Eukaryotic_translation_initiation_factor_eIF2A_pu tative/Pfam:PF08662

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor eIF2A, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6X4_LEIDO

TriTrypDb:

LdBPK_160690.1 , LdCL_160012100 , LDHU3_16.0830

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H6X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6X4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000049	tRNA binding	5	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.409
CLV_NRD_NRD_1	10	12	PF00675	0.321
CLV_NRD_NRD_1	138	140	PF00675	0.395
CLV_NRD_NRD_1	523	525	PF00675	0.622
CLV_NRD_NRD_1	549	551	PF00675	0.744
CLV_PCSK_KEX2_1	119	121	PF00082	0.450
CLV_PCSK_KEX2_1	138	140	PF00082	0.399
CLV_PCSK_KEX2_1	523	525	PF00082	0.622
CLV_PCSK_KEX2_1	548	550	PF00082	0.702
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.446
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.702
CLV_PCSK_SKI1_1	231	235	PF00082	0.479
CLV_PCSK_SKI1_1	244	248	PF00082	0.476
CLV_PCSK_SKI1_1	312	316	PF00082	0.263
CLV_PCSK_SKI1_1	466	470	PF00082	0.284
CLV_PCSK_SKI1_1	87	91	PF00082	0.310
DEG_SPOP_SBC_1	60	64	PF00917	0.497
DOC_MAPK_gen_1	11	18	PF00069	0.350
DOC_MAPK_gen_1	450	459	PF00069	0.472
DOC_MAPK_MEF2A_6	11	20	PF00069	0.420
DOC_PP4_FxxP_1	275	278	PF00568	0.561
DOC_USP7_MATH_1	176	180	PF00917	0.686
DOC_USP7_MATH_1	415	419	PF00917	0.500
DOC_USP7_UBL2_3	238	242	PF12436	0.378
DOC_WW_Pin1_4	101	106	PF00397	0.477
DOC_WW_Pin1_4	118	123	PF00397	0.575
DOC_WW_Pin1_4	274	279	PF00397	0.538
DOC_WW_Pin1_4	329	334	PF00397	0.472
DOC_WW_Pin1_4	492	497	PF00397	0.530
LIG_14-3-3_CanoR_1	244	249	PF00244	0.471
LIG_14-3-3_CanoR_1	312	319	PF00244	0.534
LIG_14-3-3_CanoR_1	347	353	PF00244	0.472
LIG_14-3-3_CanoR_1	466	475	PF00244	0.528
LIG_14-3-3_CanoR_1	83	87	PF00244	0.458
LIG_APCC_ABBA_1	18	23	PF00400	0.418
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	438	442	PF00533	0.487
LIG_BRCT_BRCA1_1	444	448	PF00533	0.472
LIG_BRCT_BRCA1_1	99	103	PF00533	0.515
LIG_CSL_BTD_1	275	278	PF09270	0.561
LIG_FHA_1	106	112	PF00498	0.389
LIG_FHA_1	245	251	PF00498	0.348
LIG_FHA_1	299	305	PF00498	0.510
LIG_FHA_1	411	417	PF00498	0.514
LIG_FHA_1	533	539	PF00498	0.664
LIG_FHA_1	60	66	PF00498	0.395
LIG_FHA_2	149	155	PF00498	0.404
LIG_FHA_2	183	189	PF00498	0.659
LIG_FHA_2	323	329	PF00498	0.498
LIG_FHA_2	332	338	PF00498	0.463
LIG_FHA_2	360	366	PF00498	0.493
LIG_FHA_2	64	70	PF00498	0.463
LIG_LIR_Apic_2	273	278	PF02991	0.506
LIG_LIR_Gen_1	112	117	PF02991	0.428
LIG_LIR_Gen_1	279	287	PF02991	0.529
