LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania donovani
UniProt:
A0A3S5H6Y1_LEIDO
TriTrypDb:
LdBPK_161030.1 * , LdCL_160015400 , LDHU3_16.1240
Length:
944

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 26
GO:0005794 Golgi apparatus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

A0A3S5H6Y1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Y1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 35
GO:0016740 transferase activity 2 35
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.552
CLV_C14_Caspase3-7 615 619 PF00656 0.357
CLV_MEL_PAP_1 185 191 PF00089 0.446
CLV_NRD_NRD_1 151 153 PF00675 0.557
CLV_NRD_NRD_1 177 179 PF00675 0.548
CLV_NRD_NRD_1 208 210 PF00675 0.418
CLV_NRD_NRD_1 34 36 PF00675 0.605
CLV_NRD_NRD_1 523 525 PF00675 0.523
CLV_NRD_NRD_1 526 528 PF00675 0.482
CLV_NRD_NRD_1 561 563 PF00675 0.554
CLV_NRD_NRD_1 599 601 PF00675 0.557
CLV_NRD_NRD_1 677 679 PF00675 0.450
CLV_NRD_NRD_1 823 825 PF00675 0.553
CLV_PCSK_FUR_1 524 528 PF00082 0.460
CLV_PCSK_FUR_1 597 601 PF00082 0.488
CLV_PCSK_KEX2_1 151 153 PF00082 0.570
CLV_PCSK_KEX2_1 177 179 PF00082 0.517
CLV_PCSK_KEX2_1 34 36 PF00082 0.605
CLV_PCSK_KEX2_1 481 483 PF00082 0.406
CLV_PCSK_KEX2_1 523 525 PF00082 0.463
CLV_PCSK_KEX2_1 526 528 PF00082 0.422
CLV_PCSK_KEX2_1 599 601 PF00082 0.526
CLV_PCSK_KEX2_1 651 653 PF00082 0.347
CLV_PCSK_KEX2_1 677 679 PF00082 0.450
CLV_PCSK_KEX2_1 823 825 PF00082 0.553
CLV_PCSK_PC1ET2_1 481 483 PF00082 0.397
CLV_PCSK_PC1ET2_1 651 653 PF00082 0.332
CLV_PCSK_SKI1_1 124 128 PF00082 0.632
CLV_PCSK_SKI1_1 178 182 PF00082 0.481
CLV_PCSK_SKI1_1 233 237 PF00082 0.528
CLV_PCSK_SKI1_1 340 344 PF00082 0.571
CLV_PCSK_SKI1_1 394 398 PF00082 0.460
CLV_PCSK_SKI1_1 448 452 PF00082 0.533
CLV_PCSK_SKI1_1 565 569 PF00082 0.511
CLV_PCSK_SKI1_1 677 681 PF00082 0.523
CLV_PCSK_SKI1_1 785 789 PF00082 0.545
CLV_PCSK_SKI1_1 869 873 PF00082 0.532
DEG_APCC_DBOX_1 306 314 PF00400 0.554
DEG_Nend_Nbox_1 1 3 PF02207 0.536
DOC_CKS1_1 161 166 PF01111 0.395
DOC_CKS1_1 234 239 PF01111 0.519
DOC_CKS1_1 684 689 PF01111 0.503
DOC_CYCLIN_yCln2_LP_2 567 573 PF00134 0.302
DOC_CYCLIN_yCln2_LP_2 70 76 PF00134 0.528
DOC_MAPK_DCC_7 651 661 PF00069 0.426
DOC_MAPK_gen_1 318 327 PF00069 0.454
DOC_MAPK_gen_1 392 401 PF00069 0.438
DOC_MAPK_gen_1 560 569 PF00069 0.391
DOC_MAPK_gen_1 651 661 PF00069 0.488
DOC_MAPK_HePTP_8 680 692 PF00069 0.500
DOC_MAPK_MEF2A_6 168 175 PF00069 0.391
