Membrane transport protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane transport protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6X7_LEIDO

TriTrypDb:

LdBPK_160800.1 , LdCL_160013300 , LDHU3_16.0960

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S5H6X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6X7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0009914	hormone transport	4	9
GO:0009987	cellular process	1	9
GO:0010817	regulation of hormone levels	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0060918	auxin transport	5	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0080162	endoplasmic reticulum to cytosol auxin transport	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.542
CLV_C14_Caspase3-7	623	627	PF00656	0.680
CLV_C14_Caspase3-7	632	636	PF00656	0.568
CLV_NRD_NRD_1	106	108	PF00675	0.620
CLV_NRD_NRD_1	450	452	PF00675	0.269
CLV_NRD_NRD_1	495	497	PF00675	0.352
CLV_PCSK_KEX2_1	268	270	PF00082	0.399
CLV_PCSK_KEX2_1	394	396	PF00082	0.310
CLV_PCSK_KEX2_1	495	497	PF00082	0.352
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.384
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.305
CLV_PCSK_PC7_1	390	396	PF00082	0.305
CLV_PCSK_SKI1_1	252	256	PF00082	0.380
CLV_PCSK_SKI1_1	472	476	PF00082	0.352
CLV_PCSK_SKI1_1	495	499	PF00082	0.248
CLV_PCSK_SKI1_1	639	643	PF00082	0.391
CLV_PCSK_SKI1_1	715	719	PF00082	0.337
CLV_PCSK_SKI1_1	723	727	PF00082	0.279
DEG_Nend_UBRbox_2	1	3	PF02207	0.634
DEG_SPOP_SBC_1	331	335	PF00917	0.481
DEG_SPOP_SBC_1	530	534	PF00917	0.552
DOC_ANK_TNKS_1	510	517	PF00023	0.505
DOC_CKS1_1	405	410	PF01111	0.552
DOC_CYCLIN_RxL_1	492	499	PF00134	0.472
DOC_MAPK_DCC_7	145	155	PF00069	0.427
DOC_MAPK_DCC_7	472	482	PF00069	0.520
DOC_MAPK_gen_1	107	114	PF00069	0.382
DOC_MAPK_gen_1	143	155	PF00069	0.375
DOC_MAPK_gen_1	255	265	PF00069	0.584
DOC_MAPK_gen_1	394	402	PF00069	0.505
DOC_MAPK_HePTP_8	655	667	PF00069	0.395
DOC_MAPK_MEF2A_6	107	114	PF00069	0.382
DOC_MAPK_MEF2A_6	13	22	PF00069	0.349
DOC_MAPK_MEF2A_6	146	155	PF00069	0.357
DOC_MAPK_MEF2A_6	57	65	PF00069	0.599
DOC_MAPK_MEF2A_6	658	667	PF00069	0.395
DOC_MAPK_MEF2A_6	66	73	PF00069	0.460
DOC_MAPK_MEF2A_6	689	697	PF00069	0.302
DOC_PP1_RVXF_1	721	728	PF00149	0.470
DOC_PP2B_LxvP_1	175	178	PF13499	0.325
DOC_PP2B_LxvP_1	281	284	PF13499	0.716
DOC_PP2B_LxvP_1	699	702	PF13499	0.405
DOC_PP4_FxxP_1	92	95	PF00568	0.339
DOC_USP7_MATH_1	331	335	PF00917	0.542
DOC_USP7_MATH_1	355	359	PF00917	0.486
DOC_USP7_MATH_1	389	393	PF00917	0.484
DOC_USP7_MATH_1	530	534	PF00917	0.565
DOC_USP7_MATH_1	704	708	PF00917	0.332
DOC_USP7_UBL2_3	142	146	PF12436	0.546
DOC_USP7_UBL2_3	252	256	PF12436	0.534
DOC_USP7_UBL2_3	448	452	PF12436	0.493
DOC_WW_Pin1_4	126	131	PF00397	0.543
DOC_WW_Pin1_4	340	345	PF00397	0.422
