Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6V5_LEIDO

TriTrypDb:

LdBPK_151150.1 , LdCL_150017000 , LDHU3_15.1450

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005634	nucleus	5	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1

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Expansion

Sequence features

A0A3S5H6V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6V5

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006383	transcription by RNA polymerase III	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0000992	RNA polymerase III cis-regulatory region sequence-specific DNA binding	7	1
GO:0000995	RNA polymerase III general transcription initiation factor activity	2	1
GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	8	1
GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.490
CLV_NRD_NRD_1	141	143	PF00675	0.438
CLV_NRD_NRD_1	162	164	PF00675	0.341
CLV_NRD_NRD_1	209	211	PF00675	0.335
CLV_NRD_NRD_1	406	408	PF00675	0.801
CLV_PCSK_KEX2_1	141	143	PF00082	0.426
CLV_PCSK_KEX2_1	162	164	PF00082	0.352
CLV_PCSK_KEX2_1	209	211	PF00082	0.335
CLV_PCSK_KEX2_1	408	410	PF00082	0.694
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.694

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I166	Leptomonas seymouri	68%	100%
A0A1X0NU06	Trypanosomatidae	37%	100%
A0A3R7MLE9	Trypanosoma rangeli	40%	100%
A4H880	Leishmania braziliensis	84%	100%
A4HWK6	Leishmania infantum	100%	100%
C9ZXT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QF67	Leishmania major	95%	100%
V5BK49	Trypanosoma cruzi	38%	100%

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