DOC_MAPK_MEF2A_6 394 403 PF00069 0.434
DOC_MAPK_MEF2A_6 562 571 PF00069 0.391
DOC_MAPK_MEF2A_6 683 692 PF00069 0.498
DOC_MAPK_MEF2A_6 766 773 PF00069 0.550
DOC_PP1_RVXF_1 906 913 PF00149 0.406
DOC_PP2B_LxvP_1 567 570 PF13499 0.391
DOC_PP2B_LxvP_1 70 73 PF13499 0.521
DOC_PP2B_LxvP_1 872 875 PF13499 0.463
DOC_PP4_FxxP_1 234 237 PF00568 0.521
DOC_PP4_FxxP_1 684 687 PF00568 0.470
DOC_USP7_MATH_1 101 105 PF00917 0.569
DOC_USP7_MATH_1 245 249 PF00917 0.547
DOC_USP7_MATH_1 354 358 PF00917 0.564
DOC_USP7_MATH_1 440 444 PF00917 0.347
DOC_USP7_MATH_1 516 520 PF00917 0.470
DOC_USP7_MATH_1 629 633 PF00917 0.431
DOC_USP7_MATH_1 66 70 PF00917 0.698
DOC_USP7_MATH_1 861 865 PF00917 0.531
DOC_USP7_MATH_1 916 920 PF00917 0.533
DOC_WW_Pin1_4 133 138 PF00397 0.524
DOC_WW_Pin1_4 144 149 PF00397 0.539
DOC_WW_Pin1_4 160 165 PF00397 0.403
DOC_WW_Pin1_4 178 183 PF00397 0.527
DOC_WW_Pin1_4 233 238 PF00397 0.615
DOC_WW_Pin1_4 325 330 PF00397 0.420
DOC_WW_Pin1_4 394 399 PF00397 0.329
DOC_WW_Pin1_4 582 587 PF00397 0.529
DOC_WW_Pin1_4 683 688 PF00397 0.502
DOC_WW_Pin1_4 78 83 PF00397 0.596
LIG_14-3-3_CanoR_1 124 132 PF00244 0.633
LIG_14-3-3_CanoR_1 177 181 PF00244 0.496
LIG_14-3-3_CanoR_1 307 311 PF00244 0.488
LIG_14-3-3_CanoR_1 363 368 PF00244 0.434
LIG_14-3-3_CanoR_1 378 382 PF00244 0.352
LIG_14-3-3_CanoR_1 442 447 PF00244 0.370
LIG_14-3-3_CanoR_1 482 492 PF00244 0.494
LIG_14-3-3_CanoR_1 51 58 PF00244 0.568
LIG_14-3-3_CanoR_1 526 536 PF00244 0.330
LIG_14-3-3_CanoR_1 770 774 PF00244 0.542
LIG_14-3-3_CanoR_1 791 799 PF00244 0.467
LIG_14-3-3_CanoR_1 940 944 PF00244 0.546
LIG_Actin_WH2_2 257 274 PF00022 0.382
LIG_Actin_WH2_2 348 365 PF00022 0.622
LIG_Actin_WH2_2 466 483 PF00022 0.360
LIG_BIR_III_2 605 609 PF00653 0.468
LIG_BRCT_BRCA1_1 104 108 PF00533 0.538
LIG_BRCT_BRCA1_1 584 588 PF00533 0.387
LIG_BRCT_BRCA1_1 728 732 PF00533 0.590
LIG_EH_1 254 258 PF12763 0.432
LIG_EH1_1 214 222 PF00400 0.323
LIG_eIF4E_1 468 474 PF01652 0.416
LIG_FHA_1 121 127 PF00498 0.798
LIG_FHA_1 190 196 PF00498 0.376
LIG_FHA_1 279 285 PF00498 0.372
LIG_FHA_1 301 307 PF00498 0.561
LIG_FHA_1 608 614 PF00498 0.523
LIG_FHA_1 876 882 PF00498 0.446
LIG_FHA_1 922 928 PF00498 0.433
LIG_FHA_2 161 167 PF00498 0.390
LIG_FHA_2 179 185 PF00498 0.409
LIG_FHA_2 278 284 PF00498 0.446
LIG_FHA_2 332 338 PF00498 0.550
LIG_FHA_2 544 550 PF00498 0.252
LIG_FHA_2 628 634 PF00498 0.353
LIG_FHA_2 642 648 PF00498 0.417
LIG_LIR_Apic_2 924 928 PF02991 0.407
LIG_LIR_Apic_2 938 944 PF02991 0.480
LIG_LIR_Gen_1 193 204 PF02991 0.419
LIG_LIR_Gen_1 453 464 PF02991 0.313
LIG_LIR_Gen_1 633 643 PF02991 0.395
LIG_LIR_Gen_1 686 697 PF02991 0.448
LIG_LIR_Gen_1 930 939 PF02991 0.530
LIG_LIR_LC3C_4 895 900 PF02991 0.505
LIG_LIR_Nem_3 193 199 PF02991 0.382
LIG_LIR_Nem_3 416 422 PF02991 0.419
LIG_LIR_Nem_3 538 544 PF02991 0.264
LIG_LIR_Nem_3 566 571 PF02991 0.291
LIG_LIR_Nem_3 585 591 PF02991 0.348
LIG_LIR_Nem_3 633 639 PF02991 0.380
LIG_LIR_Nem_3 686 692 PF02991 0.492
LIG_LIR_Nem_3 729 735 PF02991 0.441
LIG_LIR_Nem_3 882 887 PF02991 0.494
LIG_MAD2 124 132 PF02301 0.525
LIG_MAD2 791 799 PF02301 0.496
LIG_MYND_1 167 171 PF01753 0.518
LIG_Pex14_2 257 261 PF04695 0.404
LIG_PTB_Apo_2 401 408 PF02174 0.392
LIG_PTB_Apo_2 654 661 PF02174 0.407
LIG_PTB_Phospho_1 401 407 PF10480 0.395
LIG_PTB_Phospho_1 654 660 PF10480 0.446
LIG_REV1ctd_RIR_1 541 551 PF16727 0.271
LIG_RPA_C_Fungi 897 909 PF08784 0.436
LIG_SH2_CRK 196 200 PF00017 0.437
LIG_SH2_GRB2like 402 405 PF00017 0.526
LIG_SH2_GRB2like 660 663 PF00017 0.447
LIG_SH2_SRC 689 692 PF00017 0.494
LIG_SH2_SRC 746 749 PF00017 0.588
LIG_SH2_STAP1 528 532 PF00017 0.441
LIG_SH2_STAP1 548 552 PF00017 0.191
LIG_SH2_STAT3 803 806 PF00017 0.544
LIG_SH2_STAT5 162 165 PF00017 0.433
LIG_SH2_STAT5 407 410 PF00017 0.383
LIG_SH2_STAT5 468 471 PF00017 0.463
LIG_SH2_STAT5 528 531 PF00017 0.419
LIG_SH2_STAT5 536 539 PF00017 0.335
LIG_SH2_STAT5 591 594 PF00017 0.402
LIG_SH2_STAT5 660 663 PF00017 0.443
LIG_SH2_STAT5 689 692 PF00017 0.510
LIG_SH3_2 522 527 PF14604 0.381
LIG_SH3_3 131 137 PF00018 0.587
LIG_SH3_3 150 156 PF00018 0.602
LIG_SH3_3 161 167 PF00018 0.558
LIG_SH3_3 22 28 PF00018 0.550
LIG_SH3_3 250 256 PF00018 0.491
LIG_SH3_3 519 525 PF00018 0.406
LIG_SH3_3 79 85 PF00018 0.535
LIG_SH3_3 830 836 PF00018 0.473
LIG_SH3_3 920 926 PF00018 0.436
LIG_SH3_3 93 99 PF00018 0.552
LIG_SUMO_SIM_anti_2 460 467 PF11976 0.384
LIG_SUMO_SIM_anti_2 895 901 PF11976 0.494
LIG_SUMO_SIM_par_1 219 224 PF11976 0.384
LIG_SUMO_SIM_par_1 323 328 PF11976 0.456
LIG_SUMO_SIM_par_1 877 883 PF11976 0.480
LIG_SUMO_SIM_par_1 895 901 PF11976 0.311
LIG_SxIP_EBH_1 514 527 PF03271 0.368
LIG_TRAF2_1 163 166 PF00917 0.415
LIG_TRAF2_1 722 725 PF00917 0.567
LIG_TRAF2_1 745 748 PF00917 0.562
LIG_TYR_ITIM 194 199 PF00017 0.507
LIG_WRC_WIRS_1 195 200 PF05994 0.425
MOD_CDK_SPK_2 233 238 PF00069 0.494
MOD_CDK_SPK_2 582 587 PF00069 0.421
