD_PIKK_1	173	179	PF00454	0.727
MOD_PIKK_1	67	73	PF00454	0.526
MOD_PIKK_1	76	82	PF00454	0.414
MOD_PKA_1	142	148	PF00069	0.724
MOD_PKA_1	160	166	PF00069	0.593
MOD_PKA_2	105	111	PF00069	0.500
MOD_PKA_2	142	148	PF00069	0.724
MOD_PKA_2	160	166	PF00069	0.631
MOD_PKA_2	239	245	PF00069	0.560
MOD_PKA_2	269	275	PF00069	0.582
MOD_PKB_1	164	172	PF00069	0.607
MOD_Plk_1	52	58	PF00069	0.477
MOD_Plk_2-3	82	88	PF00069	0.567
MOD_Plk_4	269	275	PF00069	0.563
MOD_Plk_4	52	58	PF00069	0.447
MOD_Plk_4	82	88	PF00069	0.567
MOD_ProDKin_1	11	17	PF00069	0.570
MOD_ProDKin_1	131	137	PF00069	0.737
MOD_ProDKin_1	215	221	PF00069	0.719
MOD_SUMO_for_1	159	162	PF00179	0.684
TRG_ER_diArg_1	105	107	PF00400	0.556
TRG_ER_diArg_1	142	144	PF00400	0.730
TRG_ER_diArg_1	157	159	PF00400	0.681
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT54	Leptomonas seymouri	33%	94%
A4HX42	Leishmania infantum	100%	100%
E9AQV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEM0	Leishmania major	87%	100%