ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6W3_LEIDO

TriTrypDb:

LdBPK_151650.1 , LdCL_150021800 , LDHU3_15.1980

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.635
CLV_C14_Caspase3-7	26	30	PF00656	0.441
CLV_C14_Caspase3-7	338	342	PF00656	0.587
CLV_C14_Caspase3-7	361	365	PF00656	0.648
CLV_C14_Caspase3-7	400	404	PF00656	0.679
CLV_NRD_NRD_1	217	219	PF00675	0.414
CLV_NRD_NRD_1	271	273	PF00675	0.563
CLV_NRD_NRD_1	374	376	PF00675	0.672
CLV_NRD_NRD_1	4	6	PF00675	0.588
CLV_NRD_NRD_1	437	439	PF00675	0.486
CLV_NRD_NRD_1	84	86	PF00675	0.496
CLV_NRD_NRD_1	9	11	PF00675	0.534
CLV_PCSK_KEX2_1	217	219	PF00082	0.414
CLV_PCSK_KEX2_1	376	378	PF00082	0.652
CLV_PCSK_KEX2_1	4	6	PF00082	0.580
CLV_PCSK_KEX2_1	418	420	PF00082	0.557
CLV_PCSK_KEX2_1	437	439	PF00082	0.394
CLV_PCSK_KEX2_1	86	88	PF00082	0.484
CLV_PCSK_KEX2_1	9	11	PF00082	0.543
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.656
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.608
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.605
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.550
CLV_PCSK_PC7_1	414	420	PF00082	0.589
CLV_PCSK_PC7_1	5	11	PF00082	0.648
CLV_PCSK_SKI1_1	243	247	PF00082	0.432
CLV_PCSK_SKI1_1	274	278	PF00082	0.558
CLV_PCSK_SKI1_1	414	418	PF00082	0.542
CLV_PCSK_SKI1_1	419	423	PF00082	0.505
CLV_PCSK_SKI1_1	437	441	PF00082	0.419
CLV_PCSK_SKI1_1	510	514	PF00082	0.723
CLV_PCSK_SKI1_1	536	540	PF00082	0.648
DEG_SCF_FBW7_1	460	467	PF00400	0.611
DOC_CKS1_1	527	532	PF01111	0.654
DOC_CYCLIN_RxL_1	414	426	PF00134	0.627
DOC_CYCLIN_RxL_1	507	517	PF00134	0.757
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.469
DOC_MAPK_DCC_7	173	181	PF00069	0.469
DOC_MAPK_gen_1	272	279	PF00069	0.600
DOC_MAPK_MEF2A_6	532	539	PF00069	0.571
DOC_PP1_RVXF_1	119	126	PF00149	0.434
DOC_PP4_FxxP_1	70	73	PF00568	0.419
DOC_PP4_FxxP_1	76	79	PF00568	0.474
DOC_PP4_MxPP_1	71	74	PF00568	0.392
DOC_USP7_MATH_1	506	510	PF00917	0.641
DOC_WW_Pin1_4	347	352	PF00397	0.641
DOC_WW_Pin1_4	43	48	PF00397	0.440
DOC_WW_Pin1_4	460	465	PF00397	0.663
DOC_WW_Pin1_4	516	521	PF00397	0.705
DOC_WW_Pin1_4	526	531	PF00397	0.773
LIG_14-3-3_CanoR_1	101	105	PF00244	0.688
LIG_14-3-3_CanoR_1	233	242	PF00244	0.572
LIG_14-3-3_CanoR_1	431	439	PF00244	0.611
LIG_Actin_WH2_2	228	245	PF00022	0.547
LIG_BIR_III_2	517	521	PF00653	0.538
LIG_eIF4E_1	55	61	PF01652	0.385
LIG_FHA_1	151	157	PF00498	0.436
LIG_FHA_1	48	54	PF00498	0.430
LIG_FHA_1	482	488	PF00498	0.669
