Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H6U8_LEIDO

TriTrypDb:

LdBPK_150680.1 , LdCL_150011900 , LDHU3_15.0860

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.728
CLV_C14_Caspase3-7	213	217	PF00656	0.673
CLV_C14_Caspase3-7	278	282	PF00656	0.621
CLV_C14_Caspase3-7	379	383	PF00656	0.610
CLV_C14_Caspase3-7	617	621	PF00656	0.749
CLV_NRD_NRD_1	513	515	PF00675	0.732
CLV_PCSK_FUR_1	511	515	PF00082	0.728
CLV_PCSK_KEX2_1	208	210	PF00082	0.731
CLV_PCSK_KEX2_1	513	515	PF00082	0.673
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.731
CLV_PCSK_SKI1_1	412	416	PF00082	0.717
CLV_PCSK_SKI1_1	58	62	PF00082	0.687
DEG_SCF_FBW7_1	21	28	PF00400	0.838
DEG_SPOP_SBC_1	301	305	PF00917	0.713
DEG_SPOP_SBC_1	353	357	PF00917	0.751
DEG_SPOP_SBC_1	558	562	PF00917	0.732
DOC_ANK_TNKS_1	269	276	PF00023	0.723
DOC_CKS1_1	140	145	PF01111	0.621
DOC_CKS1_1	22	27	PF01111	0.852
DOC_CKS1_1	343	348	PF01111	0.702
DOC_CYCLIN_RxL_1	55	64	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	400	403	PF00134	0.588
DOC_PP1_RVXF_1	56	62	PF00149	0.709
DOC_PP2B_LxvP_1	246	249	PF13499	0.716
DOC_PP2B_LxvP_1	400	403	PF13499	0.588
DOC_PP2B_LxvP_1	414	417	PF13499	0.624
DOC_PP4_MxPP_1	247	250	PF00568	0.795
DOC_PP4_MxPP_1	298	301	PF00568	0.813
DOC_USP7_MATH_1	118	122	PF00917	0.771
DOC_USP7_MATH_1	195	199	PF00917	0.840
DOC_USP7_MATH_1	229	233	PF00917	0.720
DOC_USP7_MATH_1	301	305	PF00917	0.713
DOC_USP7_MATH_1	310	314	PF00917	0.714
DOC_USP7_MATH_1	319	323	PF00917	0.717
DOC_USP7_MATH_1	388	392	PF00917	0.710
DOC_USP7_MATH_1	614	618	PF00917	0.839
DOC_USP7_MATH_1	681	685	PF00917	0.665
DOC_WW_Pin1_4	139	144	PF00397	0.823
DOC_WW_Pin1_4	163	168	PF00397	0.772
DOC_WW_Pin1_4	17	22	PF00397	0.816
DOC_WW_Pin1_4	183	188	PF00397	0.793
DOC_WW_Pin1_4	198	203	PF00397	0.729
DOC_WW_Pin1_4	222	227	PF00397	0.710
DOC_WW_Pin1_4	25	30	PF00397	0.722
DOC_WW_Pin1_4	250	255	PF00397	0.709
DOC_WW_Pin1_4	257	262	PF00397	0.740
DOC_WW_Pin1_4	288	293	PF00397	0.693
DOC_WW_Pin1_4	296	301	PF00397	0.727
DOC_WW_Pin1_4	326	331	PF00397	0.812
DOC_WW_Pin1_4	342	347	PF00397	0.640
DOC_WW_Pin1_4	354	359	PF00397	0.649
DOC_WW_Pin1_4	45	50	PF00397	0.837
DOC_WW_Pin1_4	53	58	PF00397	0.772
DOC_WW_Pin1_4	69	74	PF00397	0.760
LIG_14-3-3_CanoR_1	16	20	PF00244	0.840
LIG_14-3-3_CanoR_1	302	311	PF00244	0.719
LIG_14-3-3_CanoR_1	412	417	PF00244	0.712
LIG_14-3-3_CanoR_1	426	431	PF00244	0.437
LIG_14-3-3_CanoR_1	58	64	PF00244	0.709
LIG_14-3-3_CanoR_1	67	73	PF00244	0.716
LIG_APCC_ABBA_1	645	650	PF00400	0.766
LIG_BIR_II_1	1	5	PF00653	0.735
LIG_BRCT_BRCA1_1	436	440	PF00533	0.586
LIG_BRCT_BRCA1_1	641	645	PF00533	0.669
LIG_BRCT_BRCA1_1	650	654	PF00533	0.576
LIG_CtBP_PxDLS_1	249	253	PF00389	0.723
LIG_deltaCOP1_diTrp_1	650	654	PF00928	0.787
LIG_EVH1_1	401	405	PF00568	0.569
LIG_FHA_1	106	112	PF00498	0.831
LIG_FHA_1	171	177	PF00498	0.766
LIG_FHA_1	343	349	PF00498	0.801
LIG_FHA_1	45	51	PF00498	0.845
LIG_FHA_1	486	492	PF00498	0.638
LIG_FHA_1	54	60	PF00498	0.635
LIG_FHA_1	74	80	PF00498	0.510
LIG_FHA_2	114	120	PF00498	0.760
LIG_FHA_2	463	469	PF00498	0.677
LIG_FHA_2	473	479	PF00498	0.410
LIG_IBAR_NPY_1	341	343	PF08397	0.682
LIG_IBAR_NPY_1	646	648	PF08397	0.664
LIG_IRF3_LxIS_1	148	153	PF10401	0.813
LIG_LIR_Gen_1	437	448	PF02991	0.707
LIG_LIR_Gen_1	478	486	PF02991	0.583
LIG_LIR_Nem_3	313	317	PF02991	0.642
LIG_LIR_Nem_3	437	443	PF02991	0.599
LIG_LIR_Nem_3	478	483	PF02991	0.560
LIG_LIR_Nem_3	62	66	PF02991	0.704
LIG_LIR_Nem_3	642	648	PF02991	0.671
LIG_PAM2_1	643	655	PF00658	0.675
LIG_PROFILIN_1	402	408	PF00235	0.684
LIG_SH2_CRK	314	318	PF00017	0.704
LIG_SH2_CRK	343	347	PF00017	0.799
LIG_SH2_CRK	66	70	PF00017	0.716
LIG_SH2_SRC	648	651	PF00017	0.683
LIG_SH2_STAP1	473	477	PF00017	0.658
LIG_SH2_STAP1	610	614	PF00017	0.820
LIG_SH2_STAP1	648	652	PF00017	0.671
LIG_SH2_STAT3	529	532	PF00017	0.818
LIG_SH2_STAT5	220	223	PF00017	0.696
LIG_SH2_STAT5	430	433	PF00017	0.637
LIG_SH2_STAT5	677	680	PF00017	0.718
LIG_SH3_1	399	405	PF00018	0.583
LIG_SH3_3	137	143	PF00018	0.689
LIG_SH3_3	199	205	PF00018	0.728
LIG_SH3_3	255	261	PF00018	0.739
LIG_SH3_3	327	333	PF00018	0.812
LIG_SH3_3	399	405	PF00018	0.583
LIG_SH3_3	444	450	PF00018	0.578
LIG_SH3_3	81	87	PF00018	0.674
LIG_SUMO_SIM_par_1	148	153	PF11976	0.711
LIG_SUMO_SIM_par_1	172	177	PF11976	0.688
LIG_TRAF2_1	465	468	PF00917	0.613
LIG_TRAF2_1	87	90	PF00917	0.790
LIG_WW_2	405	408	PF00397	0.685
LIG_WW_3	299	303	PF00397	0.709
MOD_CDC14_SPxK_1	299	302	PF00782	0.709
MOD_CDK_SPK_2	53	58	PF00069	0.691
MOD_CDK_SPxK_1	296	302	PF00069	0.718
MOD_CK1_1	106	112	PF00069	0.729
MOD_CK1_1	139	145	PF00069	0.770
MOD_CK1_1	170	176	PF00069	0.823
MOD_CK1_1	186	192	PF00069	0.754
MOD_CK1_1	197	203	PF00069	0.816
MOD_CK1_1	2	8	PF00069	0.726
MOD_CK1_1	227	233	PF00069	0.699
MOD_CK1_1	253	259	PF00069	0.703
MOD_CK1_1	303	309	PF00069	0.731
MOD_CK1_1	324	330	PF00069	0.729
MOD_CK1_1	357	363	PF00069	0.637
MOD_CK1_1	391	397	PF00069	0.685
MOD_CK1_1	452	458	PF00069	0.723
MOD_CK1_1	461	467	PF00069	0.744
MOD_CK1_1	509	515	PF00069	0.798
MOD_CK1_1	517	523	PF00069	0.711
MOD_CK1_1	53	59	PF00069	0.665
MOD_CK1_1	608	614	PF00069	0.745
MOD_CK1_1	655	661	PF00069	0.714
MOD_CK1_1	675	681	PF00069	0.640
MOD_CK1_1	77	83	PF00069	0.743
MOD_CK2_1	113	119	PF00069	0.825
MOD_CK2_1	461	467	PF00069	0.621
MOD_GlcNHglycan	1	4	PF01048	0.662
MOD_GlcNHglycan	119	123	PF01048	0.793
MOD_GlcNHglycan	125	128	PF01048	0.798
MOD_GlcNHglycan	152	155	PF01048	0.727
MOD_GlcNHglycan	169	172	PF01048	0.608
MOD_GlcNHglycan	202	205	PF01048	0.775
MOD_GlcNHglycan	212	215	PF01048	0.720
MOD_GlcNHglycan	231	234	PF01048	0.724
MOD_GlcNHglycan	326	329	PF01048	0.820
MOD_GlcNHglycan	334	337	PF01048	0.500
MOD_GlcNHglycan	392	396	PF01048	0.681
MOD_GlcNHglycan	508	511	PF01048	0.702
MOD_GlcNHglycan	52	55	PF01048	0.663
MOD_GlcNHglycan	520	523	PF01048	0.740
MOD_GlcNHglycan	537	540	PF01048	0.732
MOD_GlcNHglycan	603	606	PF01048	0.729
MOD_GlcNHglycan	607	610	PF01048	0.567
MOD_GlcNHglycan	616	619	PF01048	0.836
MOD_GlcNHglycan	654	657	PF01048	0.698
MOD_GlcNHglycan	76	79	PF01048	0.818
MOD_GSK3_1	103	110	PF00069	0.731
MOD_GSK3_1	113	120	PF00069	0.738
MOD_GSK3_1	125	132	PF00069	0.688
MOD_GSK3_1	135	142	PF00069	0.726
MOD_GSK3_1	163	170	PF00069	0.794
MOD_GSK3_1	17	24	PF00069	0.803
MOD_GSK3_1	194	201	PF00069	0.736
MOD_GSK3_1	25	32	PF00069	0.725
MOD_GSK3_1	250	257	PF00069	0.724
MOD_GSK3_1	279	286	PF00069	0.727
MOD_GSK3_1	296	303	PF00069	0.727
MOD_GSK3_1	349	356	PF00069	0.720
MOD_GSK3_1	450	457	PF00069	0.654
MOD_GSK3_1	458	465	PF00069	0.601
MOD_GSK3_1	514	521	PF00069	0.725
MOD_GSK3_1	601	608	PF00069	0.697
MOD_GSK3_1	648	655	PF00069	0.623
MOD_GSK3_1	69	76	PF00069	0.722
MOD_N-GLC_1	111	116	PF02516	0.734
MOD_N-GLC_1	25	30	PF02516	0.765
MOD_N-GLC_1	250	255	PF02516	0.730
MOD_N-GLC_1	284	289	PF02516	0.838
MOD_N-GLC_1	461	466	PF02516	0.644
MOD_N-GLC_1	518	523	PF02516	0.736
MOD_N-GLC_1	67	72	PF02516	0.819
MOD_N-GLC_1	74	79	PF02516	0.723
MOD_NEK2_1	1	6	PF00069	0.835
MOD_NEK2_1	150	155	PF00069	0.713
MOD_NEK2_1	169	174	PF00069	0.740
MOD_NEK2_1	349	354	PF00069	0.716
MOD_NEK2_1	535	540	PF00069	0.605
MOD_NEK2_1	654	659	PF00069	0.807
MOD_NEK2_1	673	678	PF00069	0.725
MOD_PIKK_1	174	180	PF00454	0.804
MOD_PIKK_1	264	270	PF00454	0.835
MOD_PIKK_1	29	35	PF00454	0.759
MOD_PIKK_1	357	363	PF00454	0.637
MOD_PIKK_1	514	520	PF00454	0.843
MOD_PIKK_1	681	687	PF00454	0.811
MOD_PIKK_1	8	14	PF00454	0.824
MOD_PK_1	344	350	PF00069	0.707
MOD_PKA_1	208	214	PF00069	0.676
MOD_PKA_2	128	134	PF00069	0.831
MOD_PKA_2	15	21	PF00069	0.833
MOD_PKA_2	208	214	PF00069	0.676
MOD_PKA_2	301	307	PF00069	0.810
MOD_PKA_2	601	607	PF00069	0.812
MOD_PKA_2	681	687	PF00069	0.698
MOD_Plk_1	74	80	PF00069	0.724
MOD_Plk_4	321	327	PF00069	0.704
MOD_Plk_4	344	350	PF00069	0.678
MOD_Plk_4	426	432	PF00069	0.516
MOD_ProDKin_1	139	145	PF00069	0.821
MOD_ProDKin_1	163	169	PF00069	0.775
MOD_ProDKin_1	17	23	PF00069	0.816
MOD_ProDKin_1	183	189	PF00069	0.794
MOD_ProDKin_1	198	204	PF00069	0.727
MOD_ProDKin_1	222	228	PF00069	0.707
MOD_ProDKin_1	25	31	PF00069	0.724
MOD_ProDKin_1	250	256	PF00069	0.710
MOD_ProDKin_1	257	263	PF00069	0.741
MOD_ProDKin_1	288	294	PF00069	0.694
MOD_ProDKin_1	296	302	PF00069	0.730
MOD_ProDKin_1	326	332	PF00069	0.810
MOD_ProDKin_1	342	348	PF00069	0.641
MOD_ProDKin_1	354	360	PF00069	0.650
MOD_ProDKin_1	45	51	PF00069	0.837
MOD_ProDKin_1	53	59	PF00069	0.770
MOD_ProDKin_1	69	75	PF00069	0.763
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.584
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.710
TRG_ENDOCYTIC_2	314	317	PF00928	0.710
TRG_ENDOCYTIC_2	66	69	PF00928	0.712
TRG_ENDOCYTIC_2	694	697	PF00928	0.712
TRG_ER_diArg_1	511	514	PF00400	0.725
TRG_ER_diArg_1	540	543	PF00400	0.797

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J0	Leptomonas seymouri	40%	97%
A4HWG3	Leishmania infantum	100%	100%
E9AI50	Leishmania braziliensis	78%	99%
E9AQ63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFC0	Leishmania major	90%	97%