Sterol carrier protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nonspecific lipid-transfer protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6U0_LEIDO

TriTrypDb:

LdBPK_150280.1 , LdCL_150007700 , LDHU3_15.0370

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6U0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.500
CLV_NRD_NRD_1	209	211	PF00675	0.416
CLV_NRD_NRD_1	237	239	PF00675	0.521
CLV_NRD_NRD_1	323	325	PF00675	0.533
CLV_NRD_NRD_1	381	383	PF00675	0.508
CLV_PCSK_KEX2_1	126	128	PF00082	0.509
CLV_PCSK_KEX2_1	155	157	PF00082	0.424
CLV_PCSK_KEX2_1	160	162	PF00082	0.390
CLV_PCSK_KEX2_1	18	20	PF00082	0.506
CLV_PCSK_KEX2_1	185	187	PF00082	0.484
CLV_PCSK_KEX2_1	209	211	PF00082	0.392
CLV_PCSK_KEX2_1	237	239	PF00082	0.532
CLV_PCSK_KEX2_1	323	325	PF00082	0.500
CLV_PCSK_KEX2_1	381	383	PF00082	0.379
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.536
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.424
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.390
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.502
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.514
CLV_PCSK_PC7_1	156	162	PF00082	0.423
CLV_PCSK_SKI1_1	26	30	PF00082	0.326
CLV_PCSK_SKI1_1	381	385	PF00082	0.437
DEG_APCC_DBOX_1	160	168	PF00400	0.355
DEG_APCC_DBOX_1	185	193	PF00400	0.506
DEG_APCC_DBOX_1	2	10	PF00400	0.425
DEG_Nend_UBRbox_3	1	3	PF02207	0.533
DEG_SCF_FBW7_1	46	53	PF00400	0.445
DOC_CDC14_PxL_1	164	172	PF14671	0.345
DOC_CKS1_1	47	52	PF01111	0.446
DOC_CYCLIN_yCln2_LP_2	137	143	PF00134	0.321
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.495
DOC_MAPK_gen_1	18	24	PF00069	0.432
DOC_MAPK_gen_1	209	217	PF00069	0.342
DOC_MAPK_gen_1	237	244	PF00069	0.470
DOC_MAPK_JIP1_4	238	244	PF00069	0.477
DOC_MAPK_MEF2A_6	100	109	PF00069	0.515
DOC_MAPK_MEF2A_6	210	219	PF00069	0.335
DOC_MAPK_MEF2A_6	26	33	PF00069	0.424
DOC_MAPK_NFAT4_5	26	34	PF00069	0.430
DOC_PP2B_LxvP_1	251	254	PF13499	0.418
DOC_PP4_FxxP_1	348	351	PF00568	0.334
DOC_USP7_MATH_1	125	129	PF00917	0.440
DOC_USP7_MATH_1	48	52	PF00917	0.328
DOC_USP7_MATH_1	88	92	PF00917	0.444
DOC_WW_Pin1_4	131	136	PF00397	0.499
DOC_WW_Pin1_4	376	381	PF00397	0.499
DOC_WW_Pin1_4	46	51	PF00397	0.358
DOC_WW_Pin1_4	84	89	PF00397	0.451
LIG_14-3-3_CanoR_1	184	190	PF00244	0.456
LIG_BRCT_BRCA1_1	120	124	PF00533	0.449
LIG_BRCT_BRCA1_1	261	265	PF00533	0.348
LIG_BRCT_BRCA1_1	53	57	PF00533	0.388
LIG_BRCT_BRCA1_2	120	126	PF00533	0.545
LIG_FHA_1	276	282	PF00498	0.485
LIG_FHA_1	47	53	PF00498	0.446
LIG_FHA_2	254	260	PF00498	0.570
LIG_LIR_Nem_3	285	291	PF02991	0.336
LIG_Pex14_2	148	152	PF04695	0.453
LIG_Pex14_2	348	352	PF04695	0.338
LIG_REV1ctd_RIR_1	96	102	PF16727	0.397
LIG_SH2_NCK_1	358	362	PF00017	0.456
LIG_SH2_SRC	141	144	PF00017	0.290
LIG_SH2_STAP1	146	150	PF00017	0.330
LIG_SH2_STAT5	141	144	PF00017	0.458
LIG_SH2_STAT5	240	243	PF00017	0.455
LIG_SH2_STAT5	62	65	PF00017	0.403
LIG_SH3_3	129	135	PF00018	0.458
LIG_SH3_3	137	143	PF00018	0.346
LIG_SH3_3	173	179	PF00018	0.435
LIG_SH3_3	247	253	PF00018	0.432
LIG_SUMO_SIM_anti_2	395	403	PF11976	0.351
LIG_TRAF2_1	188	191	PF00917	0.506
LIG_TRAF2_1	220	223	PF00917	0.390
LIG_TRAF2_1	256	259	PF00917	0.579
MOD_CDK_SPK_2	376	381	PF00069	0.533
MOD_CDK_SPxK_1	376	382	PF00069	0.528
MOD_CK1_1	128	134	PF00069	0.448
MOD_CK1_1	172	178	PF00069	0.469
MOD_CK1_1	51	57	PF00069	0.376
MOD_CK1_1	87	93	PF00069	0.445
MOD_CK2_1	185	191	PF00069	0.445
MOD_CK2_1	253	259	PF00069	0.521
MOD_Cter_Amidation	235	238	PF01082	0.541
MOD_GlcNHglycan	171	174	PF01048	0.458
MOD_GlcNHglycan	246	250	PF01048	0.427
MOD_GlcNHglycan	392	395	PF01048	0.320
MOD_GlcNHglycan	53	56	PF01048	0.432
MOD_GSK3_1	115	122	PF00069	0.459
MOD_GSK3_1	259	266	PF00069	0.358
MOD_GSK3_1	275	282	PF00069	0.331
MOD_GSK3_1	46	53	PF00069	0.445
MOD_GSK3_1	80	87	PF00069	0.433
MOD_N-GLC_1	128	133	PF02516	0.460
MOD_NEK2_1	392	397	PF00069	0.326
MOD_NEK2_1	67	72	PF00069	0.493
MOD_PKA_1	185	191	PF00069	0.514
MOD_PKA_2	185	191	PF00069	0.514
MOD_Plk_1	128	134	PF00069	0.433
MOD_ProDKin_1	131	137	PF00069	0.493
MOD_ProDKin_1	376	382	PF00069	0.494
MOD_ProDKin_1	46	52	PF00069	0.359
MOD_ProDKin_1	84	90	PF00069	0.450
MOD_SUMO_for_1	159	162	PF00179	0.392
TRG_ENDOCYTIC_2	292	295	PF00928	0.306
TRG_ER_diArg_1	184	187	PF00400	0.494
TRG_ER_diArg_1	237	239	PF00400	0.524
TRG_ER_diArg_1	3	6	PF00400	0.435
TRG_ER_diArg_1	322	324	PF00400	0.542
TRG_ER_diArg_1	380	382	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB7	Leptomonas seymouri	79%	100%
A0A0S4JDZ8	Bodo saltans	61%	100%
A0A422NT95	Trypanosoma rangeli	59%	100%
A4H7Z7	Leishmania braziliensis	92%	100%
A4HWC5	Leishmania infantum	100%	100%
C9ZUV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
D1AB74	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)	24%	100%
E9AQ25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O26884	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O62742	Oryctolagus cuniculus	31%	74%
P07857	Bos taurus	28%	75%
P11915	Rattus norvegicus	29%	74%
P22307	Homo sapiens	28%	74%
P32020	Mus musculus	27%	74%
Q4QFF6	Leishmania major	95%	100%
Q58944	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
V5BHW0	Trypanosoma cruzi	62%	87%