LIG_LIR_Gen_1	438	448	PF02991	0.505
LIG_LIR_Gen_1	64	75	PF02991	0.502
LIG_LIR_Nem_3	247	251	PF02991	0.499
LIG_LIR_Nem_3	279	285	PF02991	0.518
LIG_LIR_Nem_3	297	302	PF02991	0.356
LIG_LIR_Nem_3	391	395	PF02991	0.458
LIG_LIR_Nem_3	438	443	PF02991	0.505
LIG_LIR_Nem_3	445	451	PF02991	0.473
LIG_LIR_Nem_3	469	475	PF02991	0.472
LIG_LIR_Nem_3	64	70	PF02991	0.461
LIG_LIR_Nem_3	85	89	PF02991	0.514
LIG_LYPXL_yS_3	472	475	PF13949	0.472
LIG_NRBOX	334	340	PF00104	0.506
LIG_Pex14_2	86	90	PF04695	0.515
LIG_SH2_CRK	251	255	PF00017	0.379
LIG_SH2_CRK	299	303	PF00017	0.458
LIG_SH2_CRK	440	444	PF00017	0.538
LIG_SH2_CRK	509	513	PF00017	0.614
LIG_SH2_NCK_1	223	227	PF00017	0.499
LIG_SH2_PTP2	282	285	PF00017	0.538
LIG_SH2_PTP2	395	398	PF00017	0.464
LIG_SH2_STAP1	67	71	PF00017	0.372
LIG_SH2_STAT5	109	112	PF00017	0.460
LIG_SH2_STAT5	156	159	PF00017	0.354
LIG_SH2_STAT5	282	285	PF00017	0.538
LIG_SH2_STAT5	38	41	PF00017	0.529
LIG_SH2_STAT5	395	398	PF00017	0.480
LIG_SH2_STAT5	67	70	PF00017	0.472
LIG_SH3_1	531	537	PF00018	0.701
LIG_SH3_3	154	160	PF00018	0.473
LIG_SH3_3	48	54	PF00018	0.502
LIG_SH3_3	531	537	PF00018	0.660
LIG_SH3_3	89	95	PF00018	0.490
LIG_SH3_4	238	245	PF00018	0.391
LIG_SUMO_SIM_anti_2	2	7	PF11976	0.450
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.541
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.460
LIG_TRAF2_1	499	502	PF00917	0.719
LIG_TYR_ITIM	65	70	PF00017	0.359
LIG_UBA3_1	233	238	PF00899	0.353
LIG_UBA3_1	338	344	PF00899	0.423
LIG_UBA3_1	5	12	PF00899	0.405
LIG_WRPW_2	237	240	PF00400	0.361
MOD_CDK_SPK_2	101	106	PF00069	0.510
MOD_CDK_SPK_2	492	497	PF00069	0.553
MOD_CK1_1	174	180	PF00069	0.661
MOD_CK1_1	294	300	PF00069	0.308
MOD_CK1_1	410	416	PF00069	0.433
MOD_CK1_1	85	91	PF00069	0.466
MOD_CK2_1	124	130	PF00069	0.451
MOD_CK2_1	148	154	PF00069	0.400
MOD_CK2_1	24	30	PF00069	0.449
MOD_CK2_1	331	337	PF00069	0.400
MOD_CK2_1	63	69	PF00069	0.474
MOD_DYRK1A_RPxSP_1	492	496	PF00069	0.524
MOD_GlcNHglycan	278	281	PF01048	0.340
MOD_GlcNHglycan	292	296	PF01048	0.330
MOD_GlcNHglycan	384	387	PF01048	0.416
MOD_GlcNHglycan	418	421	PF01048	0.386
MOD_GSK3_1	105	112	PF00069	0.344
MOD_GSK3_1	124	131	PF00069	0.339
MOD_GSK3_1	170	177	PF00069	0.574
MOD_GSK3_1	187	194	PF00069	0.734
MOD_GSK3_1	270	277	PF00069	0.287
MOD_GSK3_1	294	301	PF00069	0.300
MOD_GSK3_1	416	423	PF00069	0.371
MOD_GSK3_1	442	449	PF00069	0.410
MOD_GSK3_1	59	66	PF00069	0.448
MOD_GSK3_1	97	104	PF00069	0.385
MOD_N-GLC_1	124	129	PF02516	0.455
MOD_N-GLC_1	204	209	PF02516	0.576
