Flavoprotein monooxygenase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein monooxygenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6U9_LEIDO

TriTrypDb:

LdBPK_150760.1 , LdCL_150012600 , LDHU3_15.0950

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6U9

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	10
GO:0016491	oxidoreductase activity	2	10
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	563	567	PF00656	0.455
CLV_NRD_NRD_1	141	143	PF00675	0.445
CLV_NRD_NRD_1	196	198	PF00675	0.341
CLV_NRD_NRD_1	256	258	PF00675	0.459
CLV_NRD_NRD_1	3	5	PF00675	0.567
CLV_NRD_NRD_1	333	335	PF00675	0.544
CLV_NRD_NRD_1	344	346	PF00675	0.442
CLV_NRD_NRD_1	410	412	PF00675	0.369
CLV_NRD_NRD_1	580	582	PF00675	0.417
CLV_PCSK_KEX2_1	141	143	PF00082	0.445
CLV_PCSK_KEX2_1	196	198	PF00082	0.357
CLV_PCSK_KEX2_1	256	258	PF00082	0.459
CLV_PCSK_KEX2_1	3	5	PF00082	0.530
CLV_PCSK_KEX2_1	333	335	PF00082	0.608
CLV_PCSK_KEX2_1	409	411	PF00082	0.390
CLV_PCSK_KEX2_1	580	582	PF00082	0.463
CLV_PCSK_PC7_1	137	143	PF00082	0.453
CLV_PCSK_PC7_1	405	411	PF00082	0.365
CLV_PCSK_SKI1_1	196	200	PF00082	0.474
CLV_PCSK_SKI1_1	256	260	PF00082	0.317
CLV_PCSK_SKI1_1	569	573	PF00082	0.369
CLV_Separin_Metazoa	462	466	PF03568	0.474
DEG_APCC_DBOX_1	195	203	PF00400	0.467
DEG_APCC_DBOX_1	464	472	PF00400	0.403
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SPOP_SBC_1	168	172	PF00917	0.624
DEG_SPOP_SBC_1	175	179	PF00917	0.572
DEG_SPOP_SBC_1	309	313	PF00917	0.474
DEG_SPOP_SBC_1	472	476	PF00917	0.615
DOC_CYCLIN_RxL_1	253	261	PF00134	0.363
DOC_MAPK_MEF2A_6	182	189	PF00069	0.418
DOC_MAPK_MEF2A_6	581	590	PF00069	0.379
DOC_USP7_MATH_1	108	112	PF00917	0.710
DOC_USP7_MATH_1	169	173	PF00917	0.765
DOC_USP7_MATH_1	175	179	PF00917	0.705
DOC_USP7_MATH_1	228	232	PF00917	0.417
DOC_USP7_MATH_1	305	309	PF00917	0.595
DOC_USP7_MATH_1	336	340	PF00917	0.476
DOC_USP7_MATH_1	414	418	PF00917	0.487
DOC_USP7_MATH_1	472	476	PF00917	0.511
DOC_USP7_UBL2_3	346	350	PF12436	0.420
DOC_USP7_UBL2_3	639	643	PF12436	0.432
DOC_WW_Pin1_4	120	125	PF00397	0.738
DOC_WW_Pin1_4	176	181	PF00397	0.642
DOC_WW_Pin1_4	312	317	PF00397	0.456
DOC_WW_Pin1_4	475	480	PF00397	0.636
DOC_WW_Pin1_4	55	60	PF00397	0.526
DOC_WW_Pin1_4	582	587	PF00397	0.474
DOC_WW_Pin1_4	90	95	PF00397	0.497
LIG_14-3-3_CanoR_1	334	342	PF00244	0.483
LIG_14-3-3_CanoR_1	485	495	PF00244	0.515
LIG_14-3-3_CanoR_1	589	595	PF00244	0.490
LIG_14-3-3_CanoR_1	604	610	PF00244	0.580
LIG_14-3-3_CanoR_1	629	635	PF00244	0.449
LIG_14-3-3_CterR_2	652	655	PF00244	0.516
LIG_APCC_ABBA_1	272	277	PF00400	0.396
LIG_BRCT_BRCA1_1	440	444	PF00533	0.375
LIG_BRCT_BRCA1_1	546	550	PF00533	0.376
LIG_BRCT_BRCA1_1	76	80	PF00533	0.376
LIG_Clathr_ClatBox_1	374	378	PF01394	0.360
LIG_EH_1	521	525	PF12763	0.308
LIG_FHA_1	232	238	PF00498	0.420
LIG_FHA_1	320	326	PF00498	0.531
LIG_FHA_1	410	416	PF00498	0.502
LIG_FHA_1	503	509	PF00498	0.469
LIG_FHA_1	85	91	PF00498	0.390
LIG_FHA_2	606	612	PF00498	0.584
LIG_FHA_2	630	636	PF00498	0.462
LIG_FHA_2	86	92	PF00498	0.362
LIG_LIR_Apic_2	47	51	PF02991	0.674
LIG_LIR_Gen_1	184	194	PF02991	0.407
LIG_LIR_Gen_1	357	364	PF02991	0.336
LIG_LIR_Gen_1	441	451	PF02991	0.294
LIG_LIR_Gen_1	500	511	PF02991	0.351
LIG_LIR_Gen_1	585	594	PF02991	0.469
LIG_LIR_Nem_3	181	186	PF02991	0.447
LIG_LIR_Nem_3	188	194	PF02991	0.388
LIG_LIR_Nem_3	357	361	PF02991	0.346
LIG_LIR_Nem_3	432	438	PF02991	0.432
LIG_LIR_Nem_3	47	52	PF02991	0.531
LIG_LIR_Nem_3	500	506	PF02991	0.365
LIG_LIR_Nem_3	585	590	PF02991	0.482
LIG_LIR_Nem_3	593	597	PF02991	0.502
LIG_LIR_Nem_3	628	634	PF02991	0.522
LIG_LYPXL_yS_3	494	497	PF13949	0.389
LIG_NRBOX	254	260	PF00104	0.358
LIG_Pex14_1	347	351	PF04695	0.403
LIG_Pex14_1	606	610	PF04695	0.563
LIG_PTB_Apo_2	36	43	PF02174	0.517
LIG_PTB_Phospho_1	36	42	PF10480	0.519
LIG_SH2_CRK	136	140	PF00017	0.536
LIG_SH2_CRK	191	195	PF00017	0.439
LIG_SH2_CRK	358	362	PF00017	0.316
LIG_SH2_CRK	503	507	PF00017	0.467
LIG_SH2_CRK	551	555	PF00017	0.350
LIG_SH2_CRK	6	10	PF00017	0.667
LIG_SH2_GRB2like	557	560	PF00017	0.385
LIG_SH2_NCK_1	191	195	PF00017	0.433
LIG_SH2_NCK_1	503	507	PF00017	0.467
LIG_SH2_SRC	276	279	PF00017	0.371
LIG_SH2_SRC	634	637	PF00017	0.440
LIG_SH2_STAP1	276	280	PF00017	0.439
LIG_SH2_STAP1	351	355	PF00017	0.376
LIG_SH2_STAP1	358	362	PF00017	0.292
LIG_SH2_STAP1	546	550	PF00017	0.393
LIG_SH2_STAP1	618	622	PF00017	0.403
LIG_SH2_STAT3	42	45	PF00017	0.582
LIG_SH2_STAT3	421	424	PF00017	0.488
LIG_SH2_STAT3	449	452	PF00017	0.461
LIG_SH2_STAT3	498	501	PF00017	0.476
LIG_SH2_STAT5	15	18	PF00017	0.524
LIG_SH2_STAT5	33	36	PF00017	0.540
LIG_SH2_STAT5	467	470	PF00017	0.408
LIG_SH2_STAT5	498	501	PF00017	0.421
LIG_SH2_STAT5	631	634	PF00017	0.482
LIG_SH3_3	121	127	PF00018	0.735
LIG_SH3_3	288	294	PF00018	0.362
LIG_SH3_3	326	332	PF00018	0.402
LIG_SH3_3	445	451	PF00018	0.334
LIG_SH3_3	503	509	PF00018	0.374
LIG_SH3_3	597	603	PF00018	0.465
LIG_SUMO_SIM_par_1	373	378	PF11976	0.364
LIG_TRAF2_1	316	319	PF00917	0.486
LIG_TYR_ITIM	189	194	PF00017	0.441
LIG_TYR_ITIM	274	279	PF00017	0.445
LIG_TYR_ITIM	356	361	PF00017	0.326
LIG_WRC_WIRS_1	484	489	PF05994	0.439
MOD_CDC14_SPxK_1	179	182	PF00782	0.514
MOD_CDC14_SPxK_1	58	61	PF00782	0.473
MOD_CDK_SPxK_1	176	182	PF00069	0.553
MOD_CDK_SPxK_1	55	61	PF00069	0.504
MOD_CDK_SPxxK_3	582	589	PF00069	0.483
MOD_CK1_1	111	117	PF00069	0.612
MOD_CK1_1	125	131	PF00069	0.680
MOD_CK1_1	149	155	PF00069	0.768
MOD_CK1_1	156	162	PF00069	0.557
MOD_CK1_1	178	184	PF00069	0.572
MOD_CK1_1	231	237	PF00069	0.428
MOD_CK1_1	266	272	PF00069	0.448
MOD_CK1_1	308	314	PF00069	0.636
MOD_CK1_1	417	423	PF00069	0.505
MOD_CK1_1	473	479	PF00069	0.573
MOD_CK1_1	486	492	PF00069	0.372
MOD_CK2_1	312	318	PF00069	0.529
MOD_CK2_1	605	611	PF00069	0.531
MOD_CK2_1	85	91	PF00069	0.337
MOD_GlcNHglycan	112	116	PF01048	0.722
MOD_GlcNHglycan	155	158	PF01048	0.611
MOD_GlcNHglycan	17	21	PF01048	0.558
MOD_GlcNHglycan	171	174	PF01048	0.675
MOD_GlcNHglycan	268	271	PF01048	0.494
MOD_GlcNHglycan	342	345	PF01048	0.484
MOD_GlcNHglycan	362	365	PF01048	0.361
MOD_GlcNHglycan	416	419	PF01048	0.522
MOD_GlcNHglycan	509	512	PF01048	0.310
MOD_GlcNHglycan	563	566	PF01048	0.426
MOD_GlcNHglycan	66	69	PF01048	0.348
MOD_GlcNHglycan	76	79	PF01048	0.356
MOD_GSK3_1	118	125	PF00069	0.738
MOD_GSK3_1	146	153	PF00069	0.687
MOD_GSK3_1	174	181	PF00069	0.653
MOD_GSK3_1	231	238	PF00069	0.453
MOD_GSK3_1	304	311	PF00069	0.660
MOD_GSK3_1	336	343	PF00069	0.494
MOD_GSK3_1	392	399	PF00069	0.330
MOD_GSK3_1	409	416	PF00069	0.507
MOD_GSK3_1	438	445	PF00069	0.421
MOD_GSK3_1	470	477	PF00069	0.454
MOD_GSK3_1	625	632	PF00069	0.567
MOD_GSK3_1	9	16	PF00069	0.521
MOD_LATS_1	408	414	PF00433	0.436
MOD_N-GLC_1	296	301	PF02516	0.312
MOD_N-GLC_2	599	601	PF02516	0.461
MOD_NEK2_1	174	179	PF00069	0.622
MOD_NEK2_1	340	345	PF00069	0.429
MOD_NEK2_1	471	476	PF00069	0.536
MOD_NEK2_1	502	507	PF00069	0.395
MOD_NEK2_1	590	595	PF00069	0.400
MOD_NEK2_1	625	630	PF00069	0.575
MOD_NEK2_1	74	79	PF00069	0.457
MOD_NEK2_1	8	13	PF00069	0.547
MOD_NEK2_2	605	610	PF00069	0.573
MOD_PKA_1	409	415	PF00069	0.511
MOD_PKA_2	13	19	PF00069	0.532
MOD_PKA_2	409	415	PF00069	0.456
MOD_PKA_2	560	566	PF00069	0.497
MOD_Plk_1	118	124	PF00069	0.730
MOD_Plk_1	295	301	PF00069	0.402
MOD_Plk_1	305	311	PF00069	0.446
MOD_Plk_4	228	234	PF00069	0.417
MOD_Plk_4	493	499	PF00069	0.361
MOD_Plk_4	605	611	PF00069	0.579
MOD_Plk_4	85	91	PF00069	0.337
MOD_ProDKin_1	120	126	PF00069	0.734
MOD_ProDKin_1	176	182	PF00069	0.622
MOD_ProDKin_1	312	318	PF00069	0.446
MOD_ProDKin_1	475	481	PF00069	0.625
MOD_ProDKin_1	55	61	PF00069	0.515
MOD_ProDKin_1	582	588	PF00069	0.474
MOD_ProDKin_1	90	96	PF00069	0.499
MOD_SUMO_rev_2	343	352	PF00179	0.443
TRG_DiLeu_BaEn_2	482	488	PF01217	0.421
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.397
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.575
TRG_ENDOCYTIC_2	183	186	PF00928	0.410
TRG_ENDOCYTIC_2	191	194	PF00928	0.436
TRG_ENDOCYTIC_2	276	279	PF00928	0.446
TRG_ENDOCYTIC_2	358	361	PF00928	0.321
TRG_ENDOCYTIC_2	494	497	PF00928	0.368
TRG_ENDOCYTIC_2	503	506	PF00928	0.350
TRG_ENDOCYTIC_2	551	554	PF00928	0.344
TRG_ENDOCYTIC_2	594	597	PF00928	0.428
TRG_ENDOCYTIC_2	6	9	PF00928	0.669
TRG_ER_diArg_1	140	142	PF00400	0.439
TRG_ER_diArg_1	2	4	PF00400	0.577
TRG_ER_diArg_1	255	257	PF00400	0.448
TRG_ER_diArg_1	332	334	PF00400	0.633
TRG_ER_diArg_1	409	411	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTW3	Leptomonas seymouri	73%	100%
A0A0S4JRA1	Bodo saltans	47%	100%
A0A1X0NTX5	Trypanosomatidae	49%	100%
A4HWG9	Leishmania infantum	100%	100%
C9ZXY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQ70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QFB3	Leishmania major	96%	100%
V5DL32	Trypanosoma cruzi	54%	100%