DOC_WW_Pin1_4	404	409	PF00397	0.521
DOC_WW_Pin1_4	473	478	PF00397	0.536
DOC_WW_Pin1_4	659	664	PF00397	0.477
LIG_14-3-3_CanoR_1	320	326	PF00244	0.570
LIG_14-3-3_CanoR_1	362	371	PF00244	0.534
LIG_14-3-3_CanoR_1	451	459	PF00244	0.514
LIG_14-3-3_CanoR_1	464	468	PF00244	0.536
LIG_14-3-3_CanoR_1	599	605	PF00244	0.659
LIG_Actin_WH2_2	630	646	PF00022	0.651
LIG_BRCT_BRCA1_1	157	161	PF00533	0.390
LIG_BRCT_BRCA1_1	214	218	PF00533	0.378
LIG_BRCT_BRCA1_1	475	479	PF00533	0.552
LIG_CtBP_PxDLS_1	103	107	PF00389	0.435
LIG_CtBP_PxDLS_1	502	506	PF00389	0.515
LIG_deltaCOP1_diTrp_1	432	438	PF00928	0.493
LIG_EH1_1	39	47	PF00400	0.395
LIG_FHA_1	201	207	PF00498	0.344
LIG_FHA_1	22	28	PF00498	0.476
LIG_FHA_1	276	282	PF00498	0.640
LIG_FHA_1	30	36	PF00498	0.293
LIG_FHA_1	340	346	PF00498	0.545
LIG_FHA_1	399	405	PF00498	0.483
LIG_FHA_1	434	440	PF00498	0.515
LIG_FHA_1	577	583	PF00498	0.639
LIG_FHA_1	638	644	PF00498	0.620
LIG_FHA_2	133	139	PF00498	0.474
LIG_FHA_2	165	171	PF00498	0.381
LIG_FHA_2	619	625	PF00498	0.730
LIG_FHA_2	630	636	PF00498	0.574
LIG_LIR_Apic_2	89	95	PF02991	0.286
LIG_LIR_Gen_1	113	124	PF02991	0.438
LIG_LIR_Gen_1	149	157	PF02991	0.348
LIG_LIR_Gen_1	215	226	PF02991	0.322
LIG_LIR_Gen_1	368	377	PF02991	0.481
LIG_LIR_Gen_1	436	443	PF02991	0.469
LIG_LIR_Gen_1	466	474	PF02991	0.505
LIG_LIR_Gen_1	476	487	PF02991	0.477
LIG_LIR_Gen_1	559	569	PF02991	0.653
LIG_LIR_Gen_1	666	674	PF02991	0.374
LIG_LIR_Gen_1	7	16	PF02991	0.395
LIG_LIR_Gen_1	718	729	PF02991	0.534
LIG_LIR_Nem_3	113	119	PF02991	0.361
LIG_LIR_Nem_3	149	155	PF02991	0.399
LIG_LIR_Nem_3	158	164	PF02991	0.349
LIG_LIR_Nem_3	224	230	PF02991	0.307
LIG_LIR_Nem_3	232	238	PF02991	0.425
LIG_LIR_Nem_3	368	374	PF02991	0.481
LIG_LIR_Nem_3	399	405	PF02991	0.481
LIG_LIR_Nem_3	436	441	PF02991	0.490
LIG_LIR_Nem_3	466	470	PF02991	0.552
LIG_LIR_Nem_3	476	482	PF02991	0.477
LIG_LIR_Nem_3	552	557	PF02991	0.705
LIG_LIR_Nem_3	559	564	PF02991	0.655
LIG_LIR_Nem_3	649	655	PF02991	0.472
LIG_LIR_Nem_3	664	670	PF02991	0.378
LIG_LIR_Nem_3	7	11	PF02991	0.395
LIG_LIR_Nem_3	708	714	PF02991	0.477
LIG_LIR_Nem_3	96	102	PF02991	0.411
LIG_LYPXL_yS_3	554	557	PF13949	0.653
LIG_Pex14_2	668	672	PF04695	0.484
LIG_PTB_Apo_2	34	41	PF02174	0.362
LIG_Rb_pABgroove_1	110	118	PF01858	0.374
LIG_REV1ctd_RIR_1	90	94	PF16727	0.407
LIG_SH2_CRK	99	103	PF00017	0.415
LIG_SH2_NCK_1	116	120	PF00017	0.441
LIG_SH2_PTP2	152	155	PF00017	0.362
LIG_SH2_PTP2	227	230	PF00017	0.349
LIG_SH2_SRC	116	119	PF00017	0.349
LIG_SH2_STAP1	190	194	PF00017	0.368
LIG_SH2_STAP1	369	373	PF00017	0.505
LIG_SH2_STAP1	431	435	PF00017	0.575
LIG_SH2_STAP1	443	447	PF00017	0.481
LIG_SH2_STAP1	570	574	PF00017	0.599
LIG_SH2_STAT3	574	577	PF00017	0.658
LIG_SH2_STAT5	152	155	PF00017	0.362
LIG_SH2_STAT5	227	230	PF00017	0.303
