Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6Y0_LEIDO

TriTrypDb:

LdBPK_161000.1 , LdCL_160015200 , LDHU3_16.1200

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H6Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6Y0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	97	101	PF00082	0.506
CLV_PCSK_KEX2_1	36	38	PF00082	0.506
CLV_PCSK_KEX2_1	364	366	PF00082	0.506
CLV_PCSK_KEX2_1	91	93	PF00082	0.506
CLV_PCSK_KEX2_1	99	101	PF00082	0.373
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.506
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.506
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.506
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.373
CLV_PCSK_SKI1_1	109	113	PF00082	0.341
CLV_PCSK_SKI1_1	130	134	PF00082	0.506
CLV_PCSK_SKI1_1	273	277	PF00082	0.506
CLV_PCSK_SKI1_1	397	401	PF00082	0.506
CLV_PCSK_SKI1_1	99	103	PF00082	0.506
DEG_APCC_DBOX_1	108	116	PF00400	0.506
DEG_SPOP_SBC_1	380	384	PF00917	0.292
DOC_CYCLIN_RxL_1	270	277	PF00134	0.428
DOC_CYCLIN_RxL_1	96	105	PF00134	0.492
DOC_MAPK_gen_1	130	139	PF00069	0.506
DOC_MAPK_gen_1	59	69	PF00069	0.506
DOC_MAPK_gen_1	6	13	PF00069	0.506
DOC_MAPK_MEF2A_6	133	141	PF00069	0.506
DOC_PP1_RVXF_1	271	277	PF00149	0.506
DOC_PP1_RVXF_1	29	36	PF00149	0.506
DOC_PP2B_LxvP_1	160	163	PF13499	0.678
DOC_PP4_FxxP_1	395	398	PF00568	0.506
DOC_PP4_FxxP_1	74	77	PF00568	0.506
DOC_USP7_MATH_1	179	183	PF00917	0.767
DOC_USP7_MATH_1	203	207	PF00917	0.580
DOC_USP7_MATH_1	380	384	PF00917	0.506
DOC_USP7_UBL2_3	8	12	PF12436	0.506
DOC_WW_Pin1_4	149	154	PF00397	0.785
DOC_WW_Pin1_4	205	210	PF00397	0.627
DOC_WW_Pin1_4	240	245	PF00397	0.506
DOC_WW_Pin1_4	291	296	PF00397	0.506
LIG_14-3-3_CanoR_1	365	371	PF00244	0.506
LIG_14-3-3_CanoR_1	37	47	PF00244	0.506
LIG_14-3-3_CanoR_1	381	389	PF00244	0.241
LIG_14-3-3_CanoR_1	432	439	PF00244	0.396
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.506
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_deltaCOP1_diTrp_1	258	267	PF00928	0.506
LIG_deltaCOP1_diTrp_1	392	400	PF00928	0.506
LIG_EH_1	186	190	PF12763	0.685
LIG_FAT_LD_1	455	463	PF03623	0.670
LIG_FHA_1	269	275	PF00498	0.506
LIG_FHA_1	27	33	PF00498	0.365
LIG_FHA_1	384	390	PF00498	0.452
LIG_FHA_1	458	464	PF00498	0.660
LIG_FHA_2	39	45	PF00498	0.506
LIG_FHA_2	405	411	PF00498	0.331
LIG_LIR_Apic_2	238	244	PF02991	0.345
LIG_LIR_Apic_2	250	256	PF02991	0.345
LIG_LIR_Apic_2	384	390	PF02991	0.484
LIG_LIR_Apic_2	392	398	PF02991	0.395
LIG_LIR_Apic_2	71	77	PF02991	0.506
LIG_LIR_Gen_1	145	153	PF02991	0.757
LIG_LIR_Gen_1	68	77	PF02991	0.345
LIG_LIR_Nem_3	145	149	PF02991	0.735
LIG_LIR_Nem_3	15	21	PF02991	0.506
LIG_LIR_Nem_3	68	73	PF02991	0.345
LIG_Pex14_2	70	74	PF04695	0.506
LIG_SH2_CRK	18	22	PF00017	0.506
LIG_SH2_CRK	253	257	PF00017	0.506
LIG_SH2_CRK	367	371	PF00017	0.506
LIG_SH2_CRK	387	391	PF00017	0.175
LIG_SH2_SRC	121	124	PF00017	0.506
LIG_SH2_SRC	443	446	PF00017	0.511
LIG_SH2_STAP1	232	236	PF00017	0.506
LIG_SH2_STAT3	333	336	PF00017	0.292
LIG_SH2_STAT5	121	124	PF00017	0.441
LIG_SH2_STAT5	333	336	PF00017	0.292
LIG_SH2_STAT5	443	446	PF00017	0.573
LIG_SH3_3	138	144	PF00018	0.506
LIG_SH3_3	444	450	PF00018	0.590
LIG_SUMO_SIM_par_1	254	261	PF11976	0.506
LIG_SUMO_SIM_par_1	64	71	PF11976	0.506
LIG_UBA3_1	265	273	PF00899	0.506
