Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6X1_LEIDO

TriTrypDb:

LdBPK_160500.1 , LdCL_160009900 , LDHU3_16.0590

Length:

199

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 19
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A0A3S5H6X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6X1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.596
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DEG_SPOP_SBC_1	111	115	PF00917	0.255
DOC_MAPK_gen_1	2	12	PF00069	0.554
DOC_MAPK_MEF2A_6	2	10	PF00069	0.530
DOC_MAPK_MEF2A_6	53	60	PF00069	0.520
DOC_USP7_MATH_1	111	115	PF00917	0.268
DOC_USP7_MATH_1	19	23	PF00917	0.414
DOC_WW_Pin1_4	47	52	PF00397	0.345
LIG_14-3-3_CanoR_1	46	51	PF00244	0.330
LIG_14-3-3_CanoR_1	62	67	PF00244	0.395
LIG_BRCT_BRCA1_1	21	25	PF00533	0.427
LIG_BRCT_BRCA1_1	92	96	PF00533	0.508
LIG_FHA_1	115	121	PF00498	0.376
LIG_FHA_1	126	132	PF00498	0.427
LIG_FHA_1	18	24	PF00498	0.486
LIG_FHA_1	36	42	PF00498	0.414
LIG_FHA_1	53	59	PF00498	0.304
LIG_FHA_1	78	84	PF00498	0.437
LIG_FHA_1	86	92	PF00498	0.439
LIG_LIR_Gen_1	113	123	PF02991	0.433
LIG_LIR_Nem_3	113	119	PF02991	0.374
LIG_LIR_Nem_3	160	165	PF02991	0.330
LIG_LIR_Nem_3	22	28	PF02991	0.373
LIG_LIR_Nem_3	40	45	PF02991	0.318
LIG_Pex14_2	176	180	PF04695	0.454
LIG_SH2_STAP1	64	68	PF00017	0.420
LIG_SH2_STAP1	77	81	PF00017	0.360
LIG_SH2_STAT3	66	69	PF00017	0.316
LIG_SH2_STAT5	136	139	PF00017	0.339
LIG_SH2_STAT5	163	166	PF00017	0.327
LIG_SH2_STAT5	42	45	PF00017	0.425
LIG_SH2_STAT5	77	80	PF00017	0.293
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.311
LIG_SUMO_SIM_par_1	10	16	PF11976	0.367
LIG_WRC_WIRS_1	116	121	PF05994	0.342
MOD_CDK_SPxK_1	47	53	PF00069	0.294
MOD_CK1_1	114	120	PF00069	0.473
MOD_CK1_1	190	196	PF00069	0.705
MOD_GlcNHglycan	93	96	PF01048	0.480
MOD_GSK3_1	110	117	PF00069	0.378
MOD_GSK3_1	13	20	PF00069	0.366
MOD_GSK3_1	132	139	PF00069	0.521
MOD_GSK3_1	183	190	PF00069	0.549
MOD_GSK3_1	77	84	PF00069	0.353
MOD_GSK3_1	91	98	PF00069	0.434
MOD_NEK2_1	110	115	PF00069	0.366
MOD_NEK2_1	13	18	PF00069	0.355
MOD_NEK2_1	182	187	PF00069	0.423
MOD_NEK2_1	90	95	PF00069	0.390
MOD_PIKK_1	143	149	PF00454	0.452
MOD_PKA_2	45	51	PF00069	0.409
MOD_Plk_1	143	149	PF00069	0.439
MOD_Plk_4	115	121	PF00069	0.392
MOD_Plk_4	132	138	PF00069	0.458
MOD_Plk_4	19	25	PF00069	0.474
MOD_Plk_4	37	43	PF00069	0.291
MOD_ProDKin_1	47	53	PF00069	0.356
TRG_DiLeu_BaEn_1	160	165	PF01217	0.322
TRG_ENDOCYTIC_2	76	79	PF00928	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	29%	100%
A0A0N0P3Z6	Leptomonas seymouri	37%	88%
A0A0N0P4D5	Leptomonas seymouri	32%	96%
A0A1X0P9D7	Trypanosomatidae	30%	93%
A0A3Q8IIZ2	Leishmania donovani	33%	100%
A0A3R7KFR8	Trypanosoma rangeli	26%	100%
A0A3S7WTU4	Leishmania donovani	28%	100%
A4H8H3	Leishmania braziliensis	28%	100%
A4H8H5	Leishmania braziliensis	64%	100%
A4H8H6	Leishmania braziliensis	37%	100%
A4HWU5	Leishmania infantum	28%	100%
A4HWU7	Leishmania infantum	100%	100%
A4HWU8	Leishmania infantum	33%	100%
C9ZMZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QEX0	Leishmania major	34%	100%
Q4QEX1	Leishmania major	93%	100%
Q4QEX3	Leishmania major	30%	100%