MOD_N-GLC_1	310	315	PF02516	0.380
MOD_N-GLC_1	410	415	PF02516	0.387
MOD_N-GLC_2	348	350	PF02516	0.423
MOD_NEK2_1	172	177	PF00069	0.592
MOD_NEK2_1	310	315	PF00069	0.357
MOD_NEK2_1	382	387	PF00069	0.307
MOD_NEK2_1	442	447	PF00069	0.333
MOD_NEK2_1	90	95	PF00069	0.377
MOD_NEK2_2	124	129	PF00069	0.455
MOD_NEK2_2	82	87	PF00069	0.302
MOD_PKA_2	36	42	PF00069	0.461
MOD_PKA_2	52	58	PF00069	0.385
MOD_PKA_2	82	88	PF00069	0.469
MOD_Plk_1	12	18	PF00069	0.415
MOD_Plk_1	124	130	PF00069	0.457
MOD_Plk_1	310	316	PF00069	0.325
MOD_Plk_1	410	416	PF00069	0.410
MOD_Plk_2-3	191	197	PF00069	0.712
MOD_Plk_2-3	322	328	PF00069	0.423
MOD_Plk_4	105	111	PF00069	0.176
MOD_Plk_4	12	18	PF00069	0.404
MOD_Plk_4	124	130	PF00069	0.317
MOD_Plk_4	176	182	PF00069	0.698
MOD_Plk_4	270	276	PF00069	0.307
MOD_Plk_4	294	300	PF00069	0.330
MOD_Plk_4	348	354	PF00069	0.307
MOD_Plk_4	443	449	PF00069	0.330
MOD_Plk_4	538	544	PF00069	0.593
MOD_Plk_4	85	91	PF00069	0.517
MOD_ProDKin_1	101	107	PF00069	0.473
MOD_ProDKin_1	118	124	PF00069	0.565
MOD_ProDKin_1	274	280	PF00069	0.423
MOD_ProDKin_1	329	335	PF00069	0.330
MOD_ProDKin_1	492	498	PF00069	0.539
MOD_SUMO_for_1	287	290	PF00179	0.311
MOD_SUMO_for_1	319	322	PF00179	0.423
MOD_SUMO_rev_2	313	319	PF00179	0.316
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.490
TRG_ENDOCYTIC_2	113	116	PF00928	0.417
TRG_ENDOCYTIC_2	282	285	PF00928	0.398
TRG_ENDOCYTIC_2	299	302	PF00928	0.184
TRG_ENDOCYTIC_2	440	443	PF00928	0.423
TRG_ENDOCYTIC_2	472	475	PF00928	0.330
TRG_ENDOCYTIC_2	67	70	PF00928	0.363
TRG_ER_diArg_1	137	139	PF00400	0.408
TRG_ER_diArg_1	450	453	PF00400	0.330
TRG_ER_diArg_1	522	524	PF00400	0.612
TRG_ER_diLys_1	546	551	PF00400	0.652
TRG_NES_CRM1_1	308	322	PF08389	0.423
TRG_NLS_MonoCore_2	545	550	PF00514	0.647
TRG_NLS_MonoExtC_3	545	550	PF00514	0.647
TRG_NLS_MonoExtN_4	546	551	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC7	Leptomonas seymouri	76%	100%
A0A1X0NNW1	Trypanosomatidae	50%	99%
A0A422N2R4	Trypanosoma rangeli	51%	100%
A4H8J1	Leishmania braziliensis	87%	100%
A4HWW6	Leishmania infantum	100%	100%
C9ZPL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AQM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74965	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	96%
Q4QEV0	Leishmania major	95%	100%
Q4QRJ7	Danio rerio	25%	95%
Q54PV7	Dictyostelium discoideum	27%	91%
Q5ZKC1	Gallus gallus	24%	94%
Q7ZY11	Xenopus laevis	27%	95%
Q8BJW6	Mus musculus	25%	95%
Q9BY44	Homo sapiens	25%	94%
Q9VNX8	Drosophila melanogaster	26%	86%
V5BCM0	Trypanosoma cruzi	53%	100%