LIG_FHA_1	55	61	PF00498	0.376
LIG_FHA_2	203	209	PF00498	0.628
LIG_FHA_2	222	228	PF00498	0.507
LIG_FHA_2	338	344	PF00498	0.771
LIG_FHA_2	400	406	PF00498	0.716
LIG_FHA_2	465	471	PF00498	0.699
LIG_Integrin_RGD_1	106	108	PF01839	0.652
LIG_LIR_Apic_2	139	144	PF02991	0.376
LIG_LIR_Apic_2	343	348	PF02991	0.739
LIG_LIR_Gen_1	204	215	PF02991	0.508
LIG_LIR_Gen_1	288	297	PF02991	0.523
LIG_LIR_Gen_1	426	434	PF02991	0.602
LIG_LIR_Gen_1	473	482	PF02991	0.680
LIG_LIR_Nem_3	130	135	PF02991	0.427
LIG_LIR_Nem_3	204	210	PF02991	0.548
LIG_LIR_Nem_3	248	253	PF02991	0.429
LIG_LIR_Nem_3	288	292	PF02991	0.460
LIG_LIR_Nem_3	426	432	PF02991	0.535
LIG_LIR_Nem_3	473	477	PF02991	0.608
LIG_MYND_1	526	530	PF01753	0.686
LIG_PTB_Apo_2	149	156	PF02174	0.424
LIG_PTB_Apo_2	64	71	PF02174	0.485
LIG_REV1ctd_RIR_1	437	446	PF16727	0.710
LIG_SH2_CRK	289	293	PF00017	0.408
LIG_SH2_CRK	294	298	PF00017	0.406
LIG_SH2_GRB2like	150	153	PF00017	0.428
LIG_SH2_GRB2like	249	252	PF00017	0.525
LIG_SH2_PTP2	141	144	PF00017	0.340
LIG_SH2_PTP2	345	348	PF00017	0.737
LIG_SH2_SRC	345	348	PF00017	0.737
LIG_SH2_STAP1	147	151	PF00017	0.492
LIG_SH2_STAT3	124	127	PF00017	0.416
LIG_SH2_STAT5	124	127	PF00017	0.405
LIG_SH2_STAT5	133	136	PF00017	0.426
LIG_SH2_STAT5	141	144	PF00017	0.350
LIG_SH2_STAT5	150	153	PF00017	0.400
LIG_SH2_STAT5	345	348	PF00017	0.742
LIG_SH2_STAT5	406	409	PF00017	0.584
LIG_SH2_STAT5	428	431	PF00017	0.622
LIG_SH3_1	345	351	PF00018	0.713
LIG_SH3_2	35	40	PF14604	0.470
LIG_SH3_3	172	178	PF00018	0.450
LIG_SH3_3	32	38	PF00018	0.464
LIG_SH3_3	345	351	PF00018	0.724
LIG_SH3_3	41	47	PF00018	0.443
LIG_SH3_3	520	526	PF00018	0.698
LIG_SH3_3	527	533	PF00018	0.757
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.592
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.492
LIG_SUMO_SIM_par_1	177	183	PF11976	0.517
LIG_SUMO_SIM_par_1	199	205	PF11976	0.548
LIG_TRAF2_1	357	360	PF00917	0.650
LIG_TRAF2_2	450	455	PF00917	0.729
LIG_TRFH_1	133	137	PF08558	0.461
LIG_TYR_ITIM	292	297	PF00017	0.409
MOD_CDC14_SPxK_1	46	49	PF00782	0.531
MOD_CDK_SPK_2	531	536	PF00069	0.565
MOD_CDK_SPxK_1	43	49	PF00069	0.515
MOD_CDK_SPxK_1	526	532	PF00069	0.654
MOD_CK1_1	100	106	PF00069	0.690
MOD_CK1_1	382	388	PF00069	0.663
MOD_CK1_1	389	395	PF00069	0.658
MOD_CK1_1	396	402	PF00069	0.564
MOD_CK1_1	430	436	PF00069	0.605
MOD_CK1_1	443	449	PF00069	0.671
MOD_CK1_1	519	525	PF00069	0.657
MOD_CK1_1	531	537	PF00069	0.752
MOD_CK2_1	221	227	PF00069	0.548
MOD_CK2_1	354	360	PF00069	0.669
MOD_CK2_1	363	369	PF00069	0.647
MOD_GlcNHglycan	170	173	PF01048	0.545
MOD_GlcNHglycan	235	238	PF01048	0.511
MOD_GlcNHglycan	269	272	PF01048	0.537
MOD_GlcNHglycan	313	316	PF01048	0.593
MOD_GlcNHglycan	380	384	PF01048	0.698
MOD_GlcNHglycan	432	435	PF01048	0.608
MOD_GlcNHglycan	492	496	PF01048	0.701
MOD_GSK3_1	221	228	PF00069	0.555
MOD_GSK3_1	382	389	PF00069	0.636
MOD_GSK3_1	390	397	PF00069	0.672
MOD_GSK3_1	43	50	PF00069	0.465
MOD_GSK3_1	460	467	PF00069	0.685
MOD_N-GLC_1	285	290	PF02516	0.541
MOD_N-GLC_1	317	322	PF02516	0.588
MOD_N-GLC_1	55	60	PF02516	0.426
MOD_NEK2_1	267	272	PF00069	0.550
MOD_NEK2_1	440	445	PF00069	0.713
MOD_NEK2_1	493	498	PF00069	0.656
MOD_NEK2_1	54	59	PF00069	0.385
MOD_NEK2_2	47	52	PF00069	0.435
MOD_PIKK_1	440	446	PF00454	0.676
MOD_PIKK_1	448	454	PF00454	0.745
MOD_PKA_2	100	106	PF00069	0.651
MOD_PKA_2	430	436	PF00069	0.643
MOD_PKB_1	377	385	PF00069	0.662
MOD_Plk_1	285	291	PF00069	0.502
MOD_Plk_1	317	323	PF00069	0.592
MOD_Plk_1	47	53	PF00069	0.505
MOD_Plk_1	55	61	PF00069	0.397
MOD_Plk_2-3	337	343	PF00069	0.721
MOD_Plk_2-3	354	360	PF00069	0.654
MOD_Plk_4	100	106	PF00069	0.652
MOD_Plk_4	202	208	PF00069	0.619
MOD_Plk_4	245	251	PF00069	0.522
MOD_Plk_4	56	62	PF00069	0.390
MOD_ProDKin_1	347	353	PF00069	0.641
MOD_ProDKin_1	43	49	PF00069	0.446
MOD_ProDKin_1	460	466	PF00069	0.663
MOD_ProDKin_1	516	522	PF00069	0.708
MOD_ProDKin_1	526	532	PF00069	0.776
MOD_SUMO_for_1	489	492	PF00179	0.729
MOD_SUMO_rev_2	89	96	PF00179	0.564
TRG_DiLeu_BaEn_4	262	268	PF01217	0.587
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.679
TRG_ENDOCYTIC_2	282	285	PF00928	0.449
TRG_ENDOCYTIC_2	289	292	PF00928	0.407
TRG_ENDOCYTIC_2	294	297	PF00928	0.414
TRG_ER_diArg_1	216	218	PF00400	0.398
TRG_ER_diArg_1	240	243	PF00400	0.511
TRG_ER_diArg_1	291	294	PF00400	0.404
TRG_ER_diArg_1	374	377	PF00400	0.653
TRG_ER_diArg_1	437	439	PF00400	0.486
TRG_ER_diArg_1	8	10	PF00400	0.572
TRG_ER_diArg_1	84	87	PF00400	0.503
TRG_NLS_MonoExtC_3	3	8	PF00514	0.593
TRG_NLS_MonoExtC_3	374	379	PF00514	0.662
TRG_NLS_MonoExtN_4	2	8	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P791	Leptomonas seymouri	66%	100%
A0A1X0NGQ9	Trypanosomatidae	40%	92%
A0A3R7L2Y6	Trypanosoma rangeli	43%	91%
A4H8C6	Leishmania braziliensis	79%	100%
A4HWP7	Leishmania infantum	100%	100%
C9ZTQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	87%
E9AQF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QF21	Leishmania major	90%	100%
V5DPP9	Trypanosoma cruzi	43%	92%