Nucleolar_RNA_binding_protein_putative/GeneDB:Lmj F.15.1380

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar RNA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6V9_LEIDO

TriTrypDb:

LdBPK_151430.1 , LdCL_150019600 , LDHU3_15.1750

Length:

445

Annotations

Annotations by Jardim et al.

Nuclear proteins, nucleolar RNA binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	12
GO:0016020	membrane	2	1
GO:0030684	preribosome	3	12
GO:0031428	box C/D RNP complex	4	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	12

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6V9

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0030515	snoRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.455
CLV_C14_Caspase3-7	32	36	PF00656	0.382
CLV_C14_Caspase3-7	403	407	PF00656	0.655
CLV_NRD_NRD_1	21	23	PF00675	0.437
CLV_NRD_NRD_1	52	54	PF00675	0.365
CLV_PCSK_KEX2_1	21	23	PF00082	0.434
CLV_PCSK_KEX2_1	413	415	PF00082	0.623
CLV_PCSK_KEX2_1	436	438	PF00082	0.539
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.637
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.539

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD49	Leptomonas seymouri	94%	100%
A0A0N1PE54	Leptomonas seymouri	36%	94%
A0A0S4IXK2	Bodo saltans	43%	98%
A0A0S4JJS5	Bodo saltans	80%	100%
A0A1X0NRL9	Trypanosomatidae	38%	91%
A0A1X0NUB3	Trypanosomatidae	81%	100%
A0A3Q8IDJ5	Leishmania donovani	22%	100%
A0A3R7NI91	Trypanosoma rangeli	79%	100%
A0A3R7NLD9	Trypanosoma rangeli	41%	92%
A0A3S5H6F4	Leishmania donovani	37%	100%

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