Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6Y4_LEIDO

TriTrypDb:

LdBPK_161190.1 , LdCL_160017100 , LDHU3_16.1460

Length:

117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.669
CLV_C14_Caspase3-7	36	40	PF00656	0.598
CLV_NRD_NRD_1	96	98	PF00675	0.778
CLV_PCSK_KEX2_1	98	100	PF00082	0.669
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.669
CLV_PCSK_SKI1_1	17	21	PF00082	0.474
CLV_PCSK_SKI1_1	68	72	PF00082	0.566
CLV_PCSK_SKI1_1	7	11	PF00082	0.671
DOC_CYCLIN_RxL_1	4	14	PF00134	0.672
DOC_MAPK_MEF2A_6	42	49	PF00069	0.559
DOC_WW_Pin1_4	54	59	PF00397	0.637
LIG_14-3-3_CanoR_1	17	22	PF00244	0.564
LIG_14-3-3_CanoR_1	42	48	PF00244	0.524
LIG_AP2alpha_2	82	84	PF02296	0.503
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	105	109	PF00533	0.741
LIG_BRCT_BRCA1_1	45	49	PF00533	0.538
LIG_FHA_1	84	90	PF00498	0.588
LIG_FHA_2	20	26	PF00498	0.490
LIG_FHA_2	85	91	PF00498	0.711
LIG_FHA_2	9	15	PF00498	0.625
LIG_IRF3_LxIS_1	29	36	PF10401	0.486
LIG_MLH1_MIPbox_1	45	49	PF16413	0.422
LIG_NRBOX	28	34	PF00104	0.519
LIG_NRBOX	5	11	PF00104	0.601
LIG_PDZ_Class_1	112	117	PF00595	0.775
LIG_Pex14_1	80	84	PF04695	0.509
LIG_PTB_Apo_2	63	70	PF02174	0.497
LIG_PTB_Phospho_1	63	69	PF10480	0.497
LIG_SH2_STAP1	69	73	PF00017	0.436
LIG_TRAF2_1	72	75	PF00917	0.594
LIG_UBA3_1	62	68	PF00899	0.594
MOD_CK1_1	53	59	PF00069	0.582
MOD_CK2_1	24	30	PF00069	0.565
MOD_CK2_1	69	75	PF00069	0.562
MOD_CK2_1	8	14	PF00069	0.450
MOD_CK2_1	84	90	PF00069	0.499
MOD_GlcNHglycan	25	29	PF01048	0.556
MOD_GlcNHglycan	52	55	PF01048	0.715
MOD_GSK3_1	108	115	PF00069	0.759
MOD_GSK3_1	49	56	PF00069	0.588
MOD_N-GLC_1	50	55	PF02516	0.715
MOD_NEK2_1	33	38	PF00069	0.599
MOD_NEK2_1	49	54	PF00069	0.580
MOD_NEK2_1	84	89	PF00069	0.602
MOD_NEK2_2	19	24	PF00069	0.488
MOD_NEK2_2	43	48	PF00069	0.404
MOD_PKA_2	33	39	PF00069	0.618
MOD_PKA_2	41	47	PF00069	0.557
MOD_PKB_1	99	107	PF00069	0.706
MOD_Plk_2-3	103	109	PF00069	0.700
MOD_Plk_4	43	49	PF00069	0.530
MOD_ProDKin_1	54	60	PF00069	0.634
MOD_SUMO_rev_2	90	100	PF00179	0.622
TRG_DiLeu_BaEn_4	74	80	PF01217	0.613
TRG_NLS_MonoExtC_3	97	103	PF00514	0.664
TRG_NLS_MonoExtN_4	97	102	PF00514	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAA9	Leptomonas seymouri	63%	92%
A0A422NPT6	Trypanosoma rangeli	30%	75%
A4H8P1	Leishmania braziliensis	81%	100%
E9ACR6	Leishmania major	89%	100%
E9AGP1	Leishmania infantum	100%	100%
E9AQS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	96%