LIG_UBA3_1	357	364	PF00899	0.506
LIG_UBA3_1	69	78	PF00899	0.506
MOD_CAAXbox	469	472	PF01239	0.658
MOD_CDC14_SPxK_1	294	297	PF00782	0.506
MOD_CDK_SPK_2	151	156	PF00069	0.484
MOD_CDK_SPxK_1	291	297	PF00069	0.506
MOD_CDK_SPxxK_3	149	156	PF00069	0.672
MOD_CK1_1	302	308	PF00069	0.506
MOD_CK1_1	345	351	PF00069	0.469
MOD_CK1_1	379	385	PF00069	0.457
MOD_CK1_1	411	417	PF00069	0.506
MOD_CK1_1	448	454	PF00069	0.416
MOD_CK2_1	39	45	PF00069	0.508
MOD_GlcNHglycan	165	168	PF01048	0.802
MOD_GlcNHglycan	177	180	PF01048	0.618
MOD_GlcNHglycan	249	252	PF01048	0.370
MOD_GlcNHglycan	276	279	PF01048	0.428
MOD_GlcNHglycan	349	352	PF01048	0.389
MOD_GlcNHglycan	377	381	PF01048	0.506
MOD_GlcNHglycan	404	407	PF01048	0.506
MOD_GSK3_1	147	154	PF00069	0.616
MOD_GSK3_1	163	170	PF00069	0.666
MOD_GSK3_1	175	182	PF00069	0.613
MOD_GSK3_1	22	29	PF00069	0.506
MOD_GSK3_1	247	254	PF00069	0.506
MOD_GSK3_1	343	350	PF00069	0.435
MOD_GSK3_1	376	383	PF00069	0.441
MOD_GSK3_1	404	411	PF00069	0.353
MOD_GSK3_1	458	465	PF00069	0.656
MOD_NEK2_1	247	252	PF00069	0.506
MOD_NEK2_1	269	274	PF00069	0.506
MOD_NEK2_1	366	371	PF00069	0.370
MOD_NEK2_1	404	409	PF00069	0.428
MOD_NEK2_1	458	463	PF00069	0.662
MOD_NEK2_1	93	98	PF00069	0.506
MOD_PIKK_1	343	349	PF00454	0.506
MOD_PIKK_1	356	362	PF00454	0.291
MOD_PKA_1	230	236	PF00069	0.506
MOD_PKA_2	296	302	PF00069	0.506
MOD_PKA_2	314	320	PF00069	0.208
MOD_PKA_2	380	386	PF00069	0.506
MOD_PKA_2	431	437	PF00069	0.506
MOD_Plk_4	17	23	PF00069	0.506
MOD_Plk_4	235	241	PF00069	0.506
MOD_Plk_4	299	305	PF00069	0.433
MOD_Plk_4	458	464	PF00069	0.660
MOD_ProDKin_1	149	155	PF00069	0.786
MOD_ProDKin_1	205	211	PF00069	0.614
MOD_ProDKin_1	240	246	PF00069	0.506
MOD_ProDKin_1	291	297	PF00069	0.506
MOD_SUMO_rev_2	126	134	PF00179	0.428
MOD_SUMO_rev_2	84	93	PF00179	0.506
TRG_DiLeu_BaEn_1	281	286	PF01217	0.408
TRG_DiLeu_BaEn_1	416	421	PF01217	0.506
TRG_DiLeu_BaEn_1	467	472	PF01217	0.653
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.506
TRG_ENDOCYTIC_2	18	21	PF00928	0.506
TRG_ENDOCYTIC_2	367	370	PF00928	0.506
TRG_ENDOCYTIC_2	7	10	PF00928	0.345
TRG_NES_CRM1_1	211	225	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P759	Leptomonas seymouri	75%	100%
A0A0S4KIN4	Bodo saltans	25%	69%
A0A1X0NZD5	Trypanosomatidae	40%	95%
A0A1X0P018	Trypanosomatidae	29%	85%
A0A3R7KDC2	Trypanosoma rangeli	26%	100%
A0A3R7NBN7	Trypanosoma rangeli	36%	100%
A0A3S5IQV1	Trypanosoma rangeli	42%	100%
A4H4A1	Leishmania braziliensis	28%	100%
A4H601	Leishmania braziliensis	25%	100%
A4H8M3	Leishmania braziliensis	89%	99%
A4HFI2	Leishmania braziliensis	31%	100%
A4HWZ4	Leishmania infantum	99%	99%
C9ZLG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZVG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AE77	Leishmania major	27%	100%
E9AQQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
O43077	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	84%
O80345	Arabidopsis thaliana	24%	99%
Q01917	Crithidia fasciculata	76%	100%
Q45FA5	Physarum polycephalum	26%	100%
Q4QES1	Leishmania major	95%	99%
Q6BV06	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	78%
Q6FQ83	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	71%
V5D488	Trypanosoma cruzi	42%	100%
V5DCN7	Trypanosoma cruzi	35%	79%