Ubiquitin-like modifier-activating enzyme 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NAD/FAD dependent dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6V3_LEIDO

TriTrypDb:

LdBPK_151030.1 , LdCL_150015800 , LDHU3_15.1320

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6V3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071569	protein ufmylation	7	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	12
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0071566	UFM1 activating enzyme activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.806
CLV_C14_Caspase3-7	368	372	PF00656	0.795
CLV_NRD_NRD_1	286	288	PF00675	0.518
CLV_NRD_NRD_1	299	301	PF00675	0.539
CLV_PCSK_KEX2_1	10	12	PF00082	0.665
CLV_PCSK_KEX2_1	212	214	PF00082	0.408
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.665
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.408
CLV_PCSK_SKI1_1	238	242	PF00082	0.365
CLV_PCSK_SKI1_1	271	275	PF00082	0.564
CLV_PCSK_SKI1_1	380	384	PF00082	0.814
CLV_PCSK_SKI1_1	68	72	PF00082	0.424
DEG_SCF_FBW7_2	190	197	PF00400	0.424
DEG_SPOP_SBC_1	2	6	PF00917	0.753
DOC_CYCLIN_RxL_1	235	245	PF00134	0.375
DOC_CYCLIN_RxL_1	63	76	PF00134	0.408
DOC_MAPK_MEF2A_6	256	264	PF00069	0.424
DOC_PP1_RVXF_1	66	73	PF00149	0.408
DOC_PP2B_LxvP_1	187	190	PF13499	0.408
DOC_PP4_FxxP_1	86	89	PF00568	0.408
DOC_USP7_MATH_1	2	6	PF00917	0.753
DOC_USP7_MATH_1	385	389	PF00917	0.666
DOC_WW_Pin1_4	136	141	PF00397	0.455
DOC_WW_Pin1_4	190	195	PF00397	0.408
DOC_WW_Pin1_4	3	8	PF00397	0.784
LIG_14-3-3_CanoR_1	157	161	PF00244	0.408
LIG_Clathr_ClatBox_1	69	73	PF01394	0.493
LIG_deltaCOP1_diTrp_1	124	129	PF00928	0.408
LIG_FHA_1	157	163	PF00498	0.485
LIG_FHA_1	164	170	PF00498	0.493
LIG_FHA_1	222	228	PF00498	0.408
LIG_FHA_2	109	115	PF00498	0.441
LIG_FHA_2	119	125	PF00498	0.355
LIG_FHA_2	366	372	PF00498	0.780
LIG_IBAR_NPY_1	20	22	PF08397	0.523
LIG_LIR_Apic_2	166	170	PF02991	0.493
LIG_LIR_Gen_1	123	133	PF02991	0.408
LIG_LIR_Gen_1	19	28	PF02991	0.424
LIG_LIR_Gen_1	35	45	PF02991	0.224
LIG_LIR_Gen_1	378	389	PF02991	0.707
LIG_LIR_Gen_1	73	82	PF02991	0.399
LIG_LIR_Nem_3	123	129	PF02991	0.396
LIG_LIR_Nem_3	19	25	PF02991	0.424
LIG_LIR_Nem_3	247	252	PF02991	0.408
LIG_LIR_Nem_3	257	262	PF02991	0.408
LIG_LIR_Nem_3	35	40	PF02991	0.224
LIG_LIR_Nem_3	73	77	PF02991	0.408
LIG_NRBOX	236	242	PF00104	0.377
LIG_PCNA_PIPBox_1	225	234	PF02747	0.442
LIG_PCNA_PIPBox_1	79	88	PF02747	0.523
LIG_SH2_CRK	22	26	PF00017	0.424
LIG_SH2_NCK_1	74	78	PF00017	0.408
LIG_SH2_SRC	363	366	PF00017	0.687
LIG_SH2_STAP1	22	26	PF00017	0.424
LIG_SH2_STAP1	282	286	PF00017	0.588
LIG_SH2_STAT3	239	242	PF00017	0.477
LIG_SH2_STAT5	239	242	PF00017	0.408
LIG_SH2_STAT5	249	252	PF00017	0.408
LIG_SH2_STAT5	297	300	PF00017	0.471
LIG_SH2_STAT5	381	384	PF00017	0.814
LIG_SH3_3	109	115	PF00018	0.528
LIG_SH3_3	137	143	PF00018	0.465
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.424
LIG_SUMO_SIM_par_1	200	206	PF11976	0.408
LIG_TRAF2_1	388	391	PF00917	0.692
LIG_TYR_ITAM	19	40	PF00017	0.442
LIG_UBA3_1	392	397	PF00899	0.629
MOD_CDK_SPxxK_3	3	10	PF00069	0.776
MOD_CK1_1	139	145	PF00069	0.555
MOD_CK1_1	220	226	PF00069	0.397
MOD_CK2_1	108	114	PF00069	0.464
MOD_CK2_1	118	124	PF00069	0.393
MOD_CK2_1	350	356	PF00069	0.752
MOD_CK2_1	385	391	PF00069	0.694
MOD_GlcNHglycan	12	15	PF01048	0.646
MOD_GlcNHglycan	173	176	PF01048	0.408
MOD_GlcNHglycan	181	184	PF01048	0.402
