LeishMANIAdb
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Alpha/beta hydrolase fold/Alpha/beta hydrolase family/Carboxylesterase family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Alpha/beta hydrolase fold/Alpha/beta hydrolase family/Carboxylesterase family, putative
Gene product:
alpha/beta hydrolase fold, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H6U1_LEIDO
TriTrypDb:
LdBPK_150380.1 * , LdCL_150008700 , LDHU3_15.0480
Length:
1019

Annotations

LeishMANIAdb annotations

A hydrolase similar to plant isoprenylcysteine alpha-carbonyl methylesterase (ICME). These might have a very special topology, with 2TMs on the N-terminus.. The family has 2 paralogs in Leishmaniids.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5
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Expansion

Sequence features

A0A3S5H6U1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6U1

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 6
GO:0016787 hydrolase activity 2 6
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 141 145 PF00656 0.683
CLV_C14_Caspase3-7 575 579 PF00656 0.332
CLV_C14_Caspase3-7 818 822 PF00656 0.445
CLV_C14_Caspase3-7 963 967 PF00656 0.514
CLV_MEL_PAP_1 60 66 PF00089 0.408
CLV_NRD_NRD_1 124 126 PF00675 0.533
CLV_NRD_NRD_1 216 218 PF00675 0.566
CLV_NRD_NRD_1 272 274 PF00675 0.478
CLV_NRD_NRD_1 300 302 PF00675 0.525
CLV_NRD_NRD_1 331 333 PF00675 0.567
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Homologs

ProteinTaxonomySequence identityCoverage
A4H807 Leishmania braziliensis 70% 99%
A4HWD5 Leishmania infantum 99% 100%
E9AQ35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 97%
Q4QFE7 Leishmania major 92% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS