Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6V1_LEIDO

TriTrypDb:

LdBPK_150910.1 , LdCL_150014600 , LDHU3_15.1170

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.704
CLV_NRD_NRD_1	161	163	PF00675	0.523
CLV_NRD_NRD_1	226	228	PF00675	0.512
CLV_NRD_NRD_1	24	26	PF00675	0.558
CLV_NRD_NRD_1	398	400	PF00675	0.611
CLV_NRD_NRD_1	451	453	PF00675	0.622
CLV_NRD_NRD_1	46	48	PF00675	0.610
CLV_NRD_NRD_1	475	477	PF00675	0.540
CLV_NRD_NRD_1	52	54	PF00675	0.577
CLV_NRD_NRD_1	595	597	PF00675	0.556
CLV_NRD_NRD_1	603	605	PF00675	0.324
CLV_NRD_NRD_1	648	650	PF00675	0.576
CLV_NRD_NRD_1	654	656	PF00675	0.546
CLV_NRD_NRD_1	657	659	PF00675	0.522
CLV_NRD_NRD_1	716	718	PF00675	0.533
CLV_NRD_NRD_1	958	960	PF00675	0.638
CLV_PCSK_FUR_1	655	659	PF00082	0.609
CLV_PCSK_KEX2_1	161	163	PF00082	0.523
CLV_PCSK_KEX2_1	226	228	PF00082	0.492
CLV_PCSK_KEX2_1	272	274	PF00082	0.519
CLV_PCSK_KEX2_1	41	43	PF00082	0.615
CLV_PCSK_KEX2_1	46	48	PF00082	0.630
CLV_PCSK_KEX2_1	51	53	PF00082	0.522
CLV_PCSK_KEX2_1	595	597	PF00082	0.556
CLV_PCSK_KEX2_1	603	605	PF00082	0.324
CLV_PCSK_KEX2_1	648	650	PF00082	0.579
CLV_PCSK_KEX2_1	654	656	PF00082	0.549
CLV_PCSK_KEX2_1	657	659	PF00082	0.525
CLV_PCSK_KEX2_1	716	718	PF00082	0.526
CLV_PCSK_KEX2_1	958	960	PF00082	0.638
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.464
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.618
CLV_PCSK_PC7_1	268	274	PF00082	0.530
CLV_PCSK_PC7_1	42	48	PF00082	0.638
CLV_PCSK_SKI1_1	164	168	PF00082	0.520
CLV_PCSK_SKI1_1	227	231	PF00082	0.614
CLV_PCSK_SKI1_1	31	35	PF00082	0.603
CLV_PCSK_SKI1_1	46	50	PF00082	0.552
CLV_PCSK_SKI1_1	632	636	PF00082	0.411
CLV_PCSK_SKI1_1	687	691	PF00082	0.525
CLV_PCSK_SKI1_1	699	703	PF00082	0.519
CLV_PCSK_SKI1_1	716	720	PF00082	0.593
CLV_PCSK_SKI1_1	834	838	PF00082	0.563
CLV_PCSK_SKI1_1	959	963	PF00082	0.582
DEG_APCC_DBOX_1	163	171	PF00400	0.722
DEG_SPOP_SBC_1	463	467	PF00917	0.769
DOC_ANK_TNKS_1	647	654	PF00023	0.645
DOC_CYCLIN_RxL_1	632	641	PF00134	0.436
DOC_CYCLIN_RxL_1	696	706	PF00134	0.749
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.636
DOC_MAPK_gen_1	603	610	PF00069	0.619
DOC_MAPK_MEF2A_6	603	612	PF00069	0.546
DOC_PP1_RVXF_1	266	272	PF00149	0.748
DOC_PP1_RVXF_1	7	13	PF00149	0.734
DOC_PP2B_LxvP_1	307	310	PF13499	0.650
DOC_PP2B_LxvP_1	907	910	PF13499	0.725
DOC_PP2B_PxIxI_1	824	830	PF00149	0.683
DOC_USP7_MATH_1	119	123	PF00917	0.789
DOC_USP7_MATH_1	133	137	PF00917	0.706
DOC_USP7_MATH_1	247	251	PF00917	0.703
DOC_USP7_MATH_1	343	347	PF00917	0.694
DOC_USP7_MATH_1	507	511	PF00917	0.676
DOC_USP7_MATH_1	57	61	PF00917	0.823
DOC_USP7_MATH_1	581	585	PF00917	0.735
DOC_USP7_MATH_1	707	711	PF00917	0.791
DOC_USP7_MATH_1	77	81	PF00917	0.619
DOC_USP7_MATH_1	855	859	PF00917	0.799
DOC_USP7_MATH_1	910	914	PF00917	0.828
DOC_USP7_MATH_1	927	931	PF00917	0.649
DOC_USP7_UBL2_3	31	35	PF12436	0.830
DOC_USP7_UBL2_3	37	41	PF12436	0.798
DOC_WW_Pin1_4	135	140	PF00397	0.761
DOC_WW_Pin1_4	330	335	PF00397	0.759
DOC_WW_Pin1_4	429	434	PF00397	0.780
DOC_WW_Pin1_4	510	515	PF00397	0.753
DOC_WW_Pin1_4	53	58	PF00397	0.790
DOC_WW_Pin1_4	791	796	PF00397	0.679
DOC_WW_Pin1_4	858	863	PF00397	0.720
DOC_WW_Pin1_4	951	956	PF00397	0.726
LIG_14-3-3_CanoR_1	118	128	PF00244	0.733
LIG_14-3-3_CanoR_1	161	167	PF00244	0.696
LIG_14-3-3_CanoR_1	25	33	PF00244	0.737
LIG_14-3-3_CanoR_1	282	286	PF00244	0.744
LIG_14-3-3_CanoR_1	3	10	PF00244	0.793
LIG_14-3-3_CanoR_1	461	469	PF00244	0.750
LIG_14-3-3_CanoR_1	476	485	PF00244	0.710
LIG_14-3-3_CanoR_1	583	591	PF00244	0.709
LIG_14-3-3_CanoR_1	614	619	PF00244	0.453
LIG_14-3-3_CanoR_1	620	626	PF00244	0.551
LIG_14-3-3_CanoR_1	752	760	PF00244	0.826
LIG_Actin_WH2_2	829	844	PF00022	0.759
LIG_BRCT_BRCA1_1	180	184	PF00533	0.740
LIG_BRCT_BRCA1_1	277	281	PF00533	0.712
LIG_BRCT_BRCA1_1	321	325	PF00533	0.724
LIG_CaM_IQ_9	156	171	PF13499	0.727
LIG_DCNL_PONY_1	1	4	PF03556	0.736
LIG_deltaCOP1_diTrp_1	316	325	PF00928	0.643
LIG_FHA_1	580	586	PF00498	0.780
LIG_FHA_1	79	85	PF00498	0.828
LIG_FHA_1	814	820	PF00498	0.751
LIG_FHA_1	99	105	PF00498	0.574
LIG_FHA_2	409	415	PF00498	0.847
LIG_FHA_2	733	739	PF00498	0.768
LIG_FHA_2	792	798	PF00498	0.689
LIG_FHA_2	869	875	PF00498	0.708
LIG_LIR_Gen_1	316	325	PF02991	0.643
LIG_LIR_Gen_1	375	383	PF02991	0.645
LIG_LIR_Gen_1	420	430	PF02991	0.807
LIG_LIR_Gen_1	570	581	PF02991	0.777
LIG_LIR_Gen_1	823	832	PF02991	0.684
LIG_LIR_Gen_1	846	856	PF02991	0.698
LIG_LIR_Gen_1	892	900	PF02991	0.695
LIG_LIR_Nem_3	181	187	PF02991	0.667
LIG_LIR_Nem_3	316	321	PF02991	0.640
LIG_LIR_Nem_3	340	344	PF02991	0.747
LIG_LIR_Nem_3	375	381	PF02991	0.640
LIG_LIR_Nem_3	420	426	PF02991	0.810
LIG_LIR_Nem_3	570	576	PF02991	0.617
LIG_LIR_Nem_3	633	638	PF02991	0.411
LIG_LIR_Nem_3	697	701	PF02991	0.748
LIG_LIR_Nem_3	775	780	PF02991	0.721
LIG_LIR_Nem_3	823	829	PF02991	0.684
LIG_LIR_Nem_3	846	851	PF02991	0.690
LIG_LIR_Nem_3	892	898	PF02991	0.691
LIG_LYPXL_yS_3	341	344	PF13949	0.676
LIG_MYND_1	951	955	PF01753	0.658
LIG_PCNA_yPIPBox_3	158	167	PF02747	0.666
LIG_Pex14_1	881	885	PF04695	0.657
LIG_Pex14_1	945	949	PF04695	0.775
LIG_PROFILIN_1	139	145	PF00235	0.767
LIG_Rb_LxCxE_1	815	833	PF01857	0.622
LIG_REV1ctd_RIR_1	632	640	PF16727	0.436
LIG_SH2_PTP2	784	787	PF00017	0.632
LIG_SH2_PTP2	826	829	PF00017	0.681
LIG_SH2_SRC	209	212	PF00017	0.719
LIG_SH2_SRC	693	696	PF00017	0.743
LIG_SH2_SRC	784	787	PF00017	0.632
LIG_SH2_STAP1	365	369	PF00017	0.698
LIG_SH2_STAT3	365	368	PF00017	0.698
LIG_SH2_STAT5	392	395	PF00017	0.773
LIG_SH2_STAT5	442	445	PF00017	0.737
LIG_SH2_STAT5	784	787	PF00017	0.640
LIG_SH2_STAT5	801	804	PF00017	0.748
LIG_SH2_STAT5	826	829	PF00017	0.681
LIG_SH2_STAT5	848	851	PF00017	0.762
LIG_SH3_3	136	142	PF00018	0.814
LIG_SH3_3	174	180	PF00018	0.677
LIG_SH3_3	336	342	PF00018	0.673
LIG_SH3_3	402	408	PF00018	0.801
LIG_SH3_3	71	77	PF00018	0.735
LIG_SH3_3	757	763	PF00018	0.770
LIG_SH3_3	909	915	PF00018	0.745
LIG_SUMO_SIM_par_1	169	176	PF11976	0.761
LIG_SUMO_SIM_par_1	501	508	PF11976	0.727
LIG_TRAF2_1	412	415	PF00917	0.773
LIG_TRAF2_1	794	797	PF00917	0.691
LIG_TYR_ITIM	339	344	PF00017	0.584
LIG_TYR_ITIM	782	787	PF00017	0.541
LIG_WRC_WIRS_1	631	636	PF05994	0.411
LIG_WW_3	908	912	PF00397	0.711
MOD_CDK_SPxxK_3	951	958	PF00069	0.669
MOD_CK1_1	120	126	PF00069	0.814
MOD_CK1_1	254	260	PF00069	0.787
MOD_CK1_1	333	339	PF00069	0.612
MOD_CK1_1	394	400	PF00069	0.714
MOD_CK1_1	446	452	PF00069	0.714
MOD_CK1_1	462	468	PF00069	0.626
MOD_CK1_1	5	11	PF00069	0.748
MOD_CK1_1	502	508	PF00069	0.717
MOD_CK1_1	510	516	PF00069	0.684
MOD_CK1_1	56	62	PF00069	0.764
MOD_CK1_1	754	760	PF00069	0.759
MOD_CK1_1	858	864	PF00069	0.691
MOD_CK2_1	228	234	PF00069	0.795
MOD_CK2_1	323	329	PF00069	0.673
MOD_CK2_1	408	414	PF00069	0.752
MOD_CK2_1	462	468	PF00069	0.650
MOD_CK2_1	56	62	PF00069	0.762
MOD_CK2_1	702	708	PF00069	0.695
MOD_CK2_1	732	738	PF00069	0.735
MOD_CK2_1	791	797	PF00069	0.615
MOD_CK2_1	868	874	PF00069	0.648
MOD_Cter_Amidation	23	26	PF01082	0.785
MOD_Cter_Amidation	552	555	PF01082	0.748
MOD_Cter_Amidation	652	655	PF01082	0.708
MOD_GlcNHglycan	105	108	PF01048	0.788
MOD_GlcNHglycan	119	122	PF01048	0.584
MOD_GlcNHglycan	131	134	PF01048	0.647
MOD_GlcNHglycan	180	183	PF01048	0.585
MOD_GlcNHglycan	188	191	PF01048	0.573
MOD_GlcNHglycan	258	261	PF01048	0.738
MOD_GlcNHglycan	335	338	PF01048	0.619
MOD_GlcNHglycan	393	396	PF01048	0.736
MOD_GlcNHglycan	4	7	PF01048	0.679
MOD_GlcNHglycan	42	45	PF01048	0.850
MOD_GlcNHglycan	445	448	PF01048	0.746
MOD_GlcNHglycan	461	464	PF01048	0.543
MOD_GlcNHglycan	468	472	PF01048	0.787
MOD_GlcNHglycan	479	482	PF01048	0.504
MOD_GlcNHglycan	488	491	PF01048	0.492
MOD_GlcNHglycan	509	512	PF01048	0.676
MOD_GlcNHglycan	522	525	PF01048	0.738
MOD_GlcNHglycan	585	588	PF01048	0.610
MOD_GlcNHglycan	705	708	PF01048	0.736
MOD_GlcNHglycan	709	712	PF01048	0.731
MOD_GlcNHglycan	753	756	PF01048	0.699
MOD_GlcNHglycan	857	860	PF01048	0.661
MOD_GlcNHglycan	912	915	PF01048	0.788
MOD_GlcNHglycan	929	932	PF01048	0.587
MOD_GlcNHglycan	936	939	PF01048	0.717
MOD_GSK3_1	120	127	PF00069	0.754
MOD_GSK3_1	129	136	PF00069	0.742
MOD_GSK3_1	150	157	PF00069	0.709
MOD_GSK3_1	241	248	PF00069	0.808
MOD_GSK3_1	251	258	PF00069	0.701
MOD_GSK3_1	294	301	PF00069	0.731
MOD_GSK3_1	305	312	PF00069	0.652
MOD_GSK3_1	319	326	PF00069	0.574
MOD_GSK3_1	333	340	PF00069	0.479
MOD_GSK3_1	391	398	PF00069	0.694
MOD_GSK3_1	42	49	PF00069	0.779
MOD_GSK3_1	429	436	PF00069	0.680
MOD_GSK3_1	455	462	PF00069	0.720
MOD_GSK3_1	463	470	PF00069	0.707
MOD_GSK3_1	498	505	PF00069	0.686
MOD_GSK3_1	53	60	PF00069	0.663
MOD_GSK3_1	579	586	PF00069	0.741
MOD_GSK3_1	703	710	PF00069	0.765
MOD_GSK3_1	787	794	PF00069	0.604
MOD_GSK3_1	923	930	PF00069	0.821
MOD_GSK3_1	98	105	PF00069	0.675
MOD_N-GLC_1	621	626	PF02516	0.621
MOD_N-GLC_1	702	707	PF02516	0.662
MOD_N-GLC_2	419	421	PF02516	0.679
MOD_NEK2_1	103	108	PF00069	0.670
MOD_NEK2_1	2	7	PF00069	0.764
MOD_NEK2_1	281	286	PF00069	0.681
MOD_NEK2_1	288	293	PF00069	0.617
MOD_NEK2_1	319	324	PF00069	0.542
MOD_NEK2_1	33	38	PF00069	0.673
MOD_NEK2_1	381	386	PF00069	0.733
MOD_NEK2_1	393	398	PF00069	0.685
MOD_NEK2_1	443	448	PF00069	0.744
MOD_NEK2_1	455	460	PF00069	0.594
MOD_NEK2_1	475	480	PF00069	0.520
MOD_NEK2_1	485	490	PF00069	0.566
MOD_NEK2_1	498	503	PF00069	0.746
MOD_NEK2_1	572	577	PF00069	0.653
MOD_NEK2_1	623	628	PF00069	0.652
MOD_NEK2_1	638	643	PF00069	0.324
MOD_NEK2_1	701	706	PF00069	0.732
MOD_NEK2_1	773	778	PF00069	0.633
MOD_NEK2_1	849	854	PF00069	0.606
MOD_NEK2_2	630	635	PF00069	0.436
MOD_NEK2_2	868	873	PF00069	0.631
MOD_OFUCOSY	293	298	PF10250	0.595
MOD_PIKK_1	275	281	PF00454	0.612
MOD_PK_1	150	156	PF00069	0.645
MOD_PK_1	25	31	PF00069	0.810
MOD_PKA_1	25	31	PF00069	0.810
MOD_PKA_1	46	52	PF00069	0.801
MOD_PKA_1	554	560	PF00069	0.712
MOD_PKA_2	114	120	PF00069	0.778
MOD_PKA_2	2	8	PF00069	0.760
MOD_PKA_2	24	30	PF00069	0.656
MOD_PKA_2	281	287	PF00069	0.584
MOD_PKA_2	381	387	PF00069	0.635
MOD_PKA_2	46	52	PF00069	0.825
MOD_PKA_2	475	481	PF00069	0.696
MOD_PKA_2	60	66	PF00069	0.602
MOD_PKA_2	613	619	PF00069	0.399
MOD_PKA_2	751	757	PF00069	0.812
MOD_PKA_2	910	916	PF00069	0.735
MOD_PKB_1	356	364	PF00069	0.434
MOD_Plk_1	301	307	PF00069	0.743
MOD_Plk_1	455	461	PF00069	0.717
MOD_Plk_1	621	627	PF00069	0.619
MOD_Plk_1	672	678	PF00069	0.561
MOD_Plk_2-3	228	234	PF00069	0.717
MOD_Plk_2-3	672	678	PF00069	0.561
MOD_Plk_4	124	130	PF00069	0.658
MOD_Plk_4	281	287	PF00069	0.686
MOD_Plk_4	319	325	PF00069	0.525
MOD_Plk_4	343	349	PF00069	0.689
MOD_Plk_4	499	505	PF00069	0.764
MOD_Plk_4	572	578	PF00069	0.656
MOD_Plk_4	60	66	PF00069	0.620
MOD_Plk_4	614	620	PF00069	0.374
MOD_Plk_4	732	738	PF00069	0.706
MOD_Plk_4	876	882	PF00069	0.588
MOD_ProDKin_1	135	141	PF00069	0.706
MOD_ProDKin_1	330	336	PF00069	0.713
MOD_ProDKin_1	429	435	PF00069	0.739
MOD_ProDKin_1	510	516	PF00069	0.704
MOD_ProDKin_1	53	59	PF00069	0.752
MOD_ProDKin_1	791	797	PF00069	0.600
MOD_ProDKin_1	858	864	PF00069	0.655
MOD_ProDKin_1	951	957	PF00069	0.666
TRG_DiLeu_BaEn_1	824	829	PF01217	0.603
TRG_DiLeu_BaEn_2	315	321	PF01217	0.637
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.691
TRG_ENDOCYTIC_2	341	344	PF00928	0.594
TRG_ENDOCYTIC_2	378	381	PF00928	0.768
TRG_ENDOCYTIC_2	631	634	PF00928	0.407
TRG_ENDOCYTIC_2	784	787	PF00928	0.531
TRG_ENDOCYTIC_2	826	829	PF00928	0.546
TRG_ENDOCYTIC_2	848	851	PF00928	0.714
TRG_ER_diArg_1	161	164	PF00400	0.660
TRG_ER_diArg_1	46	48	PF00400	0.791
TRG_ER_diArg_1	51	53	PF00400	0.766
TRG_ER_diArg_1	595	597	PF00400	0.706
TRG_ER_diArg_1	602	604	PF00400	0.585
TRG_ER_diArg_1	647	649	PF00400	0.735
TRG_ER_diArg_1	654	657	PF00400	0.690
TRG_ER_diArg_1	715	717	PF00400	0.727
TRG_ER_diArg_1	840	843	PF00400	0.711
TRG_ER_diArg_1	957	959	PF00400	0.725
TRG_NLS_MonoExtN_4	31	38	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.717
TRG_Pf-PMV_PEXEL_1	717	722	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL01	Leptomonas seymouri	36%	100%
A4H857	Leishmania braziliensis	72%	98%
A4HWI3	Leishmania infantum	100%	100%
E9AQ84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QF99	Leishmania major	87%	99%