MOD_GlcNHglycan	340	343	PF01048	0.773
MOD_GlcNHglycan	358	361	PF01048	0.680
MOD_GSK3_1	127	134	PF00069	0.503
MOD_GSK3_1	217	224	PF00069	0.394
MOD_N-GLC_1	118	123	PF02516	0.493
MOD_NEK2_1	350	355	PF00069	0.602
MOD_NEK2_2	233	238	PF00069	0.442
MOD_PKA_1	10	16	PF00069	0.652
MOD_PKA_2	10	16	PF00069	0.698
MOD_PKA_2	127	133	PF00069	0.555
MOD_PKA_2	156	162	PF00069	0.408
MOD_Plk_1	325	331	PF00069	0.689
MOD_Plk_2-3	36	42	PF00069	0.555
MOD_Plk_2-3	73	79	PF00069	0.528
MOD_Plk_4	108	114	PF00069	0.528
MOD_Plk_4	52	58	PF00069	0.411
MOD_ProDKin_1	136	142	PF00069	0.455
MOD_ProDKin_1	190	196	PF00069	0.408
MOD_ProDKin_1	3	9	PF00069	0.780
MOD_SUMO_for_1	211	214	PF00179	0.424
MOD_SUMO_rev_2	257	266	PF00179	0.555
MOD_SUMO_rev_2	326	336	PF00179	0.755
MOD_SUMO_rev_2	376	382	PF00179	0.788
TRG_ENDOCYTIC_2	22	25	PF00928	0.424
TRG_ENDOCYTIC_2	252	255	PF00928	0.394
TRG_ENDOCYTIC_2	37	40	PF00928	0.424
TRG_ENDOCYTIC_2	381	384	PF00928	0.600
TRG_ENDOCYTIC_2	74	77	PF00928	0.408
TRG_NLS_Bipartite_1	287	304	PF00514	0.502
TRG_NLS_MonoExtC_3	299	305	PF00514	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F3	Leptomonas seymouri	76%	94%
A0A0N0P8E8	Leptomonas seymouri	24%	88%
A0A0S4JGN9	Bodo saltans	72%	96%
A0A1X0NTY2	Trypanosomatidae	71%	99%
A0A3R7JZ58	Trypanosoma rangeli	72%	100%
A0A422NC72	Trypanosoma rangeli	29%	81%
A1A4L8	Bos taurus	27%	88%
A2BDX3	Mus musculus	27%	87%
A4H870	Leishmania braziliensis	87%	100%
A4HWJ5	Leishmania infantum	100%	100%
A5DSR2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	24%	88%
A6ZT19	Saccharomyces cerevisiae (strain YJM789)	23%	91%
A7MAZ3	Bos taurus	49%	99%
A8XEQ8	Caenorhabditis briggsae	62%	93%
B0WQV1	Culex quinquefasciatus	48%	100%
B3LSM6	Saccharomyces cerevisiae (strain RM11-1a)	23%	91%
B3NUC9	Drosophila erecta	50%	100%
B4GKQ3	Drosophila persimilis	30%	89%
B4GYC7	Drosophila persimilis	48%	100%
B4IK21	Drosophila sechellia	51%	99%
B4JIY0	Drosophila grimshawi	48%	100%
B4KI53	Drosophila mojavensis	26%	88%
B4L1K2	Drosophila mojavensis	50%	100%
B4M357	Drosophila virilis	61%	100%
B4NDE5	Drosophila willistoni	60%	99%
B4PYA4	Drosophila yakuba	51%	99%
B4R345	Drosophila simulans	51%	99%
B5DS72	Drosophila pseudoobscura pseudoobscura	29%	89%
B5VK45	Saccharomyces cerevisiae (strain AWRI1631)	23%	91%
B9VJ80	Bombyx mori	61%	100%
C3YZ51	Branchiostoma floridae	50%	99%
C9ZXU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
D0A640	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
D1GY43	Drosophila ananassae	62%	100%
E9AQ96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O23034	Arabidopsis thaliana	61%	93%
P38820	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	91%
P91430	Caenorhabditis elegans	62%	95%
Q17DT0	Aedes aegypti	62%	100%
Q29HT0	Drosophila pseudoobscura pseudoobscura	50%	100%
Q29PG5	Drosophila pseudoobscura pseudoobscura	29%	89%
Q3KQ23	Xenopus laevis	61%	100%
Q4QF87	Leishmania major	94%	100%
Q54C02	Dictyostelium discoideum	61%	100%
Q5M7A4	Rattus norvegicus	62%	99%
Q5R8X4	Pongo abelii	62%	99%
Q6BHZ2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	89%
Q6GLG7	Xenopus tropicalis	62%	100%
Q6IVA4	Gallus gallus	60%	100%
Q6K6K7	Oryza sativa subsp. japonica	62%	95%
Q8AWD2	Danio rerio	25%	87%
Q8VE47	Mus musculus	60%	99%
Q9GZZ9	Homo sapiens	62%	99%
Q9VYY3	Drosophila melanogaster	51%	99%
V5BPQ6	Trypanosoma cruzi	68%	100%
X1WER2	Danio rerio	49%	100%