SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6V7_LEIDO

TriTrypDb:

LdBPK_151280.1 , LdCL_150018100 , LDHU3_15.1580

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	398	404	PF00089	0.592
CLV_NRD_NRD_1	238	240	PF00675	0.239
CLV_NRD_NRD_1	242	244	PF00675	0.239
CLV_NRD_NRD_1	245	247	PF00675	0.239
CLV_NRD_NRD_1	3	5	PF00675	0.603
CLV_NRD_NRD_1	359	361	PF00675	0.594
CLV_NRD_NRD_1	404	406	PF00675	0.736
CLV_PCSK_FUR_1	239	243	PF00082	0.291
CLV_PCSK_KEX2_1	238	240	PF00082	0.240
CLV_PCSK_KEX2_1	241	243	PF00082	0.237
CLV_PCSK_KEX2_1	245	247	PF00082	0.235
CLV_PCSK_KEX2_1	3	5	PF00082	0.600
CLV_PCSK_KEX2_1	358	360	PF00082	0.467
CLV_PCSK_KEX2_1	404	406	PF00082	0.739
CLV_PCSK_PC7_1	234	240	PF00082	0.367
CLV_PCSK_PC7_1	241	247	PF00082	0.284
CLV_PCSK_SKI1_1	216	220	PF00082	0.345
CLV_PCSK_SKI1_1	234	238	PF00082	0.190
CLV_PCSK_SKI1_1	295	299	PF00082	0.302
CLV_PCSK_SKI1_1	344	348	PF00082	0.681
CLV_PCSK_SKI1_1	52	56	PF00082	0.337
DEG_APCC_DBOX_1	215	223	PF00400	0.345
DEG_APCC_DBOX_1	233	241	PF00400	0.198
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CYCLIN_RxL_1	47	59	PF00134	0.403
DOC_MAPK_DCC_7	87	96	PF00069	0.478
DOC_MAPK_gen_1	189	195	PF00069	0.471
DOC_MAPK_HePTP_8	84	96	PF00069	0.476
DOC_MAPK_MEF2A_6	87	96	PF00069	0.488
DOC_USP7_MATH_1	175	179	PF00917	0.461
DOC_USP7_MATH_1	375	379	PF00917	0.607
DOC_USP7_MATH_1	384	388	PF00917	0.677
DOC_USP7_MATH_1	394	398	PF00917	0.592
DOC_USP7_UBL2_3	83	87	PF12436	0.353
DOC_WW_Pin1_4	149	154	PF00397	0.466
DOC_WW_Pin1_4	385	390	PF00397	0.762
DOC_WW_Pin1_4	59	64	PF00397	0.512
LIG_14-3-3_CanoR_1	133	140	PF00244	0.526
LIG_14-3-3_CanoR_1	181	185	PF00244	0.379
LIG_14-3-3_CanoR_1	270	279	PF00244	0.398
LIG_14-3-3_CanoR_1	28	36	PF00244	0.372
LIG_14-3-3_CanoR_1	313	320	PF00244	0.405
LIG_14-3-3_CanoR_1	47	55	PF00244	0.450
LIG_14-3-3_CanoR_1	58	63	PF00244	0.462
LIG_APCC_ABBA_1	258	263	PF00400	0.555
LIG_APCC_ABBA_1	36	41	PF00400	0.384
LIG_BRCT_BRCA1_1	23	27	PF00533	0.260
LIG_BRCT_BRCA1_1	314	318	PF00533	0.451
LIG_BRCT_BRCA1_1	7	11	PF00533	0.522
LIG_BRCT_BRCA1_2	7	13	PF00533	0.500
LIG_CaM_IQ_9	208	223	PF13499	0.452
LIG_eIF4E_1	230	236	PF01652	0.506
LIG_FHA_1	142	148	PF00498	0.412
LIG_FHA_1	213	219	PF00498	0.313
LIG_FHA_1	272	278	PF00498	0.454
LIG_FHA_1	59	65	PF00498	0.454
LIG_FHA_1	70	76	PF00498	0.317
LIG_FHA_2	291	297	PF00498	0.487
LIG_LIR_Gen_1	152	158	PF02991	0.532
LIG_LIR_Gen_1	183	191	PF02991	0.348
LIG_LIR_Gen_1	209	219	PF02991	0.431
LIG_LIR_Nem_3	166	172	PF02991	0.524
LIG_LIR_Nem_3	209	214	PF02991	0.326
LIG_LIR_Nem_3	8	14	PF02991	0.542
LIG_MLH1_MIPbox_1	23	27	PF16413	0.260
LIG_Pex14_2	163	167	PF04695	0.404
LIG_Pex14_2	318	322	PF04695	0.328
LIG_PTB_Apo_2	200	207	PF02174	0.463
LIG_REV1ctd_RIR_1	24	32	PF16727	0.269
LIG_SH2_CRK	320	324	PF00017	0.342
LIG_SH2_STAP1	154	158	PF00017	0.450
LIG_SH2_STAT5	116	119	PF00017	0.301
LIG_SH2_STAT5	261	264	PF00017	0.533
LIG_SH3_5	226	230	PF00018	0.470
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.445
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.482
LIG_SUMO_SIM_par_1	290	296	PF11976	0.430
LIG_SUMO_SIM_par_1	326	332	PF11976	0.482
LIG_SUMO_SIM_par_1	76	82	PF11976	0.400
LIG_TRAF2_1	183	186	PF00917	0.399
LIG_TRAF2_1	299	302	PF00917	0.438
LIG_TYR_ITIM	259	264	PF00017	0.341
MOD_CDK_SPxxK_3	149	156	PF00069	0.464
MOD_CDK_SPxxK_3	385	392	PF00069	0.613
MOD_CK1_1	141	147	PF00069	0.581
MOD_CK1_1	312	318	PF00069	0.288
MOD_CK1_1	59	65	PF00069	0.485
MOD_CK1_1	82	88	PF00069	0.381
MOD_CK2_1	133	139	PF00069	0.538
MOD_CK2_1	180	186	PF00069	0.362
MOD_CK2_1	290	296	PF00069	0.217
MOD_CK2_1	326	332	PF00069	0.482
MOD_CK2_1	400	406	PF00069	0.591
MOD_GlcNHglycan	121	124	PF01048	0.299
MOD_GlcNHglycan	135	138	PF01048	0.371
MOD_GlcNHglycan	231	234	PF01048	0.421
MOD_GlcNHglycan	314	317	PF01048	0.456
MOD_GlcNHglycan	381	384	PF01048	0.653
MOD_GSK3_1	129	136	PF00069	0.439
MOD_GSK3_1	17	24	PF00069	0.360
MOD_GSK3_1	375	382	PF00069	0.661
MOD_GSK3_1	39	46	PF00069	0.427
MOD_GSK3_1	396	403	PF00069	0.734
MOD_GSK3_1	54	61	PF00069	0.564
MOD_GSK3_1	69	76	PF00069	0.330
MOD_GSK3_1	79	86	PF00069	0.332
MOD_N-GLC_1	265	270	PF02516	0.274
MOD_N-GLC_1	271	276	PF02516	0.273
MOD_NEK2_1	119	124	PF00069	0.303
MOD_NEK2_1	193	198	PF00069	0.410
MOD_NEK2_1	2	7	PF00069	0.536
MOD_NEK2_1	309	314	PF00069	0.459
MOD_NEK2_1	43	48	PF00069	0.489
MOD_NEK2_1	54	59	PF00069	0.327
MOD_NEK2_1	79	84	PF00069	0.533
MOD_PIKK_1	46	52	PF00454	0.407
MOD_PKA_2	180	186	PF00069	0.361
MOD_PKA_2	2	8	PF00069	0.637
MOD_PKA_2	212	218	PF00069	0.330
MOD_PKA_2	312	318	PF00069	0.468
MOD_PKA_2	400	406	PF00069	0.725
MOD_PKA_2	46	52	PF00069	0.450
MOD_Plk_1	39	45	PF00069	0.494
MOD_Plk_2-3	326	332	PF00069	0.482
MOD_Plk_4	278	284	PF00069	0.371
MOD_Plk_4	39	45	PF00069	0.340
MOD_Plk_4	74	80	PF00069	0.303
MOD_ProDKin_1	149	155	PF00069	0.462
MOD_ProDKin_1	385	391	PF00069	0.759
MOD_ProDKin_1	59	65	PF00069	0.511
MOD_SUMO_for_1	206	209	PF00179	0.482
MOD_SUMO_rev_2	369	378	PF00179	0.618
TRG_DiLeu_BaEn_1	142	147	PF01217	0.368
TRG_DiLeu_BaEn_4	363	369	PF01217	0.539
TRG_ENDOCYTIC_2	116	119	PF00928	0.283
TRG_ENDOCYTIC_2	154	157	PF00928	0.452
TRG_ENDOCYTIC_2	184	187	PF00928	0.372
TRG_ENDOCYTIC_2	261	264	PF00928	0.406
TRG_ENDOCYTIC_2	320	323	PF00928	0.337
TRG_ER_diArg_1	2	4	PF00400	0.664
TRG_ER_diArg_1	237	239	PF00400	0.277
TRG_ER_diArg_1	240	243	PF00400	0.272
TRG_ER_diArg_1	244	246	PF00400	0.267
TRG_ER_diArg_1	358	360	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL6	Leptomonas seymouri	68%	100%
A0A0S4JNX3	Bodo saltans	50%	100%
A0A1X0P9L0	Trypanosomatidae	60%	100%
A4H888	Leishmania braziliensis	86%	100%
A4HWL1	Leishmania infantum	100%	100%
C9ZMN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QF56	Leishmania major	94%	100%
V5BKH7	Trypanosoma cruzi	62%	100%