Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6U3_LEIDO

TriTrypDb:

LdBPK_150480.1 , LdCL_150009700 , LDHU3_15.0580

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.651
CLV_PCSK_SKI1_1	33	37	PF00082	0.581
DEG_Nend_UBRbox_3	1	3	PF02207	0.629
DEG_SCF_TRCP1_1	16	22	PF00400	0.559
DEG_SPOP_SBC_1	105	109	PF00917	0.683
DOC_USP7_MATH_1	105	109	PF00917	0.700
DOC_USP7_MATH_1	111	115	PF00917	0.682
DOC_USP7_MATH_1	194	198	PF00917	0.698
DOC_USP7_MATH_1	258	262	PF00917	0.709
DOC_USP7_MATH_1	293	297	PF00917	0.622
DOC_USP7_UBL2_3	49	53	PF12436	0.693
DOC_WW_Pin1_4	114	119	PF00397	0.654
DOC_WW_Pin1_4	206	211	PF00397	0.738
DOC_WW_Pin1_4	279	284	PF00397	0.708
LIG_14-3-3_CanoR_1	136	144	PF00244	0.752
LIG_14-3-3_CanoR_1	177	181	PF00244	0.648
LIG_14-3-3_CanoR_1	244	249	PF00244	0.647
LIG_eIF4E_1	4	10	PF01652	0.584
LIG_FHA_1	105	111	PF00498	0.803
LIG_FHA_1	130	136	PF00498	0.695
LIG_FHA_1	212	218	PF00498	0.819
LIG_FHA_1	284	290	PF00498	0.773
LIG_FHA_1	338	344	PF00498	0.615
LIG_FHA_1	55	61	PF00498	0.828
LIG_FHA_2	227	233	PF00498	0.647
LIG_FHA_2	297	303	PF00498	0.701
LIG_FHA_2	313	319	PF00498	0.584
LIG_LIR_Gen_1	92	101	PF02991	0.646
LIG_LIR_Nem_3	117	122	PF02991	0.659
LIG_LIR_Nem_3	30	35	PF02991	0.584
LIG_LIR_Nem_3	92	96	PF02991	0.709
LIG_SH2_STAP1	106	110	PF00017	0.640
LIG_SH2_STAT5	106	109	PF00017	0.710
LIG_SH2_STAT5	4	7	PF00017	0.648
LIG_SH3_1	183	189	PF00018	0.788
LIG_SH3_3	183	189	PF00018	0.734
LIG_SH3_3	95	101	PF00018	0.707
LIG_SUMO_SIM_anti_2	107	115	PF11976	0.722
MOD_CDC14_SPxK_1	282	285	PF00782	0.745
MOD_CDK_SPxK_1	279	285	PF00069	0.799
MOD_CK1_1	114	120	PF00069	0.717
MOD_CK1_1	179	185	PF00069	0.580
MOD_CK1_1	187	193	PF00069	0.617
MOD_CK1_1	206	212	PF00069	0.627
MOD_CK1_1	247	253	PF00069	0.585
MOD_CK1_1	296	302	PF00069	0.551
MOD_CK2_1	296	302	PF00069	0.602
MOD_CK2_1	312	318	PF00069	0.579
MOD_CK2_1	96	102	PF00069	0.698
MOD_GlcNHglycan	139	142	PF01048	0.737
MOD_GlcNHglycan	16	19	PF01048	0.630
MOD_GlcNHglycan	166	169	PF01048	0.818
MOD_GlcNHglycan	196	199	PF01048	0.720
MOD_GlcNHglycan	205	208	PF01048	0.698
MOD_GlcNHglycan	252	255	PF01048	0.821
MOD_GlcNHglycan	295	298	PF01048	0.644
MOD_GlcNHglycan	64	67	PF01048	0.773
MOD_GlcNHglycan	85	88	PF01048	0.738
MOD_GlcNHglycan	93	96	PF01048	0.611
MOD_GSK3_1	101	108	PF00069	0.657
MOD_GSK3_1	14	21	PF00069	0.775
MOD_GSK3_1	154	161	PF00069	0.730
MOD_GSK3_1	209	216	PF00069	0.803
MOD_GSK3_1	244	251	PF00069	0.743
MOD_GSK3_1	279	286	PF00069	0.716
MOD_GSK3_1	337	344	PF00069	0.615
MOD_GSK3_1	54	61	PF00069	0.714
MOD_N-GLC_1	164	169	PF02516	0.720
MOD_N-GLC_1	217	222	PF02516	0.816
MOD_N-GLC_1	244	249	PF02516	0.731
MOD_N-GLC_1	89	94	PF02516	0.793
MOD_N-GLC_2	169	171	PF02516	0.708
MOD_NEK2_1	122	127	PF00069	0.667
MOD_NEK2_1	176	181	PF00069	0.600
MOD_NEK2_1	213	218	PF00069	0.782
MOD_NEK2_1	246	251	PF00069	0.695
MOD_NEK2_1	312	317	PF00069	0.524
MOD_NEK2_1	336	341	PF00069	0.585
MOD_NEK2_1	9	14	PF00069	0.697
MOD_PIKK_1	258	264	PF00454	0.709
MOD_PKA_2	176	182	PF00069	0.645
MOD_Plk_1	101	107	PF00069	0.673
MOD_Plk_1	244	250	PF00069	0.705
MOD_Plk_1	317	323	PF00069	0.742
MOD_Plk_1	89	95	PF00069	0.688
MOD_Plk_4	220	226	PF00069	0.701
MOD_ProDKin_1	114	120	PF00069	0.654
MOD_ProDKin_1	206	212	PF00069	0.738
MOD_ProDKin_1	279	285	PF00069	0.710
MOD_SUMO_for_1	52	55	PF00179	0.729
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.600
TRG_ENDOCYTIC_2	119	122	PF00928	0.597
TRG_ENDOCYTIC_2	32	35	PF00928	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU81	Leptomonas seymouri	49%	100%
A4H815	Leishmania braziliensis	69%	92%
A4HWE5	Leishmania infantum	99%	100%
E9AQ45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QFD7	Leishmania major	92%	100%