Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6X5_LEIDO

TriTrypDb:

LdBPK_160720.1 , LdCL_160012400 , LDHU3_16.0860

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A0A3S5H6X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	276	278	PF00675	0.440
CLV_NRD_NRD_1	334	336	PF00675	0.370
CLV_NRD_NRD_1	504	506	PF00675	0.666
CLV_PCSK_KEX2_1	109	111	PF00082	0.679
CLV_PCSK_KEX2_1	276	278	PF00082	0.440
CLV_PCSK_KEX2_1	334	336	PF00082	0.370
CLV_PCSK_KEX2_1	504	506	PF00082	0.666
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.662
CLV_PCSK_SKI1_1	450	454	PF00082	0.501
DEG_APCC_DBOX_1	457	465	PF00400	0.511
DEG_Nend_UBRbox_2	1	3	PF02207	0.552
DEG_SCF_FBW7_2	482	489	PF00400	0.527
DEG_SPOP_SBC_1	444	448	PF00917	0.439
DEG_SPOP_SBC_1	75	79	PF00917	0.578
DOC_CYCLIN_RxL_1	212	220	PF00134	0.404
DOC_CYCLIN_RxL_1	331	339	PF00134	0.359
DOC_MAPK_gen_1	109	119	PF00069	0.487
DOC_MAPK_MEF2A_6	110	119	PF00069	0.504
DOC_MAPK_MEF2A_6	406	414	PF00069	0.318
DOC_MAPK_RevD_3	262	277	PF00069	0.417
DOC_PP1_RVXF_1	375	382	PF00149	0.434
DOC_PP2B_LxvP_1	124	127	PF13499	0.382
DOC_PP2B_LxvP_1	195	198	PF13499	0.599
DOC_PP2B_LxvP_1	99	102	PF13499	0.572
DOC_USP7_MATH_1	143	147	PF00917	0.326
DOC_USP7_MATH_1	229	233	PF00917	0.378
DOC_USP7_MATH_1	360	364	PF00917	0.524
DOC_USP7_MATH_1	384	388	PF00917	0.400
DOC_USP7_MATH_1	469	473	PF00917	0.545
DOC_USP7_MATH_1	491	495	PF00917	0.586
DOC_USP7_MATH_1	59	63	PF00917	0.481
DOC_USP7_MATH_1	82	86	PF00917	0.573
DOC_USP7_MATH_1	95	99	PF00917	0.523
DOC_WW_Pin1_4	482	487	PF00397	0.779
LIG_14-3-3_CanoR_1	28	34	PF00244	0.481
LIG_14-3-3_CanoR_1	319	328	PF00244	0.490
LIG_14-3-3_CanoR_1	456	462	PF00244	0.503
LIG_14-3-3_CanoR_1	504	511	PF00244	0.553
LIG_14-3-3_CanoR_1	520	529	PF00244	0.379
LIG_14-3-3_CanoR_1	96	102	PF00244	0.573
LIG_Actin_WH2_2	135	152	PF00022	0.382
LIG_Actin_WH2_2	445	460	PF00022	0.454
LIG_BRCT_BRCA1_1	117	121	PF00533	0.437
LIG_BRCT_BRCA1_1	372	376	PF00533	0.469
LIG_CSL_BTD_1	124	127	PF09270	0.382
LIG_eIF4E_1	395	401	PF01652	0.387
LIG_FHA_1	192	198	PF00498	0.576
LIG_FHA_1	211	217	PF00498	0.373
LIG_FHA_1	343	349	PF00498	0.395
LIG_FHA_1	506	512	PF00498	0.683
LIG_FHA_2	37	43	PF00498	0.533
LIG_FHA_2	397	403	PF00498	0.421
LIG_FHA_2	476	482	PF00498	0.662
LIG_FHA_2	505	511	PF00498	0.547
LIG_LIR_Gen_1	29	34	PF02991	0.660
LIG_LIR_Nem_3	118	124	PF02991	0.433
LIG_LIR_Nem_3	29	33	PF02991	0.458
LIG_LIR_Nem_3	345	349	PF02991	0.532
LIG_LIR_Nem_3	373	379	PF02991	0.518
LIG_LIR_Nem_3	387	391	PF02991	0.426
LIG_PDZ_Class_1	524	529	PF00595	0.532
LIG_Pex14_1	30	34	PF04695	0.477
LIG_Pex14_2	121	125	PF04695	0.434
LIG_SH2_GRB2like	395	398	PF00017	0.360
LIG_SH2_NCK_1	369	373	PF00017	0.601
LIG_SH2_SRC	417	420	PF00017	0.393
LIG_SH2_STAT5	346	349	PF00017	0.528
LIG_SH2_STAT5	395	398	PF00017	0.360
LIG_SH2_STAT5	417	420	PF00017	0.393
LIG_SH3_3	16	22	PF00018	0.608
LIG_SH3_3	196	202	PF00018	0.530
LIG_SH3_3	298	304	PF00018	0.434
LIG_SUMO_SIM_anti_2	17	22	PF11976	0.539
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.483
