Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6Y7_LEIDO

TriTrypDb:

LdBPK_161330.1 , LdCL_160018500 , LDHU3_16.1620

Length:

Annotations

LeishMANIAdb annotations

A small membrane protein family highy conserved in KInetoplastids but otherwise unique.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H6Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.520
CLV_PCSK_FUR_1	92	96	PF00082	0.440
CLV_PCSK_KEX2_1	25	27	PF00082	0.388
CLV_PCSK_KEX2_1	94	96	PF00082	0.520
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.406
CLV_PCSK_SKI1_1	95	99	PF00082	0.436
DOC_MAPK_gen_1	47	53	PF00069	0.599
DOC_MAPK_gen_1	92	99	PF00069	0.703
DOC_MAPK_RevD_3	79	95	PF00069	0.544
LIG_deltaCOP1_diTrp_1	44	52	PF00928	0.555
LIG_FHA_1	12	18	PF00498	0.434
LIG_PDZ_Class_2	94	99	PF00595	0.670
LIG_Pex14_2	52	56	PF04695	0.614
LIG_SH2_STAT5	21	24	PF00017	0.439
MOD_CK2_1	77	83	PF00069	0.634
MOD_N-GLC_1	77	82	PF02516	0.342
MOD_NEK2_1	19	24	PF00069	0.422
MOD_NEK2_2	77	82	PF00069	0.560
MOD_Plk_1	77	83	PF00069	0.541
TRG_ER_diArg_1	91	94	PF00400	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V5	Leptomonas seymouri	76%	100%
A4H8Q6	Leishmania braziliensis	93%	100%
A4HX25	Leishmania infantum	100%	100%
C9ZVX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AQT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEN9	Leishmania major	97%	100%