Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6T8_LEIDO

TriTrypDb:

LdBPK_150210.1 , LdCL_150007000 , LDHU3_15.0290

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H6T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.550
CLV_NRD_NRD_1	254	256	PF00675	0.619
CLV_NRD_NRD_1	54	56	PF00675	0.556
CLV_NRD_NRD_1	70	72	PF00675	0.384
CLV_PCSK_KEX2_1	119	121	PF00082	0.547
CLV_PCSK_KEX2_1	54	56	PF00082	0.577
CLV_PCSK_KEX2_1	70	72	PF00082	0.368
CLV_PCSK_SKI1_1	240	244	PF00082	0.689
CLV_PCSK_SKI1_1	79	83	PF00082	0.493
DEG_SCF_FBW7_1	130	135	PF00400	0.726
DEG_SCF_FBW7_1	26	32	PF00400	0.649
DOC_CKS1_1	140	145	PF01111	0.776
DOC_CKS1_1	26	31	PF01111	0.752
DOC_MAPK_gen_1	177	185	PF00069	0.629
DOC_MAPK_gen_1	197	206	PF00069	0.258
DOC_MAPK_JIP1_4	10	16	PF00069	0.726
DOC_MAPK_MEF2A_6	179	187	PF00069	0.590
DOC_MAPK_MEF2A_6	200	208	PF00069	0.368
DOC_USP7_MATH_1	133	137	PF00917	0.617
DOC_USP7_MATH_1	33	37	PF00917	0.805
DOC_WW_Pin1_4	128	133	PF00397	0.813
DOC_WW_Pin1_4	139	144	PF00397	0.726
DOC_WW_Pin1_4	25	30	PF00397	0.781
DOC_WW_Pin1_4	46	51	PF00397	0.806
LIG_14-3-3_CanoR_1	54	60	PF00244	0.678
LIG_14-3-3_CanoR_1	79	86	PF00244	0.705
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BIR_III_1	1	5	PF00653	0.618
LIG_BIR_III_3	1	5	PF00653	0.618
LIG_EH1_1	201	209	PF00400	0.434
LIG_FHA_1	199	205	PF00498	0.369
LIG_FHA_1	273	279	PF00498	0.423
LIG_FHA_1	30	36	PF00498	0.733
LIG_FHA_2	123	129	PF00498	0.801
LIG_FHA_2	26	32	PF00498	0.775
LIG_FHA_2	41	47	PF00498	0.707
LIG_LIR_Gen_1	58	67	PF02991	0.633
LIG_LIR_Nem_3	271	276	PF02991	0.476
LIG_LIR_Nem_3	58	62	PF02991	0.597
LIG_NRBOX	182	188	PF00104	0.473
LIG_Pex14_2	219	223	PF04695	0.455
LIG_SH2_PTP2	193	196	PF00017	0.468
LIG_SH2_PTP2	210	213	PF00017	0.376
LIG_SH2_STAT5	193	196	PF00017	0.403
LIG_SH2_STAT5	210	213	PF00017	0.333
LIG_SH2_STAT5	259	262	PF00017	0.387
LIG_SH2_STAT5	66	69	PF00017	0.598
LIG_SH2_STAT5	74	77	PF00017	0.632
LIG_SH3_3	12	18	PF00018	0.788
LIG_SH3_3	137	143	PF00018	0.765
LIG_SH3_3	147	153	PF00018	0.654
LIG_SH3_3	23	29	PF00018	0.787
LIG_TRAF2_1	58	61	PF00917	0.610
LIG_TYR_ITIM	191	196	PF00017	0.462
LIG_TYR_ITIM	208	213	PF00017	0.477
LIG_UBA3_1	206	214	PF00899	0.526
LIG_UBA3_1	237	243	PF00899	0.469
LIG_WRC_WIRS_1	42	47	PF05994	0.672
MOD_CK1_1	49	55	PF00069	0.767
MOD_CK2_1	55	61	PF00069	0.609
MOD_GlcNHglycan	135	138	PF01048	0.463
MOD_GlcNHglycan	99	102	PF01048	0.440
MOD_GSK3_1	128	135	PF00069	0.790
MOD_GSK3_1	229	236	PF00069	0.530
MOD_GSK3_1	25	32	PF00069	0.801
MOD_GSK3_1	268	275	PF00069	0.421
MOD_GSK3_1	33	40	PF00069	0.781
MOD_N-GLC_1	40	45	PF02516	0.503
MOD_N-GLC_1	79	84	PF02516	0.502
MOD_NEK2_1	198	203	PF00069	0.469
MOD_NEK2_1	209	214	PF00069	0.592
MOD_NEK2_1	268	273	PF00069	0.414
MOD_PKA_2	9	15	PF00069	0.695
MOD_Plk_1	40	46	PF00069	0.678
MOD_Plk_1	82	88	PF00069	0.692
MOD_Plk_4	233	239	PF00069	0.499
MOD_Plk_4	268	274	PF00069	0.490
MOD_Plk_4	9	15	PF00069	0.680
MOD_ProDKin_1	128	134	PF00069	0.817
MOD_ProDKin_1	139	145	PF00069	0.725
MOD_ProDKin_1	25	31	PF00069	0.783
MOD_ProDKin_1	46	52	PF00069	0.804
MOD_SUMO_for_1	242	245	PF00179	0.508
TRG_ENDOCYTIC_2	193	196	PF00928	0.425
TRG_ENDOCYTIC_2	210	213	PF00928	0.351
TRG_ER_diArg_1	118	121	PF00400	0.720
TRG_ER_diArg_1	176	179	PF00400	0.633
TRG_ER_diArg_1	70	72	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS0	Leptomonas seymouri	34%	97%
A0A1X0NTM8	Trypanosomatidae	28%	100%
A4H7Z0	Leishmania braziliensis	67%	100%
A4HWB8	Leishmania infantum	98%	100%
C9ZNV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AQ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFG3	Leishmania major	86%	100%
V5AWM4	Trypanosoma cruzi	27%	100%