Proteasome_26S_non-ATPase_subunit_9_putative/Gene DB:LmjF.16.0290

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome 26S non-ATPase subunit 9, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6W9_LEIDO

TriTrypDb:

LdBPK_160300.1 , LdCL_160007900 , LDHU3_16.0360

Length:

257

Annotations

Annotations by Jardim et al.

Proteasome, proteasome 26S non-ATPase subunit 9

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6W9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043248	proteasome assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070682	proteasome regulatory particle assembly	7	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.430
CLV_NRD_NRD_1	215	217	PF00675	0.413
CLV_NRD_NRD_1	37	39	PF00675	0.310
CLV_PCSK_KEX2_1	131	133	PF00082	0.431
CLV_PCSK_KEX2_1	140	142	PF00082	0.359
CLV_PCSK_KEX2_1	37	39	PF00082	0.308
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.489
CLV_PCSK_PC7_1	33	39	PF00082	0.381
CLV_PCSK_SKI1_1	29	33	PF00082	0.408
CLV_PCSK_SKI1_1	43	47	PF00082	0.194
DEG_APCC_DBOX_1	32	40	PF00400	0.278
DEG_APCC_DBOX_1	94	102	PF00400	0.318
DEG_Nend_UBRbox_3	1	3	PF02207	0.688
DOC_ANK_TNKS_1	233	240	PF00023	0.437
DOC_MAPK_gen_1	150	160	PF00069	0.422
DOC_MAPK_MEF2A_6	153	160	PF00069	0.400
DOC_USP7_MATH_1	19	23	PF00917	0.634
DOC_WW_Pin1_4	164	169	PF00397	0.366
DOC_WW_Pin1_4	57	62	PF00397	0.244
LIG_EH1_1	3	11	PF00400	0.439
LIG_FHA_1	187	193	PF00498	0.578
LIG_FHA_1	49	55	PF00498	0.300
LIG_FHA_2	114	120	PF00498	0.495
LIG_FHA_2	185	191	PF00498	0.431
LIG_FHA_2	21	27	PF00498	0.620
LIG_FHA_2	92	98	PF00498	0.339
LIG_LIR_Apic_2	13	18	PF02991	0.478
LIG_LIR_Gen_1	103	114	PF02991	0.389
LIG_LIR_Nem_3	103	109	PF02991	0.389
LIG_PCNA_yPIPBox_3	95	109	PF02747	0.371
LIG_SH2_CRK	106	110	PF00017	0.389
LIG_SH2_CRK	15	19	PF00017	0.472
LIG_SH2_CRK	183	187	PF00017	0.476
LIG_SH2_STAT5	56	59	PF00017	0.389
LIG_SH3_3	212	218	PF00018	0.443
LIG_SH3_3	226	232	PF00018	0.458
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.461
LIG_SUMO_SIM_par_1	7	14	PF11976	0.558
LIG_TRAF2_1	116	119	PF00917	0.517
LIG_TRAF2_1	168	171	PF00917	0.495
LIG_TYR_ITIM	181	186	PF00017	0.338
MOD_CK2_1	113	119	PF00069	0.484
MOD_CK2_1	164	170	PF00069	0.565
MOD_CK2_1	184	190	PF00069	0.226
MOD_CK2_1	201	207	PF00069	0.309
MOD_GSK3_1	83	90	PF00069	0.468
MOD_N-GLC_2	77	79	PF02516	0.371
MOD_PIKK_1	113	119	PF00454	0.482
MOD_PIKK_1	184	190	PF00454	0.368
MOD_PKA_2	149	155	PF00069	0.378
MOD_PKA_2	200	206	PF00069	0.399
MOD_PKA_2	87	93	PF00069	0.303
MOD_Plk_1	20	26	PF00069	0.608
MOD_Plk_4	104	110	PF00069	0.309
MOD_ProDKin_1	164	170	PF00069	0.371
MOD_ProDKin_1	57	63	PF00069	0.244
TRG_DiLeu_BaEn_4	34	40	PF01217	0.230
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.389
TRG_ENDOCYTIC_2	106	109	PF00928	0.389
TRG_ENDOCYTIC_2	183	186	PF00928	0.345
TRG_ER_diArg_1	131	134	PF00400	0.534
TRG_ER_diArg_1	36	38	PF00400	0.381
TRG_ER_diArg_1	64	67	PF00400	0.371
TRG_NES_CRM1_1	103	118	PF08389	0.211
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I787	Leptomonas seymouri	72%	98%
A0A0S4ITV9	Bodo saltans	39%	100%
A0A1X0NG23	Trypanosomatidae	38%	100%
A0A3R7M5T2	Trypanosoma rangeli	41%	100%
A4H8F4	Leishmania braziliensis	82%	100%
A4HWS8	Leishmania infantum	100%	100%
C9ZW47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AQI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O00233	Homo sapiens	30%	100%
O94393	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P40555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q10920	Caenorhabditis elegans	29%	100%
Q3SZ19	Bos taurus	31%	100%
Q4QEZ1	Leishmania major	96%	100%
Q552Y8	Dictyostelium discoideum	22%	98%
Q9CR00	Mus musculus	31%	100%
Q9VFS8	Drosophila melanogaster	35%	100%
Q9WTV5	Rattus norvegicus	32%	100%
V5AKS5	Trypanosoma cruzi	46%	100%