MOD_CDK_SPxxK_3 144 151 PF00069 0.524
MOD_CK1_1 248 254 PF00069 0.505
MOD_CK1_1 309 315 PF00069 0.451
MOD_CK1_1 357 363 PF00069 0.564
MOD_CK1_1 4 10 PF00069 0.530
MOD_CK1_1 53 59 PF00069 0.595
MOD_CK1_1 624 630 PF00069 0.387
MOD_CK1_1 65 71 PF00069 0.579
MOD_CK2_1 160 166 PF00069 0.408
MOD_CK2_1 178 184 PF00069 0.441
MOD_CK2_1 543 549 PF00069 0.276
MOD_CK2_1 641 647 PF00069 0.434
MOD_CK2_1 665 671 PF00069 0.497
MOD_CK2_1 742 748 PF00069 0.407
MOD_CK2_1 814 820 PF00069 0.555
MOD_DYRK1A_RPxSP_1 178 182 PF00069 0.335
MOD_GlcNHglycan 104 107 PF01048 0.559
MOD_GlcNHglycan 109 113 PF01048 0.558
MOD_GlcNHglycan 250 253 PF01048 0.543
MOD_GlcNHglycan 3 6 PF01048 0.538
MOD_GlcNHglycan 357 360 PF01048 0.547
MOD_GlcNHglycan 441 445 PF01048 0.511
MOD_GlcNHglycan 485 488 PF01048 0.602
MOD_GlcNHglycan 626 629 PF01048 0.367
MOD_GlcNHglycan 64 67 PF01048 0.602
MOD_GlcNHglycan 668 671 PF01048 0.488
MOD_GlcNHglycan 793 796 PF01048 0.484
MOD_GlcNHglycan 8 11 PF01048 0.551
MOD_GlcNHglycan 863 866 PF01048 0.538
MOD_GSK3_1 120 127 PF00069 0.657
MOD_GSK3_1 219 226 PF00069 0.373
MOD_GSK3_1 422 429 PF00069 0.391
MOD_GSK3_1 49 56 PF00069 0.616
MOD_GSK3_1 61 68 PF00069 0.575
MOD_GSK3_1 90 97 PF00069 0.583
MOD_LATS_1 361 367 PF00433 0.414
MOD_N-GLC_1 199 204 PF02516 0.463
MOD_N-GLC_1 394 399 PF02516 0.413
MOD_N-GLC_1 483 488 PF02516 0.569
MOD_N-GLC_1 61 66 PF02516 0.577
MOD_NEK2_1 1 6 PF00069 0.555
MOD_NEK2_1 108 113 PF00069 0.831
MOD_NEK2_1 223 228 PF00069 0.390
MOD_NEK2_1 271 276 PF00069 0.617
MOD_NEK2_1 306 311 PF00069 0.436
MOD_NEK2_1 355 360 PF00069 0.566
MOD_NEK2_1 362 367 PF00069 0.488
MOD_NEK2_1 476 481 PF00069 0.399
MOD_NEK2_1 543 548 PF00069 0.454
MOD_NEK2_1 552 557 PF00069 0.401
MOD_NEK2_1 595 600 PF00069 0.494
MOD_NEK2_1 753 758 PF00069 0.379
MOD_NEK2_1 921 926 PF00069 0.434
MOD_PIKK_1 271 277 PF00454 0.581
MOD_PIKK_1 450 456 PF00454 0.328
MOD_PIKK_1 90 96 PF00454 0.540
MOD_PK_1 814 820 PF00069 0.653
MOD_PKA_1 526 532 PF00069 0.308
MOD_PKA_2 176 182 PF00069 0.493
MOD_PKA_2 271 277 PF00069 0.404
MOD_PKA_2 278 284 PF00069 0.564
MOD_PKA_2 300 306 PF00069 0.519
MOD_PKA_2 355 361 PF00069 0.500
MOD_PKA_2 362 368 PF00069 0.380
MOD_PKA_2 377 383 PF00069 0.397
MOD_PKA_2 50 56 PF00069 0.735
MOD_PKA_2 526 532 PF00069 0.298
MOD_PKA_2 769 775 PF00069 0.537
MOD_PKB_1 524 532 PF00069 0.304
MOD_Plk_1 641 647 PF00069 0.407
MOD_Plk_2-3 219 225 PF00069 0.377
MOD_Plk_2-3 300 306 PF00069 0.611