LIG_SUMO_SIM_par_1	215	220	PF11976	0.349
LIG_SUMO_SIM_par_1	410	416	PF11976	0.323
LIG_SUMO_SIM_par_1	46	51	PF11976	0.474
LIG_SUMO_SIM_par_1	8	14	PF11976	0.570
LIG_TRAF2_1	39	42	PF00917	0.570
LIG_WW_1	198	201	PF00397	0.472
MOD_CK1_1	108	114	PF00069	0.556
MOD_CK1_1	167	173	PF00069	0.393
MOD_CK1_1	494	500	PF00069	0.595
MOD_CK1_1	5	11	PF00069	0.591
MOD_CK1_1	67	73	PF00069	0.755
MOD_CK2_1	108	114	PF00069	0.696
MOD_CK2_1	177	183	PF00069	0.594
MOD_CK2_1	36	42	PF00069	0.509
MOD_CK2_1	396	402	PF00069	0.429
MOD_CK2_1	475	481	PF00069	0.663
MOD_CK2_1	504	510	PF00069	0.475
MOD_GlcNHglycan	166	169	PF01048	0.339
MOD_GlcNHglycan	218	222	PF01048	0.481
MOD_GlcNHglycan	280	283	PF01048	0.573
MOD_GlcNHglycan	314	317	PF01048	0.614
MOD_GlcNHglycan	373	376	PF01048	0.653
MOD_GlcNHglycan	439	442	PF01048	0.472
MOD_GlcNHglycan	471	474	PF01048	0.580
MOD_GlcNHglycan	67	70	PF01048	0.603
MOD_GlcNHglycan	7	10	PF01048	0.620
MOD_GlcNHglycan	84	87	PF01048	0.636
MOD_GSK3_1	145	152	PF00069	0.388
MOD_GSK3_1	197	204	PF00069	0.570
MOD_GSK3_1	229	236	PF00069	0.455
MOD_GSK3_1	239	246	PF00069	0.341
MOD_GSK3_1	29	36	PF00069	0.473
MOD_GSK3_1	320	327	PF00069	0.526
MOD_GSK3_1	433	440	PF00069	0.514
MOD_GSK3_1	465	472	PF00069	0.494
MOD_GSK3_1	505	512	PF00069	0.617
MOD_GSK3_1	91	98	PF00069	0.665
MOD_N-GLC_1	243	248	PF02516	0.479
MOD_N-GLC_1	396	401	PF02516	0.360
MOD_N-GLC_1	469	474	PF02516	0.596
MOD_NEK2_1	149	154	PF00069	0.331
MOD_NEK2_1	217	222	PF00069	0.336
MOD_NEK2_1	233	238	PF00069	0.386
MOD_NEK2_1	33	38	PF00069	0.479
MOD_NEK2_1	336	341	PF00069	0.349
MOD_NEK2_1	342	347	PF00069	0.371
MOD_NEK2_1	371	376	PF00069	0.555
MOD_NEK2_1	396	401	PF00069	0.385
MOD_NEK2_1	435	440	PF00069	0.532
MOD_NEK2_1	465	470	PF00069	0.551
MOD_NEK2_1	74	79	PF00069	0.594
MOD_NEK2_2	131	136	PF00069	0.371
MOD_NEK2_2	210	215	PF00069	0.400
MOD_NEK2_2	445	450	PF00069	0.544
MOD_PIKK_1	491	497	PF00454	0.636
MOD_PKA_1	504	510	PF00069	0.555
MOD_PKA_2	149	155	PF00069	0.304
MOD_PKA_2	312	318	PF00069	0.473
MOD_PKA_2	426	432	PF00069	0.453
MOD_PKA_2	457	463	PF00069	0.509
MOD_PKA_2	504	510	PF00069	0.555
MOD_PKA_2	64	70	PF00069	0.706
MOD_PKA_2	95	101	PF00069	0.591
MOD_PKB_1	63	71	PF00069	0.572
MOD_Plk_1	396	402	PF00069	0.364
MOD_Plk_4	229	235	PF00069	0.519
MOD_Plk_4	29	35	PF00069	0.484
MOD_Plk_4	342	348	PF00069	0.377
MOD_Plk_4	396	402	PF00069	0.500
MOD_Plk_4	494	500	PF00069	0.573
MOD_ProDKin_1	482	488	PF00069	0.784
MOD_SUMO_rev_2	416	422	PF00179	0.389
TRG_DiLeu_BaEn_1	510	515	PF01217	0.475
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.464
TRG_ENDOCYTIC_2	346	349	PF00928	0.441
TRG_ER_diArg_1	275	277	PF00400	0.439
TRG_ER_diArg_1	333	335	PF00400	0.377
TRG_ER_diArg_1	504	506	PF00400	0.659
TRG_ER_diArg_1	63	66	PF00400	0.552
TRG_NLS_MonoExtC_3	108	114	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG7	Leptomonas seymouri	35%	100%
A4H8J4	Leishmania braziliensis	70%	100%
A4HWW9	Leishmania infantum	99%	100%
E9AQN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QEU7	Leishmania major	85%	100%