LIG_SH2_STAT5	238	241	PF00017	0.289
LIG_SH2_STAT5	325	328	PF00017	0.505
LIG_SH2_STAT5	729	732	PF00017	0.313
LIG_SH2_STAT5	746	749	PF00017	0.317
LIG_SH3_3	199	205	PF00018	0.321
LIG_SH3_3	424	430	PF00018	0.590
LIG_SH3_3	552	558	PF00018	0.708
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.511
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.586
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.323
LIG_SUMO_SIM_anti_2	690	696	PF11976	0.405
LIG_SUMO_SIM_par_1	152	159	PF11976	0.351
LIG_SUMO_SIM_par_1	203	210	PF11976	0.382
LIG_SUMO_SIM_par_1	68	74	PF11976	0.373
LIG_SUMO_SIM_par_1	693	698	PF11976	0.351
LIG_TRAF2_1	621	624	PF00917	0.756
LIG_TRFH_1	554	558	PF08558	0.703
LIG_TYR_ITIM	114	119	PF00017	0.439
LIG_TYR_ITIM	150	155	PF00017	0.377
LIG_UBA3_1	259	268	PF00899	0.554
LIG_UBA3_1	669	676	PF00899	0.491
MOD_CDK_SPxxK_3	130	137	PF00069	0.507
MOD_CDK_SPxxK_3	404	411	PF00069	0.505
MOD_CK1_1	129	135	PF00069	0.560
MOD_CK1_1	207	213	PF00069	0.380
MOD_CK1_1	214	220	PF00069	0.383
MOD_CK1_1	31	37	PF00069	0.328
MOD_CK1_1	329	335	PF00069	0.540
MOD_CK1_1	339	345	PF00069	0.512
MOD_CK1_1	517	523	PF00069	0.482
MOD_CK1_1	585	591	PF00069	0.680
MOD_CK1_1	74	80	PF00069	0.428
MOD_CK2_1	132	138	PF00069	0.473
MOD_CK2_1	164	170	PF00069	0.385
MOD_CK2_1	309	315	PF00069	0.524
MOD_CK2_1	340	346	PF00069	0.529
MOD_CK2_1	451	457	PF00069	0.529
MOD_CK2_1	618	624	PF00069	0.750
MOD_Cter_Amidation	392	395	PF01082	0.305
MOD_GlcNHglycan	223	226	PF01048	0.554
MOD_GlcNHglycan	240	243	PF01048	0.259
MOD_GlcNHglycan	365	368	PF01048	0.371
MOD_GlcNHglycan	391	394	PF01048	0.311
MOD_GlcNHglycan	42	45	PF01048	0.427
MOD_GlcNHglycan	453	456	PF01048	0.305
MOD_GlcNHglycan	533	536	PF01048	0.326
MOD_GlcNHglycan	612	615	PF01048	0.449
MOD_GlcNHglycan	79	82	PF01048	0.427
MOD_GlcNHglycan	99	102	PF01048	0.562
MOD_GSK3_1	126	133	PF00069	0.555
MOD_GSK3_1	200	207	PF00069	0.330
MOD_GSK3_1	27	34	PF00069	0.404
MOD_GSK3_1	275	282	PF00069	0.664
MOD_GSK3_1	326	333	PF00069	0.570
MOD_GSK3_1	334	341	PF00069	0.587
MOD_GSK3_1	350	357	PF00069	0.479
MOD_GSK3_1	36	43	PF00069	0.347
MOD_GSK3_1	363	370	PF00069	0.554
MOD_GSK3_1	373	380	PF00069	0.531
MOD_GSK3_1	384	391	PF00069	0.454
MOD_GSK3_1	407	414	PF00069	0.534
MOD_GSK3_1	46	53	PF00069	0.287
MOD_GSK3_1	514	521	PF00069	0.470
MOD_GSK3_1	659	666	PF00069	0.428
MOD_GSK3_1	683	690	PF00069	0.418
MOD_GSK3_1	700	707	PF00069	0.405
MOD_GSK3_1	738	745	PF00069	0.391
MOD_N-GLC_1	36	41	PF02516	0.374
MOD_N-GLC_1	705	710	PF02516	0.349
MOD_NEK2_1	221	226	PF00069	0.361
MOD_NEK2_1	229	234	PF00069	0.329
MOD_NEK2_1	373	378	PF00069	0.547
MOD_NEK2_1	381	386	PF00069	0.564
MOD_NEK2_1	388	393	PF00069	0.407
MOD_NEK2_1	4	9	PF00069	0.337
MOD_NEK2_1	40	45	PF00069	0.379
MOD_NEK2_1	46	51	PF00069	0.336
MOD_NEK2_1	52	57	PF00069	0.366
MOD_NEK2_1	529	534	PF00069	0.513
MOD_NEK2_1	65	70	PF00069	0.453
MOD_NEK2_1	687	692	PF00069	0.402
MOD_NEK2_1	738	743	PF00069	0.379
MOD_NEK2_2	398	403	PF00069	0.505
MOD_NEK2_2	663	668	PF00069	0.362
MOD_PIKK_1	195	201	PF00454	0.364
MOD_PIKK_1	275	281	PF00454	0.620
MOD_PIKK_1	319	325	PF00454	0.505
MOD_PIKK_1	379	385	PF00454	0.552
MOD_PK_1	146	152	PF00069	0.410
MOD_PKA_1	146	152	PF00069	0.404
MOD_PKA_1	451	457	PF00069	0.515
MOD_PKA_1	629	635	PF00069	0.681
MOD_PKA_2	319	325	PF00069	0.526
MOD_PKA_2	389	395	PF00069	0.536
MOD_PKA_2	463	469	PF00069	0.590
MOD_PKA_2	646	652	PF00069	0.490
MOD_PKA_2	65	71	PF00069	0.495
MOD_PKA_2	683	689	PF00069	0.427
MOD_Plk_1	36	42	PF00069	0.265
MOD_Plk_1	398	404	PF00069	0.505
MOD_Plk_1	687	693	PF00069	0.331
MOD_Plk_1	705	711	PF00069	0.222
MOD_Plk_2-3	117	123	PF00069	0.448
MOD_Plk_4	204	210	PF00069	0.338
MOD_Plk_4	4	10	PF00069	0.335
MOD_Plk_4	463	469	PF00069	0.481
MOD_Plk_4	478	484	PF00069	0.481
MOD_Plk_4	501	507	PF00069	0.482
MOD_Plk_4	518	524	PF00069	0.462
MOD_Plk_4	590	596	PF00069	0.661
MOD_Plk_4	600	606	PF00069	0.705
MOD_Plk_4	629	635	PF00069	0.678
MOD_Plk_4	646	652	PF00069	0.502
MOD_Plk_4	65	71	PF00069	0.491
MOD_Plk_4	663	669	PF00069	0.381
MOD_Plk_4	687	693	PF00069	0.299
MOD_Plk_4	705	711	PF00069	0.285
MOD_Plk_4	732	738	PF00069	0.324
MOD_Plk_4	742	748	PF00069	0.346
MOD_ProDKin_1	126	132	PF00069	0.544
MOD_ProDKin_1	340	346	PF00069	0.422
MOD_ProDKin_1	404	410	PF00069	0.521
MOD_ProDKin_1	473	479	PF00069	0.536
MOD_ProDKin_1	659	665	PF00069	0.477
MOD_SUMO_for_1	441	444	PF00179	0.505
MOD_SUMO_rev_2	444	450	PF00179	0.536
TRG_DiLeu_BaEn_1	559	564	PF01217	0.670
TRG_DiLeu_BaEn_4	559	565	PF01217	0.640
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.601
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.505
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.660
TRG_ENDOCYTIC_2	116	119	PF00928	0.295
TRG_ENDOCYTIC_2	152	155	PF00928	0.362
TRG_ENDOCYTIC_2	227	230	PF00928	0.313
TRG_ENDOCYTIC_2	554	557	PF00928	0.653
TRG_ENDOCYTIC_2	714	717	PF00928	0.602
TRG_ENDOCYTIC_2	99	102	PF00928	0.412
TRG_ER_diArg_1	494	496	PF00400	0.552
TRG_ER_diArg_1	543	546	PF00400	0.688
TRG_ER_diArg_1	597	600	PF00400	0.693
TRG_NLS_MonoCore_2	141	146	PF00514	0.539
TRG_NLS_MonoExtC_3	141	146	PF00514	0.531
TRG_NLS_MonoExtN_4	139	146	PF00514	0.539
TRG_NLS_MonoExtN_4	252	259	PF00514	0.575
TRG_NLS_MonoExtN_4	448	455	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL2	Leptomonas seymouri	52%	100%
A0A422ND25	Trypanosoma rangeli	34%	100%
A4H8K4	Leishmania braziliensis	69%	99%
A4HWX7	Leishmania infantum	100%	100%
C9ZW27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AQN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QET9	Leishmania major	90%	100%