MOD_Plk_2-3 805 811 PF00069 0.578
MOD_Plk_4 13 19 PF00069 0.525
MOD_Plk_4 194 200 PF00069 0.419
MOD_Plk_4 331 337 PF00069 0.526
MOD_Plk_4 422 428 PF00069 0.391
MOD_Plk_4 516 522 PF00069 0.414
MOD_Plk_4 621 627 PF00069 0.370
MOD_ProDKin_1 133 139 PF00069 0.525
MOD_ProDKin_1 144 150 PF00069 0.537
MOD_ProDKin_1 160 166 PF00069 0.400
MOD_ProDKin_1 178 184 PF00069 0.523
MOD_ProDKin_1 233 239 PF00069 0.621
MOD_ProDKin_1 325 331 PF00069 0.424
MOD_ProDKin_1 394 400 PF00069 0.322
MOD_ProDKin_1 582 588 PF00069 0.526
MOD_ProDKin_1 683 689 PF00069 0.501
MOD_ProDKin_1 78 84 PF00069 0.596
MOD_SUMO_rev_2 901 910 PF00179 0.635
TRG_DiLeu_BaEn_1 165 170 PF01217 0.524
TRG_DiLeu_BaEn_1 918 923 PF01217 0.454
TRG_DiLeu_BaEn_4 165 171 PF01217 0.505
TRG_DiLeu_LyEn_5 165 170 PF01217 0.392
TRG_ENDOCYTIC_2 196 199 PF00928 0.459
TRG_ENDOCYTIC_2 573 576 PF00928 0.352
TRG_ENDOCYTIC_2 660 663 PF00928 0.447
TRG_ENDOCYTIC_2 689 692 PF00928 0.507
TRG_ENDOCYTIC_2 932 935 PF00928 0.398
TRG_ER_diArg_1 150 152 PF00400 0.521
TRG_ER_diArg_1 321 324 PF00400 0.476
TRG_ER_diArg_1 33 35 PF00400 0.577
TRG_ER_diArg_1 391 394 PF00400 0.442
TRG_ER_diArg_1 522 524 PF00400 0.532
TRG_ER_diArg_1 525 527 PF00400 0.441
TRG_ER_diArg_1 557 560 PF00400 0.362
TRG_ER_diArg_1 597 600 PF00400 0.491
TRG_ER_diArg_1 676 678 PF00400 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 42% 100%
A0A3Q8IAD3 Leishmania donovani 53% 100%
A0A3Q8IAF8 Leishmania donovani 86% 100%
A0A3Q8IAK8 Leishmania donovani 89% 100%
A0A3Q8IJ32 Leishmania donovani 81% 100%
A0A3S7WTZ8 Leishmania donovani 65% 92%
A0A3S7WU13 Leishmania donovani 81% 100%
A0A422NAR5 Trypanosoma rangeli 43% 100%
A4H8M5 Leishmania braziliensis 65% 100%
A4H8M7 Leishmania braziliensis 70% 100%
A4H8N0 Leishmania braziliensis 51% 100%
A4H8N1 Leishmania braziliensis 51% 100%
A4HWZ5 Leishmania infantum 81% 100%
A4HWZ6 Leishmania infantum 99% 100%
A4HWZ8 Leishmania infantum 91% 100%
A4HX00 Leishmania infantum 66% 100%
A4HX01 Leishmania infantum 53% 95%
A4HX05 Leishmania infantum 88% 100%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
Q4QER2 Leishmania major 52% 100%
Q4QER3 Leishmania major 62% 100%
Q4QER4 Leishmania major 85% 95%
Q4QER5 Leishmania major 73% 100%
Q4QER6 Leishmania major 73% 100%
Q4QER7 Leishmania major 81% 100%
Q4QER8 Leishmania major 76% 100%
Q4QER9 Leishmania major 87% 98%
Q4QES0 Leishmania major 76% 100%
V5ANJ8 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS