Tubulin tyrosine ligase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin tyrosine ligase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6X0_LEIDO

TriTrypDb:

LdBPK_160390.1 , LdCL_160008800 , LDHU3_16.0470

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S5H6X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6X0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0018095	protein polyglutamylation	7	8
GO:0018193	peptidyl-amino acid modification	5	8
GO:0018200	peptidyl-glutamic acid modification	6	8
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	10
GO:0004835	tubulin-tyrosine ligase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	7
GO:0016874	ligase activity	2	10
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	8
GO:0016881	acid-amino acid ligase activity	4	8
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0070739	protein-glutamic acid ligase activity	3	2
GO:0070740	tubulin-glutamic acid ligase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.566
CLV_NRD_NRD_1	100	102	PF00675	0.777
CLV_NRD_NRD_1	103	105	PF00675	0.720
CLV_NRD_NRD_1	225	227	PF00675	0.654
CLV_NRD_NRD_1	330	332	PF00675	0.596
CLV_NRD_NRD_1	363	365	PF00675	0.471
CLV_NRD_NRD_1	392	394	PF00675	0.338
CLV_NRD_NRD_1	485	487	PF00675	0.311
CLV_NRD_NRD_1	55	57	PF00675	0.659
CLV_NRD_NRD_1	71	73	PF00675	0.775
CLV_PCSK_FUR_1	101	105	PF00082	0.567
CLV_PCSK_FUR_1	328	332	PF00082	0.603
CLV_PCSK_KEX2_1	100	102	PF00082	0.684
CLV_PCSK_KEX2_1	103	105	PF00082	0.646
CLV_PCSK_KEX2_1	196	198	PF00082	0.676
CLV_PCSK_KEX2_1	225	227	PF00082	0.654
CLV_PCSK_KEX2_1	330	332	PF00082	0.596
CLV_PCSK_KEX2_1	363	365	PF00082	0.516
CLV_PCSK_KEX2_1	402	404	PF00082	0.353
CLV_PCSK_KEX2_1	484	486	PF00082	0.311
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.670
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.632
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.654
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.280
CLV_PCSK_SKI1_1	14	18	PF00082	0.644
CLV_PCSK_SKI1_1	399	403	PF00082	0.280
CLV_PCSK_SKI1_1	501	505	PF00082	0.312
CLV_PCSK_SKI1_1	767	771	PF00082	0.312
CLV_PCSK_SKI1_1	779	783	PF00082	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DEG_SCF_FBW7_1	83	89	PF00400	0.688
DEG_SPOP_SBC_1	283	287	PF00917	0.606
DOC_CKS1_1	83	88	PF01111	0.688
DOC_MAPK_gen_1	196	204	PF00069	0.623
DOC_MAPK_gen_1	619	627	PF00069	0.553
DOC_MAPK_MEF2A_6	619	627	PF00069	0.553
DOC_MAPK_NFAT4_5	620	628	PF00069	0.553
DOC_MAPK_RevD_3	184	197	PF00069	0.606
DOC_PP1_RVXF_1	707	714	PF00149	0.542
DOC_PP1_RVXF_1	777	783	PF00149	0.518
DOC_USP7_MATH_1	165	169	PF00917	0.757
DOC_USP7_MATH_1	189	193	PF00917	0.662
DOC_USP7_MATH_1	208	212	PF00917	0.571
DOC_USP7_MATH_1	229	233	PF00917	0.672
DOC_USP7_MATH_1	274	278	PF00917	0.641
DOC_USP7_MATH_1	30	34	PF00917	0.596
DOC_USP7_MATH_1	303	307	PF00917	0.825
DOC_USP7_MATH_1	320	324	PF00917	0.731
DOC_USP7_MATH_1	438	442	PF00917	0.542
DOC_USP7_MATH_1	584	588	PF00917	0.783
DOC_USP7_MATH_1	593	597	PF00917	0.752
DOC_USP7_MATH_1	653	657	PF00917	0.570
DOC_USP7_MATH_1	755	759	PF00917	0.521
DOC_USP7_MATH_1	91	95	PF00917	0.677
DOC_USP7_UBL2_3	59	63	PF12436	0.617
DOC_USP7_UBL2_3	8	12	PF12436	0.597
DOC_WW_Pin1_4	135	140	PF00397	0.639
DOC_WW_Pin1_4	21	26	PF00397	0.649
DOC_WW_Pin1_4	279	284	PF00397	0.683
DOC_WW_Pin1_4	44	49	PF00397	0.629
DOC_WW_Pin1_4	529	534	PF00397	0.528
DOC_WW_Pin1_4	570	575	PF00397	0.703
DOC_WW_Pin1_4	586	591	PF00397	0.603
DOC_WW_Pin1_4	753	758	PF00397	0.513
DOC_WW_Pin1_4	82	87	PF00397	0.689
DOC_WW_Pin1_4	92	97	PF00397	0.590
LIG_14-3-3_CanoR_1	104	111	PF00244	0.642
LIG_14-3-3_CanoR_1	250	259	PF00244	0.537
LIG_14-3-3_CanoR_1	415	419	PF00244	0.513
LIG_14-3-3_CanoR_1	451	457	PF00244	0.505
LIG_14-3-3_CanoR_1	56	66	PF00244	0.570
LIG_14-3-3_CanoR_1	81	86	PF00244	0.672
LIG_Actin_WH2_2	704	722	PF00022	0.534
LIG_APCC_ABBA_1	475	480	PF00400	0.513
LIG_BIR_III_4	174	178	PF00653	0.643
LIG_BIR_III_4	433	437	PF00653	0.468
LIG_BRCT_BRCA1_1	32	36	PF00533	0.567
LIG_BRCT_BRCA1_1	370	374	PF00533	0.529
LIG_BRCT_BRCA1_1	457	461	PF00533	0.511
LIG_BRCT_BRCA1_1	575	579	PF00533	0.642
LIG_deltaCOP1_diTrp_1	354	359	PF00928	0.475
LIG_eIF4E_1	609	615	PF01652	0.513
LIG_eIF4E_1	736	742	PF01652	0.513
LIG_FHA_1	197	203	PF00498	0.665
LIG_FHA_1	420	426	PF00498	0.486
LIG_FHA_1	466	472	PF00498	0.501
LIG_FHA_1	486	492	PF00498	0.513
LIG_FHA_1	580	586	PF00498	0.602
LIG_FHA_1	65	71	PF00498	0.644
LIG_FHA_1	759	765	PF00498	0.616
LIG_FHA_1	775	781	PF00498	0.425
LIG_FHA_1	87	93	PF00498	0.799
LIG_FHA_2	251	257	PF00498	0.537
LIG_FHA_2	390	396	PF00498	0.513
LIG_FHA_2	418	424	PF00498	0.513
LIG_FHA_2	761	767	PF00498	0.513
LIG_Integrin_isoDGR_2	223	225	PF01839	0.596
LIG_LIR_Apic_2	468	472	PF02991	0.513
LIG_LIR_Gen_1	354	362	PF02991	0.420
LIG_LIR_Gen_1	411	421	PF02991	0.511
LIG_LIR_Gen_1	641	652	PF02991	0.476
LIG_LIR_Gen_1	687	695	PF02991	0.465
LIG_LIR_Nem_3	354	358	PF02991	0.434
LIG_LIR_Nem_3	395	401	PF02991	0.514
LIG_LIR_Nem_3	411	416	PF02991	0.513
LIG_LIR_Nem_3	630	635	PF02991	0.529
LIG_LIR_Nem_3	641	647	PF02991	0.553
LIG_LIR_Nem_3	687	691	PF02991	0.472
LIG_LIR_Nem_3	732	736	PF02991	0.610
LIG_LIR_Nem_3	810	815	PF02991	0.569
LIG_MAD2	779	787	PF02301	0.513
LIG_PCNA_PIPBox_1	659	668	PF02747	0.513
LIG_PDZ_Class_2	812	817	PF00595	0.455
LIG_Pex14_2	478	482	PF04695	0.511
LIG_Pex14_2	688	692	PF04695	0.461
LIG_PTB_Apo_2	707	714	PF02174	0.513
LIG_SH2_CRK	398	402	PF00017	0.513
LIG_SH2_CRK	413	417	PF00017	0.513
LIG_SH2_CRK	469	473	PF00017	0.480
LIG_SH2_CRK	632	636	PF00017	0.553
LIG_SH2_CRK	716	720	PF00017	0.513
LIG_SH2_CRK	738	742	PF00017	0.513
LIG_SH2_NCK_1	469	473	PF00017	0.513
LIG_SH2_PTP2	626	629	PF00017	0.526
LIG_SH2_SRC	604	607	PF00017	0.482
LIG_SH2_STAP1	738	742	PF00017	0.513
LIG_SH2_STAT5	404	407	PF00017	0.513
LIG_SH2_STAT5	604	607	PF00017	0.553
LIG_SH2_STAT5	609	612	PF00017	0.553
LIG_SH2_STAT5	626	629	PF00017	0.580
LIG_SH2_STAT5	638	641	PF00017	0.553
LIG_SH2_STAT5	694	697	PF00017	0.511
LIG_SH2_STAT5	702	705	PF00017	0.511
LIG_SH3_3	183	189	PF00018	0.810
LIG_SH3_3	571	577	PF00018	0.643
LIG_SH3_3	778	784	PF00018	0.523
LIG_SH3_3	85	91	PF00018	0.663
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.626
LIG_SUMO_SIM_par_1	452	458	PF11976	0.482
LIG_TYR_ITAM	395	416	PF00017	0.513
LIG_TYR_ITIM	396	401	PF00017	0.513
LIG_TYR_ITIM	714	719	PF00017	0.513
LIG_WRC_WIRS_1	456	461	PF05994	0.573
LIG_WRC_WIRS_1	525	530	PF05994	0.563
LIG_WW_1	783	786	PF00397	0.511
LIG_WW_2	90	93	PF00397	0.608
MOD_CDK_SPK_2	573	578	PF00069	0.550
MOD_CDK_SPxxK_3	529	536	PF00069	0.533
MOD_CK1_1	106	112	PF00069	0.708
MOD_CK1_1	19	25	PF00069	0.578
MOD_CK1_1	234	240	PF00069	0.767
MOD_CK1_1	282	288	PF00069	0.691
MOD_CK1_1	306	312	PF00069	0.660
MOD_CK1_1	455	461	PF00069	0.482
MOD_CK1_1	555	561	PF00069	0.716
MOD_CK1_1	570	576	PF00069	0.722
MOD_CK1_1	583	589	PF00069	0.608
MOD_CK1_1	664	670	PF00069	0.492
MOD_CK1_1	758	764	PF00069	0.534
MOD_CK1_1	82	88	PF00069	0.690
MOD_CK1_1	95	101	PF00069	0.689
MOD_CK2_1	551	557	PF00069	0.653
MOD_Cter_Amidation	194	197	PF01082	0.662
MOD_Cter_Amidation	223	226	PF01082	0.596
MOD_Cter_Amidation	617	620	PF01082	0.353
MOD_GlcNHglycan	105	108	PF01048	0.647
MOD_GlcNHglycan	18	21	PF01048	0.653
MOD_GlcNHglycan	182	185	PF01048	0.671
MOD_GlcNHglycan	210	213	PF01048	0.688
MOD_GlcNHglycan	218	221	PF01048	0.730
MOD_GlcNHglycan	237	240	PF01048	0.834
MOD_GlcNHglycan	276	279	PF01048	0.776
MOD_GlcNHglycan	295	298	PF01048	0.692
MOD_GlcNHglycan	322	325	PF01048	0.661
MOD_GlcNHglycan	425	428	PF01048	0.326
MOD_GlcNHglycan	440	443	PF01048	0.336
MOD_GlcNHglycan	557	560	PF01048	0.765
MOD_GlcNHglycan	563	566	PF01048	0.717
MOD_GlcNHglycan	582	585	PF01048	0.600
MOD_GlcNHglycan	595	598	PF01048	0.566
MOD_GlcNHglycan	8	11	PF01048	0.824
MOD_GlcNHglycan	97	100	PF01048	0.786
MOD_GSK3_1	106	113	PF00069	0.611
MOD_GSK3_1	131	138	PF00069	0.715
MOD_GSK3_1	15	22	PF00069	0.562
MOD_GSK3_1	165	172	PF00069	0.763
MOD_GSK3_1	2	9	PF00069	0.641
MOD_GSK3_1	231	238	PF00069	0.636
MOD_GSK3_1	269	276	PF00069	0.716
MOD_GSK3_1	278	285	PF00069	0.653
MOD_GSK3_1	302	309	PF00069	0.626
MOD_GSK3_1	365	372	PF00069	0.468
MOD_GSK3_1	419	426	PF00069	0.534
MOD_GSK3_1	44	51	PF00069	0.678
MOD_GSK3_1	461	468	PF00069	0.513
MOD_GSK3_1	524	531	PF00069	0.563
MOD_GSK3_1	551	558	PF00069	0.682
MOD_GSK3_1	579	586	PF00069	0.697
MOD_GSK3_1	600	607	PF00069	0.340
MOD_GSK3_1	71	78	PF00069	0.682
MOD_GSK3_1	753	760	PF00069	0.523
MOD_GSK3_1	799	806	PF00069	0.493
MOD_GSK3_1	82	89	PF00069	0.732
MOD_GSK3_1	91	98	PF00069	0.632
MOD_N-GLC_1	208	213	PF02516	0.646
MOD_N-GLC_1	579	584	PF02516	0.768
MOD_N-GLC_1	678	683	PF02516	0.320
MOD_N-GLC_1	753	758	PF02516	0.312
MOD_N-GLC_1	774	779	PF02516	0.232
MOD_N-GLC_2	567	569	PF02516	0.628
MOD_NEK2_1	284	289	PF00069	0.711
MOD_NEK2_1	461	466	PF00069	0.513
MOD_NEK2_1	528	533	PF00069	0.573
MOD_NEK2_1	579	584	PF00069	0.684
MOD_NEK2_1	600	605	PF00069	0.437
MOD_NEK2_1	628	633	PF00069	0.513
MOD_NEK2_1	647	652	PF00069	0.513
MOD_NEK2_1	759	764	PF00069	0.513
MOD_NEK2_1	774	779	PF00069	0.513
MOD_NEK2_2	245	250	PF00069	0.591
MOD_NEK2_2	370	375	PF00069	0.470
MOD_NEK2_2	414	419	PF00069	0.471
MOD_PIKK_1	322	328	PF00454	0.611
MOD_PIKK_1	485	491	PF00454	0.513
MOD_PIKK_1	495	501	PF00454	0.513
MOD_PIKK_1	584	590	PF00454	0.623
MOD_PKA_1	103	109	PF00069	0.671
MOD_PKA_1	196	202	PF00069	0.664
MOD_PKA_1	485	491	PF00069	0.511
MOD_PKA_1	519	525	PF00069	0.496
MOD_PKA_1	57	63	PF00069	0.642
MOD_PKA_2	103	109	PF00069	0.671
MOD_PKA_2	196	202	PF00069	0.664
MOD_PKA_2	306	312	PF00069	0.762
MOD_PKA_2	365	371	PF00069	0.478
MOD_PKA_2	414	420	PF00069	0.513
MOD_PKA_2	485	491	PF00069	0.513
MOD_PKA_2	71	77	PF00069	0.833
MOD_PKB_1	77	85	PF00069	0.647
MOD_Plk_1	245	251	PF00069	0.595
MOD_Plk_1	774	780	PF00069	0.432
MOD_Plk_1	79	85	PF00069	0.632
MOD_Plk_2-3	131	137	PF00069	0.638
MOD_Plk_2-3	729	735	PF00069	0.511
MOD_Plk_4	106	112	PF00069	0.560
MOD_Plk_4	524	530	PF00069	0.577
MOD_Plk_4	540	546	PF00069	0.478
MOD_Plk_4	600	606	PF00069	0.389
MOD_ProDKin_1	135	141	PF00069	0.639
MOD_ProDKin_1	21	27	PF00069	0.650
MOD_ProDKin_1	279	285	PF00069	0.679
MOD_ProDKin_1	44	50	PF00069	0.632
MOD_ProDKin_1	529	535	PF00069	0.528
MOD_ProDKin_1	570	576	PF00069	0.702
MOD_ProDKin_1	586	592	PF00069	0.602
MOD_ProDKin_1	753	759	PF00069	0.513
MOD_ProDKin_1	82	88	PF00069	0.686
MOD_ProDKin_1	92	98	PF00069	0.593
MOD_SUMO_for_1	126	129	PF00179	0.602
MOD_SUMO_rev_2	344	350	PF00179	0.623
MOD_SUMO_rev_2	517	522	PF00179	0.468
TRG_AP2beta_CARGO_1	641	651	PF09066	0.513
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.551
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.513
TRG_DiLeu_BaLyEn_6	764	769	PF01217	0.513
TRG_DiLeu_BaLyEn_6	810	815	PF01217	0.291
TRG_ENDOCYTIC_2	398	401	PF00928	0.513
TRG_ENDOCYTIC_2	413	416	PF00928	0.445
TRG_ENDOCYTIC_2	626	629	PF00928	0.546
TRG_ENDOCYTIC_2	632	635	PF00928	0.543
TRG_ENDOCYTIC_2	716	719	PF00928	0.513
TRG_ENDOCYTIC_2	738	741	PF00928	0.513
TRG_ER_diArg_1	327	330	PF00400	0.611
TRG_ER_diArg_1	362	364	PF00400	0.481
TRG_ER_diArg_1	484	486	PF00400	0.511
TRG_ER_diArg_1	798	801	PF00400	0.488
TRG_NES_CRM1_1	660	675	PF08389	0.513
TRG_NLS_MonoCore_2	55	60	PF00514	0.625
TRG_NLS_MonoCore_2	99	104	PF00514	0.610
TRG_NLS_MonoExtC_3	99	104	PF00514	0.635
TRG_NLS_MonoExtN_4	100	107	PF00514	0.648
TRG_NLS_MonoExtN_4	56	61	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX5	Leptomonas seymouri	61%	100%
A0A3Q8IDL7	Leishmania donovani	24%	100%
A4H8G3	Leishmania braziliensis	72%	95%
A4HWT7	Leishmania infantum	100%	100%
A4HYN9	Leishmania infantum	24%	100%
E9AID0	Leishmania braziliensis	24%	100%
E9AQJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QCW7	Leishmania major	23%	100%
Q4QEY2	Leishmania major	89%	99%