Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6T6_LEIDO

TriTrypDb:

LdBPK_150080.1 , LdCL_150005700 , LDHU3_15.0110

Length:

321

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6T6

PDB structure(s): 7ane_p

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.640
CLV_NRD_NRD_1	118	120	PF00675	0.419
CLV_NRD_NRD_1	133	135	PF00675	0.460
CLV_NRD_NRD_1	2	4	PF00675	0.609
CLV_NRD_NRD_1	99	101	PF00675	0.428
CLV_PCSK_KEX2_1	133	135	PF00082	0.409
CLV_PCSK_KEX2_1	144	146	PF00082	0.504
CLV_PCSK_KEX2_1	158	160	PF00082	0.354
CLV_PCSK_KEX2_1	2	4	PF00082	0.609
CLV_PCSK_KEX2_1	311	313	PF00082	0.714
CLV_PCSK_KEX2_1	35	37	PF00082	0.419
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.409
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.504
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.354
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.714
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.412
CLV_PCSK_SKI1_1	144	148	PF00082	0.390
CLV_PCSK_SKI1_1	178	182	PF00082	0.421
CLV_PCSK_SKI1_1	91	95	PF00082	0.433
DEG_APCC_DBOX_1	118	126	PF00400	0.408
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DOC_CKS1_1	194	199	PF01111	0.460
DOC_PP4_FxxP_1	45	48	PF00568	0.427
DOC_PP4_MxPP_1	57	60	PF00568	0.427
DOC_USP7_MATH_1	99	103	PF00917	0.439
DOC_USP7_UBL2_3	169	173	PF12436	0.581
DOC_WW_Pin1_4	193	198	PF00397	0.458
DOC_WW_Pin1_4	258	263	PF00397	0.700
DOC_WW_Pin1_4	296	301	PF00397	0.529
DOC_WW_Pin1_4	310	315	PF00397	0.598
LIG_14-3-3_CanoR_1	103	113	PF00244	0.419
LIG_14-3-3_CanoR_1	2	12	PF00244	0.580
LIG_APCC_ABBA_1	147	152	PF00400	0.540
LIG_deltaCOP1_diTrp_1	22	31	PF00928	0.429
LIG_deltaCOP1_diTrp_1	50	58	PF00928	0.430
LIG_FHA_1	223	229	PF00498	0.641
LIG_FHA_1	82	88	PF00498	0.529
LIG_FHA_2	21	27	PF00498	0.521
LIG_FHA_2	225	231	PF00498	0.694
LIG_FHA_2	251	257	PF00498	0.696
LIG_FHA_2	267	273	PF00498	0.476
LIG_FHA_2	78	84	PF00498	0.519
LIG_LIR_Apic_2	43	49	PF02991	0.423
LIG_LIR_Apic_2	6	12	PF02991	0.572
LIG_LIR_Gen_1	171	182	PF02991	0.440
LIG_LIR_Gen_1	29	37	PF02991	0.416
LIG_LIR_Gen_1	50	60	PF02991	0.431
LIG_LIR_Nem_3	126	132	PF02991	0.406
LIG_LIR_Nem_3	29	34	PF02991	0.560
LIG_LIR_Nem_3	50	55	PF02991	0.403
LIG_NRBOX	246	252	PF00104	0.628
LIG_Pex14_1	24	28	PF04695	0.432
LIG_Pex14_1	51	55	PF04695	0.397
LIG_SH2_CRK	9	13	PF00017	0.517
LIG_SH2_GRB2like	112	115	PF00017	0.424
LIG_SH2_PTP2	46	49	PF00017	0.409
LIG_SH2_SRC	46	49	PF00017	0.409
LIG_SH2_STAT5	174	177	PF00017	0.559
LIG_SH2_STAT5	295	298	PF00017	0.511
LIG_SH2_STAT5	46	49	PF00017	0.409
LIG_SH3_3	301	307	PF00018	0.587
LIG_UBA3_1	183	192	PF00899	0.589
MOD_CDK_SPxxK_3	310	317	PF00069	0.804
MOD_CK1_1	224	230	PF00069	0.597
MOD_CK1_1	243	249	PF00069	0.547
MOD_CK1_1	260	266	PF00069	0.410
MOD_CK1_1	77	83	PF00069	0.495
MOD_CK2_1	173	179	PF00069	0.444
MOD_CK2_1	20	26	PF00069	0.516
MOD_CK2_1	243	249	PF00069	0.599
MOD_CK2_1	266	272	PF00069	0.576
MOD_GlcNHglycan	170	173	PF01048	0.479
MOD_GlcNHglycan	242	245	PF01048	0.545
MOD_GSK3_1	217	224	PF00069	0.520
MOD_GSK3_1	258	265	PF00069	0.596
MOD_GSK3_1	266	273	PF00069	0.515
MOD_GSK3_1	289	296	PF00069	0.618
MOD_GSK3_1	77	84	PF00069	0.526
MOD_N-GLC_1	74	79	PF02516	0.507
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	257	262	PF00069	0.696
MOD_NEK2_1	286	291	PF00069	0.649
MOD_NEK2_1	40	45	PF00069	0.432
MOD_NEK2_2	266	271	PF00069	0.571
MOD_PIKK_1	185	191	PF00454	0.586
MOD_PIKK_1	77	83	PF00454	0.503
MOD_PKA_1	2	8	PF00069	0.615
MOD_PKA_2	1	7	PF00069	0.611
MOD_PKA_2	222	228	PF00069	0.622
MOD_PKA_2	99	105	PF00069	0.415
MOD_Plk_1	152	158	PF00069	0.456
MOD_Plk_1	178	184	PF00069	0.409
MOD_Plk_1	67	73	PF00069	0.495
MOD_Plk_2-3	85	91	PF00069	0.588
MOD_Plk_4	178	184	PF00069	0.410
MOD_Plk_4	198	204	PF00069	0.616
MOD_ProDKin_1	193	199	PF00069	0.459
MOD_ProDKin_1	258	264	PF00069	0.693
MOD_ProDKin_1	296	302	PF00069	0.535
MOD_ProDKin_1	310	316	PF00069	0.598
MOD_SUMO_rev_2	166	171	PF00179	0.447
TRG_DiLeu_BaEn_1	179	184	PF01217	0.576
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.539
TRG_ENDOCYTIC_2	112	115	PF00928	0.426
TRG_ENDOCYTIC_2	129	132	PF00928	0.392
TRG_ENDOCYTIC_2	151	154	PF00928	0.401
TRG_ENDOCYTIC_2	174	177	PF00928	0.559
TRG_ENDOCYTIC_2	52	55	PF00928	0.395
TRG_ER_diArg_1	1	3	PF00400	0.616
TRG_NLS_Bipartite_1	119	137	PF00514	0.377
TRG_NLS_Bipartite_1	144	161	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM8	Leptomonas seymouri	77%	100%
A0A0S4KJ11	Bodo saltans	54%	94%
A0A1X0NU97	Trypanosomatidae	65%	100%
A0A422NSE6	Trypanosoma rangeli	65%	100%
A4H7X8	Leishmania braziliensis	88%	100%
A4HWA5	Leishmania infantum	100%	100%
C9ZNU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AQ05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QFH6	Leishmania major	97%	100%
V5DCQ2	Trypanosoma cruzi	67%	100%