LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H6Y7_LEIDO
TriTrypDb:
LdBPK_161330.1 , LdCL_160018500 , LDHU3_16.1620
Length:
99

Annotations

LeishMANIAdb annotations

A small membrane protein family highy conserved in KInetoplastids but otherwise unique.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S5H6Y7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Y7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 94 96 PF00675 0.520
CLV_PCSK_FUR_1 92 96 PF00082 0.440
CLV_PCSK_KEX2_1 25 27 PF00082 0.388
CLV_PCSK_KEX2_1 94 96 PF00082 0.520
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.406
CLV_PCSK_SKI1_1 95 99 PF00082 0.436
DOC_MAPK_gen_1 47 53 PF00069 0.599
DOC_MAPK_gen_1 92 99 PF00069 0.703
DOC_MAPK_RevD_3 79 95 PF00069 0.544
LIG_deltaCOP1_diTrp_1 44 52 PF00928 0.555
LIG_FHA_1 12 18 PF00498 0.434
LIG_PDZ_Class_2 94 99 PF00595 0.670
LIG_Pex14_2 52 56 PF04695 0.614
LIG_SH2_STAT5 21 24 PF00017 0.439
MOD_CK2_1 77 83 PF00069 0.634
MOD_N-GLC_1 77 82 PF02516 0.342
MOD_NEK2_1 19 24 PF00069 0.422
MOD_NEK2_2 77 82 PF00069 0.560
MOD_Plk_1 77 83 PF00069 0.541
TRG_ER_diArg_1 91 94 PF00400 0.697

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2V5 Leptomonas seymouri 76% 100%
A4H8Q6 Leishmania braziliensis 93% 100%
A4HX25 Leishmania infantum 100% 100%
C9ZVX1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AQT9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QEN9 Leishmania major 97% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS